Asian Journal of Transfusion Science最新文献

{"title":"Blood component utilization in hospitalized COVID-19 patients: Experience from a dedicated COVID-19 center.","authors":"Rahul Chaurasia, Richa Aggarwal, Sapna Chopra, Saloni Gupta, Irfan Altaf, Hem Chandra Pandey, Gopal Kumar Patidar, Kapil Dev Soni, Arulselvi Subramanian, Anjan Trikha","doi":"10.4103/ajts.ajts_179_21","DOIUrl":"10.4103/ajts.ajts_179_21","url":null,"abstract":"<p><strong>Background: </strong>Blood transfusion services were seriously affected during COVID-19 not only due to limited availability of blood components but also due to gap in the clinical knowledge about the need for transfusion in COVID-19 patients. However, understanding the transfusion needs is essential for inventory management. We analyzed the utilization of blood components in hospitalized COVID-19 patients and recorded the outcome of the patients who were transfused.</p><p><strong>Materials and methods: </strong>The study included all COVID-19 patients who underwent transfusions over a time period. Patient details included demographics, clinical condition, comorbidities, laboratory parameters, and outcome. Details of transfusion were collected from the blood bank and patient records.</p><p><strong>Results: </strong>Of 3052 hospitalized COVID-19 patients, 395 (12.9%) were transfused blood components and were included in the study. Comorbidities were identified in 85% of these patients. Red blood cell (RBC) was transfused in 348 (11.4%) with a mean of 2.3 units/patient. Similarly, platelets and fresh frozen plasma were transfused in 3.3% of patients (mean 6.2 units) and 3% (mean 4.9 units), respectively. Transfusion triggers were largely restrictive in nature. Patients with haemato-oncologic conditions required significantly higher numbers of RBCs and random donor platelets. RBCs transfusion were also higher in patients requiring intensive care unit care and ventilatory support. Blood components usage was not affected by severity of COVID-19 disease, comorbidity index, or coagulopathy.</p><p><strong>Conclusion: </strong>Blood utilization in COVID-19 patients is typically low. Blood components were mainly required by patients with preexisting comorbidities, or those requiring critical care. RBCs were the predominant blood component transfused. Coagulopathy associated with COVID-19 did not necessitate transfusion.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"108-113"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood transfusion knowledge and practice among nurses in Turkey: A scenario sample.","authors":"Asiye Durmaz Akyol, Hülya Kankaya, Filiz Özel, Gülbin Konakçı","doi":"10.4103/0973-6247.375888","DOIUrl":"10.4103/0973-6247.375888","url":null,"abstract":"<p><strong>Background: </strong>In the maintenance of this important application, it is very important to ensure safety and to prevent complications. Therefore, it must be careful in the transfusion of blood and blood component.</p><p><strong>Aim: </strong>The aim of the study was to define nurses' blood transfusion-related knowledge levels and applications.</p><p><strong>Study settings and design: </strong>The study sample consisted of nurses who worked in a medical faculty hospital, two education and research hospitals and two state hospitals in Turkey. The study was performed with 116 nurses.</p><p><strong>Materials and methods: </strong>\"Nurse Information Form\", \"The Blood Transfusion Knowledge Questionnaire\" and \"The scenario form and a video taken on the errors and drawbacks related to blood transfusion\" were used as data collection instruments.</p><p><strong>Statistical analysis used: </strong>The statistical analysis was performed using SPSS for Windows version 17.0. The sociodemographic data obtained from the study were assessed by numbers frequency and percentage distribution. The blood transfusion knowledge scores of the independent variables and, the relationship between knowledge scores and units were analysis by chi-square, Mann Whitney-U and, Kruskal-Wallis tests.</p><p><strong>Results: </strong>The nurses' mean scores for the blood transfusion knowledge level were 61.81 ± 10.18 (ranging between 0 and 79) for the overall scale. There was a significant relationship between the clinics and questions on pre-transfusion patient preparation knowledge and their mean total knowledge score. The nurses' mean scores for the blood transfusion-related scenario knowledge levels were 36.42 ±15.42 for the overall scenario scores.</p><p><strong>Conclusions: </strong>Based on this, the nurses' knowledge levels about blood transfusion are partly adequate in terms of their mean knowledge scores, and insufficient in terms of their mean scenario knowledge scores.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"24 1","pages":"79-84"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83255369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India.","authors":"Virender Singh, Ajay Kumar Baranwal, Amit Kumar Biswas, Ratish Chandra Mishra, Ishawar Singh","doi":"10.4103/ajts.ajts_111_22","DOIUrl":"10.4103/ajts.ajts_111_22","url":null,"abstract":"<p><strong>Introduction: </strong>Beta-thalassemia trait (BTT) and iron-deficiency anemia (IDA) are the most common causes of microcytic hypochromic anemia (MHA). Concomitant presence of both BTT and IDA can cause a more severe form of anemia that may increase morbidity and mortality. Therefore, the present study was conducted to check the prevalence and assess the impact of IDA on various hematological parameters in BTT subjects.