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Current developments, limitations and future directions of CAR T-cell therapy CAR - t细胞治疗的现状、局限性和未来发展方向
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.3000298
Daniel Tianlin Yang
{"title":"Current developments, limitations and future directions of CAR T-cell therapy","authors":"Daniel Tianlin Yang","doi":"10.1117/12.3000298","DOIUrl":"https://doi.org/10.1117/12.3000298","url":null,"abstract":"Since CAR T-cell therapies were authorized for clinical use in 2017, it has demonstrated massive potential in treating hematological malignancies, with more than 750 active CAR T-cell therapies currently under development around the world. However, despite the successes, many side effects and limitations still remain for this relatively new cancer treatment which is preventing the more extensive usage of this therapy. Thus, more innovative solutions must be established to eliminate or reduce the issues regarding the therapy. This paper will review some of the past and current developments of CAR T-cell therapy, some issues, limitations and its effect on the efficacy of the treatment as well as some of the novel methods and future directions which can be utilized to reduce or eliminate many of the limitations.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116388177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Domestic technology review of microneedle patents 国内微针专利技术综述
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.3000296
Yaoxin Chen, Yuan Cong
{"title":"Domestic technology review of microneedle patents","authors":"Yaoxin Chen, Yuan Cong","doi":"10.1117/12.3000296","DOIUrl":"https://doi.org/10.1117/12.3000296","url":null,"abstract":"Microneedle is a new type of drug delivery technology, which forms tiny pores on the surface of the skin through a special needle-like structure to break through the skin barrier and deliver drugs to the body with high efficiency, thus promoting drug penetration and absorption, which plays an important role in drug delivery. In recent years, with the continuous development of microneedle technology, the application field of microneedles has become more and more extensive, and the research of microneedles has become the hot spot of research and development today. This article has conducted a statistical analysis of the application trend, applicant's source, legal status, technical application and preparation process of patent applications in this field, and focused on summarizing the technical application of domestic microneedle patents in the field of pharmaceutical technology, medical beauty and several mainstream preparation processes. The statistical analysis was also conducted to summarise the technical applications of domestic microneedle patents in the fields of pharmaceutical technology and medical aesthetics and several mainstream preparation processes.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129355199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population pharmacokinetics of levetiracetam in juvenile epilepsy patients in Shaanxi province 左乙拉西坦在陕西省青少年癫痫患者中的人群药动学研究
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692624
Jinming Zhang, Lei Shi, Jingjie Yu, Qianting Yang
{"title":"Population pharmacokinetics of levetiracetam in juvenile epilepsy patients in Shaanxi province","authors":"Jinming Zhang, Lei Shi, Jingjie Yu, Qianting Yang","doi":"10.1117/12.2692624","DOIUrl":"https://doi.org/10.1117/12.2692624","url":null,"abstract":"To establish a population pharmacokinetic model of levetiracetam for minors in Shaanxi Province, determine the covariates that affect the pharmacokinetic parameters and the mathematical relationship between them. One hundred and forty samples of patient blood concentrations were collected from minors in Shaanxi Province, and 77 samples were included. The population pharmacokinetic model was established by NONMEM software and validated by the bootstrapping method. A one-compartment model with first-order absorption best described the data. In the final model, the typical population values of CL/F, V/F, and Ka are 2.52 L/h, 23.9 L and 1.28 ℎ−1 respectively, and age is the only remaining covariate affecting the pharmacokinetic parameters of levetiracetam. This model can be used to predict individual palsma concentrations and help formulate a clinical individual drug administration plan for a specific patient population.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128899547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of plyometric training on the explosive force of lower limb of football players: a meta analysis 增强式训练对足球运动员下肢爆发力的影响:meta分析
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692051
Shuyuan Du
