International Conference on Modern Medicine and Global Health最新文献

{"title":"Mechanism of Qi-Jing-Sheng-Bai granule and leucogen in the treatment of leukopenia based on transcriptome","authors":"Yijie Liu","doi":"10.1117/12.2692215","DOIUrl":"https://doi.org/10.1117/12.2692215","url":null,"abstract":"Traditional Chinese medicine compound preparation Qi-Jing-Sheng-Bai granule (QJSB) is used for the treatment of leukopenia. Its mechanism has not been discussed in depth in previous studies, so it is not clear at present. Leucogen is also a drug used to treat leukopenia, but its mechanism at the transcriptome level is not well understood. We find the mechanism of QJSB and Leucogen's transcriptome-based treatment of leukopenia, and the similarities and differences of mechanism between the two drugs in the treatment of leukopenia in this study. The result shows that both QJSB and Leucogen might regulate arachidonic acid metabolism pathway in the treatment of leukopenia. However, the molecular biological changes associated with the treatment of leukopenia with the two drugs are very different. QJSB may also treat leukopenia by regulating primary immunodeficiency, osteoclast differentiation, and TNF signaling pathway. Leucogen can also treat leukopenia by regulating oxidative phosphorylation and citrate cycle (TCA cycle). Through these studies, we can better understand the mechanism of QJSB and Leucogen in the treatment of leukopenia, which is very important for the clinical application of QJSB, and also provides help for the choice of drugs for different leukopenia patients.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115734054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the potential impact of COVID-19 government response on HIV prevention in the United States","authors":"Yijia Sun","doi":"10.1117/12.2692218","DOIUrl":"https://doi.org/10.1117/12.2692218","url":null,"abstract":"Ending the HIV Epidemic in the U.S. (EHE) was a program launched by the U.S. Department of Health and Human Services to reduce the number of new diagnoses and scale up prevention and treatment services. However, the COVID-19 pandemic in 2020 has halted its progress due to extensive government mitigating efforts. We aimed to assess the relationship between the state-level COVID-19 policy stringency and interruptions to HIV prevention and treatment services in the United States in 2020 to monitor our effort better to end the HIV epidemic. In this observational study, we collected five leading indicators for government to track the EHE progress, including diagnoses rate, HIV testing and positive rate, PrEP-to-Need ratio, and viral suppression. Pandemic control measures were quantified using the Oxford Government Response Tracker Stringency Index for each state. Multiple linear and logistic regressions were used to explore the association between COVID-19 policy stringency and HIV prevention outcomes. Geographically weighted regression was then used to examine the spatial distributions of the associations. We found that the more stringent COVID-19 government response was significantly correlated with decreased diagnoses rate but insignificantly with reduced HIV tests, increased HIV positive rate, and increased odds of falling viral suppression. PrEP-to-Need ratio was positively correlated with the COVID-19 government response but negatively correlated with COVID cases. Such correlation was stronger in the Northeast and weaker in the middle part of the United States. Our finding implied that a more stringent COVID-19 government response resulted in new HIV infections that were undetected and not yet linked with clinics and health departments. PrEP use was improved by the stringent COVID-19 government response mainly because of concurrent expansions on PrEP delivery services, but it still was negatively affected by the COVID-19 pandemic. We also found a concerning trend in HIV target groups of decreasing viral suppression rate and prevention use, which needed more attention.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124155229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction and comparison of stimulation techniques applied to sensate prosthetics","authors":"Xuanyun Qiu","doi":"10.1117/12.2692049","DOIUrl":"https://doi.org/10.1117/12.2692049","url":null,"abstract":"The recovery of the amputees has high relation with the usage of the sensate prosthesis, where stimulation technology plays a vital role in the tactile sense delivery. This literature review aims at stating the category and advantages of the current stimulation measures by offering five former research instances. The estimate about characteristics of MT stimulation, ET stimulation and VT stimulation are also given in the study, then the conclusion is state as MT stimulation demonstrated the best accuracy, while ET stimulation has a faster transmission speed and VT stimulation is thought to be more tolerable.