The Journal of Clinical and Scientific Research最新文献

A comparative study on effect of 4% gelatin and dextran-40 on blood glucose levels during surgery under subarachnoid block – A randomised, prospective study 4%明胶和葡聚糖-40对蛛网膜下腔阻滞手术期间血糖水平影响的比较研究——一项随机、前瞻性研究

The Journal of Clinical and Scientific Research Pub Date : 2021-07-01 DOI: 10.4103/JCSR.JCSR_85_20

Sreehari Kunichetty Gajula, Sreenivasulu Bhadri, Madhusudan Mukkara

{"title":"A comparative study on effect of 4% gelatin and dextran-40 on blood glucose levels during surgery under subarachnoid block – A randomised, prospective study","authors":"Sreehari Kunichetty Gajula, Sreenivasulu Bhadri, Madhusudan Mukkara","doi":"10.4103/JCSR.JCSR_85_20","DOIUrl":"https://doi.org/10.4103/JCSR.JCSR_85_20","url":null,"abstract":"Background: Stress response to surgery induces hyperglycaemia to limited extent. An additive hyperglycaemic response, secondary to the metabolism of intravenous fluids, can thus prove detrimental to the well-being of the patient, if ignored. Methods: We compared the effects of 4% gelatin and dextran-40 on blood glucose levels during surgery under subarachnoid block and their potential to induce hyperglycaemia. Sixty American Society of Anesthesiologists grade I and II patients were randomised into two groups, 30 patients in each. Group 1 patients were preloaded with 4% Gelatin (10 mL/kg) and Group 2 patients were preloaded with dextran-40 in normal saline (10 mL/kg), over a period of 30 min. Just prior to preloading, base line capillary blood glucose (CBG) level was noted this is followed by subsequent readings at 20 min interval until 100 min from base line reading. All patients received normal saline (0.9%) as a maintenance fluid. Under strict aseptic precautions, subarachnoid block using 15 mg of hyperbaric bupivacaine at L3-L4 or L4-L5 level was given after preloading. Results: The CBG levels in both the groups at 20, 40, 60, 80 and 100 min from base line were within physiological limits. In group 2, the maximum CBG level was found at 60 min from onset of preloading (P = 0.017), when compared with corresponding CBG level in Group 1. Preloading the patients prior to subarachnoid block with 4% gelatin or dextran 40 do not raise CBG levels significantly above the physiological limits.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"280 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127476239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing face of clinical chemistry laboratory under the influence of industry and technology 工业和技术影响下临床化学实验室面貌的变化

The Journal of Clinical and Scientific Research Pub Date : 2017-04-01 DOI: 10.15380/2277-5706.JCSR.17.03.004

Naidu Ks

引用次数: 0

Molecular mechanisms underlying diabetic microvascular complications 糖尿病微血管并发症的分子机制

The Journal of Clinical and Scientific Research Pub Date : 2016-04-01 DOI: 10.15380/2277-5706.JCSR.16.01.003

A. Bitla, N. Devi, V. Kiranmayi

引用次数: 1

Urinary enzymes and microalbuminuria as biomarkers of renal dysfunction after contrast administration 尿酶和微量蛋白尿作为对比剂给药后肾功能障碍的生物标志物

The Journal of Clinical and Scientific Research Pub Date : 2015-10-01 DOI: 10.15380/2277-5706.JCSR.14.055

Ashalatha Vl, A. Bitla, M. Suchitra, D. Rajasekhar, S. Kumar, A. Lakshmi, S. Pvln