{"title":"The effect of plyometric training on the explosive force of lower limb of football players: a meta analysis","authors":"Shuyuan Du","doi":"10.1117/12.2692051","DOIUrl":"https://doi.org/10.1117/12.2692051","url":null,"abstract":"Plyometric Training refers to the practice method of muscles that play the maximum strength in the shortest time. Its physiological basis is the use of elastic potential energy and the reflection principle of muscle tissue to increase the activity of the reflection of neurons. Plyometric Training are widely used in training as a strategy for enhancing explosive force. This paper uses the Meta analysis research method to investigate the intervention effect of Plyometric Training (PT) on football players' lower limbs. This study uses Review Manager 5.4 and Stata MP 17 Software to meta-analyze 187 football players from 7 included paper by countermovement jump (CMJ) test, squat jump (SJ) test, 10-meter sprint test, and 30-meter sprint test, and the Cochrane risk bias evaluation tool is used to evaluate the quality of the literature, and the random effect model is used for analysis and heterogeneity testing. The results of the study are: (1) Plyometric Training can effectively increase the height of countermovement jump (MD = 4.27, 95%CI [2.14, 6.41], P <0.05); (2) Plyometric Training can effectively increase the height of squat jump (MD = 3.1, 95%CI [0.78, 5.41], P <0.05); (3) Plyometric Training can effectively reduce the completion time of 10-meter sprint (MD =-0.11, 95%CI [-0.19, -0.03], P <0.05); (4) Plyometric Training can effectively reduce the completion time of 30-meter sprint (MD = -0.37, 95%CI [-0.46, -0.27], P <0.05). This paper found that Plyometric Training can significantly improve the explosive force of football players, including jumping ability and sprint speed. As a training method, Plyometric Training plays an important role in promoting football performance. It is recommended to develop athletes' lower limb sports ability in physical training and sport training to improve the training efficiency of athletes.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114172428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of animal models in the treatment of diabetes mellitus 动物模型在糖尿病治疗中的作用
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692775
Siqi Zhang
{"title":"The role of animal models in the treatment of diabetes mellitus","authors":"Siqi Zhang","doi":"10.1117/12.2692775","DOIUrl":"https://doi.org/10.1117/12.2692775","url":null,"abstract":"Diabetes mellitus is normally classified into type 1 diabetes and type 2 diabetes. The auto-immune malfunction of insulin-producing pancreatic beta cells is known to cause type 1 diabetes. Type 2 diabetes mellitus is triggered by insulin resistance and a beta cell inability to produce the required amount of insulin. Animal models of type 1 diabetes vary from mice that acquire auto-immune diabetes spontaneously to pharmacological ablation for pancreatic beta cells. Obese and non-obese are types of animal models with variable levels of insulin sensitivity and beta cell failure are used to simulate type 2 diabetes. This study discusses some current models utilized in treating T1DM and T2DM based on relevant literature and statistical data. The use of transgene and knockout mice models is also explored. An over-one animal model should ideally be utilized to mimic the variability exhibited in diabetes individuals. The research found that animal models have several advantages in treating diabetes, and success depends on the precision and animal model types used.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134243614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the treatment and intervention modalities of radiation oral mucositis 放射性口腔黏膜炎的治疗与干预方法研究进展
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692194
Lokman Cheung
{"title":"Advances in the treatment and intervention modalities of radiation oral mucositis","authors":"Lokman Cheung","doi":"10.1117/12.2692194","DOIUrl":"https://doi.org/10.1117/12.2692194","url":null,"abstract":"Radiotherapy is currently an important modality in the treatment of malignant tumours, but while it improves patient survival, it also increases the risk of patient infection-related complications to some extent. Radiation-induced oral mucositis (RIOM), a common complication following radiotherapy, is commonly seen in patients with head and neck malignancies treated with radiotherapy measures. The current knowledge of RIOM has led to the development of appropriate treatment and prevention measures, but due to the lack of adequate clinical practice and evidence for most of these interventions, a more uniform and comprehensive treatment system has yet to be developed. This review will summarise the current interventions and treatments for RIOM.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134641134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatty liver prediction: a multivariable linear regression model based on transient elastography using routine biochemical indicators and waist circumference 脂肪肝预测:基于瞬态弹性图的多变量线性回归模型，使用常规生化指标和腰围
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692637
Jingwen Chen
{"title":"Fatty liver prediction: a multivariable linear regression model based on transient elastography using routine biochemical indicators and waist circumference","authors":"Jingwen Chen","doi":"10.1117/12.2692637","DOIUrl":"https://doi.org/10.1117/12.2692637","url":null,"abstract":"Fatty liver disease is now the second most common liver disease after viral hepatitis, and its increasing prevalence and younger age of onset are posing a serious threat to human health worldwide. However, as early fatty liver is a reversible disease, early diagnosis has an important impact on timely treatment measures. The majority of current liver fat prediction methods have a high threshold of understanding, and some indicators of influencing factors are difficult to obtain, which does not meet the public's need for daily self-monitoring of liver fat content and does not facilitate the detection of asymptomatic early fatty liver. This study, therefore, investigated the association between liver fat accumulation