Powder Technology最新文献

{"title":"Advances in nanocarrier-based nose-to-brain drug delivery systems for neurological disorders - A comprehensive review","authors":"Hesam Kamyab ,&nbsp;Sajad Jamalpour ,&nbsp;Elham Khalili ,&nbsp;Saravanan Rajendran","doi":"10.1016/j.powtec.2026.122244","DOIUrl":"10.1016/j.powtec.2026.122244","url":null,"abstract":"<div><div>One promising technology to address the limitations of conventional drug delivery for central nervous system (CNS) disorders is the nose-to-brain drug delivery system. The anatomical advantages of the nasal route, which enable direct transport of therapeutics from the nasal cavity to the brain while bypassing the blood-brain barrier, underpin the growing interest in this innovative approach. This review emphasizes the significance of the nasal cavity's structural features, particularly its rich vascularization and high permeability, which facilitate rapid drug absorption and a swift onset of action, making it a viable pathway for neurological treatments. It also examines the roles of various nanocarriers, such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, lipid nanocapsules, cubosomes, nanoemulsions, nanogels, exosomes, gold nanoparticles, magnetic nanoparticles, quantum dots, and mesoporous silica nanoparticles, in enhancing drug delivery efficiency and targeting precision within this system. To mitigate the potential toxicity of nanoparticles to the nasal mucosa, the review discusses recent advances in formulation strategies, including surface modification, the use of advanced materials, tailoring particle characteristics, and designing novel formulations to optimize release kinetics, drug stability, and targeting specificity. These strategies aim to improve absorption while minimizing adverse effects.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"474 ","pages":"Article 122244"},"PeriodicalIF":4.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZIF-8 derived N-doped carbon framework synergistically enhances WO3 for the photocatalytic degradation of gaseous acetaldehyde","authors":"Beibei Cai,&nbsp;Shuhao Sun,&nbsp;Fei He","doi":"10.1016/j.powtec.2026.122264","DOIUrl":"10.1016/j.powtec.2026.122264","url":null,"abstract":"<div><div>This study developed a nitrogen-doped carbon framework derived from ZIF-8 pyrolysis (NC_Z8) as a novel non-metallic co-catalyst and composited it with WO₃ for acetaldehyde degradation. The prepared 2% NC_Z8/WO₃ composite demonstrated enhanced photocatalytic performance, achieving 95.6% mineralization efficiency for acetaldehyde within 90 min under visible light irradiation, significantly higher than that of pure WO₃. Characterization results revealed that the nitrogen-rich carbon framework functions through multiple synergistic mechanisms: acting as an efficient electron acceptor to promote charge separation, enhancing reactant adsorption and mass transfer through an increased BET specific surface area, and facilitating the formation of oxygen vacancies and the adsorption of light. Additionally, the photocatalytic degradation mechanism of acetaldehyde was elucidated through <em>in situ</em> diffuse reflectance infrared Fourier transform spectroscopy (<em>in situ</em> DRIFTS) and electron spin resonance (ESR) spectroscopy. This study offers a sustainable, noble-metal-free strategy for modifying WO₃-based photocatalysts and deepens the understanding of the mechanistic role of MOF-derived carbon materials in the photocatalytic purification of volatile organic compounds.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"474 ","pages":"Article 122264"},"PeriodicalIF":4.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical study on the fine particle deposition in a squared duct bend during high-speed pneumatic conveying using the Thornton and Ning elastic-perfectly plastic adhesive particle contact model","authors":"Shiguang Zhang ,&nbsp;Hongwei Cao ,&nbsp;Hao Chen ,&nbsp;Quan Zhang ,&nbsp;Huanpeng Liu","doi":"10.1016/j.powtec.2026.122248","DOIUrl":"10.1016/j.powtec.2026.122248","url":null,"abstract":"<div><div>Fine particles are found to easily deposit on the wall of bends during high-speed pneumatic conveying, under which the plastic deformation is non-negligible due to critical particle–wall collisions. Therefore, this study aims to investigate the effect of plastic deformation on fine particle deposition. The Thornton and Ning (TN) elastic-perfectly plastic adhesive particle contact model, which considers the plastic deformation into particle deposition, is utilized to numerically investigate <span><math><mrow><mn>50</mn><mspace></mspace><mtext>µm</mtext></mrow></math></span> fine particle deposition in a squared duct bend (cultivation ratio equals 1.76) from Kliafas’ experiment under high bulk velocity <span><math><mrow><mn>52</mn><mo>.