N-(1-hydroxybutan-2-yl)-4-nitrobenzene sulfonamide: A novel organocatalyst for an effective one-pot synthesis of α-amino phosphonates

This study emphasizes an efficient method for a one-pot, three-component reaction of aromatic aldehyde/ketone, amines, and dialkyl phosphite to produce α-Amino phosphonates. This reaction was catalyzed by a novel organocatalyst N-(1-hydroxybutan-2-yl)-4-nitrobenzene sulfonamide. The acidity of the synthesized catalyst was increased due to SO₂-NH group which was used in Kabachnik Field reaction. The main advantages of the current method include inexpensive, non-toxic, efficient organo catalyst, high yields, a reduced reaction time, green solvent, an easy experimental method, a simple workup procedure, and the suitability of the catalyst to withstand a wide range of substrate scope All aromatic, heterocyclic aldehydes and cyclic ketone variations reacted effectively producing greater yields of the respective α-amino phosphonates in a shorter reaction time (26) examples. Additionally, the catalyst was easily recovered and reused over several cycles without significantly decreasing effectiveness. This provides economic and environmental benefits.