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The role of brown adipose tissue in the thermogenesis and the treatment of obesity 褐色脂肪组织在产热和肥胖治疗中的作用
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692771
Jingwei Wei
{"title":"The role of brown adipose tissue in the thermogenesis and the treatment of obesity","authors":"Jingwei Wei","doi":"10.1117/12.2692771","DOIUrl":"https://doi.org/10.1117/12.2692771","url":null,"abstract":"Due to the complex pathogenesis of obesity and the increasing number of obese patients, researchers have worked on how to deal with obesity. Researchers have found that brown adipose tissue (BAT) has an impact on the treatment of obese patients. The review introduces basic knowledge related to BAT characteristics, cold exposure to activate BAT, and the activation pathway of BAT, including the UCP1-dependent signaling pathway and the UCP1-independent signaling pathway, in order to investigate the novel technology on treating obesity by focusing on BAT. Moreover, the review summarizes the novel therapies to combat obesity through BAT. The therapies incorporate BAT transplantation, transformation of white adipose tissue, and artificial means to activate BAT by either using pharmaceutical ways or controlling the expression of genes. Through the multiple ways to increase the BAT mass in the human body, the results show that obesity can be partially alleviated. However, future studies still need to reveal the integrated mechanism of treating obesity with changing BAT mass.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134159917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on response mechanism for public health emergencies: COVID-19 and SARS 突发公共卫生事件应对机制研究:COVID-19和SARS
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692870
Ruijie He
{"title":"Research on response mechanism for public health emergencies: COVID-19 and SARS","authors":"Ruijie He","doi":"10.1117/12.2692870","DOIUrl":"https://doi.org/10.1117/12.2692870","url":null,"abstract":"In the past decade, China has experienced two outbreaks of large-scale transmission of respiratory diseases caused by coronaviruses, namely SARS at the end of 2002 and COVID-19 at the end of 2019. This paper conducts a comparative analysis based on the data collected from WHO coronavirus database, NCHS of CDC, and articles on National Center for Biotechnology Center to review and summarise China's anti-epidemic measures during SARS and COVID-19. The significance of comparing the responses to the two outbreaks is to study the development of epidemiology in China over the past ten years and the establishment and improvement of the response mechanism to major public health events. Through a review of a large number of literature, it can be seen that the emergence of SARS exposed the weaknesses of China's public health system, but it was also an opportunity for the development of a health crisis management system. After only more than ten years of system improvement, in the face of the COVID-19 pandemic, China has stepped up to a new level in terms of response speed, decisiveness in decision-making, and intensity of policy implementation.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134297200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the mechanism of learning, memory formation and defects in humans 研究人类学习、记忆形成和缺陷的机制
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692348
Yueping Wang
{"title":"Investigating the mechanism of learning, memory formation and defects in humans","authors":"Yueping Wang","doi":"10.1117/12.2692348","DOIUrl":"https://doi.org/10.1117/12.2692348","url":null,"abstract":"Learning memory is essential for everyday living of humans. Activities taking place in different areas of the human brain including the frontal, parietal, temporal and occipital lobe give rise to learning, memory encoding, processing and retrieval. Publicly available databases, including PubMed and Scopus were searched for relevant articles using relevant keywords, such as memory, memory defects, learning. Learning is the process of acquiring information through experience and memory is related to the reservation and storing of memory in to one’s brain. The two major categories of learning are associative and non-associative learning. Memory consists of 3 parts, sensory memory, short-term memory and long-term memory. All these takes parts in the learning cycle with the process of gathering, reflection, creating and testing. Memory retrieval can be affected by various factors such as time and memory type. Also, problems in retrieval can be caused by diseases such as dementia. Some of the diseases can be cured while others still lack an effective radical cure. This review provides a classification about learning and memory together with its mechanisms and related disorders. While our knowledge of memory encoding, processing and retrieval has been expanded significantly over the past few decades, more research is required to understand the mechanism of memory formation to find treatment for diseases associated with learning and memory.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122354924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast cancer vaccine: analysis of potential therapeutic vaccines and effects 乳腺癌疫苗:潜在治疗性疫苗及其效果分析
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692643
Jiayi Ji
