Separation and Purification Technology最新文献

{"title":"A blueprint for TFF format selection: Hollow fibers and flat sheets for ultrafiltration of AAV","authors":"Luke McCarney, Akshay Gutha Ravichandran, Shawn Tansey, Mike Dango, Nicholas Marchand","doi":"10.1016/j.seppur.2025.133064","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.133064","url":null,"abstract":"Over decades of development, the roles for tangential flow filter formats used in recombinant protein processing, including monoclonal antibodies, have become well-defined. In upstream applications the low shear environment in hollow fibers is utilized to recirculate cells without impacting product quality. Flat sheet cassettes are typically used in downstream applications, as their higher turbulence enables faster processing in smaller footprints. However, platform processes for many emerging therapies (e.g. viral vectors, cell therapies, nucleic acids) are still in their infancy, and the roles for TFF formats have yet to be defined. Interestingly, there are many examples of drug developers using different filter formats in the same application. With such a broad range of modalities entering the clinic, each with unique product and process requirements, TFF format optimization is likely to become a more routine step in process development. Here we provide a four-step template to optimize TFF filter formats for bioprocessing. The approach is demonstrated using one of the most common viral vectors in development today, adeno-associated virus (AAV). It includes data from several common AAV serotypes at multiple locations along the downstream process. First, design space limits are defined for parameters such as flow and pressure. In the second and third steps, process conditions are optimized and then applied to achieve the process targets for concentration and/or diafiltration. The TFF formats are compared using key performance outputs such as flux, purity, and yield. Finally, a manufacturing assessment is used to compare formats for factors including cost, facility fit, and sustainability.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"3 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and regulation of acidic and redox sites in Mn-based spinel for low temperature selective catalytic reduction of NO with NH3","authors":"Sensheng Hou, De Fang, Fenghe Sheng, Feng He, Junlin Xie","doi":"10.1016/j.seppur.2025.133054","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.133054","url":null,"abstract":"The selective catalytic reduction of NO with NH₃ (NH₃-SCR) was examined through the introduction of Mg, Co, Ni, Cu, and Zn into the tetrahedral sites of Mn-based spinels. A comprehensive series of characterization techniques were employed to systematically explore the impact of A²⁺ on the physical, chemical properties and catalytic reaction performance of these Mn-based spinels. The successful synthesis of five distinct of Mn-based spinel catalysts was confirmed through structural characterization. Among these, the Mn-based spinel with Mg occupying the tetrahedral site (MgMO) demonstrated unoccupied Mn³⁺ t_2g orbitals, elevated d-band center, and a pronounced Jahn-Teller effect. These features endowed it with superior acidity and moderate redox capacity. It showcased exceptional catalytic performance across all test temperatures. Separated acidic and basic centers within MgMO effectively adsorbed NH₃ and active NO_x species, subsequently converting them into N₂ and H₂O via the Langmuir-Hinshelwood (L-H) mechanism. In contrast, despite its similar electronic structure, the ZnMO catalyst displayed weak low-temperature denitrification activity due to the amphoteric character of Zn-O and a diminished Jahn-Teller effect. The d-band centers of the CoMO, NiMO, and CuMO catalysts were located far from the Fermi level because of nearly fully occupied 3d orbitals, which resulted in reduced NH₃ adsorption capacity. Although the presence of Aⁿ⁺/A⁽ⁿ⁺¹⁾⁺ and Mn³⁺/Mn²⁺ ion pairs amplified their redox capacity, it also instigated over-oxidation of NH₃ and the transformation of active NO_x, thereby encroaching upon reactive sites and consequently hindering the L-H reaction pathway at lower temperatures. This study contributes valuable insights into understanding the regulation of A²⁺ on the properties of Mn-based spinels and NH₃-SCR performance.