Results in Chemistry最新文献

{"title":"Novel N-quaternary coumarin-3-yl-imidazo[1,2-a]pyridines as fluorescent hybrids: Their synthesis and biological evaluation in cancer cells","authors":"Karla Armendariz-Barrientos ,&nbsp;Luis A. Pérez ,&nbsp;Selene Lagunas-Rivera ,&nbsp;Yolanda Alcaraz-Contreras ,&nbsp;Marco A. García-Revilla ,&nbsp;Heriberto Prado-Garcia ,&nbsp;Rocío García-Becerra ,&nbsp;Miguel A. Vazquez","doi":"10.1016/j.rechem.2024.101959","DOIUrl":"10.1016/j.rechem.2024.101959","url":null,"abstract":"<div><div>Hybrid coumarin-3-yl-imidazo[1,2-<em>a</em>]pyridines were used to synthesize novel derivatives of quaternary salts <strong>5a-c</strong> and <strong>6a,b</strong>, employing ethyl iodide and benzyl bromide as alkylating agents. The molecular patterns of Total Polar Surface Area (TPSA) coincide with substituent polarity at positions 6 or 7, along with the substituent at the quaternary N. Notably, most polar molecules contain an amino group at position 7, followed by those substituted with −OMe at position 6. Conversely, molecules lacking substituents are the least polar. Despite existing as salts, the polarity of the compounds does not experience a substantial increase. Nonetheless, solubility experiences a notable decrease, particularly for the <strong>6a-c</strong> series, due to the potent hydrophobic effect of the benzyl substituent at the N position. A similar phenomenon is observed with the ethyl substituent in the <strong>5a-c</strong> series, albeit with a less pronounced hydrophobic impact. To assess the effect of the quaternary hybrid coumarin-3-yl-imidazo[1,2-<em>a</em>]pyridines on proliferation, both breast (MDA-MB-231) and prostate (PC3) cancer cell lines were utilized. The biological assessment of these cancer cell lines demonstrated that compounds <strong>4a, 4c,</strong> and <strong>5c</strong> exhibit noteworthy antiproliferative effects on MDA-MB-231 (Inhibitory concentration at 50 % (IC₅₀) values of 2.27 µM, 3.76 µM, and 0.113 µM, respectively) and PC3 (IC₅₀ values of 1.03 µM, 0.527 µM, and 0.888 µM, respectively). Furthermore, these same structures demonstrated substantial fluorescence emissions localized within the cytoplasm. Additionally, compounds decreased the G2/M phase of the cell cycle and increased the SubG1 phase. These findings suggest that these novel hybrids have promising applications in cancer treatment.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101959"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alkali metal salt modulated visible photocatalytic degradation of tetracycline hydrochloride by g-C3N4: Degradation pathway, mechanism and toxicity assessment","authors":"Yujie Jiao ,&nbsp;Sujin Lu ,&nbsp;Ru Li ,&nbsp;Qikai Liu ,&nbsp;Yongxia Ma ,&nbsp;Fei Fu ,&nbsp;Yaqi Mao ,&nbsp;Yang Liu","doi":"10.1016/j.rechem.2025.102047","DOIUrl":"10.1016/j.rechem.2025.102047","url":null,"abstract":"<div><div>The frequent occurrence of tetracycline antibiotics in natural water systems poses a substantial risk to aquatic ecosystems and human health. Achieving efficient degradation of tetracyclines in aqueous environments using visible light is therefore of critical importance. In this study, CaCl₂-modified melamine precursors were employed to synthesize CaCNx with varied microstructures through molten salt-assisted calcination, enabling high-efficiency visible-light-driven degradation of tetracycline in water. The results indicated that CaCNx demonstrated remarkable catalytic performance in degrading TC-HCl, with CaCN1 synthesized using 1 mol/L CaCl₂ in the precursor exhibiting the highest degradation efficiency, achieving a rate 3.58 times greater than that of CN. In the degradation of tetracycline hydrochloride (TC-HCl) by CaCN1, ·O₂⁻ was identified as playing a more significant role than ·OH. Furthermore, LC-MS analysis detected seven degradation by-products, which enabled the proposal of a degradation mechanism and two pathways for TC-HCl degradation by CaCN1. Toxicity validation tests revealed that the TC-HCl prodrug caused acute toxicity (p &lt; 0.0001) to <em>Chlorella vulgaris</em> (p &lt; 0.001) and <em>Vibrio fischeri</em> (p &lt; 0.001), whereas its acute toxicity to <em>C. vulgaris</em> (p &lt; 0.01) and <em>V. fischeri</em> (p &lt; 0.01) was significantly reduced following degradation. This study presents a straightforward and efficient approach for visible light-driven degradation of tetracycline in situ within aqueous environments.