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Immune therapy in colorectal cancer 结直肠癌的免疫治疗
IF 4.2
Colorectal Cancer Pub Date : 2017-06-21 DOI: 10.2217/CRC-2017-0002
A. Lapeyre-Prost, M. Terme, S. Pernot, E. Marcheteau, Anne-Laure Pointet, T. Voron, E. Tartour, J. Taieb
{"title":"Immune therapy in colorectal cancer","authors":"A. Lapeyre-Prost, M. Terme, S. Pernot, E. Marcheteau, Anne-Laure Pointet, T. Voron, E. Tartour, J. Taieb","doi":"10.2217/CRC-2017-0002","DOIUrl":"https://doi.org/10.2217/CRC-2017-0002","url":null,"abstract":"The evidence that the immune system, when rightly stimulated, can eradicate cancer cells, combined with the latest knowledge about antitumor immunity, has led to recent progress in cancer immunotherapy. While infiltration of tumors with immune cells is described in advanced stage colorectal cancer (CRC), the first data concerning the clinical efficacy of immune-targeted therapies in CRC patients were disappointing. The evidence of tumor responses in CRC patients with microsatellite instability treated with immune checkpoint blockers has renewed the interest for research in the field of CRC immunotherapy. In this article, we briefly review the role of T lymphocytes infiltrating CRC tumors in order to introduce a brief history of CRC immunotherapy and then current trials involving immune-based strategies and particularly immune checkpoint blockers.","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2017-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/CRC-2017-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45018124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Survival benefits in colorectal adenocarcinoma with the use of metformin among a black diabetic inner city population. 在市区黑人糖尿病患者中使用二甲双胍对结直肠癌患者的生存益处
IF 4.2
Colorectal Cancer Pub Date : 2017-01-01 Epub Date: 2017-06-21 DOI: 10.2217/crc-2017-0001
Roger C Zhu, Kirk Rattanakorn, Steven Pham, Divya Mallam, Thomas McIntyre, Moro O Salifu, Irini Youssef, Samy I McFarlane, Shivakumar Vignesh
{"title":"Survival benefits in colorectal adenocarcinoma with the use of metformin among a black diabetic inner city population.","authors":"Roger C Zhu,&nbsp;Kirk Rattanakorn,&nbsp;Steven Pham,&nbsp;Divya Mallam,&nbsp;Thomas McIntyre,&nbsp;Moro O Salifu,&nbsp;Irini Youssef,&nbsp;Samy I McFarlane,&nbsp;Shivakumar Vignesh","doi":"10.2217/crc-2017-0001","DOIUrl":"https://doi.org/10.2217/crc-2017-0001","url":null,"abstract":"<p><p>We assessed the association of metformin use with survival in colorectal cancer in a population consists mostly of African-American and Afro-Caribbean patients. We identified 585 colorectal cancer patients, 167 (28.6%) and 418 (71.5%) were as diabetic (DM) and nondiabetic, respectively. The diagnosis of diabetes did not impact cancer survival or extent of disease. Overall, DMs with metformin use (D+M+) have better overall survival than both DMs without metformin use (D+M∼) and nondiabetics (D∼M∼), with a mean survival of 109.9 months compared with 95.7 and 106.1 months, respectively (log-rank p < 0.05). The use of metformin shows significant reduction of risk of mortality compared with nonusers (hazard ratio: 0.34; 95% CI: 0.15-0.81; p = 0.01). Use of insulin and status of diabetes did not have a significant impact on overall cancer survival.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc-2017-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35714554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Examining connections between screening for breast, cervical and prostate cancer and colorectal cancer screening. 研究乳腺癌、子宫颈癌和前列腺癌筛查与结直肠癌筛查之间的联系。
IF 4.2
Colorectal Cancer Pub Date : 2014-06-01 DOI: 10.2217/crc.14.18
Michael D Wirth, Heather M Brandt, Heather Dolinger, James W Hardin, Patricia A Sharpe, Jan M Eberth
{"title":"Examining connections between screening for breast, cervical and prostate cancer and colorectal cancer screening.","authors":"Michael D Wirth, Heather M Brandt, Heather Dolinger, James W Hardin, Patricia A Sharpe, Jan M Eberth","doi":"10.2217/crc.14.18","DOIUrl":"10.2217/crc.14.18","url":null,"abstract":"<p><strong>Aim: </strong>To compare participation in breast, cervical and prostate cancer screening with colorectal cancer (CRC) screening.</p><p><strong>Materials & methods: </strong>This random digit-dialed survey includes participants (aged 50-75 years) from South Carolina (USA). Past participation information in fecal occult blood test, flexible sigmoidoscopy, colonoscopy, mammography, clinical breast examination, Pap test, prostate-specific antigen and digital rectal examination was obtained.Adjusted odds ratios are reported.