</p><p><strong>Subjects and methods: </strong>The present study was conducted at the department of immunohematology and blood transfusion after taking ethical clearance and written informed consent from all the participants. One hundred and sixty-eight known cases of BTT were included in this study. Out of these, 88 were females and the remaining 80 were males with ages ranging from 9 to 65 years. Blood samples collected in ethylenediaminetetraacetic acid and sterile vacutainers were assessed for complete blood count, serum iron, total iron-binding capacity (TIBC), and ferritin. All the data were analyzed using IBM SPSS Statistics software version 28.0.1.1 (15).</p><p><strong>Results: </strong>The majority of the patients had MHA on peripheral blood smears. Thirty-nine (23.21%) out of 168 BTT subjects were found to have IDA. Hemoglobin, mean corpuscular volume, mean cell hemoglobin, and mean cell hemoglobin concentration levels were significantly reduced in patients of Group I (BTT with IDA) when compared to Group II (BTT without IDA). The mean (± standard deviation) value of serum iron, total TIBC, and ferritin showed significant differences between the two groups.</p><p><strong>Discussions and conclusion: </strong>High prevalence of IDA in patients of BTT in the current study suggests that there is a need for careful evaluation in the differentiation and diagnosis of BTT and IDA, especially in females, as IDA is more common in females. Moreover, IDA has a significant impact on various hematological parameters in BTT subjects.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"48-52"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of coronavirus disease 2019 vaccination on donor deferral pattern in a tertiary care hospital of ESIC, New Delhi.","authors":"Hanisha Jain, Bharat Singh, Anita Mittal","doi":"10.4103/ajts.ajts_79_22","DOIUrl":"10.4103/ajts.ajts_79_22","url":null,"abstract":"<p><strong>Background: </strong>Blood transfusion is an integral part of the health-care system. A healthy donor is important for safe blood transfusion. Donors are selected based on the deferral criteria given by the Drugs and Cosmetics Act 1940 and amended thereof. Coronavirus disease 2019 (COVID-19) vaccination became mandatory after the spread of COVID-19 pandemic and was included in the deferral criteria.</p><p><strong>Objective: </strong>The objective was to study and analyze the impact of COVID-19 vaccination on the deferral pattern in blood donors.</p><p><strong>Materials and methods: </strong>A retrospective study was carried out in the Department of Immunohematology and Blood Transfusion for pre-COVID period from January 2019 to December 2019 for the most common reason of deferral before COVID-19 and for comparison for donor deferral with COVID-19 period. Then, a retrospective study was carried out over a period of 12 months from February 2021 to January 2022. The demographic details of donors such as age, gender, voluntary or replacement donation, and temporary and permanent reasons for deferral were recorded. The data were entered in the MS Excel sheet and descriptive statistics were calculated.</p><p><strong>Results: </strong>The total numbers of registered donors were 7064. Six thousand two hundred and sixty-four donors were accepted for donation, of which voluntary donations were 4478 (71.48%). The deferred donors were 800 (11.3%). Seven hundred and thirty-eight (92.26%) deferred donors were male; the most common cause of temporary deferral was COVID-19 vaccination 179 (22.37%), followed by low hemoglobin 162 (20.25%). The common causes of permanent deferral were high blood pressure 36 (5.17%) and history of unknown jaundice 10 (1.43%).</p><p><strong>Conclusion: </strong>COVID-19 vaccination had a significant impact on the pattern of donor deferral. However, this was only a temporary situation till the pandemic is over. The loss of potential donors has adversely impacted the transfusion services.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"53-57"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turning gravity upside down: What led to reversing the position of red blood cells above plasma after centrifugation.","authors":"Azeez Mohammed, Shamee Shastry, Deepika Chenna, Deep Madkaiker, Ganesh Mohan, Tom Devasia","doi":"10.4103/ajts.ajts_197_23","DOIUrl":"10.4103/ajts.ajts_197_23","url":null,"abstract":"","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"183-184"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study to assess Vitamin D and serum ferritin levels among prospective female blood donors with low hemoglobin levels.","authors":"Anila Mani, Amita Radhakrishnan Nair, Debasish Gupta","doi":"10.4103/ajts.ajts_13_22","DOIUrl":"10.4103/ajts.ajts_13_22","url":null,"abstract":"<p><strong>Introduction: </strong>Anemia is one of the leading causes of deferral from blood donation. Classically, an individual's iron status is assessed with respect to serum ferritin (S. ferritin) levels. S. ferritin levels vary with phases of the menstrual cycle and may not reflect the actual iron stores. Currently, there are certain studies that explain the role of Vitamin D in erythropoiesis. The present study was conducted to assess the emerging association of Vitamin D with hemoglobin (Hb) levels among the female blood donor population.