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 102047"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational identification of anti-cancer compounds targeting the RNA-binding domain of human FOX-1 protein (RBFOX1)","authors":"Muhammad Tahir ul Qamar ,&nbsp;Pablo Sanz-Jimenez ,&nbsp;Shaima Rabeea Banoon ,&nbsp;Xi-Tong Zhu ,&nbsp;Fahad M. Aldakheel ,&nbsp;Nahlah Makki Almansour ,&nbsp;Leen A. Aldaiji ,&nbsp;Wafa Abdullah I. Al-Megrin ,&nbsp;Faisal Ahmad","doi":"10.1016/j.rechem.2024.102004","DOIUrl":"10.1016/j.rechem.2024.102004","url":null,"abstract":"<div><div>The transcription factor RBFOX1 is essential for cellular proliferation and has shown upregulation in many human cancers. The overexpression of this gene correlates with the motility of cancer cells, their ability to invade surrounding tissues. The aforementioned processes are pivotal in cancer progression, making RBFOX1 a significant target for innovative cancer therapies. The present study seeks to identify new inhibitor compounds that obstruct the biological processes of the target protein associated with cancer. Results shows that control (3S,5aS,6R,8aS,9R,10S,12R,12aS)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol (artenimol) reflecting the binding affinities of −7.9 kcal/mol, Top1 (4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic acid) shows −8.7 kcal/mol and Top2 (R)-1-carboxy-5-((S)-2-((2R,4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl)-2-(2-phenylacetamido)acetamido)pentan-1-aminium indicating −8.2 k cal/mol. Additional, molecular dynamic simulation studies shows significant stability during RMSD and RMSF analyses over a 100 ns timescale. Binding domain residues i.e. Phe52, Arg10, Thr84, Ala85 and Arg86 has demonstrated the stability of the system due to robust hydrogen bonds. All of the top hit inhibitor exhibited more stability in comparison to the control inhibitor, where it penetrated deeply, as depicted in PCA analysis. Binding energies and Waterswap calculations significantly refines our comprehensive simulation model. Consequently, our findings provide a potential framework for researchers to further explore in vivo and in vitro analyses of inhibitors targeting the HBFOX1 gene, representing a potential advancement in cancer treatment.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 102004"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization extraction process of Shenghua Decoction and evaluation of its analgesic effects","authors":"Zhonghui Pu ,&nbsp;Lijuan Chen ,&nbsp;Huaidan Liu ,&nbsp;Jingzhu Deng ,&nbsp;Li Li ,&nbsp;Liang Xiong ,&nbsp;Liuying Li","doi":"10.1016/j.rechem.2024.102017","DOIUrl":"10.1016/j.rechem.2024.102017","url":null,"abstract":"<div><div>Shenghua Decoction (SHD) is a very famous formula that has been used for treating postpartum diseases in China. However, there has been no study published, to date, reporting the preparation process and analgesic effects of SHD. This study aimed to optimize the high-content SHD production process and investigate its analgesic activity. Taking the content of ferulic acid and senkyunolide I determined by HPLC as indexes, the effect on SHD of several extraction processing variables, including liquid–solid ratio, soaking time, decocting time and ethanol precipitation concentration, had been examined by using Box-Behnken design (BBD) with three levels and four factors were adopted for optimizing SHD extraction process, and the optimized conditions were further validated. The analgesic activity of SHD was assessed, based on mouse pain response to hot plate and intraperitoneally injected acetic acid. The optimized values of SHD extraction process variables were found to be 40 mL/g of liquid–solid ratio, 2 h of soaking time, 1.5 h of decocting time, 70 % of ethanol precipitation concentration. The optimum conditions led to maximal combined content of ferulic acid and senkyunolide I at 1.2336 mg/g averaged from three validation tests (<em>RSD</em> = 1.84 %, n = 3), 0.9347 mg/g for ferulic acid and 0.2989 mg/g for senkyunolide I, and the bias ratio was 1.82 % compared with the predicted value of 1.251 mg/g, indicating the experimental values obtained from the BBD model agreed with that of the predicted values.</div><div>Analgesic activity results indicated that SHD at all doses significantly reduced the number of twists induced by glacial acetic acid dose-dependently, and prolonged latency of foot licking to varying degrees at every stage of mice hot-plate test. This study not only developed a rapid and sensitive process that was successfully utilized for extracting SHD, but also discovered SHD with analgesic activity, which provided helpful information for further study.