{"title":"Breast cancer vaccine: analysis of potential therapeutic vaccines and effects","authors":"Jiayi Ji","doi":"10.1117/12.2692643","DOIUrl":"https://doi.org/10.1117/12.2692643","url":null,"abstract":"Many vaccinations have been developed for the prevention and treatment of cancer since the hepatitis B vaccine for liver cancer received approval as the first cancer vaccine. So far, three cancer vaccines have been approved by the FDA, but none of them is used to treat breast cancer. Scientific research focusing on the development of breast cancer vaccines had been an ongoing topic and several potential vaccine therapies have emerged. Globo-H is a suitable candidate for metastatic and triple negative breast cancer, which requires carrier protein or adjuvants conjugation induce antibody response against identified cancer antigen. Suitable adjuvant such as lipid-based carrier monophosphorylate lipid A (MPLA) is required for proper level of immune stimulation. Another large category of breast cancer vaccine is related to a commonly expressed receptor of the cancer cell’s surface: HER2/neu. E75 and GP2 directly target HERs and induce immune response for HLA A2/A3+ patients. AE37, on the other hands, is more potent for treating triple negative patients with low level of HER2 expression on cancer cells. AE37’s ability to induce T-cell immune response is related to structural conformation of MHC class II epitope driven by the linkage of li-Key-peptide, and it does not rely on high level of HER2 expression to induce T-cell mediated immune response. Overall, AE37 seems to be the most potential candidate for cancer vaccine, but its effectiveness does require further clinical trials to be proven.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124735365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on the global coronavirus infection and prevention control 全球冠状病毒感染及防控研究
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692182
Zimeng Guan
{"title":"Research on the global coronavirus infection and prevention control","authors":"Zimeng Guan","doi":"10.1117/12.2692182","DOIUrl":"https://doi.org/10.1117/12.2692182","url":null,"abstract":"This paper mainly intends to collect and sort out their COVID-19 epidemic data by selecting several typical countries in different regions. Then, this paper combines with the local epidemic prevention policies and vaccination rates of each country. The selected countries are the United States in North America, the United Kingdom in Europe, and the Republic of South Africa in Africa, two developed countries and one developing country. Additionally, it explores whether national policies and vaccination rates have a certain impact on confirmed cases. At the same time, the policies and other aspects of these countries will be compared with the confirmed cases. As a result, it finds that policies and vaccination rats are the important parts of the protection during COVID-19, and it may have something to do with the country's economic development. Finally, this paper suggests that the government should formulate appropriate policies to benefit the people, to comfort the people's emotions and give them appropriate protection.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127950637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver cancer screening: risk stratification indication from other main digestive cancer in Chinese populations 肝癌筛查:中国人群中其他主要消化道肿瘤的风险分层指征
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692925
Yujie Zhao
{"title":"Liver cancer screening: risk stratification indication from other main digestive cancer in Chinese populations","authors":"Yujie Zhao","doi":"10.1117/12.2692925","DOIUrl":"https://doi.org/10.1117/12.2692925","url":null,"abstract":"Liver cancer is one of the primary causes of death, and its incidence is increasing every year. In China, liver cancer also occupies a major position among the national diseases. To improve the effectiveness of existing procedures for hepatocellular carcinoma screening and surveillance recommended by Chinese public health authorities, this paper analyzes and summarizes the risk prediction models of other gastrointestinal malignancies (esophageal cancer, gastric cancer, and colorectal cancer) by means of a literature review. This article suggests that individual risk scoring systems can be designed to adapt to liver cancer screening strategies.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123010505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting the mechanism of pyramidal neurons in synaptic integration by high-frequency electrical stimulation and patch clamp 高频电刺激和膜片钳对锥体神经元突触整合机制的预测
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2691851
Xidong Wu
{"title":"Predicting the mechanism of pyramidal neurons in synaptic integration by high-frequency electrical stimulation and patch clamp","authors":"Xidong Wu","doi":"10.1117/12.2691851","DOIUrl":"https://doi.org/10.1117/12.2691851","url":null,"abstract":"Pyramidal neurons are one of the most important types of neurons in the cerebral cortex, which play a key role in many cognitive and behavioral functions. With the rapid development of artificial intelligence technology, researchers have begun to focus on developing more advanced and efficient artificial neural network models. However, the function of biological neural networks in the brain and the roles of different types of neurons are still not fully understood. Studying pyramidal neurons can help researchers develop more advanced and efficient artificial intelligence technologies. This paper aims to explore the mechanism of pyramidal neurons in synaptic integration and describes in detail the basic components of neurons, the morphological and functional characteristics of pyramidal neurons, and the structure and function of the dendritic spine. Exploring the mechanisms of spatial and temporal integration, nonlinear integration, gradient signal integration, and frequency encoding in synaptic integration of pyramidal neurons through patch clamp and high-frequency electrical stimulation methods.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131382123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving antidepressant: from SSRIs to psychedelic 进化中的抗抑郁药:从SSRIs到迷幻药
