对有大肠癌遗传风险的患者进行化学预防。

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2012-01-01 DOI:10.2217/crc.12.22

Christina M Laukaitis, Steven H Erdman, Eugene W Gerner

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引用次数: 0

摘要

众所周知，一些遗传综合征会带来罹患结直肠癌的高风险。针对这些患者的现行医疗实践标准包括基因检测、筛查和外科手术。针对这些综合征的药物疗法数量有限，而且通常未获得任何监管机构的批准用于这些遗传群体。本综述将讨论在对疾病过程的机理认识方面取得的进展，从而开发出有前景的药物疗法。潜在化疗药物的临床试验必须侧重于减少遗传综合征患者的疾病相关事件，包括癌症和癌症相关死亡率。

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Chemoprevention in patients with genetic risk of colorectal cancers.

A number of genetic syndromes are known to convey a high risk of colorectal cancer. Current standards of medical practice for these patients involve genetic testing followed by screening and surgical procedures. Pharmaceutical therapies for any of these syndromes are limited in number and are generally not approved by any regulatory body for applications in these genetic groups. This review discusses advances in mechanistic understanding of the disease processes leading to the development of promising pharmaceutical therapies. Clinical trials of potential chemotherapeutic agents must focus on the reduction of disease-related events, including cancer and cancer-related mortality, in patients with genetic syndromes.

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来源期刊

Colorectal Cancer ONCOLOGY-

自引率

0.00%

发文量

期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.