Asian Journal of Transfusion Science最新文献

{"title":"Prevalence of hepatitis B and C markers in blood donors deferred from donating blood due to hepatitis-related risk factors.","authors":"Ushasree Ravula, Suchet Sachdev, Ajay Kumar Duseja, Arnab Pal, Jasmeet Kaur, Rekha Hans, Ratti Ram Sharma, Neelam Marwaha","doi":"10.4103/ajts.ajts_190_25","DOIUrl":"10.4103/ajts.ajts_190_25","url":null,"abstract":"<p><strong>Introduction: </strong>The donor selection criteria are developed to identify and defer the blood donors at risk of infections for an appropriate duration of time to allow time for the infectious agent to elicit an immune response for the purpose of diagnostic detection.</p><p><strong>Materials and methods: </strong>This was an observational study to compare the prevalence of markers of hepatitis B and hepatitis C in 1000 donors deferred on hepatitis-related risk factors, with 62,328 donors selected for donations on quality-assured enzyme-linked immunosorbent assay and individual unit nucleic acid testing (NAT).</p><p><strong>Results: </strong>In 1000 deferred donors, 8 (0.8%), 10 (1%), and 17 (1.7%) were reactive for hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (HCV) antibodies, and initial NAT; 8 (0.8%) and 7 (0.7%) discriminated against hepatitis B virus (HBV) and HCV, respectively. In 62,328 selected donors, 260 (0.4%), 267 (0.4%), and 76 (0.12%) were reactive for HBsAg, anti-HCV antibodies, and initial NAT; 26 (0.04%) and 8 (0.01%) discriminated against HBV and HCV, respectively. NAT yield was 4 (0.4%, <i>n</i> = 982) in deferred donors and 76 (0.1%, <i>n</i> = 62253) in selected blood donors. The deferral could exclude 1-2 HBV and/or HCV-reactive blood donors from entering the quarantine blood supply for every 100 donors with a history of hepatitis-related risk factors. The history of high-risk behavior was a statistically significant risk factor for the presence of markers of hepatitis B and C in deferred donors.</p><p><strong>Conclusion: </strong>The study highlights the need for surveillance of hepatitis-related risk factors in the potential blood donor population to generate evidence for periodic updates to the donor selection criteria.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"67-73"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and hormonal stress response during blood donation in healthy voluntary donors.","authors":"A M Gayathri, Debasish Gupta, George Paul Thaliath, R Abhilash","doi":"10.4103/ajts.ajts_50_24","DOIUrl":"10.4103/ajts.ajts_50_24","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to assess the physiological and hormonal stress response during blood donation in healthy voluntary donors.</p><p><strong>Background: </strong>Blood donation is a stressful event which can cause adverse reactions in this altruistic attempt. This can lead to a reduction in the precious donor population, and there are very less studies on levels of physiological (heart rate and blood pressure [BP]) and hormonal stress in the blood donation. Our attempt is to understand whether there is really a quantifiable physiological and/or hormonal stress during the process of blood donation and whether responses differed in terms of between age, gender, and experience of donors in the blood donation.</p><p><strong>Materials and methods: </strong>Randomly selected eligible seventy whole blood donors were selected for the study after obtaining written informed consent. They were medically assessed before selecting and saliva samples were collected just before needle insertion for assessment of salivary cortisol levels. A 2 ml blood sample for serum cortisol assessment from the blood bag tubing at the end of the donation was also collected.</p><p><strong>Results: </strong>Stress indicators during donation are compared between different age groups as well as experience of blood donation, and no association is found between them. BP is found to have an association to gender, and salivary cortisol levels were found to be higher in 69 out of 70 blood donors.</p><p><strong>Conclusion: </strong>Salivary cortisol can be used as a tool for acute stress assessment in blood donation. The response patterns differ between age, women and men, and first-time versus experienced donors.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"28-34"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody-mediated rejection of transplanted kidney associated with anti-Jka alloantibodies: An interesting case report with review of literature.","authors":"Rasika Dhawan Setia, Mitu Dogra, Rajan Duggal, Vishal Saxena, Jasbir Singh, Anil Handoo","doi":"10.4103/ajts.ajts_214_24","DOIUrl":"10.4103/ajts.ajts_214_24","url":null,"abstract":"<p><p>There is increasing evidence for renal expression of non-ABO minor blood group antigens on the renal endothelium of the vasa recta and tubular epithelial cells. The role of antibodies to minor blood group antigens posing as an immunological risk to the transplanted allograft is under-recognized. We present one interesting case of a 40-year-old male patient who developed antibody-mediated rejection (AMR), leading to graft loss despite multiple interventions. Interestingly, he was found to have antibodies to the Kidd red-cell antigen, Jka, which later was found to be also present in his kidney donor. In the absence of anti-HLA antibodies, we believe preformed donor-specific anti-Jka antibodies best explain AMR in our case. With our case report, we want to highlight the catastrophic potential of antibodies against blood group antigens expressed on renal allografts in donor-recipient mismatched pairs, especially when these antibodies are already present in the recipient.