{"title":"Modelling O/sub 2/ and CO/sub 2/ dissociation curves of newborn infants","authors":"E. A. Lynch, T. B. Waggener","doi":"10.1109/NEBC.1991.154585","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154585","url":null,"abstract":"In order to study gas exchange and respiratory control system stability in the newborn period, a model of the O/sub 2/ and CO/sub 2/ dissociation curves is developed which incorporates the changes in hemoglobin with age. The model is a modification of Grodin's equations. The dissociation curves generated by the computer model take into account hematocrit, bicarbonate concentration, pH, barometric pressure, the Bohr effect, the Haldane effect, and the effect of postnatal age on hemoglobin type. They provide improved accuracy in modeling gas exchange and respiratory control system stability in infants.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114628562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brain death: a simulation study for non-invasive detection","authors":"R. Rao, J. LaCourse","doi":"10.1109/NEBC.1991.154572","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154572","url":null,"abstract":"A simulation study done on a mathematical model of the human arterial system from the heart to the eye and the brain is presented. Pressure changes in the eye over time were investigated to delineate cerebral lesions that may be indicators of progressive brain death. It is shown that an inverse relationship exists between intracranial pressure (ICP) and the intraocular pressure (IOP). IOP changes have been found to be a reliable indicator of brain death and may help in early noninvasive diagnosis of this condition.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132546877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A neural cell model of MSO","authors":"Y. Han, S. Colburn","doi":"10.1109/NEBC.1991.154610","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154610","url":null,"abstract":"An explicit model of neural processing for individual cells in the medial superior olive (MSO) is developed. It is based on available physiological data and consists of a descriptive model of input patterns (characterizing the bushy cells in the AVCN) and an explicit MSO cell model that is expressed in terms of membrane conductances and potentials. The formulation of this model permits the evaluation of the reasonableness of parameter choices such as conductance values and time constants. For a given set of parameters, the MSO cell model generates patterns of firing, and these simulated output patterns are compared to actual patterns from physiological studies. Specific comparisons include discharge rates, vector strengths, and period histograms. It is argued that the results of these studies will provide insights into the binaural signal processing in MSO neurons and will provide a front-end for models of binaural psychophysics.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129959512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution of myocardial constitutive relations","authors":"R. Strumpf, J. Humphrey, F. Yin","doi":"10.1109/NEBC.1991.154560","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154560","url":null,"abstract":"Major developments in the assessment of myocardial constitutive relations are outlined as they illustrate the progressive sophistication in experimental soft tissue mechanics. An evolution in the determination of constitutive relations is described that includes a variety of experimental techniques and different approaches to data analysis. Three approaches to the determination of a specific functional form are considered. One approach relies on the assumption of a particular form. The second approach utilizes data to directly infer the functional form. The third approach is based on the properties and kinematics of all the material's constituents. Data from macroscopic tests then guide selection of a particular relation.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"368 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134018420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Control of robotic motion with neuron-like elements","authors":"S. Wolpert","doi":"10.1109/NEBC.1991.154565","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154565","url":null,"abstract":"Using a controller made up of models of biological nerve cells, a controller network for a robotic limb was designed that incorporates pertinent environmental information into its motion directives, and does so without the need for conventional computers. Feedback information pertaining to the position, velocity, and acceleration of the robotic limb is encoded into compatible frequency-based signals and factored into an overall formula for the control of motion. The controller network was designed to be upwardly compatible with a virtually limitless amount of feedback data pertaining to its environment. This method is more comprehensive than conventional robotic controllers and with other applications of the controller network, such as prosthetics, the motion of electronically controlled limbs should become more lifelike.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130065010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Locations of discontinuities as priors for improved Bayesian reconstructions from projections (emission tomography)","authors":"M. Lee, G. Gindi, Anand Rangarajan, I. Zubal","doi":"10.1109/NEBC.1991.154598","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154598","url":null,"abstract":"A Bayesian image reconstruction method from projection data using explicit discontinuity locations as priors is proposed. The algorithm seeks smooth solutions with occasional discontinuities with a special coupling term that influences the creation of discontinuities in the vicinity of the significant locations. It is shown that the reconstruction corresponds to the use of a generic piecewise smoothness constraint. The model incorporates prior knowledge of discontinuity location into a reconstruction algorithm. The results appear favorable.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130094457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acoustical resonance analysis of airway structure","authors":"M. Epstein, P. Conard","doi":"10.1109/NEBC.1991.154582","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154582","url":null,"abstract":"Differences in the spectrum of reflected sound for mechanical airways models of different structure are examined. Two mechanical lung models were designed and built for this study. The first used a silicon lung model, the Zavala lung. The second model consisted of a rigid plastic Y-piece connection with the stem forming the trachea and the two branches, the major bronchi. Comparison of spectra for 100-4000 Hz for the two models showed similarities in the locations of the resonant peaks between 300 and 2000 Hz. The spectra for frequencies above 2500 Hz were very different. The Zavala model spectra display multiple peaks between 2500 and 4000 Hz. In contrast, the simple model showed no significant power above 2500 Hz. This result indicates that spectra analysis of the reflected sound can be used to identify the presence of the smaller airways in the Zavala model.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134537520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Auditory image processing in a virtual acoustic environment","authors":"A. Kulkarni, H. Colburn","doi":"10.1109/NEBC.1991.154609","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154609","url":null,"abstract":"A system is described that simulates free-field source at different locations through headphones, and experiments that make use of that system are discussed. The system makes use of commercially available components and incorporates automatic compensation for head motion. It also allows an interactive mode in which the subject modifies the simulated acoustic environment by changing her/his hand position. Some preliminary experiments related to the relative importance of several factors that influence perceptions of auditory image space are reported.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115584934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensitivity of phase III slope to FRC and breathing pattern in a single-path airway model","authors":"J.D. Schwardt, G. Neufeld, P. Scherer","doi":"10.1109/NEBC.1991.154590","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154590","url":null,"abstract":"A numerical solution of the convection-diffusion equation with an alveolar source term in a single-path model (SPM) of airway gas transport simulates steady state CO/sub 2/ washout. The SPM is used to examine the effects of independent changes to adjustable model parameters of lung volume and breathing pattern on the slope of phase III of the single breath CO/sub 2/ washout curve. The parameters investigated include functional residual capacity (FRC), tidal volume (V/sub T/), and breathing frequency (f). Reduced tidal volume causes significant steepening of phase III with calculated slopes as high as 2.4%/1 compared to 0.76%/1 from a standard V/sub T/ of 750 ml. The tidal volume sensitivity of phase III slope is in good agreement with experimental data. Variations in FRC and f cause only slight changes in calculated slopes with values from 0.6 to 1.1%/1.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"52 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120920753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coordinating advice and actual treatment","authors":"T. Russ","doi":"10.1109/NEBC.1991.154674","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154674","url":null,"abstract":"The author focuses on identifying the current treatment, allowing time for therapy to take effect, and coordinating the advice with the actual execution of treatment plans. These problems were encountered during the implementation of an expert system for treatment of diabetic ketoacidosis. The programming system, called the temporal control structure (TCS), is a temporal data dependency manager that maintains a temporal database and automatically updates decisions that are based on information that changes. Data can be stored either as point events or as intervals. When an expert system is programmed, the data dependencies of all of the decisions are declared. By tracing the dependency structure, the TCS can assure the complete propagation of information as it arrives and changes. The programmer is relieved of the burden of explicitly calling for the recalculation of affected decisions. The use of the TCS allows the flexible implementation of reasoning systems that manipulate data that arrives during the course of the consultation.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123865163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}