软性乙状结肠镜筛查的问题与挑战。

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2012-08-01 DOI:10.2217/crc.12.33

Akeem O Adebogun, Christine D Berg, Adeyinka O Laiyemo

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引用次数: 4

摘要

1992年，两项实施良好的病例对照研究使用了来自两个不同健康维护组织的数据，结果表明乙状结肠镜检查后结直肠癌(CRC)死亡率降低59-79%。这些研究强调了使用基于人群的内镜筛查降低结直肠癌死亡率的可能性。随着光纤技术的发展，软性乙状结肠镜(FS)筛查方式的广泛采用，提高了该技术的应用难度。迄今为止，在随机临床试验中，FS是唯一被证明可以降低死亡率的内镜筛查方式。本文回顾了乙状结肠镜的发展，其在结直肠癌筛查中的应用，以及目前这种已证实的筛查方式的作用减弱，并探讨了基于人群的FS筛查的新领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Concerns and challenges in flexible sigmoidoscopy screening.

In 1992, two well-conducted case-control studies used data from two different health maintenance organizations and demonstrated a 59-79% reduction in mortality from colorectal cancer (CRC) following exposure to sigmoidoscopy. These studies highlight the possibility of reducing mortality from CRC using population-based endoscopic screening. The development of fiber optics improved the technology, and the ease of performing flexible sigmoidoscopy (FS) with widespread adoption of this screening modality. To date, FS is the only endoscopic screening modality that has been shown to reduce mortality in randomized clinical trials. This article reviews the development of sigmoidoscopy, its use in CRC screening and the current reduced role of this proven screening modality, and explores new frontiers for population-based FS screening.

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来源期刊

Colorectal Cancer ONCOLOGY-

自引率

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.