New uric acid excretory drugs research progress in the treatment of hyperuricemia

Abstract

With the development of the national economy and changes in people's living habits and dietary structures, diseases caused by high concentrations of uric acid (UA) are becoming more frequent in daily life. Hyperuricemia, in particular, is on the rise and affecting younger individuals. Although UA excretory drugs are available, they have low efficacy and significant side effects. Therefore, the search for UA-lowering drugs is crucial. This paper aims to introduce the pathological mechanism of hyperuricemia and the UA excretory drugs that have been marketed and tested and to briefly review their therapeutic effects and limitations. We will analyze new UA excretory drugs in terms of their mechanism of action, clinical study results, and safety to provide new ideas and feasible ways for the development of new UA-lowering drugs and the treatment of hyperuricemia in the future.