International Conference on Modern Medicine and Global Health最新文献_第3页

Stem cells and iPSCs in neural chronic degenerative disease 干细胞和多能干细胞在神经慢性退行性疾病中的作用

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692209

Haohong Liu

{"title":"Stem cells and iPSCs in neural chronic degenerative disease","authors":"Haohong Liu","doi":"10.1117/12.2692209","DOIUrl":"https://doi.org/10.1117/12.2692209","url":null,"abstract":"Chronic degenerative diseases are characterized by memory decline, motor dysfunction, and nerve necrosis, including Alzheimer's disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), etc. Reasons for some of the chronic degenerative diseases’ formations are still unknown, but Brain-blood barrier (BBB) corruption is a common well-known phenomenon in these diseases. BBB model, one of the most popular in vitro models, has been made for studying chronic degenerative diseases for many decades. It can be constructed simply in a culture dish, or a more complicated model such as organ-on-a-chip. Regenerative Medicine gives chances for treating this disease without knowing its formation reasons. iBMEC differentiation protocol has been improved for many years and several 2D and 3D iBMEC BBB models have been made. Besides iMBEC, iPSC-derived neural stem cells (iNSC) are also popular topics for studying chronic degenerative diseases since they have the potential to efficiently improve the motor and brain function of the patients with chronic degenerative diseases. This paper introduces and discusses the contributions of BBB models, iPSC-induced brain nerve cells including (i)BMEC and (i)NSCs, out of which (i)NSCs brain nerve cells are induced in vitro and applied in transplanting.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130464215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influential factors of stroke: depression, Alzheimer's disease 中风的影响因素:抑郁症、阿尔茨海默病

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2691854

Chao Ping

{"title":"Influential factors of stroke: depression, Alzheimer's disease","authors":"Chao Ping","doi":"10.1117/12.2691854","DOIUrl":"https://doi.org/10.1117/12.2691854","url":null,"abstract":"The research on risk factors and influencing factors of stroke is a hot field of current research. Important progress has been made in the study of stroke-related risk factors such as hypertension, diabetes, atrial fibrillation, diet, physical activity, smoking, and alcohol abuse. However, there are still gaps in the study of immutable risk factors such as age, sex, race, transient ischemic attack (TIA), and psychological factors that are important triggers of stroke. In addition, it has been demonstrated that stroke poses a danger for developing Alzheimer's disease, but there is still a lack of uniform explanation as to whether Alzheimer's disease is a risk factor for stroke. Therefore, combining previous research and relevant literature, this article mainly analyzes two parts: The first part analyzes the causes of the high incidence of stroke in the elderly from a psychological perspective, mainly analyzing the impact of depression, and the second part explores whether Alzheimer's disease poses a danger for developing stroke by analyzing the potential common pathway between Alzheimer's disease and stroke. The elderly is more likely to have negative emotions such as depression, which can directly induce stroke, or indirectly increase the risk of stroke by increasing the risk of hypertension, diabetes, etc. The susceptibility to negative emotions is one of the psychological factors that contributes to the high incidence of stroke in the elderly. Alzheimer's disease can induce or exacerbate stroke. The dementia and cognitive impairment brought on by Alzheimer's disease can raise the chance of stroke. There are potential mechanism connections between the two on amyloid proteins β (Aβ) toxicity, Tau protein, and oxidative stress.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114190260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of immunotherapy with chemotherapy on triple-negative breast cancer 免疫治疗与化疗治疗三阴性乳腺癌的比较

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692921

Ruiting Zhou

引用次数: 0

CRISPR-Cas system: revolutionizing plant breeding and gene therapy CRISPR-Cas系统:革新植物育种和基因治疗

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692353

Tianyi Song, Jingwen Wang, Yinxuan Wu

{"title":"CRISPR-Cas system: revolutionizing plant breeding and gene therapy","authors":"Tianyi Song, Jingwen Wang, Yinxuan Wu","doi":"10.1117/12.2692353","DOIUrl":"https://doi.org/10.1117/12.2692353","url":null,"abstract":"Gene editing refers to the deletion, replacement, and insertion of target genes to obtain new functions. Nowadays, ZFN, TALEN and CRISPR-Cas are known as the three major technologies of gene editing which are used widely on more and more occasions. The common points of these three editing tools are that the recognition region contains the target DNA sequence and the DNA cleavage functional region. As a revolutionary tool in the field of life sciences, CRISPR-Cas and its derivative editing technologies may revolutionize biological research and affect personalized medicine in the future. Herein, the feature of CRISPR-Cas system and the process of discovery were summarized. Additionally, its principle mechanism was described in detail in this paper. Besides, CRISPR-Cas also played an important role in plant-related fields and gene therapy which were mentioned. However, there were problems in the application of technology, and the discussion started from the ethical controversy brought about by this technology. This review aims to deepen the understanding of gene editing technology, gain a deeper understanding of its functions, and provide theoretical support for subsequent research.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125749942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phospholipid bioconjugation: advancements and applications in prodrug development and metabolic labeling 磷脂生物偶联:在前药开发和代谢标记方面的进展和应用