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126903019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of action, side effects and clinical application of L-carnitine","authors":"Qingyang Xue","doi":"10.1117/12.2692918","DOIUrl":"https://doi.org/10.1117/12.2692918","url":null,"abstract":"With the rapid development of urban technology, people have higher and higher requirements for their appearance, especially some young women, who lose weight at all costs, so various means of weight loss have come into being. Weight loss pills have remarkable effects on weight loss, but most of them are accompanied by strong adverse effects. The main object of this study is the new weight loss drug, L-carnitine, an amino acid derivative that is extremely common and widely used in the medical field and is currently used mainly for weight loss and nutrient supplementation, but it also has many drawbacks and hidden dangers. This paper summarizes the current research progress, physiological effects, and side effects of L-carnitine by literature analysis, and provides a reference for future research. This paper found that L-carnitine is mainly used to transport long-chain fatty acids, help digestion, promote normal metabolism of branched-chain amino acids, relieve toxic acyl groups, participate in membrane repair, and maintain membrane stability; however, L-carnitine also has certain side effects, the most common of which are intestinal digestive problems and circulatory system abnormalities, and, in some cases, to affect the mental status of the user.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125177431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke prediction using machine learning models","authors":"Junyi Li","doi":"10.1117/12.2692928","DOIUrl":"https://doi.org/10.1117/12.2692928","url":null,"abstract":"Stroke is a medical emergency that occurs when blood flow to a part of the brain is interrupted or when a blood vessel in the brain ruptures. It is the fifth leading cause of death and a significant cause of disability in the United States. Certain health conditions and lifestyles increase the risk of stroke, including high blood pressure, high cholesterol, heart disease, obesity, and diabetes. This paper presents a stroke prediction system based on various health conditions and other attributes using 7 machine learning models including random forest, kneighbors and so on. The methodology section outlines data collection, processing, and machine learning model selection and evaluation metrics. The results and discussion section presents detailed analysis and results from exploratory data analysis and machine learning classifiers. Finally, the conclusion section summarizes the paper and provides future directions for the project. The study aims to contribute to the prevention of stroke and improve healthcare outcomes for patients.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131697422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application and therapeutic mechanism of Durvalumab and Tremelimumab monotherapy or combination in tumor treatment","authors":"Xuan Hou, Hidetoshi Kochi, Pengshan Li, Qi Shen","doi":"10.1117/12.2692346","DOIUrl":"https://doi.org/10.1117/12.2692346","url":null,"abstract":"Monoclonal antibodies (mAbs) have transformed from scientific tools to potent human therapeutics. Monoclonal antibody therapy has become an important treatment modality for cancer due to its strong specificity and remarkable curative effect. Among them, Durvalumab is a PD-L1 inhibitor. In anticipation of achieving a better clinical response with different drugs in combination therapy, the researchers decided to combine Durvalumab with the anti-CTLA-4 drug Tremelimumab. In addition, this type of immunotherapy is actively used as a novel treatment option for various cancers. This paper reviews the mechanism of action of Durvalumab and Tremelimumab in prospective randomized trials as a single or combination therapy for cancer and their applicability to different tumor types.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134356869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal exposure to PM10’s effect on infant birth weight and the term low birth weight in the counties of the US, 2007-2020","authors":"Jiazhuo Cheng, Binghan Yan, Tianqi Lu, Yumeng Zhang","doi":"10.1117/12.2692422","DOIUrl":"https://doi.org/10.1117/12.2692422","url":null,"abstract":"Background: Not many studies have investigated the relationship between maternal exposure to ambient particulate matter, especially matter with an aerodynamic diameter of less than 10 μm (PM10) during pregnancy, and the rate of low birth weight. Limited studies have been conducted in broad national areas for over many years. Method: Data on birth weight and air pollution from 2007 to 2020 in the US counties is collected, including 628 counties. Logarithmic transformed LAD regression was used to examine the association between air pollutants, especially PM10, and birth weight. Results: PM10 demonstrated a negative impact on the term LBW and most birth weight categories. A trend was observed: as birth weight categories increase, the magnitude of the PM10 estimate decreases as birth weight approaches the normal range, from 0.0064 to 0.0008. After examining the associations between birth weight categories and the term LBW, a negative association between PM10 level and birth weight is found for LBW categories. Conclusion: The impact of PM10 on regular-weighted babies is less significant than on low-weighted babies, and an increased risk of low birth weight with increasing PM10 levels was not found.