Asian Journal of Transfusion Science最新文献

{"title":"Therapeutic plasma exchange using apheresis: Clinical experience and outcomes in neurological and non-neurological cases at a tertiary care center in western India.","authors":"Shashikant Baraku Patil, Satyajit Singh Gill, Sandeep Borse, Nilesh Bhandari, Sulaxmi Kurade-Aher","doi":"10.4103/ajts.ajts_195_24","DOIUrl":"10.4103/ajts.ajts_195_24","url":null,"abstract":"<p><strong>Introduction: </strong>Therapeutic plasma exchange (TPE) is a procedure used to treat various neurological and non-neurological disorders by removing and replacing a patient's plasma to eliminate disease-causing substances. Here, we present our experience using TPE to treat various diseases with an apheresis machine.</p><p><strong>Aim: </strong>To evaluate the safety and efficacy of TPE as a treatment modality in various patients with neurological and non-neurological diseases admitted in tertiary care center in western India.</p><p><strong>Methodology: </strong>A retrospective analysis of 152 TPE procedures was conducted over 3 years (April 2021-April 2024) in a Western Indian tertiary care hospital. The study involved 39 patients aged 7-72 years. Clinical improvement was assessed through relevant investigations before, during, and after TPE procedures.</p><p><strong>Results: </strong>Thirty-nine patients were studied, with Guillain-Barre Syndrome (GBS) being the most common indication for TPE, followed by acute liver failure (ALF) and myasthenia gravis (MG). Clinical improvement was seen in 76.19% (16/21) of GBS patients, 12.5 (1/8) of ALF, and 100% (5/5) of MG patients. 13/18 (72.22%) patients in the neurological category showed complete recovery even after replacement of 0.5-0.9 plasma volume (<i>n</i> = 18). The adverse reaction rate for TPE was 5.92% (9 events in 152 cycles), most common being allergic reactions and paresthesia.</p><p><strong>Conclusion: </strong>TPE is safe and efficient treatment modality for the treatment of neurological and non-neurological diseases. Our experience highlights TPE's safety and efficacy. One group in the neurological category showed improvement even with low-volume exchanges (0.5-0.9 PV). Further research is required to enhance the understanding and use of TPE in patient care.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"114-120"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of acute liver failure during pregnancy by therapeutic plasma exchange - A multidisciplinary approach.","authors":"Rishabh Bose, Aswin K Mohan, Vaidehi Prasanth, Davis Cherian, Om Kumari, Ashish Jain, Daljit Kaur, Gita Negi, Anand Sharma","doi":"10.4103/ajts.ajts_169_23","DOIUrl":"10.4103/ajts.ajts_169_23","url":null,"abstract":"<p><p>Therapeutic plasma exchange (TPE) has been associated to improve survival in critically ill patients with liver failure who are not anticipated to survive until liver transplantation. In pregnant patients with acute liver failure (ALF), standard volume TPE can be done, foreseeing complications such as fetal distress, hypofibrinogenemia, hypercalcemia, and adverse transfusion reactions. TPE has been demonstrated to lower inflammatory cytokine levels, modify adaptive immunity with the potential to minimize infection susceptibility, and lower albumin and water-bound toxin levels in liver failure. In this article, the multidisciplinary approach, efficacy, and technical considerations were elaborated in the management of a young pregnant female diagnosed with ALF by TPE.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"158-162"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restless legs syndrome in frequent blood donors and its relationship with ferritin levels and red cell indices.","authors":"Davood U Bava, Gita Negi, Ravi Gupta, Sushant Kumar Meinia, Ranjan Mukharjee, Aswin K Mohan","doi":"10.4103/ajts.ajts_181_21","DOIUrl":"10.4103/ajts.ajts_181_21","url":null,"abstract":"<p><strong>Introduction: </strong>Restless legs syndrome (RLS) is characterized by an urge to move the legs or arms, associated with uncomfortable sensations. Frequent blood donation is one of the known risk factors for RLS. Earlier studies have shown that the prevalence of RLS varies between 4% and 18% among blood donors. The present study was done to assess the prevalence of RLS among repeat blood donors and to find out its correlates in Indian population.