The Journal of Clinical and Scientific Research最新文献_第5页

Sodium stibogluconate as first-line treatment for post kala-azar dermal leishmaniasis 硬葡萄糖酸钠作为黑热病后皮肤利什曼病的一线治疗

The Journal of Clinical and Scientific Research Pub Date : 2014-04-01 DOI: 10.15380/2277-5706.JCSR.13.036

K. S. Dhillon, K. Varshney

引用次数: 0

Central nervous system infections in the intensive care unit 重症监护室的中枢神经系统感染

The Journal of Clinical and Scientific Research Pub Date : 2014-04-01 DOI: 10.15380/2277-5706.JCSR.13.044

B. Vengamma, M. Rajguru, B. C. Prasad, V. R. Chandra

{"title":"Central nervous system infections in the intensive care unit","authors":"B. Vengamma, M. Rajguru, B. C. Prasad, V. R. Chandra","doi":"10.15380/2277-5706.JCSR.13.044","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.13.044","url":null,"abstract":"Neurological infections constitute an uncommon, but important aetiological cause requiring admission to an intensive care unit (ICU). In addition, health-care associated neurological infections may develop in critically ill patients admitted to an ICU for other indications. Central nervous system infections can develop as complications in ICU patients including post-operative neurosurgical patients. While bacterial infections are the most common cause, mycobacterial and fungal infections are also frequently encountered. Delay in institution of specific treatment is considered to be the single most important poor prognostic factor. Empirical antibiotic therapy must be initiated while awaiting specific culture and sensitivity results. Choice of empirical antimicrobial therapy should take into consideration the most likely pathogens involved, locally prevalent drug-resistance patterns, underlying predisposing, co-morbid conditions, and other factors, such as age, immune status. Further, the antibiotic should adequately penetrate the blood-brain and bloodcerebrospinal fluid barriers. The presence of a focal collection of pus warrants immediate surgical drainage. Following strict aseptic precautions during surgery, hand-hygiene and care of catheters, devices constitute important preventive measures. A high index of clinical suspicion and aggressive efforts at identification of aetiological cause and early institution of specific treatment in patients with neurological infections can be life saving.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126551106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Subclinical hypothyroidism - when to treat? 亚临床甲状腺功能减退-何时治疗?

The Journal of Clinical and Scientific Research Pub Date : 2014-04-01 DOI: 10.15380/2277-5706.JCSR.14.011

C. Rao, V. Suresh, A. Sachan

引用次数: 0

Primary vaginal Ewing’s sarcoma/primitive neuroectodermal tumour: diagnostic and treatment challenges 原发性阴道尤文氏肉瘤/原始神经外胚层肿瘤:诊断和治疗的挑战

The Journal of Clinical and Scientific Research Pub Date : 2014-04-01 DOI: 10.15380/2277-5706.JCSR.13.033

Pranabandhu Das, K. Gunaseelan, D. Basu, R. Ananthakrishnan, K. Reddy

{"title":"Primary vaginal Ewing’s sarcoma/primitive neuroectodermal tumour: diagnostic and treatment challenges","authors":"Pranabandhu Das, K. Gunaseelan, D. Basu, R. Ananthakrishnan, K. Reddy","doi":"10.15380/2277-5706.JCSR.13.033","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.13.033","url":null,"abstract":"Extra osseous Ewing’s sarcoma/primitive neuroectodermal tumour (PNET) of the genital tract of women is scarcely described in the literature and involvement of the vagina is even rarer with a very few cases reported so far. We present 50-year-old-woman who presented with a vaginal mass that was diagnosed to be a malignant round cell tumour which later was confirmed to be primary vaginal Ewing’s sarcoma/PNET on light microscopy and immunohistochemical staining. She was then treated with induction chemotherapy followed by local radiotherapy and further maintenance chemotherapy. This rare case of primary vaginal Ewing’s sarcoma/PNET emphasizes the need for combining morphological features with immunohistochemistry with a panel of antibodies in establishing the diagnosis of Ewing’s sarcoma/PNET at an uncommon site. Further, the case also highlights the use of induction chemotherapy followed by radiation therapy and subsequent maintenance chemotherapy as a treatment modality. Das P, Gunaseelan K, Basu D, Ananthakrishnan R, Reddy KS. A rare case of primary vaginal ewing’s sarcoma/ primitiveneuroectodermal tumour : diagnostic and treatment challenges. J Clin Sci Res 2014;3:145-9. DOI: http://dx.doi.org/ 10.15380/2277-5706.JCSR.13.033. Corresponding author: Dr Pranabandhu Das, Assistant Professor, Department of Radiation Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India. e-mail: daspranabandhu@gmail.com Received: 01 June, 2013. Vaginal Ewing's sarcoma/PNET Das et al","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"26 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131805502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Changes in pre- and post-donation haematological parameters in plateletpheresis donors 采血小板献血者捐献前后血液学参数的变化

The Journal of Clinical and Scientific Research Pub Date : 2014-04-01 DOI: 10.15380/2277-5706.JCSR.13.046

