{"title":"Research progress of dietary fiber and its regulation of intestinal flora to improve type 2 diabetes mellitus","authors":"Mingke Chi","doi":"10.1117/12.2692594","DOIUrl":"https://doi.org/10.1117/12.2692594","url":null,"abstract":"At present, the pathogenesis of type 2 diabetes melitus is still unclear, and clinical treatment lacks effective means of cure. In recent years, with the deepening of the understanding of \"flora gut brain axis\", more studies have confirmed that the structural diversity of intestinal flora and various metabolites play an important role in regulating blood glucose and other functions. Dietary fiber refers to carbohydrate substances in plant meals that the human gastrointestinal tract is unable to digest. It has the function of providing energy and enhancing body immunity, and plays a vital role in human health. Intestinal microflora can digest dietary fiber, and different dietary fiber has different regulatory effects on intestinal microorganisms, thus leading to the disease and promoting human health. In the recent past, the impact of dietary fiber and intestinal flora on T2DM has gradually attracted widespread attention of scientists. In this paper, from the influence of intestinal flora on T2DM patients and induced mechanism, and study the mechanism of dietary fiber, and to some dietary fiber to the research direction of gastrointestinal tract of diabetes patients progress is summarized and elaborated, hope to some researchers want to know this direction to help the literature.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124399788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An overview of current prosthetic sensory rehabilitation and future development","authors":"Jiaxing Huang","doi":"10.1117/12.2692419","DOIUrl":"https://doi.org/10.1117/12.2692419","url":null,"abstract":"Sensory substitution is an essential part of prosthetics. Rehabilitation of sensory feedback systems can considerably improve the quality of life for the disabled population. It can restore lost visual and auditory functions, and it can also enhance prosthetic limb activities by providing users with sensory feedback. The major purpose of this study was to examine prosthetic implants for auditory, olfactory, and tactile restorations. In addition, the research contributes to the literature database by discussing aspects that affect the efficacy of prosthetic sensory substitutes, as well as present technical limitations and future goals. In order to examine the current state of sensory rehabilitation utilizing prosthesis, a search of the UBC library's journal collection yielded 33 articles for this review. The title and abstract of relevant literature studies are reviewed. The complete text is then examined to confirm its legitimacy and summarize the necessary information. The finding suggests that sensory rehabilitation with prosthesis could considerably improve the quality of life for users. Tactile and visual rehabilitation are still in the research phase, although hearing prostheses have been widely adopted. Both tactile and visual substitutes require additional development prior to commercial entry. Additionally, training is typically necessary to maximize effectiveness. On the long-term effects of invasive sensory replacements, more research is required.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121471513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relationship between intestinal microflora and mental health diseases in children and adolescents and related treatment","authors":"Yi Chen, Xiaotian Liu, Xiang Zhang","doi":"10.1117/12.2691843","DOIUrl":"https://doi.org/10.1117/12.2691843","url":null,"abstract":"The intestinal flora is known as the second human genome, plays an essential role in regulating human physical health and mental health. The intestinal flora affects the central nervous system through neurological, immune, endocrine and metabolic pathways. The intestinal flora of this special group of children and adolescents is influenced by many factors and the dysbiosis of intestinal flora can affect some neuropsychiatric diseases, such as the Autism spectrum disorder (ASD), the Attention deficit hyperactivity disorder (ADHD) and also the depression. Currently, clinical study has proven that the use of the probiotics and the fecal transplants to regulate intestinal flora has achieved good results in the treating psychiatric disorders. This article reviews the role of intestinal flora in various neuropsychiatric diseases in children and adolescents in the recent yearsl.Aiming to summarize the association between the psychiatric disorders such as ASD, ADHD and adolescent depression and gut flora. As well as this paper takes the latest clinical therapeutic research, in order to discover more potential value of gut flora regulation in the treatment of psychiatric disorders.