</p><p><strong>Materials and methods: </strong>This study was done for a period of 1 year from April 2019 to March 2020. Two hundred donors who fulfilled the definition of \"regular donor\" by National AIDS Control Organization were enrolled by convenient sampling. Responses to the Hindi version of CHRLS questionnaire for RLS were noted, and history of number of previous blood donations was taken. Estimation of red cell indices and serum ferritin levels was also done.</p><p><strong>Results: </strong>Two hundred donors were selected for analysis. Out of which, 198 donors were males (99%). RLS was reported in only four donors (2%) and all of them were males. This was comparable to population prevalence of RLS reported in this region.</p><p><strong>Conclusion: </strong>The prevalence of RLS among repeat blood donors in Indian population was comparable to the general population. Our findings could be reassuring for the frequent donors. Inclusion of basic questions on symptoms of RLS in the donor screening questionnaire can be useful in detecting impending iron deficiency, though its impact on a big scale is doubtful.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"8 1","pages":"104-107"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75679629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotational thromboelastometry and patient blood management: A narrative review.","authors":"Elham Khalaf-Adeli, Fatemeh Tobeyani","doi":"10.4103/ajts.ajts_18_23","DOIUrl":"10.4103/ajts.ajts_18_23","url":null,"abstract":"<p><p>Limitation of standard coagulation tests in early detection of coagulopathy leads to empirical decision-making for the management of the coagulopathy, which in many cases is accompanied by improper transfusion. Some studies have investigated the role of rotational thromboelastometry (ROTEM) in reducing the need for blood products in different clinical conditions, which have been associated with different results. Whether ROTEM as a point of care test reduces the need for transfusion in all clinical settings is still a question. A brief introduction of methodology of ROTEM and its role in patient blood management (PBM) approach is explored in this review. Search was performed to find literature describing ROTEM applied for decrease in transfusion requirements. Specific search terms were \"Thromboelastometry,\" \"ROTEM,\" \"Cardiac surgical procedures,\" \"Trauma,\" \"wounds and injuries\" \"Liver transplantation,\" \"obstetric\" \"Transfusion,\" and \"PBM.\" we reached to 75 publications for this review after application of our search strategy. The number of publications in the field of obstetric was insufficient for review and conclusion. The available evidence supports the helpfulness of ROTEM test in reducing the need for blood transfusions in surgery or trauma. However, it is need to further investigation to evaluate the benefit and efficacy of ROTEM in other medical conditions such as obstetric hemorrhage.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"130-137"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of blood group discrepancy and serological evaluation of weak B phenotype in a healthy blood donor: A case report from West Bengal.","authors":"Sourav Mukherjee, Anuja Ghosh Dastidar, Vikash Kumar, Purushottam Chatterjee","doi":"10.4103/ajts.ajts_21_21","DOIUrl":"10.4103/ajts.ajts_21_21","url":null,"abstract":"<p><p>Several weaker subgroups of B have been described (e.g. B3, Bx, Bm, and Bel) which are very infrequently encountered. These subgroups show weaker and variable serologic reactivity with the commonly used human polyclonal antisera, thus causing group discrepancy and dilemma to resolve these problems and mismatch blood transfusion. Here, we present a case of weak B subgroup detected in a 40-year-old male voluntary blood donor. His red cells showed weak agglutination with anti-B and anti-AB, and in his serum, there were potent anti-A and weak anti-B which were not detected at 37°C. After adsorption with anti-B, an eluate was prepared from the patient's cells which agglutinate with B and AB cells but did not agglutinate with A or O cells. His probable blood group is Bx. With special serological testing, a rare group is detected and decision is made to provide blood to the right patient at the right time.