Journal of Xenobiotics最新文献_第4页

Phytotoxic Effects and Agricultural Potential of Nanofertilizers: A Study Using Zeolite, Zinc Oxide, and Titanium Dioxide Under Controlled Conditions. 纳米肥料的植物毒性效应和农业潜力：沸石、氧化锌和二氧化钛在受控条件下的研究。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-08-01 DOI: 10.3390/jox15040123

Ezequiel Zamora-Ledezma, Glenda Leonela Loor Aragundi, Willian Stalyn Guamán Marquines, Michael Anibal Macías Pro, José Vicente García Díaz, Henry Antonio Pacheco Gil, Julián Mauricio Botero Londoño, Mónica Andrea Botero Londoño, Camilo Zamora-Ledezma

{"title":"Phytotoxic Effects and Agricultural Potential of Nanofertilizers: A Study Using Zeolite, Zinc Oxide, and Titanium Dioxide Under Controlled Conditions.","authors":"Ezequiel Zamora-Ledezma, Glenda Leonela Loor Aragundi, Willian Stalyn Guamán Marquines, Michael Anibal Macías Pro, José Vicente García Díaz, Henry Antonio Pacheco Gil, Julián Mauricio Botero Londoño, Mónica Andrea Botero Londoño, Camilo Zamora-Ledezma","doi":"10.3390/jox15040123","DOIUrl":"10.3390/jox15040123","url":null,"abstract":"Nanofertilizers (NFs) and engineered nanoparticles (NPs) are increasingly used in agriculture, yet their environmental safety remains poorly understood. This study evaluated the comparative phytotoxicity of zinc oxide (ZnO), titanium dioxide (TiO2), and clinoptilolite nanoparticles, three commercial nanofertilizers, and potassium dichromate (K2Cr2O7) using Lactuca sativa seeds under adapted OECD-208 protocol conditions. Seeds were exposed to varying concentrations of each xenobiotic material (0.5-3% for NFs; 10-50% for NPs), with systematic assessment of seedling survival, root and hypocotyl length, dry biomass, germination index (GI), and median effective concentration (EC50) values. Nanofertilizers demonstrated significantly greater phytotoxicity than engineered nanoparticles despite lower application concentrations. The toxicity ranking was established as NF1 > NF3 > NF2 > NM2 > NM1 > NM3, with NF1 being most toxic (EC50 = 1.2%). Nanofertilizers caused 45-78% reductions in root length and 30-65% decreases in dry biomass compared with controls. GI values dropped to ≤70% in NF1 and NF3 treatments, indicating concentration-dependent growth inhibition. While nanofertilizers offer agricultural benefits, their elevated phytotoxicity compared with conventional nanoparticles necessitates rigorous pre-application safety assessment. These findings emphasize the critical need for standardized evaluation protocols incorporating both physiological and ecotoxicological endpoints to ensure safe xenobiotic nanomaterial deployment in agricultural systems.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review on Contamination of Marine Species by Chromium and Zinc: Effects on Animal Health and Risk to Consumer Health. 海洋物种受铬和锌污染的系统综述：对动物健康的影响和对消费者健康的风险。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-08-01 DOI: 10.3390/jox15040121

Alexandre Mendes Ramos-Filho, Paloma de Almeida Rodrigues, Adriano Teixeira de Oliveira, Carlos Adam Conte-Junior

{"title":"A Systematic Review on Contamination of Marine Species by Chromium and Zinc: Effects on Animal Health and Risk to Consumer Health.","authors":"Alexandre Mendes Ramos-Filho, Paloma de Almeida Rodrigues, Adriano Teixeira de Oliveira, Carlos Adam Conte-Junior","doi":"10.3390/jox15040121","DOIUrl":"10.3390/jox15040121","url":null,"abstract":"Potentially toxic elements, such as chromium (Cr) and zinc (Zn), play essential roles in humans and animals. However, the harmful effects of excessive exposure to these elements through food remain unknown. In this sense, this study aimed to evaluate the anthropogenic contamination of chromium and zinc in aquatic biota and seafood consumers. Based on the PRISMA protocol, 67 articles were selected for this systematic review. The main results point to a wide distribution of these elements, which have familiar emission sources in the aquatic environment, especially in highly industrialized regions. Significant concentrations of both have been reported in different fish species, which sometimes represent a non-carcinogenic risk to consumer health and a carcinogenic risk related to Cr exposure. New studies should be encouraged to fill gaps, such as the characterization of the toxicity of these essential elements through fish consumption, determination of limit concentrations updated by international regulatory institutions, especially for zinc, studies on the influence of abiotic factors on the toxicity and bioavailability of elements in the environment, and those that evaluate the bioaccessibility of these elements in a simulated digestion system when in high concentrations.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension in People Exposed to Environmental Cadmium: Roles for 20-Hydroxyeicosatetraenoic Acid in the Kidney. 环境镉暴露人群的高血压：20-羟基二碳四烯酸在肾脏中的作用。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-08-01 DOI: 10.3390/jox15040122