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133290138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart disease diagnosis using deep neural network","authors":"Chenrui Zhang","doi":"10.1117/12.2692429","DOIUrl":"https://doi.org/10.1117/12.2692429","url":null,"abstract":"Heart disease is one of the leading causes of death, accounting for 16 percent of the world’s total deaths. For patients, early detection and timely treatment of heart disease are significantly important. Traditional methods of diagnosing heart disease, however, are both expensive and time consuming for low-income groups. Existing research shows that by analysing large amounts of complex healthcare data, the use of machine learning in medicine can improve efficiency and lower cost. The author wants to develop a model that reads patients’ physiological characteristics to predict if they have heart disease or not. This technique provides affordable and fast access to heart disease diagnosis for low-income people. The author uses the deep neural network as model and also uses 40,000 heart disease cases from the Centers for Disease Control and Prevention (CDC) as our data set. This data set contains 16 physiological features of patients. In the beginning, our model has the accuracy of 75.26%. After increasing the data set, our model has the accuracy of 76.63%.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116159746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress in relationship between gut microbiota and Alzheimer’s disease","authors":"Donglai Li, Yuhan Li, Zhou Zhang","doi":"10.1117/12.2691850","DOIUrl":"https://doi.org/10.1117/12.2691850","url":null,"abstract":"Alzheimer's disease(AD) is a type of dementia brought on by the central nervous system (CNS)'s chronic, progressive, irreversible degeneration. Its etiology is numerous and unclear. Currently, there is no effective cure for the disease. With the aging of the population, Alzheimer's disease is receiving increasing attention. A complex ecology of thousands of bacteria make up the intestinal microbiota, both beneficial and harmful bacteria. According to recent in-depth research on intestinal flora, it has been found that it can participate in signal transmission involving the brain and the gut. The crucial role of gut microbiota in the CNS is further illustrated by the fact that intestinal microflora can affect the central nervous system in a number of different ways, such as the release of neurotransmitters. By modifying the makeup and composition of the gut microbiota, there are numerous methods to enhance cognitive function in Alzheimer's patients. This article introduces the relevant research progress in order to provide references for further research and studying of the part gut microbiota plays in Alzheimer's disease.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121788115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular health management of menopausal women","authors":"Yuqiao Liu","doi":"10.1117/12.2692356","DOIUrl":"https://doi.org/10.1117/12.2692356","url":null,"abstract":"Cardiovascular disease (CVD) is the main reason of woman in death. Menopause is the turning point of global women's health. When women enter menopause, their sex hormone levels decline, leading the greatest risk of heart disease. During the same period, cardiovascular events will also lead to premature menopause, and there is a two-way relationship between them. Chinese and foreign academic circles are making efforts to change the current situation of women's CVD, especially the cardiovascular health of menopausal women. Menopausal hormone therapy (MHT) can not only effectively relieve menopausal symptoms such as vasorelaxation and contraction, but also improve the development of cardiovascular disease. In the past decades, the effect of hormone therapy on menopause cardiovascular condition has been controversial. Existing research shows that early use of menopausal hormone replacement therapy for young women or postmenopausal women is more beneficial to the cardiovascular system, but primary or secondary prevention is not recommended in new sequential diseases. At the same time, non-hormone therapy is also the cornerstone of cardiovascular disease prevention.","PeriodicalId":432989,"journal":{"name":"International Conference on Modern Medicine and Global Health","volume":"27 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116722425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}