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"138-140"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A unique case of red blood cell agglutination reaction on glass surface in otherwise normal sample.","authors":"Neema Tiwari, Archita Kansal Tiwari, Rani Bansal, Shivani Tomar","doi":"10.4103/ajts.ajts_17_22","DOIUrl":"10.4103/ajts.ajts_17_22","url":null,"abstract":"<p><p>Autoimmune hemolytic anemias (AIHAs) are not very common, and autoimmunity is an important cause of hemolytic anemia, especially in female population. Some primary AIHAs are cold or warm agglutinin mediated anemia. Autoimmune reaction leads to macrophage activation as well as conversion of normal RBCs into spherocytes leading to their destruction and causing hemolysis leading to anemia. Rarely autoimmune phenomena can lead to agglutination however Cold agglutinin disease or Warm agglutinin disease have specific tests which are diagnostic for them. Here, we highlight a known case of Grave's disease who was admitted to the emergency and on sampling the peripheral blood repeated agglutination/clumping of RBCs occurred on glass surface but nothing happened in the plastic EDTA tube. This to the authors was extremely puzzling phenomena which occurred even on repeat sample for the case, Hence the authors warranted a need to discuss this.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"173-176"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing type and screen method replacing conventional antiglobulin crossmatch procedure for compatibility testing in elective protocol in a tertiary care hospital.","authors":"I Suresh Kumar, Rajendra G Kulkarni, Dibyajyoti Sahoo, Abhishekh Basavarajegowda","doi":"10.4103/ajts.ajts_112_22","DOIUrl":"10.4103/ajts.ajts_112_22","url":null,"abstract":"<p><strong>Introduction: </strong>Pretransfusion testing is an essential and important investigation to provide safe and fully compatible packed red blood cell (PRBC) unit to the recipient to prevent the fatal hemolytic transfusion reaction. Type and screen (T and S) procedure is one of the effective approaches in pretransfusion testing in which antibody screen (AS) negative recipients are transfused with an immediate saline phase compatible PRBC unit. In order to explore the feasibility of implementing T and S protocol in our institute, this study was carried out. The main aim of our study was to compare the T and S protocol in AS-negative recipients with anti-human globulin (AHG) phase crossmatch in patients requiring PRBC under elective protocol.</p><p><strong>Materials and methods: </strong>Our study was a cross-sectional analytical study carried out in all the elective blood samples with a history of transfusion or pregnancy. In our study, 849 elective blood samples were subjected to antibody screening by reagent 3 red cell screening panel and AS-negative blood samples were subjected to immediate saline phase crossmatch, and compatible units were issued to the patients. The same samples were subjected to AHG phase crossmatch for validation.</p><p><strong>Results: </strong>Among 14,705 elective requests for PRBC 849 patients had a history of transfusion or pregnancy. Of 849 patients, no case was found to be positive for antibody screening. Totally around 1028 PRBC units were saline crossmatched and totally 677 PRBC units were issued to the patients under T and S protocol. Not even a single case where AHG crossmatch was incompatible when antibody screening was negative. There was a perfect agreement between T and S method and AHG phase crossmatch. Crossmatch transfusion ratio was reduced from 2.1-1.5 with the implementation of T and S protocol.</p><p><strong>Conclusion: </strong>This study validated and showed that there was a perfect agreement between T and S protocol and AHG phase crossmatch. All blood requests under elective protocol, the T and S method can be implemented for better utilization of technical workforce and better inventory management.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"23-28"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ABO blood groups and their clinical indices during COVID-19 infection.","authors":"Sreekanth Patnam, Sudha Ranganathan, Nagalla Balakrishna, Anula Divyash Singh, Rajeswari Koyyada, Swarna Deepak Kuragayala, Prerna Bommasamudram, Sasidhar Venkata Manda, Polati Vishnu Rao","doi":"10.4103/ajts.ajts_97_22","DOIUrl":"10.4103/ajts.ajts_97_22","url":null,"abstract":"<p><strong>Aim: </strong>To explore the association of ABO blood groups with COVID-19 severity, mortality, hospital stay, and their clinical indices.