and routine biochemical indicators and waist circumference, based on the reference indicators of the FLI. This study obtained a sample size of 8451 independent individuals by drawing on publicly available data from NHANES, extracted and analyzed from NHANES 2017 to March 2020 (pre-epidemic). The type of data used included examination and laboratory data, non-invasive measurement of liver fat content using transient elastography (TE). The analysis of the correlation between Albumin, Aspartate Aminotransferase, Lactate Dehydrogenase (LDH), Triglycerides, waist circumference and CAP respectively were forming by R (version 4.2.1). Through analysis, this paper found that all the above indicators are highly significantly correlated with CAP, however, the first three have a weaker correlation. Triglycerides was generally correlated with CAP. Waist circumference was highly significant and strongly correlated with CAP. Finally, an adjusted R-squared=0.4492 multivariable linear regression model with the above indicators was developed.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124652531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of type 1 diabetes 1型糖尿病的综述
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.3000022
Siyuan Han
{"title":"A review of type 1 diabetes","authors":"Siyuan Han","doi":"10.1117/12.3000022","DOIUrl":"https://doi.org/10.1117/12.3000022","url":null,"abstract":"Type 1 diabetes mellitus (T1DM) is a complex chronic disease characterized by secondary hyperglycemia. T1DM is a result of genetic and environmental causes. It is predominant in children and adolescents yet can present in adults. Classical presentations are weight loss, polydipsia or polyuria, and the risk of getting ketoacidosis. Still, the presentations of T1DM could be confusing and lead to a delay or improper treatment. Through summarizing the mechanism, and epidemiology of type 1 diabetes mellitus (T1DM) and analyzing different diagnoses and treatments of T1DM based on existing literature and data, this research aimed to determine the current effective methods of detecting and recognizing T1DM in potential patients, and the present beneficial treatments. The result shows that although T1DM is a common metabolic disease, it has not yet been fully discovered, which could lead to errors in treatment. Therefore, further research could focus on these parts, which are still confusing: precise triggering factors and more effective medicine in treatments.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131962796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Analysis on the development and application of disease surveillance 疾病监测的发展与应用分析
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692210
Boyin Sun
{"title":"Analysis on the development and application of disease surveillance","authors":"Boyin Sun","doi":"10.1117/12.2692210","DOIUrl":"https://doi.org/10.1117/12.2692210","url":null,"abstract":"Disease surveillance is used as a tool to monitor the health status and disease behavior of certain populations through systematic data collection and analysis. It is responsible for preventing the outbreak of diseases. The purpose of disease surveillance is to monitor the target population and give health workers and decision-makers accurate information, thus helping them make the right decisions and take actions to deal with upcoming situations. This paper introduces and explains the history, formation, and application of disease surveillance, indicating the importance of it to people around the globe.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133505499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in antidepressant treatment in traditional Chinese medicine related to intestinal flora 与肠道菌群相关的中药抗抑郁治疗进展
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692477
Xuan Tang
{"title":"Advances in antidepressant treatment in traditional Chinese medicine related to intestinal flora","authors":"Xuan Tang","doi":"10.1117/12.2692477","DOIUrl":"https://doi.org/10.1117/12.2692477","url":null,"abstract":"Depression is a common affective psychiatric disorder that not only affects the daily life of patients, but also leads to death by suicide in severe cases, and it is worth noting that there is a trend of younger people suffering from the disease. The etiology of depression is complex and the pathogenesis is still unclear. It has been found that intestinal flora plays an important role in the interaction between the intestine and the brain, and intestinal flora has received wide attention in the pathogenesis of depression. In recent years, the use of Traditional Chinese Medicine(TCM) methods for the treatment of depression has been effective. And the advantages of less side effects compared with western medicine show the outstanding advantages of TCM treatment. This review mainly summarizes the improvement of intestinal flora by some single and compound herbal medicines, acupuncture therapy, moxibustion and other TCM specialties, and discusses the progress and possibilities of TCM antidepressant treatment related to intestinal flora by investigating the relevant literature in recent years, to provide a theoretical basis for in-depth understanding of the pathogenesis of depression and the scientific connotation of antidepressant therapy with TCM.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114795426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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