An implantable image sensor with self-reset function for brain imaging

Abstract

We designed and fabricated an implantable image sensor high peak signal-to-noise ratio (SNR). In bio-imaging, it is often necessary to observe small changes of fluorescence, absorption, scattering. The peak SNR of a image sensor is limited by the shot-noise, which is proportional to the square root of incident light intensity. In this study, we avoid pixel saturation by self-reset function integrated in a pixel and increase the peak SNR. The pixel size is 15μm × 15μm and the peak SNR is over 60 dB We also demonstrated blood flow imaging of a rat brain surface by using the sensor.