</p><p><strong>Methods: </strong>Retrospective clinical data from 185 COVID-19 patients were stratified into four-time points based on their survival status and length of hospital stay (<8> days). Chi-square tests, two-way ANOVA, multinomial logistic regression analyses, and multivariate logistic regression analyses were used to study their associations, strengths, and risk.</p><p><strong>Results: </strong>The frequency distributions of blood groups among COVID-19 patients were A (19.45%), B (26.48%); AB (7.02%); and O (47.02%), respectively. Even though patients in the O-blood group had the highest infection rate (47.02%), patients in the AB blood group had the maximum severity and mortality and patients in the A-blood group had the most negligible mortality. The mean overall survival time among different blood groups was O (23), A (19), B (24), and AB (17) days. Mean platelet count (%), aggregate index of systemic inflammation (AISI), Platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and hospital stay were increased (<i>P</i> < 0.005) in the AB blood group among survivors >8 days. Total leukocyte count (TLC) cells/mm³ levels were increased among nonsurvivors in <8 days in the AB blood group (<i>P</i> < 0.005). Lactate dehydrogenase U/L was increased (<i>P</i> < 0.005) in A blood group of nonsurvivors of <8 days.</p><p><strong>Conclusions: </strong>Even though O blood group patients had the highest infection rate, AB group patients had the most severe disease accompanied by the least survival. Higher (AISI, PLR, SII, and higher TLC) were associated among the survivors of the AB blood group.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"4 1","pages":"85-93"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82438213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal serum and cord blood anti-A and Anti-B antibody levels as a predictor of significant hyperbilirubinemia in newborns.","authors":"Pramod Uttamlal Toshniwal, Lalitha Krishnan, Simon Kingsley, Satish Kurvila, M Manikandan","doi":"10.4103/ajts.ajts_182_21","DOIUrl":"10.4103/ajts.ajts_182_21","url":null,"abstract":"<p><strong>Background: </strong>Hemolytic disease of the newborn (HDN) was more common due to Rh incompatibility. Its prevalence has decreased due to introduction of Immunoglobulin G (IgG) prophylaxis against RhD antigen. HDN due to ABO incompatibility has become more common.</p><p><strong>Aim: </strong>The aim of this study was to study the predictive value of umbilical cord serum and maternal serum anti-A and anti-B antibody titer for the occurrence of significant hyperbilirubinemia in newborns.</p><p><strong>Settings and design: </strong>This was a prospective cohort study which included 139 \"O\" blood group mothers and their offspring with A or B blood groups.</p><p><strong>Materials and methods: </strong>We analyzed the IgG anti-A, and anti-B antibody titers from cord blood and maternal serum and correlated them with features of significant hyperbilirubinemia. Positive predictive value (PPV), negative predictive value (NPV), sensitivity and specificity were calculated.</p><p><strong>Results: </strong>Twenty-eight newborns out of 139 (20 %) developed significant hyperbilirubinemia and required phototherapy. One newborn required immunoglobulin infusion. Out of these 28 newborns' maternal serum, 22 (79%) newborns' maternal serum had IgG antibody titer of ≥128. Cord blood serum IgG antibody titer was 1:2 in all newborns, which was not significant. The direct Coombs test was positive in six (4%) newborns with maternal IgG antibody titer ≥128.</p><p><strong>Conclusion: </strong>Maternal IgG antibody titer was ≥1:128 and can predict significant hyperbilirubinemia in newborns with a sensitivity of 53.5%, specificity of 98.2%, PPV of 88%, NPV of 89%, and <i>P</i> value (<i>P</i> > 0.001).</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"73-78"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How did we find cross-match compatible blood for a male child with alloantibodies when his serum was in short supply?","authors":"Sanmukh Ratilal Joshi, Mayuri Vekariya, Priya Radadiya, Manisha Rajapara","doi":"10.4103/ajts.ajts_160_24","DOIUrl":"10.4103/ajts.ajts_160_24","url":null,"abstract":"","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 1","pages":"185-186"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}