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"223-227"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of transfusion practices and its outcome in trauma patients at an urban level 1 trauma center in India.","authors":"Rahul Chaurasia, Naveen Akhtar, Arulselvi Subramanian, Vedanand Arya, Sulekha Karjee","doi":"10.4103/ajts.ajts_28_21","DOIUrl":"10.4103/ajts.ajts_28_21","url":null,"abstract":"<p><strong>Context: </strong>Implementation of appropriate transfusion strategy in a timely manner is of paramount importance during the initial resuscitation of massively bleeding trauma patients. Assessing transfusion patterns can help in planning, resource allocation, and devising proactive strategies for the management of such patients.</p><p><strong>Aims: </strong>To analyze transfusion requirements and its triggers in massively bleeding trauma patients.</p><p><strong>Settings and design: </strong>Retrospective analysis of the transfusion practices for massively bleeding trauma patients requiring immediate blood transfusion.</p><p><strong>Methods: </strong>Clinical and transfusion details were collected from patient and the blood bank records, for massively bleeding trauma patients ≥18 years, and required at least 3 units of red blood cells (RBC's) within 1^st h of presentation.</p><p><strong>Statistical analysis used: </strong>Descriptive analysis for transfused blood components was done. Followed by regression analysis to identify predictors for transfusion.</p><p><strong>Results: </strong>A total of 215 (8.4%) patients, received at least 3 units of RBCs within the 1^st h of admission. Component utilization rates were 76% for the RBC, 56% for the random donor platelets (RDP) and 68% for the fresh frozen plasma (FFP) in the first 24 h. The ratio of 1:1:1 for RBC: FFP: RDP was achieved in 81 (37.7%) patients and was associated with improved survival at 24 h. Shock index (SI) was found to be the most significant predictor for RBC, platelets, and cryoprecipitate transfusions, whereas FFP transfusions were largely associated with deranged prothrombin time.</p><p><strong>Conclusions: </strong>Maintenance of a ratio of 1:1:1 can improve the early outcome in these patients. SI alone can be used as an important clinical tool for predicting transfusion at the time of preliminary evaluation of the bleeding trauma patients.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"81-86"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemolytic disease of fetus due to multiple alloantibodies (anti-D, anti-C, and anti-s) requiring intrauterine transfusions: A case report and review of Indian literature.","authors":"G Deepthi Krishna, Deepti Sachan","doi":"10.4103/ajts.ajts_75_24","DOIUrl":"10.4103/ajts.ajts_75_24","url":null,"abstract":"<p><p>Immune hemolytic disease of fetus (HDF) and newborn is a serious complication in pregnancy and is associated with perinatal mortality and morbidity. Intrauterine transfusion (IUT) is performed for the treatment of fetal anemia caused by red cell alloimmunization. Here, we present the case of a 28-year-old multiparous pregnant female, with a history of bad obstetric outcomes. At 24 weeks gestation, she was referred to our center requesting one unit of irradiated leuco-depleted packed red cells (LDPRC) for 2^nd IUT due to difficulty in finding a compatible unit elsewhere. A detailed immunohematology (IH) workup revealed the presence of anti-D, anti-C, and anti-s antibodies. The patient received O RhD Negative and C, and s red cell phenotype negative, crossmatch compatible, irradiated LDPRC unit for IUT. She received a total of three episodes of IUT at 24, 29, and 33 weeks of gestation and delivered a healthy female child at 36 weeks. Managing HDF with multiple antibodies requires coordination between interdisciplinary teams and an advanced IH lab along with trained staff and active involvement of transfusion medicine specialists to support early interventions and reduce HDF-related mortality.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"217-222"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passenger lymphocyte syndrome: Need for consensus on transfusion guidelines and direct anti-globulin test screening in post-liver transplantation period.","authors":"V M Jyotsnaa Grace, G Deepthi Krishna, Deepti Sachan","doi":"10.4103/ajts.ajts_166_24","DOIUrl":"10.4103/ajts.ajts_166_24","url":null,"abstract":"<p><p>In post-transplant phase, liver transplant (LT) recipients may experience anemia or hemolysis due to various immune or non-immune reasons and require prompt intervention and timely management. One such instance is when recipients of minor ABO-incompatible LT (ABOiLT) experience delayed hemolysis mediated by lymphocytes present in the graft known as passenger lymphocyte syndrome (PLS). We present a case report of a PLS in a 6-month-old child who underwent ABOiLT. On postoperative day 14, there was a drop in patient's hemoglobin, and anti-human globulin crossmatch was incompatible with recipient group (A positive) red cells. No standardized consensus exists on screening for PLS in post-LT recipients. In transplant settings, it is imperative to streamline the workflow for timely recognition and management of PLS early to prevent adverse outcomes and minimize invasive therapy. We present this case of PLS in a post-LT child to highlight the need for right algorithm of immuno-hematological workup in case of post-transplant hemolysis.