2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings最新文献

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Analysis on breathing dynamics of DNA circuits DNA电路呼吸动力学分析
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981719
M. Hirabayashi, Shukichi Tanaka, H. Kojima
{"title":"Analysis on breathing dynamics of DNA circuits","authors":"M. Hirabayashi, Shukichi Tanaka, H. Kojima","doi":"10.1109/BioCAS.2014.6981719","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981719","url":null,"abstract":"It is still not clear whether terahertz (THz) radiation can drive DNA pairing/unpairing phenomenon (breathing). Based on the assumption that DNA breathers can be generated when the system has the property to realize self-excited oscillations in the presence of the THz field, we investigate the possibility of THz control of DNA circuits with logic gates such as intelligent sensors. Our simulation results using the van der Pol equation suggest that self-excited oscillations can lead the large amplitude of vibration to create an initial stretch necessary to generate DNA breathers under appropriate nonlinear damping conditions. When the DNA structure can be designed to have such mechanisms for self-excited oscillations in the THz field, THz waves will provide a new effective method to regulate the DNA devices through the control of DNA breathing.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126768576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuromodulation of the retina from the suprachoroidal space: The Phoenix 99 implant 视网膜脉络膜上间隙的神经调节:凤凰99植入物
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981711
G. Suaning, N. Lovell, T. Lehmann
{"title":"Neuromodulation of the retina from the suprachoroidal space: The Phoenix 99 implant","authors":"G. Suaning, N. Lovell, T. Lehmann","doi":"10.1109/BioCAS.2014.6981711","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981711","url":null,"abstract":"Visual neuroprostheses aim to modulate the activity of surviving neurons of the visual system in an effort to elicit meaningful, psychophysical percepts. These percepts aim to aid a blind recipient in the conduct of day-to-day tasks such as navigation of unfamiliar environments, avoidance of obstacles, etc. The system architecture must balance myriad engineering, safety, and performance requirements including biocompatibility, charge neutrality, and the sustained provision of physiologically relevant stimuli to the visual system. At the same time, the system must become part of the target anatomy in order to interact and co-exist with surviving neuronal tissue. Here we describe a 99 channel visual neuroprosthesis with an array of 98 electrodes placed within the suprachoroidal space of the eye and a distant monopolar return electrode. Accordingly, we have created a system architecture and implemented a set of specifications that may serve to compensate for the loss of vision.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129203508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
ESL design of customizable real-time neuron networks 可定制实时神经元网络的ESL设计
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981815
M. F. V. Eijk, C. Galuzzi, A. Zjajo, Georgios Smaragdos, C. Strydis, R. V. Leuken
{"title":"ESL design of customizable real-time neuron networks","authors":"M. F. V. Eijk, C. Galuzzi, A. Zjajo, Georgios Smaragdos, C. Strydis, R. V. Leuken","doi":"10.1109/BioCAS.2014.6981815","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981815","url":null,"abstract":"In this paper, we present the design and implementation of an Inferior-Olivary Nucleus (ION) network on an FPGA device. Compared with existing neuron networks, the proposed design allows to easily customize the network topology and implement existing as well as ad-hoc topologies, in order to explore different levels of connectivities between the cells. Starting from the model of an ION cell, the model has been optimized and an ION network has been designed and implemented in multiple steps. By using the Xilinx Vivado Suite, the design has been synthesized and mapped on a Virtex 7 XC7VX550T FPGA device. Experimental results show that a network of 48 ION cells can be simulated in brain real-time using double floating-point arithmetic, which allows to precisely simulate the network's behavior.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114876859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Surface electromyography of neck strap muscles for estimating the intended pitch of a bionic voice source 用于估计仿生声源预定音高的颈带肌肉表面肌电图
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981639
Farzaneh Ahmadi, Matheus Araujo Ribeiro, M. Halaki