Soisungwan Satarug

{"title":"Hypertension in People Exposed to Environmental Cadmium: Roles for 20-Hydroxyeicosatetraenoic Acid in the Kidney.","authors":"Soisungwan Satarug","doi":"10.3390/jox15040122","DOIUrl":"10.3390/jox15040122","url":null,"abstract":"Chronic kidney disease (CKD) has now reached epidemic proportions in many parts of the world, primarily due to the high incidence of diabetes and hypertension. By 2040, CKD is predicted to be the fifth-leading cause of years of life lost. Developing strategies to prevent CKD and to reduce its progression to kidney failure is thus of great public health significance. Hypertension is known to be both a cause and a consequence of kidney damage and an eminently modifiable risk factor. An increased risk of hypertension, especially among women, has been linked to chronic exposure to the ubiquitous food contaminant cadmium (Cd). The mechanism is unclear but is likely to involve its action on the proximal tubular cells (PTCs) of the kidney, where Cd accumulates. Here, it leads to chronic tubular injury and a sustained drop in the estimated glomerular filtration rate (eGFR), a common sequela of ischemic acute tubular necrosis and acute and chronic tubulointerstitial inflammation, all of which hinder glomerular filtration. The present review discusses exposure levels of Cd that have been associated with an increased risk of hypertension, albuminuria, and eGFR ≤ 60 mL/min/1.73 m2 (low eGFR) in environmentally exposed people. It highlights the potential role of 20-hydroxyeicosatetraenoic acid (20-HETE), the second messenger produced in the kidneys, as the contributing factor to gender-differentiated effects of Cd-induced hypertension. Use of GFR loss and albumin excretion in toxicological risk calculation, and derivation of Cd exposure limits, instead of β2-microglobulin (β2M) excretion at a rate of 300 µg/g creatinine, are recommended.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Farmworkers to Urban Residents: Mapping Multi-Class Pesticide Exposure Gradients in Morocco via Urinary Biomonitoring. 从农场工人到城市居民：通过尿液生物监测绘制摩洛哥多类农药暴露梯度。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-07-23 DOI: 10.3390/jox15040120

Zineb Ben Khadda, Andrei-Flavius Radu, Souleiman El Balkhi, Fagroud Mustapha, Yahya El Karmoudi, Gabriela Bungau, Pierre Marquet, Tarik Sqalli Houssaini, Sanae Achour

{"title":"From Farmworkers to Urban Residents: Mapping Multi-Class Pesticide Exposure Gradients in Morocco via Urinary Biomonitoring.","authors":"Zineb Ben Khadda, Andrei-Flavius Radu, Souleiman El Balkhi, Fagroud Mustapha, Yahya El Karmoudi, Gabriela Bungau, Pierre Marquet, Tarik Sqalli Houssaini, Sanae Achour","doi":"10.3390/jox15040120","DOIUrl":"10.3390/jox15040120","url":null,"abstract":"Pesticide exposure gradients between occupational, para-occupational, and general populations remain poorly characterized in North African agricultural contexts. This study evaluates urinary pesticide levels among farmers, indirectly exposed individuals, and a control group in Morocco's Fez-Meknes region. A cross-sectional survey measured pesticide concentrations using LC-MS/MS in urine samples collected from 154 adults residing in both rural and urban areas. A questionnaire was used to gather information from participants regarding factors that may elevate the risk of pesticide exposure. The results revealed that farmers exhibited the highest concentrations of pesticides in their urine, including compounds classified as Ia/Ib by the World Health Organization. Indirectly exposed individuals showed moderate levels of contamination, with notable detections such as dichlofluanid (22.13 µg/L), while the control group had residual traces of neonicotinoids, notably imidacloprid (2.05 µg/L). Multivariate analyses revealed several sociodemographic factors significantly associated with increased pesticide exposure. The main risk factors identified included low education, residence in an agricultural area, and the consumption of untreated water (wells/rivers). Conversely, wearing personal protective equipment was associated with reduced urinary concentrations. This study highlights intense occupational exposure among farmers, secondary environmental contamination among residents living near treated areas, and the widespread dispersion of pesticide residues into urban areas.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Wound Healing: The Impact of Treatment with Antimicrobial Nanoparticles and Mesenchymal Stem Cells. 皮肤伤口愈合：抗菌纳米颗粒和间充质干细胞治疗的影响。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-07-18 DOI: 10.3390/jox15040119