</p><p><strong>Materials and methods: </strong>A hospital-based cross-sectional study was conducted on 111 female blood donors over 1 year. The association of Hb levels with Vitamin D and S. ferritin levels, dietary factors, frequency of blood donations, and the number of pregnancies was analyzed.</p><p><strong>Results: </strong>The prevalence of Vitamin D deficiency was 80.18% (<i>n</i> = 89) in this study. Among donors with low Hb levels, 24.32% (<i>n</i> = 27) had low ferritin and 51.34% (<i>n</i> = 57) had low Vitamin D levels. 18.01% (<i>n</i> = 20) of the donors had low Hb levels with coexistent low ferritin and low Vitamin D levels.</p><p><strong>Conclusion: </strong>It is imperative to replenish the iron stores of blood donors who face deferral from blood donation due to low Hb levels. This is a preliminary study from India which looks into the Hb levels of female donors with regard to their Vitamin D status. Those females who were found to be deficient in Hb and Vitamin D levels were referred to treating clinicians for supplementation and dietary modifications. The major goal of this study was to bring those women who got deferred due to low Hb levels back to the voluntary blood donor pool once they replenished their iron stores.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"17-22"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical analytes in centrifuged blood samples could be affected by the age of subjects in different time periods and storage temperatures.","authors":"Mahsa Yazdanbakhsh, Mohammad Reza Deyhim, Hanieh Jafary, Mohammad Hessam Rafiee, Mohammad Moradi","doi":"10.4103/ajts.ajts_178_21","DOIUrl":"10.4103/ajts.ajts_178_21","url":null,"abstract":"<p><strong>Background and objectives: </strong>Collection and providing standard blood samples for examination is critical for all medical laboratories. Currently, for all blood samples taken from the elderly and young people, the same preparation protocol is applied. We hypothesized that the blood taken from older individuals is more vulnerable to preparation conditions compared with the younger ones. This study aimed to assess the effect of storage duration and temperature on biochemical analytes in serum samples taken from old and young participants.</p><p><strong>Materials and methods: </strong>Blood samples from 30 healthy participants including 15 young people (eight males and seven females, 20-35 years old) and 15 elderly people (eight males and seven females, 60-75 years old) were collected. For each participant, serum sample tubes stored at different time intervals (2 and 24 h) and temperatures (4°C, 25°C, and - 20°C). The biochemical analytes were examined by an automated analyzer. Total antioxidant capacity was assayed by a commercial kit. Nitric oxide metabolites were measured by Griess reagent.</p><p><strong>Results and conclusion: </strong>Intragroup analysis in young and older participants showed that lactate dehydrogenase levels were significant in 2 h incubation time at 20-24°C and in 24-h incubation times at 20-24°C and 4°C compared with the baseline time (T0) (<i>P</i> < 0.05). Intergroup analysis showed that glucose and urea levels were higher among the older participants than the youth group at baseline and 24 h times (<i>P</i> < 0.05). Furthermore, the magnesium and nitric oxide levels were higher in the youth group than the elderly ones at baseline and 24 h times (<i>P</i> < 0.05).</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"27 1","pages":"58-64"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78587724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of knowledge, attitude, and response regarding transfusion-transmitted infections in blood donors sero-reactive for viral markers during postdonation counselling as an attempt to identify and bridge the gaps in the blood donation process.","authors":"Anju Dubey, Atul Sonker","doi":"10.4103/ajts.ajts_174_24","DOIUrl":"10.4103/ajts.ajts_174_24","url":null,"abstract":"<p><strong>Background: </strong>Donor notification and counseling have been mandated by the Indian action plan for blood safety to facilitate the early diagnosis and subsequent management of sero-reactive blood donors as well as to prevent the spread of infection through subsequent blood donations. This retrospective and questionnaire-based study was conducted with the aim of understanding the level of knowledge, difference in attitudes, and pattern of responses of sero-reactive blood donors which could aid in designing of clear and unambiguous donor educational program as well as enhance the effectiveness of donor selection procedures. Furthermore, the rates of donors' response to notification and compliance to clinical referral were assessed to find the areas which require improvement.