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Principle, application and prospect of CRISPR-Cas9 regulatory system CRISPR-Cas9调控系统的原理、应用及展望
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692261
Zening Xiao
{"title":"Principle, application and prospect of CRISPR-Cas9 regulatory system","authors":"Zening Xiao","doi":"10.1117/12.2692261","DOIUrl":"https://doi.org/10.1117/12.2692261","url":null,"abstract":"This article mainly introduces the CRISPR-Cas9 technology, as people all know the cluster spaced short palindromic repetition associated (Cas) protein system, which is an immune mechanism widely present in bacteria and archaea. Because Crisper has the characteristics of efficient and accurate cutting and cracking of foreign DNA at specific sites, it has attracted the attention of many researchers in recent years. This paper mainly introduces the current application and development of CRISPR-Cas9 and its biggest problem — off-target problem, from the aspects of in vivo experiment and gene level, such as the construction of cell models with diseases, gene therapy for thalassemia, cell transfection and tumor. CRISPR-Cas9 can split target DNA even if the sgRNA does not match the target DNA exactly, which limits the further application of genome editing technology, especially with the methods of genetic diseases at non-targeted DNA sites. Therefore, reducing the off-target effect of CRISPR-Cas9 is of great significance for the developments and applications of this technology.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126303524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of age, race and ethnicity on the prevalence of COVID-19 in California 年龄、种族和民族对加州COVID-19流行率的影响
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692857
Junyi Li
{"title":"Impact of age, race and ethnicity on the prevalence of COVID-19 in California","authors":"Junyi Li","doi":"10.1117/12.2692857","DOIUrl":"https://doi.org/10.1117/12.2692857","url":null,"abstract":"Covid-19 is a global public health disease that has significantly impacted the world from various domains. Numerous existing studies have analyzed the association of coronavirus with different industries, with the impact of individual patient characteristics on coronavirus transmission being a topic of significant interest. In this study, linear regression models were used to examine the effects of age, race and population distribution on coronavirus morbidity and mortality using data collected on coronavirus in California, USA, for November. Statistical analysis found that coronavirus transmission was significantly influenced by race, which produces consistency with some studies today. Further research is needed on specific differences in coronavirus development between individual races. In addition, the association between age and coronavirus prevalence could not be determined due to the lack of data and limitations of statistical models. Imbalances in healthcare resources, differences in vaccination rates and living environments are all considerable reasons for the association between racial factors and coronavirus transmission. Accordingly, countermeasures can be considered to help mitigate the efficiency of coronavirus transmission and its negative effects on social development.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123455243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the role of artificial intelligence in pediatric radiography 人工智能在儿科放射学中的作用分析
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692600
Wenbin Gao
{"title":"Analysis of the role of artificial intelligence in pediatric radiography","authors":"Wenbin Gao","doi":"10.1117/12.2692600","DOIUrl":"https://doi.org/10.1117/12.2692600","url":null,"abstract":"Artificial intelligence (AI) as a technology that can increase efficiency and save human and material resources is growing rapidly in the medical field. Due to its high accuracy and speed, it has great potential in radiology, especially in the recognition of various imaging images. However, paediatric imaging has been neglected due to the limitations of various conditions in paediatrics, such as the large age differentiation. This essay focuses on various examples of successful attempts at AI in paediatric radiology through a literature analysis approach, analyzing its benefits and possible challenges. It also gets inspiration from other AI literatures and proposes more areas for future development. This paper has found a great deal of potential for AI in the field of paediatric medical imaging and more funding could be invested into its development.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131608482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical application of palbociclib as a treatment of cancer 帕博西尼治疗肿瘤的临床应用
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692211
Congming Wu