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692454

Jin Qian

引用次数: 0

Analysis of therapeutic strategies of RUNX1-RUNX1T1-induced acute myeloid leukemia based on medical interventions on different stages of leukemogenesis 基于不同白血病发生阶段医学干预的runx1 - runx1t1诱导急性髓系白血病治疗策略分析

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2691830

Langyi Zuo

{"title":"Analysis of therapeutic strategies of RUNX1-RUNX1T1-induced acute myeloid leukemia based on medical interventions on different stages of leukemogenesis","authors":"Langyi Zuo","doi":"10.1117/12.2691830","DOIUrl":"https://doi.org/10.1117/12.2691830","url":null,"abstract":"RUNX1-RUNX1T1-fusion-induced acute myeloid leukemia accounts for nearly 5% of total AML instances, and the percentage becomes higher in M2 subtype AML (10-20%). Due to t(8;21) chromosomal translocation, the fused gene suppresses the expression of all RUNX1-mediated hematopoietic genes, inhibiting the normal differentiation of myeloid cells and inducing leukemogenesis. This type of AML involves menacing symptoms from the disease and persisting adverse effects from the therapy they received. Current research regarding this type of AML mainly focuses on random individual pharmaceutical targets and biomolecular pathways. However, more attention needs to be placed on prioritizing aspects regarding different aspects of this type of AML, and future research should devote more effort to it. This paper explores if there is a correlation between the complexity of the study and specific pharmaceutical targets or pathways it focuses on. By analyzing several recent studies related to RUNX1-RUNX1T1-induced AML, a conclusion is derived that the later stage of leukemogenesis of the research target or pathway belongs to, the more complicated process and resources will be needed to complete that research. However, the significance of the study focuses on different stages of leukemogenesis weighted equally. This paper provides insights to future researchers in choosing their research area related to RUNX1-RUNX1T1-induced AML.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115223515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of travel on respiratory epidemic disease 旅行对呼吸道传染病的影响

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.3000287

Xintong Jiang

引用次数: 0

Research on optimization of two-way clustering algorithm for gene expression data analysis 基因表达数据分析的双向聚类算法优化研究

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692181

Weiheng Nie

引用次数: 0

The effects of environmental change on Clypeasteroids and adaptive evolutionary history 环境变化对clype小行星的影响及其适应演化史

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692468

Ke Wu

{"title":"The effects of environmental change on Clypeasteroids and adaptive evolutionary history","authors":"Ke Wu","doi":"10.1117/12.2692468","DOIUrl":"https://doi.org/10.1117/12.2692468","url":null,"abstract":"Clypeasteroids are irregular echinoids characterized by their flattened skeleton, sophisticated mouth parts and fluffy thorns. Their flat shapes and buried lifestyles are highly adjusted to suspension feeding, thus now ecological niches were discovered. In this paper, the integral evolutionary history from the Cretaceous period to modern times will be introduced and the interrelationship between suspension feeders and plankton will be discussed. It’s worth noting that it was the nutritive environment that contributed to their adaptive evolution by boosting the thriving of plankton. The emergence of Clypeasteroids was ultimately the result of geological evolution in the Mesozoic, especially the Cretaceous period. As the dominant species in modern benthic ecosystems, clypeasteroids are still in the face of a variety of environmental changes, such as ocean warming, ocean acidification and microplastics. It is a brand new perspective to explore the interrelationship between Clypeasteroids and the marine environment by discussing the evolutionary history influenced by plankton like algae and its ecological impact of controlling the population density of algae, and it has been concluded that the marine environmental effects distinguish because Clypeasteroids was born of dramatic environmental change caused by geological activities.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125358624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of endoscopic SLAM and the challenges 内窥镜SLAM的发展与挑战

International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2691855

Wenyue Jin

引用次数: 0