Pavel Rossner, Eliska Javorkova, Michal Sima, Zuzana Simova, Barbora Hermankova, Katerina Palacka, Zuzana Novakova, Irena Chvojkova, Tereza Cervena, Kristyna Vrbova, Anezka Vimrova, Jiri Klema, Andrea Rossnerova, Vladimir Holan

{"title":"Skin Wound Healing: The Impact of Treatment with Antimicrobial Nanoparticles and Mesenchymal Stem Cells.","authors":"Pavel Rossner, Eliska Javorkova, Michal Sima, Zuzana Simova, Barbora Hermankova, Katerina Palacka, Zuzana Novakova, Irena Chvojkova, Tereza Cervena, Kristyna Vrbova, Anezka Vimrova, Jiri Klema, Andrea Rossnerova, Vladimir Holan","doi":"10.3390/jox15040119","DOIUrl":"10.3390/jox15040119","url":null,"abstract":"An investigation into the biological mechanisms initiated in wounded skin following the application of mesenchymal stem cells (MSCs) and nanoparticles (NPs) (Ag, ZnO), either alone or combined, was performed in mice, with the aim of determining the optimal approach to accelerate the healing process. This combined treatment was hypothesized to be beneficial, as it is associated with the production of molecules supporting the healing process and antimicrobial activity. The samples were collected seven days after injury. When compared with untreated wounded animals (controls), the combined (MSCs+NPs) treatment induced the expression of Sprr2b, encoding small proline-rich protein 2B, which is involved in keratinocyte differentiation, the response to tissue injury, and inflammation. Pathways associated with keratinocyte differentiation were also affected. Ag NP treatment (alone or combined) modulated DNA methylation changes in genes involved in desmosome organization. The percentage of activated regulatory macrophages at the wound site was increased by MSC-alone and Ag-alone treatments, while the production of nitric oxide, an inflammatory marker, by stimulated macrophages was decreased by both MSC/Ag-alone and MSCs+Ag treatments. Ag induced the expression of Col1, encoding collagen-1, at the injury site. The results of the MSC and NP treatment of skin wounds (alone or combined) suggest an induction of processes accelerating the proliferative phase of healing. Thus, MSC-NP interactions are a key factor affecting global mRNA expression changes in the wound.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease. 环境异种和表观遗传修饰：对人类健康和疾病的影响。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-07-13 DOI: 10.3390/jox15040118

Ana Filipa Sobral, Andrea Cunha, Inês Costa, Mariana Silva-Carvalho, Renata Silva, Daniel José Barbosa

{"title":"Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease.","authors":"Ana Filipa Sobral, Andrea Cunha, Inês Costa, Mariana Silva-Carvalho, Renata Silva, Daniel José Barbosa","doi":"10.3390/jox15040118","DOIUrl":"10.3390/jox15040118","url":null,"abstract":"Environmental xenobiotics, including heavy metals, endocrine-disrupting chemicals (EDCs), pesticides, air pollutants, nano- and microplastics, mycotoxins, and phycotoxins, are widespread compounds that pose significant risks to human health. These substances, originating from industrial and agricultural activities, vehicle emissions, and household products, disrupt cellular homeostasis and contribute to a range of diseases, including cancer and neurodegenerative diseases, among others. Emerging evidence indicates that epigenetic alterations, such as abnormal deoxyribonucleic acid (DNA) methylation, aberrant histone modifications, and altered expression of non-coding ribonucleic acids (ncRNAs), may play a central role in mediating the toxic effects of environmental xenobiotics. Furthermore, exposure to these compounds during critical periods, such as embryogenesis and early postnatal stages, can induce long-lasting epigenetic alterations that increase susceptibility to diseases later in life. Moreover, modifications to the gamete epigenome can potentially lead to effects that persist across generations (transgenerational effects). Although these modifications represent significant health risks, many epigenetic alterations may be reversible through the removal of the xenobiotic trigger, offering potential for therapeutic intervention. This review explores the relationship between environmental xenobiotics and alterations in epigenetic signatures, focusing on how these changes impact human health, including their potential for transgenerational inheritance and their potential reversibility.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Integrative Approach to Assessing the Impact of Mercury (Hg) on Avian Behaviour: From Molecule to Movement. 评估汞（Hg）对鸟类行为影响的综合方法：从分子到运动。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-07-09 DOI: 10.3390/jox15040117

