{"title":"Preliminary results of IR spectroscopic characterization of cholesterol","authors":"N. Haq, M. Fox","doi":"10.1109/NEBC.1991.154633","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154633","url":null,"abstract":"The authors propose the use of skin over the bony prominences of the hands as a site for infrared (IR) exposure to measure blood cholesterol. Cholesterol, when exposed to IR radiation, generates an absorption spectrum Characteristic of its molecular composition. Aqueous solution of bovine cholesterol, (Sigma Chemicals) with 100mg% and 200mg% of concentration was exposed to laser using attenuated total reflection (ATR) in a Mattson FTIR spectrometer. Background data were collected by scanning air at 32 scans/sample. Following this, the sample solution was placed in the ATR prism and scanned 500 times across the sample. The background was subtracted from the sample data and an FFT was performed. The absorption spectra were thus obtained and plotted on an HP plotter. Preliminary experiments show that a unique absorbance spectrum for cholesterol exists in aqueous solutions. The authors also demonstrate the existence of absorption spectra in the blood.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115435600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A computational speech-act model of human-computer conversations","authors":"R.A. Morelli, J. Bronzino, J. Goethe","doi":"10.1109/NEBC.1991.154675","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154675","url":null,"abstract":"The authors describe a computational paradigm for representing and managing human-computer dialog in an expert clinical monitoring system. Declarative scriptlike structures, implemented in Prolog, are used to represent and manage the speech acts of the stereotypical conversations between the computer and its users, in this case clinical staff. This model is useful for rapid prototyping of the human interface and can serve as a basis for implementation of the system in an actual clinical setting. In an example, actions such as database and expert system queries are simulated through keyboard input. The chief strength of the computational model is that it permits a broad range of social and professional concerns to be identified and resolved during the design phase of system development, thereby reducing the potential negative impact of the system.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127289038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The VT model: a deterministic model of angiogenesis and biofractals based on physiological rules","authors":"M. Gottlieb","doi":"10.1109/NEBC.1991.154570","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154570","url":null,"abstract":"A vascular tree (VT) model is developed that recreates vascular embryology and anatomy. It is a nonlinear deterministic process defined via topology and set theory. The accuracy of the model is due to its foundations in natural physiology. Real and VT angiogenesis are closed-loop control systems, with vessels growing reactively in response to inputs generated by tissue growth. This system creates efficient distribution networks. Critical mathematical features of real vessels, such as density and r-net concepts, are reproduced. VT structures, like real vessels, are fractal, and the VT model explains how a fractal anatomy can arise from a nonlinear physiology. It is argued that the VT model is a suitable analog of the circulation for bioengineering or physiological studies, and it may be a generalized model for the study of biofractals.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124922542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Kleeman, C. Lewis, M. Nowak, C.J. Stalk, R. F. Altman
{"title":"The effect of cast design on the stabilization of underlying long bones","authors":"T. Kleeman, C. Lewis, M. Nowak, C.J. Stalk, R. F. Altman","doi":"10.1109/NEBC.1991.154681","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154681","url":null,"abstract":"Two composite model systems, each representing a bone overlying soft tissues and a surrounding cast, were tested for strain along the length of the bone while torsional stress was applied through the cast. The two models were identical in every dimension except that one was square in cross section, and one was circular. Three triaxial rosette strain gages, spaced evenly along the bone, generated output to a strain gage conditioner and amplifier. Data from the two models are compared. In two of the nine gages, there was a significant difference between models, with the square model displaying greater strains. Calculations of principal stress followed a similar trend with the square model displaying consistently larger values of stress. The data suggest that a quadrilateral cast design may provide added stabilization to a bone contained within, compared to the traditional form-fitting cast.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122645293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analyzing biological signals with CMAC, a neural network","authors":"E. Wilson, J. Lacourse","doi":"10.1109/NEBC.1991.154552","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154552","url":null,"abstract":"The neural network CMAC (Cerebellar Mode Arithmetic Computer) is discussed. CMAC is used as the main control device in an effort to develop a brain-computer link. If a person intends to move his/her eyes up, down, left, or right, it is hypothesized that a distinct electroencephalogram pattern exists for each intended direction. The CMAC could then be trained to recognize these four directional patterns and move a computer cursor correspondingly. Therefore, a severely handicapped person could will the cursor movement on the screen and scroll through menu driven software to control his/her environment.