International Conference on Modern Medicine and Global Health最新文献

Exercise in primary and secondary prevention of CVDs 锻炼心血管疾病的一级和二级预防

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692463

Rongzhe Ma

引用次数: 0

Therapeutic mechanisms of ellagic acid for inflammation and related conditions 鞣花酸治疗炎症及相关疾病的机制

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692865

Chenye Zhang

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Progress on the regulation of intestinal flora in rheumatic immune diseases 风湿性免疫疾病肠道菌群调控的研究进展

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2691884

Kewen Su, Yingzhi Wang

{"title":"Progress on the regulation of intestinal flora in rheumatic immune diseases","authors":"Kewen Su, Yingzhi Wang","doi":"10.1117/12.2691884","DOIUrl":"https://doi.org/10.1117/12.2691884","url":null,"abstract":"Rheumatic immune diseases (AIRD) afflict billions of patients all over the world. The treatment and remission of AIRD is an important research subject in the medical field. Currently, the commonly used treatment methods include traditional Chinese and western medicine treatment, surgical treatment, and so on, these treatments need long-term adherence, while the effect varies from person to person. Also, these traditional treatments had a low cure rate and easy recurrence. The relationship between the balance of the intestinal flora and rheumatoid disease has increasingly come to the notice of researchers in recent years. According to studies, the disruption of gut flora can influence the prevalence and progression of AIRD via multiple pathways. Various experiments have shown that the regulation of bacterial balance can alleviate the symptoms of AIRD. In this study, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) were taken as examples to explore the current application of regulating intestinal flora balance through diet, probiotics, and fecal bacteria transplantation in the treatment of rheumatic and immune diseases. At the same time, there are also deficiencies and Obstacles in the application that exist in this therapy. With more relevant studies and the improvement of the method, the treatment will get widespread acceptance.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123688766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small molecules targeting ULK1 in triple-negative breast cancer treatment 靶向ULK1的小分子在三阴性乳腺癌治疗中的应用

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692842

Qijun Li

引用次数: 0

The profile of receptor protein tyrosine kinases (RPTKs): taking AXL and DDR as examples 受体蛋白酪氨酸激酶(RPTKs)谱:以AXL和DDR为例

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692473

Mingxin Gu, Yifan Lu, Yuxin Jin

{"title":"The profile of receptor protein tyrosine kinases (RPTKs): taking AXL and DDR as examples","authors":"Mingxin Gu, Yifan Lu, Yuxin Jin","doi":"10.1117/12.2692473","DOIUrl":"https://doi.org/10.1117/12.2692473","url":null,"abstract":"Receptor protein tyrosine kinases (RPTKs) comprise a unit of cell surface proteins that bind to ligands, which can phosphorylate tyrosine residues of the target protein. As RPTKs can make the receptor's tyrosine be transphosphorylated to transmit signals through the plasma membrane, it has been verified to be a key regulator of normal cellular processes and plays a key role in the development and progression of many types of cancer. Moreover, there are already much medicine under research based on RPTKs and their targets as the extracellular domain of RPTKs can activate RPTKs and enable signal transduction by binding to the corresponding ligands. Herein, we will first introduce the structure and functions of RPTKs. Besides, the progress of the treatment of AXL receptor for liver cancer and human non-small cell lung cancer (NSCLC) and relative medicine development will also be introduced. Furthermore, the mechanism of discoidin domain receptor (DDR) in breast cancer and fibrosis and its medicine development will be included. This assay is not only intended to help people know and understand RPTKs, but also hopes to promote research and developments of related topics.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"12789 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130109717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of DNA methylation in autoimmune diseases with genome-wide association analysis 自身免疫性疾病DNA甲基化的全基因组关联分析研究

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692914

Jingjing Fan

{"title":"Investigation of DNA methylation in autoimmune diseases with genome-wide association analysis","authors":"Jingjing Fan","doi":"10.1117/12.2692914","DOIUrl":"https://doi.org/10.1117/12.2692914","url":null,"abstract":"Autoimmune diseases are defined as the immune system attacking healthy body tissue that contains self-antigens. Damage of body tissues, malfunctions of organs, and abnormal growth of organs are common symptoms of an autoimmune disease. Although the exact reason causing autoimmune diseases is yet unknown, recent studies suggest that correlations exist between the pathogenesis of autoimmune diseases and epigenetic modifications of DNA. Epigenetic modifications, including methylation of both DNA and histones, have been identified as frequently occurring in individuals with autoimmune diseases. These modifications are thought to be environment-related, which therefore can alter DNA transcription without changing the original DNA sequence. In this review, two systematic (Rheumatoid arthritis and Sjögren syndrome), and two organ-based (Type one diabetes and Hashimoto’s thyroiditis) autoimmune diseases will be discussed. Their association with epigenetic modifications are analysed by twin studies. Several differentially methylated genes and the following signalling pathways that are associated with autoimmune diseases are identified, which may be a potential target for medical treatment.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131238724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New uric acid excretory drugs research progress in the treatment of hyperuricemia 新型尿酸排泄药物治疗高尿酸血症的研究进展

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692615

Yuqi Huang

引用次数: 0

Research progress of circRNA and its role in the development of colorectal cancer circRNA在结直肠癌发生发展中的研究进展

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.3000273

Jingwen Chen

引用次数: 0

Clinical application of proteolysis targeting chimeras 靶向嵌合体蛋白水解的临床应用

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.3000206

Jinfeng Gao, Chuhan Meng, Vivian FT Yuan

引用次数: 0

Maternal mortality and its potential risk factors 产妇死亡率及其潜在危险因素

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.3000139

Xinran Xu

{"title":"Maternal mortality and its potential risk factors","authors":"Xinran Xu","doi":"10.1117/12.3000139","DOIUrl":"https://doi.org/10.1117/12.3000139","url":null,"abstract":"Background: Despite previous studies on the effects of socio-economic factors on maternal mortality, integrated risk factors and comparisons between risk factors of maternal mortality rate in the United States have not been analyzed. This study examines the maternal mortality rate and potential risk factors, including Age and Race Group distribution, healthcare insurance coverage, education attainment, state household income, state birth rate, and abortion rate. Methods: Data were collected and integrated from various sources, including CDC, National Vital Statistics, World population review, Guttmacher institute, and United States Government Census, into datasets that covered different aspects of socioeconomic and demographic development in a state-level statistics. Linear Regression and Geographically Weighted Regression models were used to find correlations between maternal mortality rates and selected socioeconomic factors. Results: The disparity between race and age groups remains as black women over 40 are much riskier of dying from maternal childbirth. The statistical model result indicates that birth rate and female household income contribution are positively correlated with maternal mortality rate, while educational attainment is negatively correlated. Geographical Weighted Regression showed the spatial patterns that the correlations are more credible in eastern states than in western states. Conclusions: Tracking socioeconomic factors that showed either a positive or negative correlation with maternal mortality is the key to reducing maternal mortality. Also, our model result was more credible among eastern states residents, while further models and analysis could be conducted with the residents of the western states to help them interpret and apply the result.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117039922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0