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"232-235"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance evaluation of hematology analyzer XN-10 (Blood Bank mode) and its comparison with flow-cytometer for quality control (QC) of leukodepleted blood components: Pilot Study.","authors":"Aseem Kumar Tiwari, Rajni Chauhan, Shubham Kashyap, Ganesh Singh Rawat, Simran Kahlon, Vaibhav Jadhav, Monisha Sethi","doi":"10.4103/ajts.ajts_223_24","DOIUrl":"10.4103/ajts.ajts_223_24","url":null,"abstract":"<p><strong>Background: </strong>The quality control of leukodepleted blood components is based on residual white blood cells (rWBCs). Routinely rWBC in leukodepleted are performed flow cytometer (FCM). Newer hematology analyzers like Sysmex XN series can count rWBC accurately.</p><p><strong>Study design and materials and methods: </strong>There were two study objectives: (1) to evaluate analytical performance of XN blood bank (BB) mode, and (2) to compare the measurement of rWBC and residual red blood cell between the XN BB mode and flow cytometer (FCM), considered \"gold standard.\" This cross sectional analytical study was conducted on three type of blood components; leukodepleted random donor platelets (LRDP), leukodepleted single donor platelets (LSDP), and leukodepleted red blood cells (LRBC) to determine performance analysis; precision (coefficients of variation), sample stability, and carry over of XN BB. Correlation and linearity was compared between XN BB and FCM.</p><p><strong>Results: </strong>In precision analysis, LRBC, LRDP, and LSDP showed good repeatability (P < 0.0001). Sample stability results revealed stability of LRDP and LRBC samples till 48 h, and LSDP sample was least stable as rWBC counts changed after 5 h. No carry over was observed in any blood component in the study. While comparing XN BB and FCM, a strong correlation was observed between the two, with P > 0.05. In addition, there was an excellent linearity between expected and observed WBC counts for LRBC and LSDP in BB mode (r2 = 0.88).</p><p><strong>Discussion: </strong>The analyzer performed very well with respect to precision, carry over, and stability. The new BB mode of the XN 10 hematology analyzer also showed highly comparable results with FCM, in terms of correlation and linearity, to determine rWBC.</p><p><strong>Conclusion: </strong>The study concluded the use of BB mode as an alternative for flow cytometric analysis for the determination of rWBC in erythrocyte concentrates, platelet concentrate, and plasma.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"13-21"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Futility of fresh frozen plasma in the correction of coagulopathy prior to image-guided drainage of infected collections: Results from a prospective case-control study.","authors":"Pradakshna Porchezhian, Navneet Arora, Ujjawal Gorsi, Lakhvinder Singh, Rekha Hans, Narender Kumar, Jasmina Ahluwalia, Pankaj Malhotra, Arihant Jain","doi":"10.4103/ajts.ajts_55_23","DOIUrl":"10.4103/ajts.ajts_55_23","url":null,"abstract":"<p><strong>Background: </strong>Fresh frozen plasma (FFP) is frequently used as prophylactic hemostatic therapy for correction of periprocedural coagulopathy. This practice is frequently based on the assumption that deranged international normalized ratio (INR) predicts the risk of periprocedural bleeding and that FFP transfusion is effective in mitigating the procedure-associated bleeding risks. There is limited evidence to support both these assumptions in the context of image-guided drainage of infected collections.</p><p><strong>Aims: </strong>The study aimed to analyze the efficacy of weight-based standard FFP dose for correction of infection-associated coagulopathy in patients with clinicoradiologically diagnosed infected collections planned for image-guided drainage.</p><p><strong>Materials and methods: </strong>In this prospective case-control study, 229 patients with clinicoradiologically diagnosed infected abdominal collection(s) planned to undergo image-guided drainage were included. Cases and controls were defined as patients with baseline INR >1.2-3 (in the absence of any other bleeding diathesis) and INR ≤1.2, respectively. Cases received 10-15 mL/kg of FFP before drainage. Costs and time delays in drainage among the two groups, efficacy of plasma transfusion in the correction of coagulopathy, incidence of transfusion reactions, bleeding complications, and inhospital mortality were analyzed.