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"76 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental investigation and 4E analysis of the optimizing nano-impregnated multi-suspended black cotton ropes conical solar distillers","authors":"Mohammed El Hadi Attia ,&nbsp;Mohamed Abdelgaied ,&nbsp;Majdi Amin ,&nbsp;K. Harby ,&nbsp;Badr H. Bedairi","doi":"10.1016/j.seppur.2025.133034","DOIUrl":"10.1016/j.seppur.2025.133034","url":null,"abstract":"<div><div>This manuscript aims to search for new effective hybrid technologies that can be combined with the conical distillers to achieve maximum distillate yield and effectively contribute to achieving water security in isolated and remote regions. This was done by integrating nano-impregnated multi-suspended black cotton ropes with the conical solar distiller basin. These suspended CuO nano-impregnated multi-black cotton ropes help to increase the rates of absorption of solar rays and thus increase the temperature of the suspended black cotton ropes, in addition to the capillary property that distinguishes this type of ropes as well as increasing the surface tension, all these positive effects help to increase the rates of evaporation and thus increase the yield of solar distillers. To achieve this experimentally, the Authors designed, fabricated, and tested three distillers; the first is a traditional conical distiller (TCSD), the second is a developed conical distiller with multi-suspended black cotton ropes (DCSD&amp;MSBCR), and a third is developed conical distiller with nano-impregnated multi-suspended black cotton ropes (DCSD&amp;NIMSBCR). These results showed that the nano-impregnated multi-suspended black cotton ropes (DCSD&amp;NIMSBCR) represent the best design that achieves an accumulative yield of 11.35 L/m² day, representing a 151.1% improvement compared to TCSD. Economically, using the nano-impregnated multi-suspended black cotton ropes (DCSD&amp;NIMSBCR) helps 59.29 % (0.0039 vs. 0.0096 $/liter) reduction in distillate water production cost compared to TCSD.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"368 ","pages":"Article 133034"},"PeriodicalIF":8.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zero-waste recycling of lithium and cobalt from lithium-ion batteries by three-stage electrodialysis","authors":"Adam Isaksson ,&nbsp;Juan Anaya Garzon ,&nbsp;Ida Strandkvist ,&nbsp;Lena Sundqvist Öqvist","doi":"10.1016/j.seppur.2025.133060","DOIUrl":"10.1016/j.seppur.2025.133060","url":null,"abstract":"<div><div>Lithium cobalt(III) oxide (LCO) is an essential component of lithium-ion batteries (LIBs) in portable devices. Electrodialysis is being researched as a sustainable refining method in the recycling of these batteries, with low chemical input and few by-products. This study presents a novel process for zero-waste recycling of LIBs using three types of electrodialysis: metathesis, acid stripping and salt splitting. LCO was leached with sulfuric acid and hydrogen peroxide to bring metals into solution, whereafter cobalt (Co) was transferred to a negatively charged chelate upon addition of ethylenediaminetetraacetic acid (EDTA). Co sulfate (CoSO₄) was used in a metathesis procedure to separate lithium (Li) from Co in the leachate, achieving a separation factor of 16.6 for Li and 41.9 for Co. The Li product was split into Li hydroxide and sulfuric acid using bipolar membranes. Sulfuric acid was added to precipitate EDTA from the Co product and 81.0% of the free acid could be stripped from the solution by electrodialysis. The Co product was evaporated and converted to CoSO₄ upon thermal treatment. Some reagents could potentially be recirculated to achieve a zero-waste process but dilute products, low current utilization and membrane fouling are challenging and make the process less efficient.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"368 ","pages":"Article 133060"},"PeriodicalIF":8.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bifunctional material derived from a Cu/Mn-MOF for the detection and degradation of thiamethoxam residues at effective concentrations: Condition optimization, mechanism exploration and toxicity analysis","authors":"Yuan-Zhen Wang,&nbsp;Ting-Yu Su,&nbsp;Jia-Jia Kou,&nbsp;Yu-Qing Zhan,&nbsp;Yi-Lin Niu,&nbsp;Liu Yang","doi":"10.1016/j.seppur.2025.133047","DOIUrl":"10.1016/j.seppur.2025.133047","url":null,"abstract":"<div><div>Thiamethoxam is a highly effective second-generation nicotinic insecticide. In this study, a new carbon-doped metal oxide <strong>Cu₂Mn₃O₈@C</strong> was successfully synthesized, demonstrating its dual functions–efficient detection and degradation of thiamethoxam. High-temperature calcination of the <strong>Cu/Mn-BDC</strong> precursor produces <strong>Cu₂Mn₃O₈@C</strong>, which exhibits exceptional electric-conducting ability and robust catalytic competence. Additionally, it functions as an electrochemical sensor with high sensitivity, detecting thiamethoxam at a LOD of 361 fmol L⁻¹. Meanwhile, 100 % degradation of thiamethoxam was achieved within 30 min under the optimized electrolytic conditions, demonstrating excellent removal efficiency. In addition, the interaction mechanism between <strong>Cu₂Mn₃O₈@C</strong> and thiamethoxam was investigated, indicating that <strong>Cu₂Mn₃O₈@C</strong> could effectively promote electron transfer and reaction activity in the electrochemical reaction. This investigation furnished a brand-new way to detect pesticide residues in the environment and groundbreaking catalytic materials for the rapid degradation of contaminants, thereby facilitating the implementation of electrochemical technology in environmental treatment.