</p><p><strong>Methods: </strong>Blood donors sero-reactive for viral markers were notified and subjected to postdonation counselling and were asked questions to assess their knowledge, attitude, and response. Retrospective analysis of data of 5 years was done. Donors were followed up by enquiring their status 6 months' postreferral.</p><p><strong>Results: </strong>Of the 1991 repeat reactive blood donors, 1256 (63.08%) responded for counseling and referral. Long distance and busy schedule were the most common reasons for nonresponse. Lack of privacy and lack of understanding were the main reason for nondisclosure of pertinent information by blood donors. On follow-up, 634 (50.48%) of those counseled actually visited the prescribed referral center.</p><p><strong>Conclusion: </strong>Donor counseling should be done by a trained counselor ensuring an understanding of the importance of transfusion-transmitted infection transmission. Donors should be informed about high-risk behavior and self-exclusion should be facilitated.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"11-16"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographics of plateletpheresis donors and session profile in a teaching institute of Punjab.","authors":"Harnoor Singh Bhardwaj, Amarjit Kaur, Rajesh Kumar, Sonia Gupta","doi":"10.4103/ajts.ajts_39_21","DOIUrl":"10.4103/ajts.ajts_39_21","url":null,"abstract":"<p><strong>Background: </strong>Over decades, increased demand of platelet transfusions for patients with various conditions led to accelerated use of technologically advanced plateletpheresis.</p><p><strong>Aims: </strong>Study the demographics of plateletpheresis donor and plateletpheresis session profile.</p><p><strong>Setting and design: </strong>Prospective, cross-sectional, open label study.</p><p><strong>Materials and methods: </strong>Plateletpheresis performed on Trima Accel (TA) and mechanical circulatory support (MCS) + during 2017-2018 on donors selected according to the guidelines.</p><p><strong>Statistical analysis: </strong>SPSS (version 17) for windows statistical package.</p><p><strong>Results: </strong>Two thousand eighty hundred and thirty-six plateletpheresis procedures were done, out of which 666 (23.48%) were done on TA while 2170 (76.51%) were done on MCS +. Maximum donors, 1437 (55.66%) were in the 21-30 years category; Mean age was 30.75 years ± 8.44 standard deviation (SD); range18-65 years. Maximum donors 1185 (41.78%) were in the 61-70 kg category with mean weight - 74.33 kg ± 9.80 SD and mean height - 170.46 cm ± 4.99 SD only 4 (0.15%) donors were females. Two thousand six (70.73%) donors were voluntary, with 1620 (57.12%) repeat donors. Mean platelet count was 272.98 ± 56.59 × 10⁹/L with maximum donors having platelet count between 200 and 300 × 10⁹/L and ranged from 157 to 508 × 10⁹/L. Mean hemoglobin of donors - 14.87 g % ± 3.16 SD; total serum protein - 6.31 g/dl ± 4.8 SD. Mean platelet yield was 3.50 × 10¹¹ ± 0.71 SD; ranged from 2.9 to 7 × 10¹¹. Plateletpheresis session profile of reactors and nonreactors showed that acid citrate dextrose used in reactors was more - 353.44 ml as compared to nonreactors - 311.72 ml. Reactors showed more volume of whole blood processed - 2899.43 ml as compared to nonreactors - 2601.63 ml. Time taken for completing the session was more in reactors - 82.40 mins as compared to nonreactors - 70.80 min. Platelet yield was 3.79 × 10¹¹ and 3.49 × 10¹¹ and plasma volume was 275.6 ml and 261.2 ml in reactors and nonreactors respectively.</p><p><strong>Conclusion: </strong>Demographics of plateletpheresis donors and session profile are vital for their safety.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"99-103"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of therapeutic plasma exchange in dengue-related microangiopathy.","authors":"Aarushi Sahni, Sarthak Wadhera, Divjot Singh Lamba, Rekha Hans, Arihant Jain, Pankaj Malhotra, Ratti Ram Sharma","doi":"10.4103/ajts.ajts_227_23","DOIUrl":"10.4103/ajts.ajts_227_23","url":null,"abstract":"<p><p>Thrombotic microangiopathies (TMAs) are a group of disorders characterized by microangiopathic hemolytic anemia and thrombocytopenia, leading to ischemic tissue injury. We, hereby, describe an interesting case of TMA secondary to dengue along with dengue encephalitis. Dengue-related TMA is rarely described. Treatment was initiated with standard-volume (1.5 plasma volume) therapeutic plasma exchange (TPE) by centrifugation method on a multifunctional cell separator (Spectra Optia, Terumo BCT, USA) within a few hours of admission based on high PLASMIC score, which led to improvement in hemolytic parameters and kidney injury. This case highlights the role of early diagnosis and early initiation of TPE is key in the management of dengue-related TMAs.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"163-166"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}