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 102017"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visible light photocatalytic degradation of tetracycline using copper ferrite nanoparticles synthesized via Glycine-Assisted combustion method","authors":"A. Dinesh ,&nbsp;K. Radhakrishnan ,&nbsp;V. Renuga ,&nbsp;Rajendra P. Patil ,&nbsp;Suriyaprakash Rajadesingu ,&nbsp;S. Suthakaran ,&nbsp;L. Guganathan ,&nbsp;Manikandan Ayyar ,&nbsp;Madhappan Santhamoorthy ,&nbsp;Lalitha Gnanasekaran ,&nbsp;Munawar Iqbal","doi":"10.1016/j.rechem.2025.102037","DOIUrl":"10.1016/j.rechem.2025.102037","url":null,"abstract":"<div><div>Copper Ferrite (CuFe₂O₄) nanoparticles (NPs) were synthesized by the combustion-assisted method using glycine as a fuel to evaluate their photocatalytic degradation efficiency for tetracycline (TC) under visible light. Several analytical methods were used to confirm the synthesized CuFe₂O₄ NPs. X-ray diffraction (XRD) was used to check the phase’s structure and purity, FT-IR was used to find out what functional groups were present, UV–Vis diffuse reflectance spectroscopy (DRS) was used to look at the optical properties, and scanning electron microscopy (SEM) was used to see the structure’s shape. These results confirm the formation of highly crystalline CuFe₂O₄ NPs. The photocatalytic degradation of TC was studied using visible light and the effect of parameters such as the concentration of the catalyst (0.5 g/L to 2.5 g/L), initial TC concentration (10– 50 mg/L) and irradiation time (30–150 min). The degradation efficiency reached a maximum value of 95.8 % for a 150 min irradiation under the optimum condition of the photocatalytic activity was further raised by 25 % by the addition of hydrogen peroxide (H₂O₂). The CuFe₂O₄ NPs had rather high recyclability after the photocatalytic process, they had 90 % of their initial activity, which was tested after the fifth run. This study shows that green synthesized CuFe₂O₄ NPs are potentially useful as reusable visible-light photocatalysts for breaking down drugs, specifically tetracycline, through oxidation in water.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 102037"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the role of flutamide, fluorouracil, and furomollugin based ionic liquids in potent anticancer agents: Quantum chemical, medicinal, molecular docking and MD simulation studies","authors":"Danish Ali ,&nbsp;Muhammad Arif Ali ,&nbsp;Muhammad Sarfraz ,&nbsp;Afifa Yousuf ,&nbsp;Rasham Zulfiqar ,&nbsp;Abdul Rauf ,&nbsp;Hong-Liang Xu ,&nbsp;Muhammad Arshad","doi":"10.1016/j.rechem.2025.102029","DOIUrl":"10.1016/j.rechem.2025.102029","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Ionic liquids (ILs) have emerged as a versatile candidate in medicinal chemistry, electrochemistry catalysis, and biotechnology. In this work, we explored the electronic interionic interactions, stability, and reactivity of FDA approved drug-based cations flutamide &lt;strong&gt;([FT1]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt;, &lt;strong&gt;[FT2]&lt;sup&gt;+&lt;/sup&gt;)&lt;/strong&gt;, fluorouracil &lt;strong&gt;([FU1]&lt;sup&gt;+&lt;/sup&gt;)&lt;/strong&gt;, and furomollugin &lt;strong&gt;([FM1]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt;, &lt;strong&gt;[FM2]&lt;sup&gt;+&lt;/sup&gt;)&lt;/strong&gt;, paired with amino acid &lt;strong&gt;[NH]&lt;sup&gt;−&lt;/sup&gt;&lt;/strong&gt;, nitrate &lt;strong&gt;[NO&lt;sub&gt;3&lt;/sub&gt;]&lt;sup&gt;−&lt;/sup&gt;&lt;/strong&gt;, and triflate &lt;strong&gt;[CF&lt;sub&gt;3&lt;/sub&gt;]&lt;sup&gt;−&lt;/sup&gt;&lt;/strong&gt; anions, in gas and solvent phases (benzene and water). Frontiers molecular orbitals (FMOs) showed that &lt;strong&gt;[FT1]&lt;sup&gt;+&lt;/sup&gt;[NH]&lt;sup&gt;–&lt;/sup&gt;&lt;/strong&gt; exhibits the smaller &lt;em&gt;E&lt;/em&gt;&lt;sub&gt;gap&lt;/sub&gt; on both gas and solvent phase from 5.24 to 4.39 eV, suggesting high reactivity and increasing solubility. Notably, the IL pair &lt;strong&gt;[FT1]&lt;sup&gt;+&lt;/sup&gt;[NH]&lt;sup&gt;–&lt;/sup&gt;&lt;/strong&gt; possessed substantial interaction energies in the gas phase (−426.64 kcal/mol), in benzene (−390.24 kcal/mol), and in water (−369.69 kcal/mol), highlighting its potential to disrupt cancer cell growth and exhibit strong anticancer efficacy. The stability of &lt;strong&gt;[FT1]&lt;sup&gt;+&lt;/sup&gt;[NH]&lt;sup&gt;–&lt;/sup&gt;&lt;/strong&gt; was further corroborated by significant Gibbs free energy and enthalpy values (−545.30 and −560.36 kcal/mol). Bioinformatics studies reveal that our studied ILs possess superior drug-likeness along with supportive medicinal chemistry parameters. Such as, toxicity evaluation based on the TOX21 pathway confirmed the non-toxic attributes of these ILs, bolstering their potential as