The SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19

Abstract

Because of the rapid spread and mutation of a novel virus called SARS-CoV-2, the efficacy of the immunogen is limited, a specific treatment is needed immediately. This paper investigates a novel lipid nanoparticle delivery system with small interfering RNA for the treatment of viral infection. This work is divided into two directions, one is to screen candidate siRNA through three experiments, and the other is to develop and screen the formula of new lipid nanoparticles. In this work, we selected the candidate siRNA and developed a new lipid nanoparticle delivery system. This work focused on two aspects, siRNA and LNP, looking for siRNA with good inhibition performance, combined with a new delivery system of lipid nanoparticle, the method can directly Inhibit viral replication and expression. This work will help to solve other similar problems in the future, it gives a great method to solve the problems in the delivery of drugs.