{"title":"Clinical application of palbociclib as a treatment of cancer","authors":"Congming Wu","doi":"10.1117/12.2692211","DOIUrl":"https://doi.org/10.1117/12.2692211","url":null,"abstract":"One of the most frequent malignant tumors in women is breast cancer, and its prevalence is rising every year. In Europe and in United States, 25 to 30 percent of all cancers in women are breast cancers. Every year, 1.3 million women are given a breast cancer diagnosis worldwide, and 400,000 of them will die from the condition. Currently, breast cancer has become the biggest threat to women's health. The causes of breast cancer are multifaceted and extremely complex. Genes like breast cancer type (BRCA) 1, BRCA2, and tumor protein p53 (P53) are linked to familial breast cancer. Breast cancer risk factors include high estrogen levels post menopause, estrogen replacement medication, early menarche, late menopause, short menstrual cycles, and other sex hormone related variables. Palbociclib, a cyclin-dependent kinases (CDKs) inhibitor, has been applied as a treatment for advanced breast cancer. It can also be combined with other chemotherapies or radiotherapies to improve its effectiveness. Despite its side effects, it is currently the better targeted drug for the treatment of breast cancer.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131624259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on the effect of microRNA on cancer microRNA在肿瘤中的作用研究进展
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692358
Zichen Miao
{"title":"Research progress on the effect of microRNA on cancer","authors":"Zichen Miao","doi":"10.1117/12.2692358","DOIUrl":"https://doi.org/10.1117/12.2692358","url":null,"abstract":"MicroRNAs (miRNAs) is a class of non-coding single-stranded RNA molecules with a length of about 22 nucleotides encoded by endogenous genes, which MicroRNAs can change the function of DNA-encoded proteins and play an important role in a variety of genes, such as DNA replication, transcriptional regulation and RNA synthesis. It has become one of the research hotspots in the field. This article mainly reviews the effect of This article mainly reviews the effect of MicroRNA on cancer.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"14 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134190667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recommendations for prevention of influenza A virus in children between three and five years old in China, 2022–2023 2022-2023年中国3 - 5岁儿童预防甲型流感病毒的建议
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2691875
Peien Jiang
{"title":"Recommendations for prevention of influenza A virus in children between three and five years old in China, 2022–2023","authors":"Peien Jiang","doi":"10.1117/12.2691875","DOIUrl":"https://doi.org/10.1117/12.2691875","url":null,"abstract":"During the yearly seasonal influenza, A virus epidemic season, China has a relatively high infection rate among children under the age of five. By the age of three, Chinese preschoolers begin to join kindergarten and engage in social life and are at risk for getting and spreading influenza A viruses. Yet, for a variety of reasons, including a lack of parental knowledge and economical restrictions, the vaccination rate among youngsters may be higher. As a consequence, a large number of children are afflicted, imposing a significant financial burden on society and families. The purpose of this paper is to examine the mechanisms of action and potential side effects of the three seasonal influenza vaccines currently in use in China, as well as the two new influenza vaccines, in order to identify a seasonal influenza vaccine that is more effective for children aged three to five and to encourage children to receive it as a proactive measure against seasonal influenza.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134499941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The application of loop-mediated isothermal amplification (LAMP) in the rapid detection of banana allergen 环介导等温扩增技术在香蕉过敏原快速检测中的应用
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692199
Shangzhi Hu
{"title":"The application of loop-mediated isothermal amplification (LAMP) in the rapid detection of banana allergen","authors":"Shangzhi Hu","doi":"10.1117/12.2692199","DOIUrl":"https://doi.org/10.1117/12.2692199","url":null,"abstract":"Bananas (Musa acuminata) have been recognized as a common cause of food allergies worldwide. To avoid allergic reactions in patients with allergies, it is important to avoid eating bananas. Therefore, sensitive and specific banana detection methods are needed to verify bananas in food. Loop-mediated isothermal amplification (LAMP) is a fast and simple DNA-based detection method, which is mainly suitable for field application or on-site analysis and screening of allergens in food production. This work describes the systematic development and selection of LAMP primers based on multiple copy genes of banana. The chemical method used allows the detection of amplified DNA using either direct observation of precipitated products or gel electrophoresis. LAMP based on AJ277278 gene is highly specific for bananas, allowing detection sensitivity of approximately sensitivity of 3.9 × 10−3 ng/μL DNA extracting solution. Different banana products can be detected at the same sensitivity level. LAMP enables simple, highly specific and sensitive detection of bananas without the need for expensive analytical equipment.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"12789 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130237069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of mass spectrometry based metabonomics in experimental diagnostics 质谱代谢组学在实验诊断中的应用