Dora Bjedov, Mirta Sudarić Bogojević, Jorge Bernal-Alviz, Goran Klobučar, Jean-Paul Bourdineaud, K M Aarif, Alma Mikuška

{"title":"An Integrative Approach to Assessing the Impact of Mercury (Hg) on Avian Behaviour: From Molecule to Movement.","authors":"Dora Bjedov, Mirta Sudarić Bogojević, Jorge Bernal-Alviz, Goran Klobučar, Jean-Paul Bourdineaud, K M Aarif, Alma Mikuška","doi":"10.3390/jox15040117","DOIUrl":"10.3390/jox15040117","url":null,"abstract":"Mercury (Hg) pollution is a widespread ecological threat with sublethal effects on wildlife. Birds, due to their ecological diversity and sensitivity, serve as effective models for evaluating the behavioural impacts of Hg exposure. This review applies Tinbergen's four questions: causation, ontogeny, function, and evolution, as an integrative framework. Mechanistically, Hg disrupts neuroendocrine pathways, gene expression, immune function, and hormone regulation, leading to behavioural changes such as reduced foraging, altered parental care, and impaired predator avoidance. Early-life exposure affects neural development, learning, and social behaviour into adulthood. Functionally, these changes reduce fitness by compromising reproduction and survival. Phylogenetic comparisons show interspecific variability, with piscivorous and insectivorous birds exhibiting high Hg burdens and sensitivity, linked to ecological roles and exposure. Behavioural responses often precede physiological or demographic effects, highlighting their value as early indicators. Both field and laboratory studies show that even low Hg concentrations can alter behaviour, though outcomes vary by species, life stage, and exposure route. Integrating behavioural endpoints into ecotoxicological risk assessments is essential to improve conservation strategies and understanding of sublethal pollutant effects on wildlife.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Butylated Hydroxyanisole (BHA) Disrupts Brain Signalling in Embryo-Larval Stage of Zebrafish Leading to Attention Deficit Hyperactivity Disorder (ADHD). 丁基羟基茴香醚（BHA）破坏斑马鱼胚胎-幼虫期导致注意缺陷多动障碍（ADHD）的大脑信号传导。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-07-09 DOI: 10.3390/jox15040116

Kandhasamy Veshaal, Ramasamy Vasantharekha, Usha Rani Balu, Mahesh Vallabi Aayush, Saheshnu Sai Balaji Pillai, Winkins Santosh, Barathi Seetharaman

{"title":"Butylated Hydroxyanisole (BHA) Disrupts Brain Signalling in Embryo-Larval Stage of Zebrafish Leading to Attention Deficit Hyperactivity Disorder (ADHD).","authors":"Kandhasamy Veshaal, Ramasamy Vasantharekha, Usha Rani Balu, Mahesh Vallabi Aayush, Saheshnu Sai Balaji Pillai, Winkins Santosh, Barathi Seetharaman","doi":"10.3390/jox15040116","DOIUrl":"10.3390/jox15040116","url":null,"abstract":"Background: Butylated hydroxyanisole (BHA) has been extensively used in several commercial industries as a preservative. It causes severe cellular and neurological damage affecting the developing fetus and might induce attention deficit hyperactivity disorder (ADHD).Methods: Zebrafish embryos were subjected to five distinct doses of BHA-0.5, 1, 2, 4, and 8 ppb up to 96 h post fertilization (hpf). Hatching rate, heart rate, and body malformations were assessed at 48 hpf, 72 hpf, and 48-96 hpf, respectively. After exposure, apoptotic activity, neurobehavioral evaluation, neurotransmitter assay, and antioxidant activity were assessed at 96 hpf. At 120 hpf, the expression of genes DRD4, COMT, 5-HTR1aa, and BDNF was evaluated by real-time PCR.Results: BHA exposure showed a delay in the hatching rate and a decrease in the heart rate of the embryo when compared with the control. Larvae exhibited developmental deformities such as bent spine, yolk sac, and pericardial edema. A higher density of apoptotic cells was observed in BHA-exposed larvae at 96 hpf. There was a decline in catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and superoxide dismutase (SOD) activity, indicating oxidative stress. There was a significant decrease in Acetylcholinesterase (AChE) activity and serotonin levels with an increase in concentration of BHA, leading to a dose-responsive increase in anxiety and impairment in memory. A significant decrease in gene expression was also observed for DRD4, COMT, 5-HTR1aa, and BDNF.Conclusions: Even at lower concentrations of BHA, zebrafish embryos suffered from developmental toxicity, anxiety, and impaired memory due to a decrease in AChE activity and serotonin levels and altered the expression of the mentioned genes.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Arsenic Exposure, Biomarkers and Lung Function in Children from Yaqui Communities in Sonora, Mexico. 墨西哥索诺拉雅基社区儿童的环境砷暴露、生物标志物和肺功能