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"368 ","pages":"Article 133047"},"PeriodicalIF":8.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing selective CO2 electroreduction to CO through strong cooperativity between Zn and porous carbon from coal gasification fine slag","authors":"Lin Jia ,&nbsp;Haorun Li ,&nbsp;Min Sun ,&nbsp;Xiaohua Liu ,&nbsp;Heng Zhang ,&nbsp;Mengbo Zou ,&nbsp;Zhihua Guo ,&nbsp;Zewei Fu ,&nbsp;Shanghong Zeng","doi":"10.1016/j.seppur.2025.133049","DOIUrl":"10.1016/j.seppur.2025.133049","url":null,"abstract":"<div><div>Coal gasification fine slag (GFS) is a solid waste produced in the coal gasification process, and its landfill disposal poses a great threat to environmental protection. Herein, the Zn supported on porous carbon derived from coal gasification fine slag was synthesized through the carbon extraction combined with facile wetness chemical impregnation, which can realize electroreduction CO₂ to CO with a FE_CO of 92.5 % at −1.1 V vs. RHE in the context of electrocatalytic CO₂ reduction. Experimental and theoretical analyses rationalize that the strong cooperativity between Zn and PC improves the formation of *COOH and *CO on the Zn sites, substantially accelerating the conversion of CO₂RR towards CO. Our results provide an effective approach to utilize residual carbon in GFS and realize internal circulation of CO₂ in chemical plants.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"368 ","pages":"Article 133049"},"PeriodicalIF":8.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic nanoconfined catalytic ozonation membranes with abundant and robust V-shaped nanopores for rapid pollutant degradation","authors":"Luyi Chai ,&nbsp;Shilong Li ,&nbsp;Runzhang Tao ,&nbsp;Yuying Jiang ,&nbsp;Lele Cui ,&nbsp;Jian Lu ,&nbsp;Yuqing Sun ,&nbsp;Wenheng Jing","doi":"10.1016/j.seppur.2025.133063","DOIUrl":"10.1016/j.seppur.2025.133063","url":null,"abstract":"<div><div>Catalytic separation membranes have emerged as promising materials for pollutant degradation and water treatment, yet their performance is often hindered by challenges such as structural instability, limited catalytic efficiency, low utilization of active sites and species, and insufficient water flux. Here, we present a biomimetic design strategy to construct high-performance nanoconfined catalytic ozonation membranes using MnO₂ as a platform. Inspired by the structural features of Echeveria and pitcher plants, we engineered a radial flower-shaped FeCo@MnO₂ membrane with V-shaped nanochannels (average size: 10.44 nm) via a one-step hydrothermal and doping process. This design achieves an exceptionally high catalytic specific surface area (110.0647 m²/g) and robust structural stability, enabling the efficient utilisation of catalytic sites and active species via the capture and concentration of pollutant molecules within the nanoconfinement. Lattice doping with Fe and Co enhances electron transfer and introduces multiple oxygen vacancies, facilitating the generation of highly oxidizing singlet oxygen (¹O₂). In a catalytic ozonation system, the membrane demonstrated near-complete removal (∼100 %) of diverse water contaminants (50 ppm) with a high reaction rate constant (0.1199 ms⁻¹), a retention time of &lt; 25 ms, and superior water treatment capacity (50 L·m⁻²·h⁻¹·bar⁻¹). This work provides a novel and effective approach for designing nanocatalytic membranes with abundant active sites and efficient active species utilization, offering significant potential for advancing high-performance membrane materials in diverse catalytic applications.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"368 ","pages":"Article 133063"},"PeriodicalIF":8.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zeolite physical mixing restores the high temperature NH3-SCR of CeO2: The crucial role of NOx activation","authors":"Qinyu Zhou ,&nbsp;Chong Tan ,&nbsp;Tianfa Tang ,&nbsp;Yu Wang ,&nbsp;Siyuan Li ,&nbsp;Meilin Tao ,&nbsp;Hongliang Zhang ,&nbsp;Liu Yang ,&nbsp;Changjin Tang","doi":"10.1016/j.seppur.2025.133009","DOIUrl":"10.1016/j.seppur.2025.133009","url":null,"abstract":"<div><div>The occurrence of NH₃ over-oxidation represents one intractable challenge for the effective application of NH₃-SCR technology. Herein, a rational NO<em>_x</em> activation strategy was innovatively proposed to counteract NH₃ over-oxidation during high temperature NH₃-SCR. As a proof of concept, the hybrid catalyst of CeO₂-ZSM-5 was explored. It was shown that the activity of CeO₂ in NH₃-SCR was profoundly improved via physically mixing with ZSM-5, achieving more than 85 % NO at 500 °C, in sharp contrast to the negative NO conversion present for pristine CeO₂. Comprehensive characterizations from NH₃-TPD, NO-TPD and <em>in situ</em> DRIFTS verified the negligible modification of NH₃ oxidation but significant alteration of surface NO<em>_x</em>. Due to the facile NO<em>_x</em> activation, the reaction of NH₃ + NO<em>_x</em> overwhelms that of NH₃ + O₂, leading to the obtainment of excellent high temperature NH₃-SCR performance. The novel strategy reported here is expected to provide valuable guidance for designing NH₃-SCR catalysts with superior high temperature performance.