</mo><mn>19</mn><mspace></mspace><mtext>m</mtext><mspace></mspace><mtext>s</mtext><msup><mrow></mrow><mrow><mi>−1</mi></mrow></msup></mrow></math></span> and <span><math><mrow><mn>33</mn><mo>.</mo><mn>09</mn><mspace></mspace><mtext>m</mtext><mspace></mspace><mtext>s</mtext><msup><mrow></mrow><mrow><mi>−1</mi></mrow></msup></mrow></math></span>. The yield stress of particles 0.25–<span><math><mrow><mn>2</mn><mo>.</mo><mn>0</mn><mspace></mspace><mtext>GPa</mtext></mrow></math></span> is selected to represent the intensities of plastic deformation. Furthermore, the relationships between particle deposition and plastic deformation under various bulk velocities (5–<span><math><mrow><mn>55</mn><mspace></mspace><mtext>m</mtext><mspace></mspace><mtext>s</mtext><msup><mrow></mrow><mrow><mi>−1</mi></mrow></msup></mrow></math></span>) and particle diameters (5–<span><math><mrow><mn>50</mn><mspace></mspace><mtext>µm</mtext></mrow></math></span>) are discussed, respectively. The results show that the simulation achieves over 90% consistency in predicting particle velocities, over 70% in predicting particle turbulence intensities, and only 0.44% error (lowest compared to collision models from previous studies) in predicting particle free region length with Kliafas’ experiment. The simulated deposition positions show 90% of particles deposited after the bend and accumulation of deposited particles in the corner, which agrees with previous experimental studies. Results also demonstrate that higher plastic deformation critically increases deposition but shows no effect under low flow velocity (<span><math><mrow><mo>≤</mo><mn>5</mn><mspace></mspace><mtext>m</mtext><mspace></mspace><mtext>s</mtext><msup><mrow></mrow><mrow><mi>−1</mi></mrow></msup></mrow></math></span>) or small particle diameter (<span><math><mrow><mo>≤</mo><mn>5</mn><mspace></mspace><mtext>µm</mtext></mrow></math></span>) for the glass system. This work will benefit the understanding and application of fine particle pneumatic conveying under high conveying speed.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"474 ","pages":"Article 122248"},"PeriodicalIF":4.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel apparatus for particle-particle single contact triboelectrification experiments","authors":"Otome Obukohwo ,&nbsp;Simon Jantač ,&nbsp;Andrew Sowinski ,&nbsp;Poupak Mehrani ,&nbsp;Holger Grosshans","doi":"10.1016/j.powtec.2026.122259","DOIUrl":"10.1016/j.powtec.2026.122259","url":null,"abstract":"<div><div>The experiment of a single contact between two sub-centimeter high-speed particles is often difficult to execute, especially if the collision must be physically and electrically isolated, as is the case for triboelectrification studies. Apparatuses designed for this type of experiment fall short of providing high-speed isolated collisions with a high probability of contact. In this article, we propose a novel apparatus that combines pneumatic conveying and acoustic levitation to provide an electrically and physically isolated, high impact speed collision between two sub-centimeter particles with a collision success rate of 93%. We can vary the pre-contact charge, material, and size of both particles, and the impact speed and angle. Test results show that triboelectrification of insulator particles is not solely driven by contact potential difference; it is a stochastic process that requires large datasets to resolve and understand. Our new apparatus can efficiently generate these datasets and provide new insights into the stochastic nature of triboelectrification, and the effect of each of the collision parameters mentioned earlier on particle-particle triboelectrification.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"474 ","pages":"Article 122259"},"PeriodicalIF":4.