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Surgical management of colorectal cancer metastases to the liver: multimodality approach and a single institutional experience. 结直肠癌肝转移的外科治疗:多模式方法和单一机构经验。
IF 4.2
Colorectal Cancer Pub Date : 2013-02-01 DOI: 10.2217/crc.12.80
Aaron U Blackham, Katrina Swett, Edward A Levine, Perry Shen
{"title":"Surgical management of colorectal cancer metastases to the liver: multimodality approach and a single institutional experience.","authors":"Aaron U Blackham,&nbsp;Katrina Swett,&nbsp;Edward A Levine,&nbsp;Perry Shen","doi":"10.2217/crc.12.80","DOIUrl":"https://doi.org/10.2217/crc.12.80","url":null,"abstract":"<p><p>Over the past 30 years, the treatment of metastatic colorectal cancer to the liver has undergone major changes. Once considered terminal and incurable, the prognosis of patients with colorectal hepatic metastases has seen dramatic improvements using modern multimodality therapy and now long-term survival and even cure are possible in some patients. Despite the advances seen in systemic therapy, hepatic resection offers the longest survival potential and remains the only curative option. Based on long-term outcomes and the improved safety of hepatic resection using modern operative techniques and critical care support, an aggressive locoregional approach to colorectal hepatic metastasis has become the standard of care. This article focuses on the management of colorectal hepatic metastases and highlights the importance of multimodality therapy. We also report our 18-year experience treating patients with hepatic resection for colorectal metastases.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"2 1","pages":"73-88"},"PeriodicalIF":4.2,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc.12.80","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32574365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Challenges and strategies for identifying biomarkers for colorectal cancer. 识别结直肠癌生物标志物的挑战和策略。
IF 4.2
Colorectal Cancer Pub Date : 2013-01-01 DOI: 10.2217/crc.13.65
Bruno Conte, Scott Kopetz
{"title":"Challenges and strategies for identifying biomarkers for colorectal cancer.","authors":"Bruno Conte,&nbsp;Scott Kopetz","doi":"10.2217/crc.13.65","DOIUrl":"https://doi.org/10.2217/crc.13.65","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"2 6","pages":"487-489"},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc.13.65","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32983384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Future of targeted agents in metastatic colorectal cancer. 转移性结直肠癌靶向药物的未来。
IF 4.2
Colorectal Cancer Pub Date : 2012-10-01 DOI: 10.2217/crc.12.52
Mauricio Burotto, Marion L Hartley, John L Marshall, Michael J Pishvaian
{"title":"Future of targeted agents in metastatic colorectal cancer.","authors":"Mauricio Burotto, Marion L Hartley, John L Marshall, Michael J Pishvaian","doi":"10.2217/crc.12.52","DOIUrl":"10.2217/crc.12.52","url":null,"abstract":"<p><p>Great strides have been made in improving the outcome of patients with metastatic colorectal cancer and targeted agents are an important part of the treatment arsenal. The approved monoclonal antibodies, bevacizumab, cetuximab and panitumumab, are part of the standard of care, yet only recently have we begun to define which patients benefit from these therapies using predictive tumor biomarkers. More recently, novel agents including aflibercept and regorafenib have had promising results and may become approved therapies. In addition, agents targeting the mTOR pathway and the TNF pathway have demonstrated early evidence of benefit. In the coming years, we may experience an influx of new therapies, possibly leading to further prolongation of patient survival or even, for some, a cure.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"1 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834580/pdf/nihms503603.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31899585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concerns and challenges in flexible sigmoidoscopy screening. 软性乙状结肠镜筛查的问题与挑战。
IF 4.2
Colorectal Cancer Pub Date : 2012-08-01 DOI: 10.2217/crc.12.33
Akeem O Adebogun, Christine D Berg, Adeyinka O Laiyemo