antitumor drugs. The metabolic prediction for &lt;strong&gt;[FM1]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt; was consistent with its expected behavior in the biological system with its likelihood ranging from 89 % to 83 %. Additionally, &lt;em&gt;in silico&lt;/em&gt; docking investigations against the protein (PDB ID: 1B38) showed that all designed ligands &lt;strong&gt;[FT1]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt;, &lt;strong&gt;[FT2]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt;, &lt;strong&gt;[FU1]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt;, &lt;strong&gt;[FM1]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt;, and &lt;strong&gt;[FM2]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt; display binding affinities values of −7.82, −6.30, −6.09, −5.86, and −7.72 kcal/mol superior to both the reference and reported drug fluorouracil. Molecular dynamics (MD) simulation reinforced the docking results by utilizing root mean square deviation (RMSD) values of &lt;strong&gt;[FT1]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt; varies from 0.147387 to 0.539310 Å and &lt;strong&gt;[FM2]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt; lies between 0.138098 Å and 0.583763 Å and root means square fluctuation (RMSF) values for &lt;strong&gt;[FT1]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt; was 0.069428–0.298235Å and &lt;strong&gt;[FM2]&lt;sup&gt;+&lt;/sup&gt;&lt;/strong&gt; 0.070097–0.364413Å provides insight into stability and the time-dependent atomic deviations. In addition, Ramachandran plots indicate that &gt;90 % of residues occupy the favored regions supporting t","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 102029"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of U(VI) by Micrococcus aloeverae: condition, kinetic and mechanism studies","authors":"Xingming Gao ,&nbsp;Mengmei Ye ,&nbsp;Wenxin Li ,&nbsp;Yong Lu ,&nbsp;Lingzhi Bao","doi":"10.1016/j.rechem.2025.102019","DOIUrl":"10.1016/j.rechem.2025.102019","url":null,"abstract":"<div><div>The ecological and environmental implications arising from the release of uranium during nuclear industry and mining activities are subject to considerable apprehension. Employing microbial agents for uranium remediation offers a promising and efficient alternative to tackle soil or wastewater contamination caused by uranium. In this work, we successfully isolated and identified a highly uranium-tolerant strain GX01, identified as <em>Micrococcus aloeverae</em>, from soil samples collected at a uranium mining site. The state, kinetics and mechanism of U(VI) removal by <em>Micrococcus aloeverae</em> were then investigated. The strain demonstrated both biotransformation and biosorption ability to U(VI), with an excellent removal capacity of 123 mg/g for U(VI) at pH 6.0. The involvement of carboxyl, amide, and amine groups in the biosorption processes was determined by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analysis. Kinetic and isothermal studies demonstrated that the biosorption of U(VI) by <em>Micrococcus aloeverae</em> followed a pseudo-second order mode and Langmuir model. These results initially established <em>Micrococcus aloeverae</em> as an idea candidate for radionuclide removal.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 102019"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of silver and gold nanoparticles using quercetin extracted from Arctium lappa by HPLC, Characterization and Estimation of antioxidant activity","authors":"Mahmood Zaki Lafta ,&nbsp;Rafah Razooq Hameed Al-Samarrai ,&nbsp;Mohamed Bouaziz","doi":"10.1016/j.rechem.2025.102028","DOIUrl":"10.1016/j.rechem.2025.102028","url":null,"abstract":"<div><div>Arctium lappa is a therapeutic plant high in bioactive components, including flavonoids, which have antioxidant, anti-inflammatory, and antibacterial effects. Quercetin, a major flavonoid, is recognized for its pharmacological properties. The purpose of this study was to extract quercetin from A. lappa and use it for the green synthesis of gold (AuNPs) and silver nanoparticles (AgNPs) to evaluate their antioxidant properties. Quercetin was extracted using the Soxhlet method with petroleum ether, chloroform, and methanol. Quercetin was purified using hydrolysis and crystallization before being characterized using HPLC, UV–Vis, FTIR, and NMR methods. Laser ablation was used to synthesize AuNPs and AgNPs, with extracted quercetin acting as a reducing agent. The nanoparticles were examined with SEM, TEM, and XRD. Antioxidant activity was measured using the DPPH free radical scavenging test, and IC50 values were generated to