</p><p><strong>Results: </strong>Among European-American women, any cervical or breast cancer screening was associated with adherence to any CRC screening. Among African-American women, mammography was associated with adherence to any CRC screening. Digital rectal examination and prostate-specific antigen tests were associated with adherence to any CRC screening test among all men.</p><p><strong>Conclusion: </strong>Future research should explore approaches inclusive of cancer screening recommendations for multiple cancer types for reduction of cancer screening disparities.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc.14.18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32602914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Surgical management of colorectal cancer metastases to the liver: multimodality approach and a single institutional experience. 结直肠癌肝转移的外科治疗:多模式方法和单一机构经验。
IF 4.2
Colorectal Cancer Pub Date : 2013-02-01 DOI: 10.2217/crc.12.80
Aaron U Blackham, Katrina Swett, Edward A Levine, Perry Shen
{"title":"Surgical management of colorectal cancer metastases to the liver: multimodality approach and a single institutional experience.","authors":"Aaron U Blackham,&nbsp;Katrina Swett,&nbsp;Edward A Levine,&nbsp;Perry Shen","doi":"10.2217/crc.12.80","DOIUrl":"https://doi.org/10.2217/crc.12.80","url":null,"abstract":"<p><p>Over the past 30 years, the treatment of metastatic colorectal cancer to the liver has undergone major changes. Once considered terminal and incurable, the prognosis of patients with colorectal hepatic metastases has seen dramatic improvements using modern multimodality therapy and now long-term survival and even cure are possible in some patients. Despite the advances seen in systemic therapy, hepatic resection offers the longest survival potential and remains the only curative option. Based on long-term outcomes and the improved safety of hepatic resection using modern operative techniques and critical care support, an aggressive locoregional approach to colorectal hepatic metastasis has become the standard of care. This article focuses on the management of colorectal hepatic metastases and highlights the importance of multimodality therapy. We also report our 18-year experience treating patients with hepatic resection for colorectal metastases.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc.12.80","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32574365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Challenges and strategies for identifying biomarkers for colorectal cancer. 识别结直肠癌生物标志物的挑战和策略。
IF 4.2
Colorectal Cancer Pub Date : 2013-01-01 DOI: 10.2217/crc.13.65
Bruno Conte, Scott Kopetz
{"title":"Challenges and strategies for identifying biomarkers for colorectal cancer.","authors":"Bruno Conte,&nbsp;Scott Kopetz","doi":"10.2217/crc.13.65","DOIUrl":"https://doi.org/10.2217/crc.13.65","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc.13.65","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32983384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Future of targeted agents in metastatic colorectal cancer. 转移性结直肠癌靶向药物的未来。
IF 4.2
Colorectal Cancer Pub Date : 2012-10-01 DOI: 10.2217/crc.12.52
Mauricio Burotto, Marion L Hartley, John L Marshall, Michael J Pishvaian
{"title":"Future of targeted agents in metastatic colorectal cancer.","authors":"Mauricio Burotto, Marion L Hartley, John L Marshall, Michael J Pishvaian","doi":"10.2217/crc.12.52","DOIUrl":"10.2217/crc.12.52","url":null,"abstract":"<p><p>Great strides have been made in improving the outcome of patients with metastatic colorectal cancer and targeted agents are an important part of the treatment arsenal. The approved monoclonal antibodies, bevacizumab, cetuximab and panitumumab, are part of the standard of care, yet only recently have we begun to define which patients benefit from these therapies using predictive tumor biomarkers. More recently, novel agents including aflibercept and regorafenib have had promising results and may become approved therapies. In addition, agents targeting the mTOR pathway and the TNF pathway have demonstrated early evidence of benefit. In the coming years, we may experience an influx of new therapies, possibly leading to further prolongation of patient survival or even, for some, a cure.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834580/pdf/nihms503603.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31899585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concerns and challenges in flexible sigmoidoscopy screening. 软性乙状结肠镜筛查的问题与挑战。
IF 4.2
Colorectal Cancer Pub Date : 2012-08-01 DOI: 10.2217/crc.12.33
Akeem O Adebogun, Christine D Berg, Adeyinka O Laiyemo