{"title":"Surface electromyography of neck strap muscles for estimating the intended pitch of a bionic voice source","authors":"Farzaneh Ahmadi, Matheus Araujo Ribeiro, M. Halaki","doi":"10.1109/BioCAS.2014.6981639","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981639","url":null,"abstract":"Despite the emerging progress in many subfields of bionics, developing a working bionic voice prosthesis for voice-loss patients has remained an unresolved research question. A bionic voice prosthesis replaces the function of a missing larynx and generates natural voice for patients who retain a functional vocal tract but have lost their voice because of surgical removal of the larynx (laryngectomy) due to larynx cancer or swallowing disorders. The main category of patients to receive this solution is laryngectomy patients. The pitch (fundamental frequency) is the highest contributor of generating natural voice for laryngectomy patients. Hence designing a bionic voice solution requires enabling the patient with a convenient mechanism to control the pitch of their substitute voice. In this research, the neuromuscular activity of the neck straps muscles is analyzed using advanced signal processing methods to provide a natural mechanism of controlling the pitch of a future bionic voice source. The result significantly improves the current state of the art techniques of using neuromuscular cues for estimating the pitch.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131988405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
A CMOS-based sensor array for in-vitro neural tissue interfacing with 4225 recording sites and 1024 stimulation sites 基于cmos的体外神经组织传感器阵列,具有4225个记录位点和1024个刺激位点
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981723
G. Bertotti, Dmytro Velychko, N. Dodel, S. Keil, D. Wolansky, B. Tillack, M. Schreiter, A. Grall, P. Jesinger, Sebastian Rohler, M. Eickenscheidt, A. Stett, Andreas Moller, K. Boven, G. Zeck, R. Thewes
{"title":"A CMOS-based sensor array for in-vitro neural tissue interfacing with 4225 recording sites and 1024 stimulation sites","authors":"G. Bertotti, Dmytro Velychko, N. Dodel, S. Keil, D. Wolansky, B. Tillack, M. Schreiter, A. Grall, P. Jesinger, Sebastian Rohler, M. Eickenscheidt, A. Stett, Andreas Moller, K. Boven, G. Zeck, R. Thewes","doi":"10.1109/BioCAS.2014.6981723","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981723","url":null,"abstract":"A CMOS-based microelectrode array (MEA) with 4225 recording sites and 1024 stimulation sites and a related data acquisition system are presented. The chip provides high spatiotemporal resolution on an active area of 1 mm × 1 mm or 2 mm × 2 mm, respectively, and allows in-vitro neural tissue interfacing experiments with full imaging capability. The entire chip surface is covered by a thin high-k dielectric layer so that electric coupling between biological tissue and solid-state chip is purely capacitive. Biological experiments reveal proper functionality of the system.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128955868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 59
Effective noise minimization in multichannel recording circuits processed in modern technologies for neurobiology experiments 神经生物学实验中多通道记录电路的有效噪声最小化
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BIOCAS.2014.6981733
P. Kmon, P. Grybos, M. Zoladz, R. Szczygiel
{"title":"Effective noise minimization in multichannel recording circuits processed in modern technologies for neurobiology experiments","authors":"P. Kmon, P. Grybos, M. Zoladz, R. Szczygiel","doi":"10.1109/BIOCAS.2014.6981733","DOIUrl":"https://doi.org/10.1109/BIOCAS.2014.6981733","url":null,"abstract":"This paper presents an effective method of input referred noise minimization (IRN) of recording stages dedicated to neurobiology experiments and processed in submicron or nanometer technologies. We analyze different approaches for IRN minimization and propose solution based on the on-chip analogue noise averaging. The proposed approach allows for almost 2.5 times IRN minimization with only 8 time power consumption increase whereas other on-chip analogue methods provides much less noise minimization efficiency. The method is confirmed by measurements of 8-channel integrated circuit fabricated in 180nm commercial process. The chip is composed of the 8-recording channels that are individually digitally assisted for enlarging IC functionality. The recording part is divided into two separate channels, i.e. an Action Potential (AP) stage and a Local Field Potential (LFP) stage. The voltage gain of the AP and LFP stages can be switched between 56/50 dB and 50/45 dB respectively. Corner frequencies of a particular stages can be digitally controlled in a wide range, i.e. the upper cut-off frequency can be changed in the 20 Hz - 2 kHz (LFP stage) while the lower cut-off frequency can be tuned at the 120 mHz - 3 kHz (LFP and AP stage). The upper cut-off frequency of the AP stage is equal to 6.9 kHz. A single recording channel is supplied from ±0.9 V and consumes about 4.8 μW of power. For a default channel configuration the Input Referred Noise is equal to 5.6 μV resulting in 4.38 of Noise Efficiency Factor (NEF) while for on-chip averaging mode enabled the IRN can be limited to 2.4 μV resulting in 5.3 of NEF.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131158805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
CY5 fluorescence measured with silicon photomultipliers 用硅光电倍增管测量CY5荧光
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981718
M. F. Santangelo, S. L. Cono, P. Vasquez, G. Fallica, S. Conoci, A. Busacca, R. Pagano, E. Sciuto, S. Lombardo, S. Libertino