compare to standard ascorbic acid.HPLC indicated that the maximum quantity of quercetin (98.6 %) was achieved using chloroform extraction. AgNPs had a spherical shape via a typical size of 20–40 nm, whereas AuNPs ranged from 80-160 nm. AgNPs had the highest antioxidant capacity (89.59 %), followed by AuNPs (83.32 %) and quercetin (73.22 %). The IC50 values were 100.4 µg/mL, 120.8 µg/mL, and 146.36 µg/mL, respectively.The researchers effectively extracted quercetin from A. lappa and created AuNPs and AgNPs with significant antioxidant characteristics. AgNPs demonstrated superior free radical scavenging activity, indicating their potential use in biomedical applications, notably antioxidant therapy. More research is needed to understand their medicinal potential fully.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 102028"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A superhydrophobic anti-flaming coating with anti-corrosion function for paper-based triboelectric nanogenerator","authors":"Yanfang Meng ,&nbsp;Junqing Zhao ,&nbsp;Wenming He","doi":"10.1016/j.rechem.2024.101983","DOIUrl":"10.1016/j.rechem.2024.101983","url":null,"abstract":"<div><div>As an effective way for energy conversion, triboelectric nanogenerators (TENGs) have aroused great attention. Particularly, the paper-based TENGs have been paid the highest emphasize for their unparalleled merits: flexibility, light weight, low cost, and recyclability under heavily allocated environmental protection. To address drawbacks of paper-based TENG (e.c. susceptible to moisture, inflammability), here, an effective superhydrophobic-flame-resistant coating for superhydrophobic and flame-resistant dual-treated paper-based TENG is, firstly, proposed. This coating was obtained by in-situ addition of fire-retardants (polyhedral methyl-silsesquioxane and ammonium polyphosphate) during the process of sol–gel reaction of two silane precursors: tetraethyl orthosilicate (TEOS) and tridecafluorooctyl triethoxysilane (FAS). This superhydrophobic-flame-resistant coating endowed paper-based TENG with excellent surfacial hydrophobicity (water contact angle above 150°) and flame-resistant properties (limit oxygen index improved by 5% compared with original sample), simultaneously. Meanwhile, the coating also exhibits outstanding anti-permeability towards water (keep WCA last more than 1 h) and resistance towards acidic corrosion. The superhydrophobic-flame-resistant modification renders the obtained TENG to work with conventional properties under humidity environment and fire protection. This paper-based TENG feasibly powers LED and alarm apparatus, demonstrating its plausibility for new approach for advanced energy harvest and conversion.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101983"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic pathways for N-arylation of benzimidazoles: A comprehensive review","authors":"Anila Ghulam ,&nbsp;Tooba Jabeen ,&nbsp;Sana Aslam ,&nbsp;Matloob Ahmad ,&nbsp;Magdi E.A. Zaki","doi":"10.1016/j.rechem.2025.102043","DOIUrl":"10.1016/j.rechem.2025.102043","url":null,"abstract":"<div><div>The <em>N</em>-arylated benzimidazoles are important structural motifs in many biologically active compounds. Due to their distinct physicochemical and structural features, they have applications in a wide range of domains, including pharmaceutical chemistry, material sciences, and catalysis. Synthetic chemists have devised a variety of methods to accomplish efficient <em>N</em>-arylation of benzimidazoles. Transition metal-based catalysis has emerged as a key strategy, utilizing metals such as copper (Cu), palladium (Pd), iron (Fe), nickel (Ni), iridium (Ir), and ruthenium (Ru). These catalysts, which are frequently supported by a variety of ligands, allow for the selective and efficient production of <em>N</em>-aryl bonds under a wide range of reaction conditions. Cross-coupling reactions, such as the Chan-Lam, Ullmann, and Buchwald-Hartwig protocols, are commonly used due to their durability and scalability. Metal-free techniques offer ecologically friendly options, and multicomponent reactions provide the benefit of convergent synthesis. Microwave-assisted reactions and photocatalyzed procedures have improved the efficiency, selectivity, and sustainability of <em>N</em>-arylation reactions. The review provides a comprehensive overview of the recent advancements and strategies employed in constructing this important class of heterocyclic compounds, highlighting their versatility and significance.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 102043"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}