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122165126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An exploration of the role of standardized remote psychological therapy for mental health problems caused by COVID-19","authors":"Jianuo Zhou","doi":"10.1117/12.2692188","DOIUrl":"https://doi.org/10.1117/12.2692188","url":null,"abstract":"Since 2019, COVID-19 has become a hot topic. The COVID-19 pandemic has detrimental effects on the physical and mental wellbeing of individuals. Presently, specialists and physicians have perfected COVID-19 treatment. Additionally, COVID-19 vaccines have been developed. Experts or physicians from urban areas or nations with advanced medical technology have instructed physicians from rural regions or countries with relatively primitive medical technology on how to treat more successfully via telemedicine. Thus, most people’s physical health issues have been resolved. However, mental issues created by COVID-19 have not yet been resolved. Through a literature-based research method, this paper investigates the mental issues that have emerged during the COVID-19 pandemic. This research identifies and explains the role of standard distant psychological counseling or treatment for COVID-19-related mental health issues. The ongoing COVID-19 pandemic may lead to elevated levels of stress and anxiety, increasing the likelihood of depression, sadness, and even suicide. Standardized telemedicine can efficiently alleviate these symptoms and accomplish the same results as face-to-face treatment through the use of the Internet. In addition, individuals can receive prompt psychological counseling or therapy during self-isolation to prevent disasters.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115503242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19","authors":"Jing Wang, Xuanhe Zhang","doi":"10.1117/12.2692598","DOIUrl":"https://doi.org/10.1117/12.2692598","url":null,"abstract":"Because of the rapid spread and mutation of a novel virus called SARS-CoV-2, the efficacy of the immunogen is limited, a specific treatment is needed immediately. This paper investigates a novel lipid nanoparticle delivery system with small interfering RNA for the treatment of viral infection. This work is divided into two directions, one is to screen candidate siRNA through three experiments, and the other is to develop and screen the formula of new lipid nanoparticles. In this work, we selected the candidate siRNA and developed a new lipid nanoparticle delivery system. This work focused on two aspects, siRNA and LNP, looking for siRNA with good inhibition performance, combined with a new delivery system of lipid nanoparticle, the method can directly Inhibit viral replication and expression. This work will help to solve other similar problems in the future, it gives a great method to solve the problems in the delivery of drugs.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123485282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular complications and long-haulers of COVID-19","authors":"Ruobing Zhao","doi":"10.1117/12.2692344","DOIUrl":"https://doi.org/10.1117/12.2692344","url":null,"abstract":"The symptoms of COVID-19 patients have been alleviated by pharmaceutical treatment, and immunization has been demonstrated to protect against SARS-CoV-2 infection. However, following COVID-19 infection, a series of clinical symptoms may persist over long period, a condition also known as long-hauler syndromes. In the present study, we review the long-hauler syndromes of COVID-19 and its potential pathophysiological mechanisms, and examine the causes and prognosis of persistent cardiovascular symptoms of long-hauler syndromes. Future treatments and management strategies for long-hauler syndromes are also one of the main focuses herein, with a special interest on several medications approved for the treatment of COVID-19 and their relation to these syndromes. This article also seeks to raise public awareness of long-hauler syndrome and its risk factors, since it posits a global challenge to the healthcare system and to the economy. If everyone works together and more and more effective management alternatives are developed as more is known about COVID-19, society will be able to safeguard the health of every person.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125015900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The single-cell RNA sequencing technology and its application","authors":"Yichen Zhang","doi":"10.1117/12.2692190","DOIUrl":"https://doi.org/10.1117/12.2692190","url":null,"abstract":"Single-cell RNA sequencing provides a methodology to analyse a specific type of cell’s gene expression under certain states simultaneously. It provides high resolution, high sensitivity and is able to detect rare cell types in order to achieve different experiment goals in clinical trials, at the same time illustrating the cell development trajectories, which allows scientists to reveal heterogeneity between different types of cells, and horizontally compare differences of genes in same cell type at its developmental stages. As a cutting-edge technology, single-cell RNA sequencing can be widely used in different types of experimental research, such as bioinformatics and molecular science, it has a promising future for development. This article introduced the development of Single-cell RNA sequencing, and it’s various approaches to encounter different purposes of using with specific types of collected sample, and discussed the applications in laboratory and why scientists prefer to use it.