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"368 ","pages":"Article 133009"},"PeriodicalIF":8.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a dual-domain application of C-Co3O4 catalyst for catalytic degradation of chlorobenzene: Unraveling the roles of oxygen vacancies in chlorobenzene removal","authors":"Ying Zhang, Caiting Li, Qi Huang, Xuan Liu, Jungang Zhao, Ziang Zhang, Le Huang, Kuang Yang, Miaomiao Hu, Miao Zhang","doi":"10.1016/j.seppur.2025.133015","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.133015","url":null,"abstract":"Oxygen defects in catalysts serve as active adsorption sites, interacting with metallic species to create active centers and modulate the electronic structure, making their engineering challenging. This study uses a sol–gel method to create C-Co₃O₄ composites with varying oxygen defect concentrations by adjusting calcination temperatures. These catalysts are utilized to catalyze the oxidation of PCDD/Fs (using chlorobenzene as a model pollutant) and toluene in the flue gas from iron sintering. C-Co₃O₄-300 achieves a T₉₀ for the selective removal of chlorobenzene at 268 °C. Even in the presence of toluene, the T₉₀ for chlorobenzene catalytic oxidation shifts to a higher temperature of 299 °C. The C-Co₃O₄-300 catalyst outperforms other C-Co₃O₄ and commercial catalysts, achieving a chlorobenzene degradation rate of 7.84 × 10⁻⁴ mol/g/h at 150 °C-four times higher than Co₃O₄-450. The C-Co₃O₄ composite structure creates interfaces that distort the lattice, increasing oxygen vacancies and enhancing lattice oxygen mobility for gas-phase adsorption. In-situ DRIFTS analysis reveals that breaking benzoquinone is the rate-limiting step in chlorobenzene oxidation. A higher concentration of oxygen vacancies promotes the cleavage of aromatic C=C bonds, thereby driving significant chlorobenzene oxidation. This study provides new insights into engineering oxygen vacancies in C-Co₃O₄ for effective VOCs remediation in thermocatalysis and advanced oxidation processes.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"16 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downstream processing of AAV based gene therapy vectors","authors":"Alois Jungbauer ,&nbsp;Scott Wheelwright","doi":"10.1016/j.seppur.2025.133051","DOIUrl":"10.1016/j.seppur.2025.133051","url":null,"abstract":"<div><div>Adeno-Associated Virus (AAV) purification remains a major challenge due to the presence of empty, overfilled, aberrantly assembled, and aggregated virions. The unfavorable empty-to-full ratio and the low viral titers necessitate purification methods with high resolution and capacity. AAV’s relatively large size (25 nm) requires chromatography materials with large pores to mitigate diffusion limitations, yet larger pores reduce binding capacity. Additionally, virus clearance strategies must be carefully designed when mammalian cells are used for virus production. Continuous ultracentrifugation presents a scalable solution for virus capture, concentration, and separation of different capsid populations, but its high infrastructure costs and limited availability hinder widespread adoption. Affinity chromatography using serotype-specific or agnostic ligands offers an alternative platform approach, enabling direct loading of clarified lysates with elution at low pH, leveraging AAV’s stability under acidic conditions. Ion exchange chromatography, while highly selective, remains difficult to standardize due to AAV’s sensitivity to electrolyte concentration, salt type, and pH, though its high resolution facilitates full-particle enrichment. However, the separation of partially filled and aberrantly filled particles remains an unmet challenge, underscoring the need for new high-capacity, high-resolution chromatography materials. To enhance AAV production efficiency and reduce costs, advancements in both upstream and downstream processing are necessary. Improved expression technologies should aim to increase titers and optimize the full-to-empty ratio, reducing purification burdens. Novel chromatography solutions, including high-resolution continuous separation techniques like Multi-Column Solvent Gradient Purification (MCSGP) and Simulated Moving Bed (SMB) chromatography, hold promise for industrial-scale purification. Optimized feedstock clarification strategies will also be critical in preventing column clogging and ensuring scalability. By addressing these challenges, the field can improve the cost-effectiveness, scalability, and efficiency of AAV production, ultimately enhancing access to gene therapies.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"368 ","pages":"Article 133051"},"PeriodicalIF":8.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}