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"316 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121836043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Magnetic stimulation of sensory evoked potentials","authors":"A. J. Jacobs, D.S. Poe","doi":"10.1109/NEBC.1991.154606","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154606","url":null,"abstract":"Preliminary results are presented from the development of a magnetic nerve stimulator capable of stimulating sensory nerve fibers. A magnetic stimulator producing fields near 3000 T/s at rates of 1 kHz was developed to initiate action potentials in sensory nerve axons at rates similar to those seen in vivo. Cortical somatosensory evoked potentials recorded following magnetic stimulation of rat tibial nerves demonstrated significant cerebral activity arising from the simulation.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129689015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A multi-window spectral analysis of circadian rhythms","authors":"A.L. Hurst, S. Reisman, W. Tapp","doi":"10.1109/NEBC.1991.154664","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154664","url":null,"abstract":"The authors investigate circadian rhythms by using a new multi-window spectral analysis computer algorithm which detects spectral peaks not resolvable by ordinary spectral analysis methods. Temperature data from two monkeys were examined with the new spectral analysis program to investigate the presence of circadian rhythms and their harmonics and to examine the data for longer period oscillations. Thirty-three day records sampled once per hour were used. Data from both monkeys show well resolved spectral peaks at periods of 24, 12, and 8 h which represents the basic circadian rhythm and its second and third harmonics. The peaks located at 24, 12, and 8 h illustrate the ability of the new spectral analysis program to resolve peaks already resolved by standard spectral analysis methods. Peaks found at 3.125 and 9.375 days in one monkey confirm the prediction of the simulation model that these low frequencies may exist in some cases.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131464368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluating the validity of the Oxylog in adults at rest and during exercise","authors":"E. Muik, K. Bell, R.B. Davis","doi":"10.1109/NEBC.1991.154622","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154622","url":null,"abstract":"The reliability of a portable oxygen consumption meter (Oxylog) before its clinical utilization is determined by comparing simultaneously collected data from an Oxylog and a Medical Graphics 2001 metabolic cart during rest and bicycle ergometer exercise in normal adults. The results indicate differences in oxygen consumption and inspiratory ventilation values between the two systems. It is proposed that frequent checks of the O/sub 2/ sensors by pumping a gas of known O/sub 2/ concentration through the device and, at the same time, using a calibrated syringe to introduce a known volume through the flowmeter will help eliminate concerns about the performance of the device.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132794920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Padmanaban, W. Ohley, G. Kass-simon, R. F. Constantino
{"title":"A model of temporal synaptic interactions","authors":"N. Padmanaban, W. Ohley, G. Kass-simon, R. F. Constantino","doi":"10.1109/NEBC.1991.154608","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154608","url":null,"abstract":"The patterned interaction between synaptic inputs on the muscle fibers of crustacean claws has been found to be important in delineating claw behavior. When the excitatory and inhibitory neurons are fired at different frequencies in the opener muscle of the cutter claw of lobster Homarus Americanus, a complex pattern of postsynaptic potentials (PSPs) is observed. To analyze the nature of these varying patterns, an electrical equivalent circuit model of a single cell with two synapses, one excitatory and one inhibitory, is used. This model is implemented using a circuit simulation program. The PSP patterns generated by this model compare favorably with the patterns obtained from experiments. Thus the model can be used to formulate a theoretical basis for such pattern generation.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115082507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A model of connective tissue micromechanics","authors":"S. Mijailovich, D. Stamenović, J. Fredberg","doi":"10.1109/NEBC.1991.154561","DOIUrl":"https://doi.org/10.1109/NEBC.1991.154561","url":null,"abstract":"Unifying concepts at the level of microstructure are developed to account for macroscopic connective tissue elasticity, energy dissipation, and its time-varying response to mechanical loads. A fiber-fiber kinetics model based on the assumption that both rate-dependent and rate-independent dissipative stresses arise in the interaction among fibers in the connective tissue matrix is established. The model accounts for the principal features observed in the tissue behavior. These include the amplitude dependence, the frequency dependence, time-amplitude and frequency-amplitude interactions, and preconditioning phenomena. The model offers a physical explanation of microstructural behavior in terms of slip and diffusion layers. The model implies that the relaxation spectrum is not simply a mechanical property of the material; it depends on loading amplitude. The model is conceptually simple. It contains only two powerful and unifying ideas-the slip and the diffusion layers.<<ETX>>","PeriodicalId":434209,"journal":{"name":"Proceedings of the 1991 IEEE Seventeenth Annual Northeast Bioengineering Conference","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1991-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123945785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}