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129612201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel pharmaceutical approaches targeting antibiotic resistance","authors":"Yuqi Zhang","doi":"10.1117/12.2691858","DOIUrl":"https://doi.org/10.1117/12.2691858","url":null,"abstract":"Since the discovery of antibiotics in 1929, antibiotics have played a pivotal role in clinical health care. However, with the widespread use of antibiotics, certain bacteria have acquired antibiotic resistance. Antibiotic resistance has become a global crisis. In this paper, we reviewed the mechanism for bacteria developing antibiotic resistance, and focus on novel treatments than can counteract bacterial resistance, including new-class antibiotics and antibody-based therapies. Chimeric peptidomimetic antibiotics, Darobactin and Lugdunin are recently identified compounds that are able to prevent or eliminate bacteria. Despite that the aim is to either act as bactericidal or toxin neutralizing antibodies, all three monoclonal antibodies that are approved for treatment of specific bacterial infection, exert actions by neutralizing released toxin. The aim is to introduce antibiotics or therapy battling infection but with low resistance tendency. Overall, investigations on developing new therapies against antibiotic resistance are warranted, especially therapies with little side effects or a direct bactericidal action.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125297721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulation of energy metabolism by eEF2K in tumor cells","authors":"Jiachai Wang","doi":"10.1117/12.2692913","DOIUrl":"https://doi.org/10.1117/12.2692913","url":null,"abstract":"Metabolic reprogramming is one of the primary characteristics of tumor cells. Aerobic glycolysis is the primary mechanism by which tumor cells and normal cells differ in their glucose metabolism. The Ca2+/CAM-dependent protein kinase known as eukaryotic elongation factor 2 kinase (eEF2K) is significantly activated in various tumor cells and is involved in the control of tumor cell survival, proliferation, invasion and metastasis. For example, it acts as a protein synthesis regulator to mediate the process of protein synthesis in tumor cells under nutrient deprivation conditions. This paper describes the main regulatory mechanism of eEF2K and three pathways that affect eEF2K. In recent years, various studies have shown that eEF2K has very different or even opposite effects in different tumor cells. Therefore, clarifying the role and mechanism of eEF2K in different tumors is of great significance for drug research and development, and eEF2K is a potential therapeutic target for the development of anticancer drugs.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"209 1-6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120930305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research on free-riders of vaccine by game-theoretic framework","authors":"Jingyuan Zhang","doi":"10.1117/12.3000293","DOIUrl":"https://doi.org/10.1117/12.3000293","url":null,"abstract":"With the COVID-19 pandemic, various countries and regions have introduced different preventive measures, with vaccination becoming one of the most effective ways to ward off COVID-19. Therefore, this paper looks at the response to the COVID-19 pandemic and analyzes individual decision-making when complying or failing to comply with vaccination and social distancing. First, free-riders are addressed as a more precise object of study in individual decision making, those who do not comply while enjoying the protection of her immunity. Such decisions are then analyzed in this paper within a game-theoretic framework with public goods. Subsequently the techniques discussed by various authors for limiting free ridership is analyzed. This goal can be achieved in several ways (through negative and positive reinforcement and appeals to altruism). Negative reinforcement forces free riders to consider the societal cost of their noncompliance with mandates. Positive reinforcement seeks to decrease the benefit free riders enjoy from non-compliance. Lastly, altruism, the personal choice to go along with the collective for the greater good, can effectively increase compliance. Overall, this essay argues that a combination of the above methods could theoretically yield a Nash equilibrium where the vast majority of the population complies to government-mandated vaccination and social distancing.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"317 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122737757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}