{"title":"CY5 fluorescence measured with silicon photomultipliers","authors":"M. F. Santangelo, S. L. Cono, P. Vasquez, G. Fallica, S. Conoci, A. Busacca, R. Pagano, E. Sciuto, S. Lombardo, S. Libertino","doi":"10.1109/BioCAS.2014.6981718","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981718","url":null,"abstract":"This paper presents an efficient optical biosensor set up for a low-level light detection, using fluorescent dyes and a novel Si-based detector. Fluorescence emitted by a traditional fluorophore, CY5, widely used as optical label in DNA microarrays, was detected using a 25 pixels Silicon photomultiplier (SiPM), a device formed by avalanche diodes operating in Geiger mode, in parallel connections. We measured the fluorescence current in different deposition (fluorophore concentration; solvent; salt concentration) and operation (angle of analysis, optical laser power, device gain) conditions. The characterization of DNA samples labeled with CY5 is also reported to demonstrate the detector potentiality to replace traditional optical readers commonly used in commercial devices.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133033735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Live demonstration: Neuromorphic event-based multi-kernel algorithm for high speed visual features tracking 现场演示:基于神经形态事件的多核高速视觉特征跟踪算法
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981681
Xavier Lagorce, Cedric Meyer, S. Ieng, David Filliat, R. Benosman
{"title":"Live demonstration: Neuromorphic event-based multi-kernel algorithm for high speed visual features tracking","authors":"Xavier Lagorce, Cedric Meyer, S. Ieng, David Filliat, R. Benosman","doi":"10.1109/BioCAS.2014.6981681","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981681","url":null,"abstract":"This demo presents a method of visual tracking using the output of an event-based asynchronous neuromorphic event-based camera. The approach is event-based thus adapted to the scene-driven properties of these sensors. The method allows to track multiple visual features in real time at a frequency of several hundreds kilohertz. It adapts to scene contents, combining both spatial and temporal correlations of events in an asynchronous iterative framework. Various kernels are used to track features from incoming events such as Gaussian, Gabor, combinations of Gabor functions and any hand-made kernel with very weak constraints. The proposed features tracking method can deal with feature variations in position, scale and orientation. The tracking performance is evaluated experimentally for each kernel to prove the robustness of the proposed solution.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133452155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A novel compressive sensing architecture for high-density biological signal recording 一种新的高密度生物信号记录压缩感知结构
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981633
Mahsa Shoaran, Hossein Afshari, A. Schmid
{"title":"A novel compressive sensing architecture for high-density biological signal recording","authors":"Mahsa Shoaran, Hossein Afshari, A. Schmid","doi":"10.1109/BioCAS.2014.6981633","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981633","url":null,"abstract":"The massive amount of data recorded by dense electrode arrays which are routinely connected to Nyquist-sampling signal conditioning blocks introduces new design challenges for implantable and wireless biological signal acquisition. Five different architectures of implantable multichannel neural recording systems are compared in terms of power and area constraints. Silicon results of a 16-channel spatial-domain compressive recording system implemented in a UMC 0.18 μm CMOS technology are presented. Applying intracranially recorded EEG signals, the proposed system achieves up to 16-times compression rate, consuming an extra compression power of 0.95 μW within a die area of 0.008 mm2 per channel.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133120245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
An implantable image sensor with self-reset function for brain imaging 一种可植入的具有自复位功能的脑成像图像传感器
2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings Pub Date : 2014-12-11 DOI: 10.1109/BioCAS.2014.6981710
K. Sasagawa, Takahiro Yamaguchi, M. Haruta, Yoshinori Sunaga, H. Takehara, T. Noda, T. Tokuda, J. Ohta
{"title":"An implantable image sensor with self-reset function for brain imaging","authors":"K. Sasagawa, Takahiro Yamaguchi, M. Haruta, Yoshinori Sunaga, H. Takehara, T. Noda, T. Tokuda, J. Ohta","doi":"10.1109/BioCAS.2014.6981710","DOIUrl":"https://doi.org/10.1109/BioCAS.2014.6981710","url":null,"abstract":"We designed and fabricated an implantable image sensor high peak signal-to-noise ratio (SNR). In bio-imaging, it is often necessary to observe small changes of fluorescence, absorption, scattering. The peak SNR of a image sensor is limited by the shot-noise, which is proportional to the square root of incident light intensity. In this study, we avoid pixel saturation by self-reset function integrated in a pixel and increase the peak SNR. The pixel size is 15μm × 15μm and the peak SNR is over 60 dB We also demonstrated blood flow imaging of a rat brain surface by using the sensor.","PeriodicalId":414575,"journal":{"name":"2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133159593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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