IF 4.4

Journal of Xenobiotics Pub Date : 2025-07-08 DOI: 10.3390/jox15040115

Ana G Dévora-Figueroa, Anaid Estrada-Vargas, Jefferey L Burgess, Paloma I Beamer, José M Guillen-Rodríguez, Leticia García-Rico, Diana Evelyn Villa-Guillen, Iram Mondaca-Fernández, Maria M Meza-Montenegro

{"title":"Environmental Arsenic Exposure, Biomarkers and Lung Function in Children from Yaqui Communities in Sonora, Mexico.","authors":"Ana G Dévora-Figueroa, Anaid Estrada-Vargas, Jefferey L Burgess, Paloma I Beamer, José M Guillen-Rodríguez, Leticia García-Rico, Diana Evelyn Villa-Guillen, Iram Mondaca-Fernández, Maria M Meza-Montenegro","doi":"10.3390/jox15040115","DOIUrl":"10.3390/jox15040115","url":null,"abstract":"Arsenic exposure in children and adults has been associated with respiratory symptoms, respiratory infections, and decreased lung function. The goal of this study was to evaluate the relationship between environmental arsenic exposure and serum pneumoproteins and lung function. A cross-sectional study was conducted including 175 children exposed to arsenic by drinking water (range: 7.4 to 91 µg/L) and soil (range: 4.76 to 35.93 mg/kg), from some Yaqui villages. Arsenic was analyzed in dust and urine using field-portable X-ray fluorescence spectrometry and ICP/OES, respectively. Serum was analyzed for Clara Cell protein (CC16) and Matrix Metalloproteinase-9 (MMP-9) using immunoassays, and lung function was evaluated by spirometry. The results showed that increased arsenic in drinking water was associated with reduced forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio (β = -0.027, p = 0.0000) whereas, contrary to expectations, arsenic in dust was associated with increased FEV1/FVC (β = 0.004, p = 0.0076). Increased urinary arsenic was associated with reduced % predicted FEV1 (β = -0.723, p = 0.0152) and reduced FEV1/FVC ratio (β = -0.022, p = 0.0222). Increased serum MMP-9 was associated with reduced FEV1/FVC ratio (β = -0.017, p = 0.0167). Children with % predicted FEV1 values less than 80 had the lowest levels of CC16 (Median 29.0 ng/mL, IQR 21.3, 37.4, p = 0.0148). As a conclusion, our study evidenced an impairment in lung function in children exposed to low arsenic levels.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspartame and Human Health: A Mini-Review of Carcinogenic and Systemic Effects. 阿斯巴甜与人类健康：对致癌性和全身效应的综述。

IF 4.4

Journal of Xenobiotics Pub Date : 2025-07-07 DOI: 10.3390/jox15040114

Nour El Doueihy, Joya Ghaleb, Karl Kfoury, Katy Kaleen Khouzami, Nicolas Nassif, Philippe Attieh, Hilda E Ghadieh, Sami Azar, Amjad Kanaan, Frederic Harb

{"title":"Aspartame and Human Health: A Mini-Review of Carcinogenic and Systemic Effects.","authors":"Nour El Doueihy, Joya Ghaleb, Karl Kfoury, Katy Kaleen Khouzami, Nicolas Nassif, Philippe Attieh, Hilda E Ghadieh, Sami Azar, Amjad Kanaan, Frederic Harb","doi":"10.3390/jox15040114","DOIUrl":"10.3390/jox15040114","url":null,"abstract":"Aspartame, a widely used artificial sweetener, has been at the center of ongoing debates concerning its safety, particularly its potential role in cancer development. This review provides an overview and analysis of the current research exploring the carcinogenic effects of aspartame. It examines findings from in vitro studies, in vivo experiments, and epidemiological investigations to offer a comprehensive perspective on the controversy. The results from these studies remain inconsistent-some suggest a possible association between high aspartame intake and increased cancer risk, while others fail to establish a conclusive link. Additionally, this review explores potential mechanisms by which aspartame could exert carcinogenic effects, focusing on its metabolic byproducts and their influence on cellular and molecular processes. Despite these investigations, the question of aspartame's safety remains unresolved. Continued research is essential to clarify its role in cancer risk and to inform evidence-based dietary guidelines.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"15 4","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0