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parametric analysis of biomass combustion in a cyclone combustor using coarse-grained CFD-DEM simulation","authors":"Xiaolong Xing ,&nbsp;Xiaoke Ku ,&nbsp;Jianzhong Lin ,&nbsp;Zhaosheng Yu","doi":"10.1016/j.powtec.2026.122255","DOIUrl":"10.1016/j.powtec.2026.122255","url":null,"abstract":"<div><div>A coarse-grained computational fluid dynamics-discrete element method (CFD-DEM) model is established to investigate the influence of operating parameters on biomass combustion in a cyclone combustor. Three key parameters, i.e., operating temperature (<em>T</em>_O), tangential inlet velocity (<em>U</em>_T), and bottom inlet velocity (<em>U</em>_B), are examined. Results show that increasing <em>T</em>_O elevates the overall parcel temperature, enhances biomass consumption, and mitigates wall erosion, while the average NO and SO₂ concentrations in the exhaust gas initially increase and then decrease with <em>T</em>_O. An increase in <em>U</em>_T raises the parcel temperature, prolongs the parcel residence time, enhances the wall parcel-hold ratio, and reduces NO concentration in the exhaust gas, but it exacerbates wall wear. As <em>U</em>_B increases, the parcel residence time reduces and the wall parcel-hold ratio increases, whereas both average NO and SO₂ concentrations in the exhaust gas first decrease and then increase, reaching minimum values at <em>U</em>_B = 7 m/s and 8 m/s, respectively. These findings provide valuable insights into optimizing the operating conditions of biomass cyclone combustors.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"474 ","pages":"Article 122255"},"PeriodicalIF":4.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mesoscopic DEM framework for cohesive soil hardening: Formulation, validation, and data-driven insights","authors":"Da Chen,&nbsp;Xiaoling Wang,&nbsp;Dawei Tong,&nbsp;Binping Wu,&nbsp;Jiajun Wang,&nbsp;Zhijian Cai","doi":"10.1016/j.powtec.2026.122151","DOIUrl":"10.1016/j.powtec.2026.122151","url":null,"abstract":"<div><div>The discrete element method (DEM) is widely adopted for investigating cohesive soil mechanisms at the microscale due to its capacity to directly capture particle-scale kinematics. However, its extension to the simulation of macroscopic behavior remains challenging. Applying insights from the microscale by merely upscaling particle sizes leads to incomplete physical mechanisms and poor response accuracy. To overcome these limitations, this study proposes a mesoscopic Hardening Plastic Cohesive (HPC) contact model, formulated through several advancements: (1) A solid-phase conservation framework accurately quantifies compressed void volume, which resolves persistent errors in porosity calculation; (2) Compression-plasticity-related parameters drive the soil's compressive strength and rebound collectively by governing the hardening level; (3) The friction coefficient between mesoscopic elements evolves with the saturating growth in the coordination number of their underlying microparticles during densification; (4) A tension-fracture-healing mechanism for cohesive soils is incorporated into the cohesion interaction against plastic yielding. High accuracy (average RMSE=0.0035) confirms the model's performance at 13%-25% moisture content by experimental validation. The key insights through Shapley Additive Explanations (SHAP) analysis reveal a decoupled control mechanism: hardening exponent <span><math><msub><mi>n</mi><mi>h</mi></msub></math></span> governs the overall compressive strength, while elastic ratio <span><math><msub><mi>λ</mi><mi>e</mi></msub></math></span> determines rebound magnitude. Critically, the saturation-increasing friction mechanism, controlled by the friction exponent <span><math><msub><mi>n</mi><mi>f</mi></msub></math></span>, is essential for correcting the flattening feature in the late stage of consolidation curves. The cohesive modulus <span><math><msub><mi>C</mi><mi>c</mi></msub></math></span> and cohesive exponent <span><math><msub><mi>n</mi><mi>c</mi></msub></math></span> further enhance simulation accuracy, particularly in the early stage of consolidation. Ultimately, the optimized calibration workflow with clear physics-informed characterization of HPC model achieves a balance between calibration efficiency and high-fidelity results.