{"title":"Concerns and challenges in flexible sigmoidoscopy screening.","authors":"Akeem O Adebogun,&nbsp;Christine D Berg,&nbsp;Adeyinka O Laiyemo","doi":"10.2217/crc.12.33","DOIUrl":"https://doi.org/10.2217/crc.12.33","url":null,"abstract":"<p><p>In 1992, two well-conducted case-control studies used data from two different health maintenance organizations and demonstrated a 59-79% reduction in mortality from colorectal cancer (CRC) following exposure to sigmoidoscopy. These studies highlight the possibility of reducing mortality from CRC using population-based endoscopic screening. The development of fiber optics improved the technology, and the ease of performing flexible sigmoidoscopy (FS) with widespread adoption of this screening modality. To date, FS is the only endoscopic screening modality that has been shown to reduce mortality in randomized clinical trials. This article reviews the development of sigmoidoscopy, its use in CRC screening and the current reduced role of this proven screening modality, and explores new frontiers for population-based FS screening.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/crc.12.33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32539764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Relationship of colorectal cancer awareness and knowledge with colorectal cancer screening. 大肠癌意识和知识与大肠癌筛查的关系。
IF 4.2
Colorectal Cancer Pub Date : 2012-01-01 DOI: 10.2217/crc.12.45
Heather M Brandt, Heather R Dolinger, Patricia A Sharpe, James W Hardin, Franklin G Berger
{"title":"Relationship of colorectal cancer awareness and knowledge with colorectal cancer screening.","authors":"Heather M Brandt, Heather R Dolinger, Patricia A Sharpe, James W Hardin, Franklin G Berger","doi":"10.2217/crc.12.45","DOIUrl":"10.2217/crc.12.45","url":null,"abstract":"<p><strong>Aim: </strong>The aim was to describe the association of awareness and knowledge with participation in colorectal cancer (CRC) screening.</p><p><strong>Materials & methods: </strong>Telephone survey research was conducted with South Carolina (USA) residents aged 50-75 years using a 144-item instrument. Data were analyzed with SAS and Stata. Adjusted odds ratios are reported.</p><p><strong>Results: </strong>Respondents (n = 1302) had heard of CRC screening (96%) and exhibited high levels of CRC awareness and knowledge; only 74% had ever been screened. Higher levels of knowledge were associated with a greater likelihood of having ever been screened (odds ratio: 1.05; 95% CI: 1.02-1.41; p < 0.001).</p><p><strong>Conclusion: </strong>Results showed high levels of awareness and knowledge, but modest participation in CRC. Transforming awareness and knowledge into CRC screening participation should be a priority.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529290/pdf/nihms435631.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33908936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemoprevention in patients with genetic risk of colorectal cancers. 对有大肠癌遗传风险的患者进行化学预防。
IF 4.2
Colorectal Cancer Pub Date : 2012-01-01 DOI: 10.2217/crc.12.22
Christina M Laukaitis, Steven H Erdman, Eugene W Gerner
{"title":"Chemoprevention in patients with genetic risk of colorectal cancers.","authors":"Christina M Laukaitis, Steven H Erdman, Eugene W Gerner","doi":"10.2217/crc.12.22","DOIUrl":"10.2217/crc.12.22","url":null,"abstract":"<p><p>A number of genetic syndromes are known to convey a high risk of colorectal cancer. Current standards of medical practice for these patients involve genetic testing followed by screening and surgical procedures. Pharmaceutical therapies for any of these syndromes are limited in number and are generally not approved by any regulatory body for applications in these genetic groups. This review discusses advances in mechanistic understanding of the disease processes leading to the development of promising pharmaceutical therapies. Clinical trials of potential chemotherapeutic agents must focus on the reduction of disease-related events, including cancer and cancer-related mortality, in patients with genetic syndromes.</p>","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162131/pdf/nihms406010.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32667738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucosal Cellular Regeneration and Colorectal Carcinogenesis 粘膜细胞再生与结直肠癌的发生
IF 4.2
Colorectal Cancer Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-85930-4_15
Ulrich A. Simanowski, N. Wright, H. Seitz
{"title":"Mucosal Cellular Regeneration and Colorectal Carcinogenesis","authors":"Ulrich A. Simanowski, N. Wright, H. Seitz","doi":"10.1007/978-3-642-85930-4_15","DOIUrl":"https://doi.org/10.1007/978-3-642-85930-4_15","url":null,"abstract":"","PeriodicalId":43638,"journal":{"name":"Colorectal Cancer","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51223659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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