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692206
Ruiqi Chen
{"title":"Application of mass spectrometry based metabonomics in experimental diagnostics","authors":"Ruiqi Chen","doi":"10.1117/12.2692206","DOIUrl":"https://doi.org/10.1117/12.2692206","url":null,"abstract":"Metabonomics is a new science, which analyzes all low molecular weight metabolites of a certain organism or cell from both qualitative and quantitative aspects. Metabonomics uses high-performance liquid chromatography (HPLC), mass spectrometry (MS) and other methods to analyze metabolites, and can identify small molecular metabolites as biomarkers for illness early detection, and at the same time can explore the pathogenesis of complex diseases. It can be found that metabonomics in the field of diagnostics although not really applied in clinical work so far, A growing number of studies using metabonomic diagnostics have been published. This paper reviews the general research methods of metabonomics and the research progress in the early diagnosis of various diseases in recent years, to promote the application of metabonomics in the field of early clinical diagnosis of diseases.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"115 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116640508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of natural antioxidants on oxidation stability and application in food 天然抗氧化剂对食品氧化稳定性的影响及其应用
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.3000134
Shuyun Xue
{"title":"Effects of natural antioxidants on oxidation stability and application in food","authors":"Shuyun Xue","doi":"10.1117/12.3000134","DOIUrl":"https://doi.org/10.1117/12.3000134","url":null,"abstract":"The common synthetic antioxidants in foods, such as 2,6-di-tert-butyl-p-toluenol toluene (BHT) and butylhydroxyanisole (BHA), have been proved to have toxic and carcinogenic effects. Long-term use will cause harm to people's health. As people pay more and more attention to their own health, non-toxic and harmless natural antioxidants gradually come into the public's view. Natural antioxidants are mainly divided into polyphenols, vitamins, flavonoids, etc. According to the research, adding polyphenols, vitamins, flavonoids and other natural antioxidants to oil can significantly reduce the peroxide value and acid value of oil and improve the oxidative stability of oil. Some natural antioxidants have higher antioxidant effects than BHT and BHA, and natural antioxidants can be added to food or used in active packaging to exert antioxidant effects. This paper reviews the composition of antioxidants and their research progress on the oxidative stability of oils and fats, and gives examples of their applications in foods, and suggests the future research and development of antioxidants.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132294341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and treatment for Huntington’s disease 亨廷顿舞蹈病的诊断和治疗
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692222
Xiaomeng Sun
{"title":"Diagnosis and treatment for Huntington’s disease","authors":"Xiaomeng Sun","doi":"10.1117/12.2692222","DOIUrl":"https://doi.org/10.1117/12.2692222","url":null,"abstract":"Huntington's disease is an autosomal dominant genetic disorder that eventually leads to the death of nerve cells in the brain. It usually starts at the age of 25-40 and lasts 15-20 years until death. The onset is insidious and the progress is slow, so it takes time for people to be aware of getting the disease. The main clinical symptoms are chronic progressive chorea-like movements, cognitive dysfunction, and abnormal mental behavior. As the condition progresses, the ability to speak, move, think, and swallow is gradually lost. The disease is caused by an abnormal amplification of the CAG mutation trinucleotide on the huntingtin gene IT-15 on the short arm of chromosome 4. This paper analyzes the clinical features, diagnosis, and treatment of Huntington's disease, and it is concluded that, at present, there is no cure for the disease and it can only be relieved by medicine or scientific means. For acute exacerbations, medication, physical therapy, and psychotherapy can be used to modify clinical symptoms. Until now, only symptomatic treatment, rehabilitation treatment, and effective prevention of Huntington's disease can help.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"170 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133685322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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