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"473 ","pages":"Article 122151"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid dry synthesis of nanosized potassium polytungstate via flame aerosol technology for benzene sensing","authors":"Adrien Baut,&nbsp;Sebastian Kravecz,&nbsp;Andreas T. Güntner","doi":"10.1016/j.powtec.2026.122238","DOIUrl":"10.1016/j.powtec.2026.122238","url":null,"abstract":"<div><div>Polytungstates are oxygen-linked assemblies of highly oxidized tungsten polyhedra, valued for their tunability and stability in diverse applications. Traditional synthesis methods (hydrothermal, solvothermal, solid-state) offer material variety but are limited in scalability and their ability to yield nanostructured materials due to long reaction times and high temperatures. Here, we introduce flame aerosol synthesis as a single-step, rapid and dry method to prepare K₂W₇O₂₂ nanoparticulate powders and coatings. Thereby, monocrystalline and phase-pure K₂W₇O₂₂ with varying crystal sizes were obtained by controlling flame temperature, residence time and metal ion concentration during particle formation by nucleation, coagulation and sintering. X-ray diffraction and electron microscopy identified the high potassium tolerance of the K₂W₇O₂₂ lattice (K/W ratio up to 0.6) and phase stability up to 400 °C, before other polytungstates and WO₃ polymorphs were formed, respectively. Porous films of such K₂W₇O₂₂ nanoparticles featured n-type semiconductor behavior that was utilized for the chemoresistive quantification of the air pollutant benzene down to 0.2 parts-per-million at 20% relative humidity. Such sensors were quite selective over other compounds (e.g. alcohols, aldehydes, ketones, CO, NH₃ or H₂), in particular to chemically similar toluene and xylene (selectivity &gt;18).</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"473 ","pages":"Article 122238"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of gas-solid two-phase flow during coalbed methane horizontal well drilling","authors":"Jiaqi Lu,&nbsp;Shengyong Hu,&nbsp;Qianwen Xue,&nbsp;Guobiao Jia,&nbsp;Tingxu Jin","doi":"10.1016/j.powtec.2025.122034","DOIUrl":"10.1016/j.powtec.2025.122034","url":null,"abstract":"<div><div>The transport of cuttings in horizontal wellbores during pneumatic drilling involves complex gas-solid two-phase flow dynamics, where insufficient cutting-carrying capacity of gas often leads to particle accumulation in horizontal sections, causing flow channel blockage. In this study, a coupled computational fluid dynamics-discrete element method (CFD-DEM) framework is employed to investigate the dynamic evolution of cuttings transport during pneumatic drilling. Key control parameters include gas injection, drill pipe rotational speed, particle diameter， and eccentricity. The results show that increasing the gas injection rate effectively suppresses cuttings accumulation, leading to a distinct nonlinear decay in the average cuttings volume fraction. Drill pipe rotation induces a helical gas flow, forming vortex structures within the gas phase field. The resulting centrifugal acceleration drives particles outward. At a rotational speed of 30 rad/min, the maximum particle velocity reaches 1.37 m/s but decreases by 37.2 % when the rotation speed increases to 40 rad/min. Drill pipe eccentricity induces asymmetric Dean vortices, causing significant particle accumulation in narrow annular gaps. At an eccentricity of e = 0.3, the cuttings volume fraction increases markedly, with an increase amplitude reaching 251.7 %. Particle diameter regulates distribution via sedimentation, inertia, and collisions, with large particle inducing flow regime transition from suspension to bed-dragged flow. A dimensionless model captures these nonlinear couplings, advancing understanding of particle transport in confined annular gas-solid flows.