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2691868
Hanyang Hong
{"title":"Evolving antidepressant: from SSRIs to psychedelic","authors":"Hanyang Hong","doi":"10.1117/12.2691868","DOIUrl":"https://doi.org/10.1117/12.2691868","url":null,"abstract":"SSRIs mediate antidepressant effects by inhibiting specific serotonin transport(SERT) and subsequent modulation of serotonin levels in the brain. This review paper provides an overview of the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs), as well as psychedelics, including their potential therapeutic applications in treating psychiatric disorders. By examining the limitations of current antidepressant treatments and highlighting the need for alternative approaches, it is necessary to explore the working mechanisms of psychedelic substances, including interaction with various receptors and neural networks in the brain and their potential role in promoting neuroplasticity, which may facilitate a reset of maladaptive neural pathways and promote new patterns of neural connectivity, potentially leading to improved mental health outcomes. Recent research on psychoplastogens, non-hallucinogenic analogs of psychedelic substances, may offer a promising alternative to traditional psychedelic therapies, including the reduced potential for adverse effects while promoting neuroplasticity, potentially improving mental health outcomes.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123646972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism of COVID-19 rebound post antiviral treatment 抗病毒治疗后COVID-19反弹的机制
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692465
Mengtian Huang
{"title":"Mechanism of COVID-19 rebound post antiviral treatment","authors":"Mengtian Huang","doi":"10.1117/12.2692465","DOIUrl":"https://doi.org/10.1117/12.2692465","url":null,"abstract":"COVID-19 have caused a great burden in health care and in terms of finance. Despite the current control of COVID-19 in many countries due to the application of vaccination and treatments, the rebound of COVID-19 symptoms or repositive cases examined by either antigen test or reverse transcription-polymerase chain reaction (RT-PCR) have been noticed in patients post recovery, especially after certain treatments. However, if the rebound was a part of natural course of COVID-19 recovery, or if it was triggered by certain factors, have not been confirmed. Herein, we reviewed the history and time course of COVID-19 rebound in patients without treatment. Further, we compared the rebound rate in patients treated with Paxlovid or Molnupiravir, the two recently approved treatments for COVID-19. In addition, the present study summarizes the possible causes and the clinical implication of studying COVID-19 rebound in patients with or without treatments. At present, the existing studies on COVID-19 rebound are not enough. More studies and data are warranted to analyze factors associated with the occurrence of COVID-19 rebound.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123698371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention and treatment of drug resistance in cancer 癌症耐药的预防与治疗
International Conference on Modern Medicine and Global Health Pub Date : 2023-09-07 DOI: 10.1117/12.2692192
Runxuan Zhao
{"title":"Prevention and treatment of drug resistance in cancer","authors":"Runxuan Zhao","doi":"10.1117/12.2692192","DOIUrl":"https://doi.org/10.1117/12.2692192","url":null,"abstract":"Cancer is a complex disease and the single greatest obstacle to increasing life expectancy worldwide in modern times. Cancer is generally characterized by uncontrolled proliferation of cells, a decline in apoptosis and irregular cell cycle. Currently among all cancers, the highest indecency of malignancy is lung cancer. Currently, therapies, including chemotherapy, serves as a core part for battling against cancer. However, a serious obstacle to treating cancer is cancer drug resistance. At least five mechanisms, including tumor microenvironment, tumor heterogeneity, decreased drug uptake, drug efflux and DNA repair alteration, are involved in the acquirement of anti-cancer drug resistance. On the other hand, new approaches have been developed and designed to target anti-cancer drug resistance. Understanding mechanistically the triggers of cancer medication tolerance contributes to another critical aspect for anti-drug resistance. First-round drugs of choice as initial chemotherapy is crucial and thus requires great attention to avoid the development of anti-cancer drug resistance.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123949490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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