</p><p><strong>Results: </strong>There were 117 cases and 112 controls. A total of 445 FFP units were utilized. The median (interquartile range) time required from diagnosis of collection to the procedure was 25.3 (20.8-40.3) hours among cases and 16.4 (8.7-20.1) hours among controls (<i>P</i> < 0.001). FFP transfusion resulted in INR normalization (≤1.2) only in 7.9% of cases (<i>n</i> = 9). Among the 81 cases who had pretransfusion INR ≥1.5, INR improved to ≤1.5 in 49 (60.4%) patients. There was an average of 2.9% decrease in INR per unit of FFP transfused. No bleeding complications were noted in patients undergoing drainage despite a persistent deranged INR (>1.5) postplasma transfusion. Transfusion reactions occurred in 17/117 (14.5%) patients. There were no deaths among the controls while five patients died among the cases.</p><p><strong>Conclusion: </strong>Prophylactic FFP transfusion for infection-associated coagulopathy leads to a significant delay in lifesaving drainage procedures. Minority of patients attain normalization of INR with FFP transfusion.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"119-125"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of platelet transfusion in modulating platelet indices and leukocyte dynamics in dengue fever patients.","authors":"Mohd Afzal, M Chandrasekar, Ashok Kumar Sah, Shagun Agarwal","doi":"10.4103/ajts.ajts_190_24","DOIUrl":"10.4103/ajts.ajts_190_24","url":null,"abstract":"<p><p>Dengue fever, a viral illness transmitted by Aedes mosquitoes, is marked by a reduction in platelet count (PLT) and changes in blood parameters, which increase the risk of complications such as hemorrhage. Platelet transfusion is frequently used to counter thrombocytopenia in dengue cases, but the precise effects on platelet indices (such as mean platelet volume [MPV] and platelet distribution width [PDW]) and leukocyte counts are still not well defined. This literature review investigates the role of platelet transfusions in modifying platelet and leukocyte dynamics in dengue patients. Studies reveal that transfusions can temporarily increase PLTs, offering short-term hemostatic stability. Changes in platelet indices post-transfusion include increased MPV and variable PDW, potentially reflecting reactive changes in the bone marrow and platelet population. Leukocyte counts show inconsistent responses, with some reports indicating a transient rise following transfusion, possibly linked to immune responses to transfused platelets. While platelet transfusion offers symptomatic relief, these findings highlight the complex interactions within the hematological system following transfusion and underscore the need for caution in transfusion practices. Further investigation is essential to delineate optimal transfusion thresholds, better predict hematological responses, and minimize potential risks associated with transfusions in dengue patients.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"20 1","pages":"189-202"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 5-year cross-sectional retrospective analysis of discard of blood and its components in the blood bank of a tertiary trauma center.","authors":"Arundhathi Shankaralingappa, K Shanti Jyoti, Thirunavukkarasu Arun Babu","doi":"10.4103/ajts.AJTS_181_20","DOIUrl":"10.4103/ajts.AJTS_181_20","url":null,"abstract":"<p><strong>Introduction: </strong>Blood transfusion is an integral part of health-care system and there is no complete suitable substitute for human blood till date. Thus, every unit of blood and its products is precious and should be used judiciously. There is a steady increase in demand for blood and its components and thus to maintain balance between demand and supply, rational use of blood and its components is the need of the hour. This study was conducted to analyze different reasons for discarding blood and its components in a tertiary trauma center so that proper recommendations can be adopted to minimize the discard rate.</p><p><strong>Materials and methods: </strong>A retrospective analytical study was carried out in Sanjay Gandhi Institute of Trauma and Orthopaedics, Bengaluru; a Tertiary Trauma Care Centre for 5 years from January 2015 to December 2019. Details of whole blood collected and blood products prepared were collected from donor register. Reasons for discard were retrieved in detail from discard register. Discard rate for each is calculated as ratio between blood and component collected to the total number of collections and it is expressed as percentage.</p><p><strong>Results: </strong>Out of 22,401 total units of whole blood and its components, 1310 units were discarded accounting for 5.85%. Platelet concentrate (PC) was commonly discarded component (18.3%) followed by whole blood (6.1%), Packed red blood cells (3.64%), and fresh frozen plasma (FFP) (2.92%). The main cause for discarding is expired shelf life (675/1310, 51.53%) followed by transfusion-transmitted infection (12.75%) and suboptimal collection (9.7%). PC was the common component discarded due to the expiry of shelf life (83.21%). FFP was discarded due to damaged blood bags commonly.</p><p><strong>Conclusion: </strong>From our observation, we conclude that strict donor selection criteria, predonation counseling, continuous regular training of technical staff involved in blood collection and processing, and adopting newer techniques such as apheresis and first-in and first-out policy will reduce the overall discard rate.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"19 2","pages":"294-297"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12614708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145542823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}