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"473 ","pages":"Article 122034"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the near-field fume diffusion characteristics of overhead welding with single weld spot on large flat wall","authors":"Xiaofen Ren ,&nbsp;Ruixiao Yang ,&nbsp;Erqiang Shi ,&nbsp;Zihao Cao ,&nbsp;Yang Yang ,&nbsp;Xin Zhang ,&nbsp;Jiaxing Li","doi":"10.1016/j.powtec.2026.122233","DOIUrl":"10.1016/j.powtec.2026.122233","url":null,"abstract":"<div><div>Welding fumes emitted during welding processes can pose significant health risks. Most existing studies have focused on the diffusion characteristics of welding fumes in flat welding, whereas the diffusion behavior during overhead welding remains poorly understood. In this study, overhead welding of large flat walls was selected as a case to conduct both experimental and numerical investigations into welding fume diffusion patterns. By capturing the spatial diffusion trajectories of welding fumes in real time, we quantified the diffusion patterns, rates, and displacements at various welding angles. In parallel, a numerical model was developed to examine the diffusion of fume particles during overhead welding, using the particle diffusion radius as an indicator for exposure risk assessment. The results indicate that fumes generated during overhead welding primarily disperse horizontally in all directions along the large flat wall. A welding angle of 70°-90° effectively reduces horizontal fume dispersion, and at 90°, fume and particle temperatures reach ambient levels within approximately 4.0 s. Furthermore, after 20 s, the horizontal dispersion radius (<em>R</em>_p) of particles with a diameter of 1 μm reaches a maximum of 0.3 m, and an empirical formula relating to <em>R</em>_p is proposed. Through comparison with flat welding, the horizontal diffusion radius of welding fume particles in overhead welding is significantly larger, measuring 1.3 times that of flat welding. These findings provide valuable references for health risk assessments in industrial workshops and for designing fume extraction systems for overhead welding.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"473 ","pages":"Article 122233"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fingerprinting of fundamental and functional properties of natural plant and mineral powders for guiding their direct or wet-granulation tableting","authors":"Yiting Wang ,&nbsp;Yufei Ni ,&nbsp;Jinzhi Li ,&nbsp;Fei Wu ,&nbsp;Lijie Zhao ,&nbsp;Yanlong Hong ,&nbsp;Lan Shen ,&nbsp;Xiao Lin","doi":"10.1016/j.powtec.2026.122235","DOIUrl":"10.1016/j.powtec.2026.122235","url":null,"abstract":"<div><div>A comprehensive evaluation was conducted on 27 directly pulverized natural medicinal plant and mineral products (DP-NPs) by analyzing their fundamental and functional characteristics. Multiple analytical methods were employed to establish different classification systems or models, as well as to investigate the influence of powder properties upon critical tablet attributes. The results indicated that: (i) The fundamental properties of DP-NPs showed considerable variation (particularly in the mineral powders), e.g., wettability (contact angle, 64.7^o to 121.7^o) and flowability (angle of repose, 42.2^o to 63.0^o); (ii) a classification system for wet-granulation suitability was established with medium and high Liquid/Solid ratio powders (e.g., leaf powders) demonstrated suitability for granulation; (iii) powders were grouped into three categories based on tableting performance: Group 2 (the best: <em>Lycii Fructus</em>/FR3, TS = 3.56 MPa under 240 MPa) &gt; Group 1 (e.g., <em>Gypsum Fibrosum</em>) &gt; Group 3 (the worst: <em>Lablab Semen Album</em>, TS = 0.01 MPa under 240 MPa) using multiple analysis; (iv) powders were categorized into three classes according to their tablet disintegration kinetics: disintegrating (e.g., root powders), expansive (e.g., leaf powders), and dissolved (FR3) ones; and (v) Elastic Net Regression modeling revealed a positive correlation between tensile strength and disintegration time of tablets for the majority of DP-NPs, identifying key variables (e.g., yield pressure) influencing the two critical quality attributes. In summary, this study provides a systematic framework for understanding and predicting the behavior of DP-NPs in tablet production, establishing a scientific foundation for rational formulation design under the Quality by Design (QbD) paradigm.</div></div>","PeriodicalId":407,"journal":{"name":"Powder Technology","volume":"473 ","pages":"Article 122235"},"PeriodicalIF":4.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}