{"title":"Concerns and challenges in flexible sigmoidoscopy screening.","authors":"Akeem O Adebogun,&nbsp;Christine D Berg,&nbsp;Adeyinka O Laiyemo","doi":"10.2217/crc.12.33","DOIUrl":"https://doi.org/10.2217/crc.12.33","url":null,"abstract":"<p><p>In 1992, two well-conducted case-control studies used data from two different health maintenance organizations and demonstrated a 59-79% reduction in mortality from colorectal cancer (CRC) following exposure to sigmoidoscopy. These studies highlight the possibility of reducing mortality from CRC using population-based endoscopic screening. The development of fiber optics improved the technology, and the ease of performing flexible sigmoidoscopy (FS) with widespread adoption of this screening modality. To date, FS is the only endoscopic screening modality that has been shown to reduce mortality in randomized clinical trials. This article reviews the development of sigmoidoscopy, its use in CRC screening and the current reduced role of this proven screening modality, and explores new frontiers for population-based FS screening.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"1 4","pages":"309-319"},"PeriodicalIF":4.2,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc.12.33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32539764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Relationship of colorectal cancer awareness and knowledge with colorectal cancer screening. 大肠癌意识和知识与大肠癌筛查的关系。
IF 4.2
Colorectal Cancer Pub Date : 2012-01-01 DOI: 10.2217/crc.12.45
Heather M Brandt, Heather R Dolinger, Patricia A Sharpe, James W Hardin, Franklin G Berger
{"title":"Relationship of colorectal cancer awareness and knowledge with colorectal cancer screening.","authors":"Heather M Brandt, Heather R Dolinger, Patricia A Sharpe, James W Hardin, Franklin G Berger","doi":"10.2217/crc.12.45","DOIUrl":"10.2217/crc.12.45","url":null,"abstract":"<p><strong>Aim: </strong>The aim was to describe the association of awareness and knowledge with participation in colorectal cancer (CRC) screening.</p><p><strong>Materials & methods: </strong>Telephone survey research was conducted with South Carolina (USA) residents aged 50-75 years using a 144-item instrument. Data were analyzed with SAS and Stata. Adjusted odds ratios are reported.</p><p><strong>Results: </strong>Respondents (n = 1302) had heard of CRC screening (96%) and exhibited high levels of CRC awareness and knowledge; only 74% had ever been screened. Higher levels of knowledge were associated with a greater likelihood of having ever been screened (odds ratio: 1.05; 95% CI: 1.02-1.41; p < 0.001).</p><p><strong>Conclusion: </strong>Results showed high levels of awareness and knowledge, but modest participation in CRC. Transforming awareness and knowledge into CRC screening participation should be a priority.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"1 5","pages":"383-396"},"PeriodicalIF":4.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529290/pdf/nihms435631.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33908936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemoprevention in patients with genetic risk of colorectal cancers. 对有大肠癌遗传风险的患者进行化学预防。
IF 4.2
Colorectal Cancer Pub Date : 2012-01-01 DOI: 10.2217/crc.12.22
Christina M Laukaitis, Steven H Erdman, Eugene W Gerner
{"title":"Chemoprevention in patients with genetic risk of colorectal cancers.","authors":"Christina M Laukaitis, Steven H Erdman, Eugene W Gerner","doi":"10.2217/crc.12.22","DOIUrl":"10.2217/crc.12.22","url":null,"abstract":"<p><p>A number of genetic syndromes are known to convey a high risk of colorectal cancer. Current standards of medical practice for these patients involve genetic testing followed by screening and surgical procedures. Pharmaceutical therapies for any of these syndromes are limited in number and are generally not approved by any regulatory body for applications in these genetic groups. This review discusses advances in mechanistic understanding of the disease processes leading to the development of promising pharmaceutical therapies. Clinical trials of potential chemotherapeutic agents must focus on the reduction of disease-related events, including cancer and cancer-related mortality, in patients with genetic syndromes.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"1 3","pages":"225-240"},"PeriodicalIF":4.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162131/pdf/nihms406010.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32667738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucosal Cellular Regeneration and Colorectal Carcinogenesis 粘膜细胞再生与结直肠癌的发生
IF 4.2
Colorectal Cancer Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-85930-4_15
Ulrich A. Simanowski, N. Wright, H. Seitz
{"title":"Mucosal Cellular Regeneration and Colorectal Carcinogenesis","authors":"Ulrich A. Simanowski, N. Wright, H. Seitz","doi":"10.1007/978-3-642-85930-4_15","DOIUrl":"https://doi.org/10.1007/978-3-642-85930-4_15","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":"1 1","pages":"225-236"},"PeriodicalIF":4.2,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51223659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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