B. Suresh, R. Arun, A. Yashovardhan, K. Deepthi, K. S. Babu, D. Jothibai

{"title":"Changes in pre- and post-donation haematological parameters in plateletpheresis donors","authors":"B. Suresh, R. Arun, A. Yashovardhan, K. Deepthi, K. S. Babu, D. Jothibai","doi":"10.15380/2277-5706.JCSR.13.046","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.13.046","url":null,"abstract":"Background: Recently the use of single donor platelet (SDP) concentrates has grown steadily due to its employment in chemotherapy protocols. Technical advances in automated cell separators have substantially improved the productivity and quality of the collection of apheresis platelets. \u0000Methods: We prospectively studied 90 healthy donors who volunteered for plateletpheresis. We compared the preand post-plateletpheresis haematological values, namely, haemoglobin (Hb), haematocrit, platelet count, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, platelet distribution width (PDW), red blood cell count, white blood cell (WBC) count and mean platelet volume (MPV) in all of them. \u0000Results: Following plateletpheresis a significant decrease in pre- and post-donation Hb (g/dL) (14.8 ± 1.097 Vs 14.5 ± 1.4; p=0.002); haematocrit (%) (43.29 ± 6.62 Vs 41.64 ± 4.96; p=0.045); platelet count (χ 109/L) (280.34 ± 54.55 Vs 175.58 ± 44.56; p< 0.001); WBC count (χ 103/μL) (8.28 ± 1.88 Vs 6.95 ± 1.76; p< 0.001); and PDW (fL) (15.96 ± 1.38 Vs 4.96 ± 0.67; p=0.053) and a slight rise in MPV (fL) (8.61 ± 0.77 Vs 8.72 ± 0.83; p=0.067) were observed. However, none of them developed clinical manifestation of anaemia or thrombocytopenia. \u0000Conclusions: Close monitoring and follow-up for these donors is indicated to prevent unfavourable events caused by these changes.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123945320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Horner’s syndrome due to Pancoast tumour 由Pancoast肿瘤引起的霍纳综合征

The Journal of Clinical and Scientific Research Pub Date : 2014-04-01 DOI: 10.15380/2277-5706.JCSR.13.051

A. Mohan, J. Harikrishna, B. Deepthi, V. Raja, P. Suneetha, Chowhan Ak, V. Devi, A. Chandra

引用次数: 0

Drug-interference in clinical chemistry analyses: pseudohypertriglyceridaemia 临床化学分析中的药物干扰:假性高甘油三酯血症

The Journal of Clinical and Scientific Research Pub Date : 2014-04-01 DOI: 10.15380/2277-5706.JCSR.13.045

P.Swathi, M. Prasanth, M. Suchitra, A. Bitla

引用次数: 0

Identification of potent inhibitors for β-secretase through structure based virtual screening and molecular dynamics simulations 通过基于结构的虚拟筛选和分子动力学模拟鉴定有效的β-分泌酶抑制剂

The Journal of Clinical and Scientific Research Pub Date : 2013-07-01 DOI: 10.15380/2277-5706.JCSR.12.058

A. Mobeen, Dibyabhaba Pradhan, Priyadarshini, M. Munikumar, S. Sandeep, A. Umamaheswari

{"title":"Identification of potent inhibitors for β-secretase through structure based virtual screening and molecular dynamics simulations","authors":"A. Mobeen, Dibyabhaba Pradhan, Priyadarshini, M. Munikumar, S. Sandeep, A. Umamaheswari","doi":"10.15380/2277-5706.JCSR.12.058","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.12.058","url":null,"abstract":"Background: Alzheimer's disease (AD) is a neurodegenerative disorder in elderly persons aged above 65 years. The cleavage of amyloid precursor protein (APP) by -secretase generates peptide fragment A42, the main cause of memory and cognitive defects in AD. Therefore, elevated level of -secretase results in accumulation of insoluble form of A peptides (senile plaques) representing the protein as an attractive drug target of AD. Methods: Five recently reported -secretase antagonist (thiazolidinediones, rosiglitazone, pioglitazone, SC7 and tartaric acid) structural analogs were searched from ligand info database and prepared using LigPrep. The crystal structure of -secretase was optimized using Maestro v9.2 protein preparation wizard applying optimized potential for liquid simulations (OPLS)-2005 force field. Structure based virtual screening was performed for -secretase from prepared ligands using virtual screening workflow of Maestro v9.2 and was ranked based on XP Gscore. Results: Eight lead molecules were identified to have better binding affinity (lower XP Gscore) compared to five existing -secretase antagonists and appear to have good pharmacological properties. Binding orientations of the lead molecules were in well agreement with existing inhibitors. Lead1 showed lowest XP Gscore (-10.72 Kcal/mol). Molecular dynamics (MD) simulations of -secretase-lead1 complex was stable in all trajectories. Conclusion: Lead1 is proposed as potent inhibitor of -secretase and thus could be considered for rational drug design","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128170638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Papanicolaou (pap) test in staff members in a tertiary health care centre in south india 在印度南部的一个三级保健中心对工作人员进行巴氏涂片检查

The Journal of Clinical and Scientific Research Pub Date : 2012-10-01 DOI: 10.15380/2277-5706.JCSR.12.039

J. Amitabh, T. Bharathi, Siva Kumar Reddy Yk, B. Manilal, R. Patnayak, B. Phaneendra

引用次数: 1

Diagnosis of viral diseases in India: at the cross roads 印度病毒性疾病的诊断:在十字路口

The Journal of Clinical and Scientific Research Pub Date : 2012-10-01 DOI: 10.15380/2277-5706.JCSR.12.055

S. Dvr

引用次数: 3