{"title":"Urinary enzymes and microalbuminuria as biomarkers of renal dysfunction after contrast administration","authors":"Ashalatha Vl, A. Bitla, M. Suchitra, D. Rajasekhar, S. Kumar, A. Lakshmi, S. Pvln","doi":"10.15380/2277-5706.JCSR.14.055","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.055","url":null,"abstract":"Background: Contrast-induced nephropathy (CIN) is a common complication after administration of intravenous iodinated contrast media. The present study evaluated the usefulness of urinary beta-N-acetyl D-glucosaminidase (u-NAG), alkaline phosphatase (u-ALP) and lactate dehydrogenase (u-LDH) as markers of tubular injury and urinary microalbumin (u-MA) as a marker of glomerular injury for early diagnosis of CIN in patients undergoing coronary interventions. \u0000Methods: One hundred and twenty patients scheduled for elective coronary angiography (CAG), with or without angioplasty with baseline serum creatinine less than 1.2 mg/dL were recruited. Serum creatinine, u-NAG, u-ALP, u-LDH and u-MA were analyzed at 0, 4 and 24 hours after administration of low-osmolal, non-ionic contrast medium. \u0000Results: CIN developed in 27 (22.5%) patients. A significant increase in u-ALP, u-LDH and in u-MA was seen in both CIN and non-CIN groups. However, no significant difference was observed in these markers between the two groups. A significant increase in u-NAG was observed only in the CIN group. \u0000Conclusions: Low osmolal, non-ionic contrast medium produced toxic insult to the glomeruli as well as renal tubules even in patients with normal baseline renal function and u-NAG can differentiate patients with CIN.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125931501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on Rh incompatibility and frequency of weak D among blood donors and patients at a tertiary care referral teaching hospital in Tirupati, Andhra Pradesh 安得拉邦蒂鲁帕蒂一家三级转诊教学医院献血者和患者Rh不相容及弱D频率的研究

The Journal of Clinical and Scientific Research Pub Date : 2015-10-01 DOI: 10.15380/2277-5706.JCSR.14.053

G. Krishna, K. S. Babu, R. Arun, D. Jothibai

{"title":"A study on Rh incompatibility and frequency of weak D among blood donors and patients at a tertiary care referral teaching hospital in Tirupati, Andhra Pradesh","authors":"G. Krishna, K. S. Babu, R. Arun, D. Jothibai","doi":"10.15380/2277-5706.JCSR.14.053","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.053","url":null,"abstract":"Background: Rh D antigen is the next most important after ABO antigens in the field of transfusion medicine. Weak D refers to reduced expression of D antigen on the red blood cell that requires an extended testing with indirect antiglobulin test (IAT) to get detected. Clinical importance of weak D arises when labelling the donor and patient, as the donor is labelled as D positive, patient as D negative. \u0000Methods: In our center all blood donor and patient samples are tested for ABO and Rh D by conventional tube technique using two anti-D reagents; anti-D immunoglobulin M (IgM) monoclonal and a blend of anti-D IgM and immunoglobulin G (IgG). The blood samples which were negative for agglutination by immediate spin method were further tested for weak-D using IgG anti-D in the IAT phase with low ionic strength solution (LISS)/Coombs’gel card. \u0000Results: A total of 46,654 blood samples were tested (22,326 donors and 24,328 patients) during the period January 2012 to August 2014. Among these 43,771 (93.82%) were Rh D positive and remaining 2,883 (6.18%) were Rh-D negative. A total of 30 individuals (16 donors and 14 patients) were weak D positive constituting 1.04% of Rh-D negatives and 0.06% of total individuals screened. \u0000Conclusions: This study shows the prevalence of weak D antigen in our population who are representative of Rayalaseema region of Andhra Pradesh. It also stresses the need to identify individuals with variant D (rather than weak or partial D) and to inform them about their status as donor and recipient of blood/organ.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127986933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Gardner's syndrome presenting as duodenal carcinoma in a young male 加德纳氏综合症表现为年轻男性的十二指肠癌

The Journal of Clinical and Scientific Research Pub Date : 2015-10-01 DOI: 10.15380/2277-5706.JCSR.14.029

M. Sriharibabu, Y. Sarma, G. Bhaskararao, S. Nayak, T. Satyaprakash

引用次数: 0

Burden of hepatitis C virus infection and its genotypes among the blood donors at Tirupati, Andhra Pradesh 安得拉邦蒂鲁帕蒂献血者丙型肝炎病毒感染负担及其基因型

The Journal of Clinical and Scientific Research Pub Date : 2015-10-01 DOI: 10.15380/2277-5706.JCSR.14.066

Anju Verma, S. Jothibai, P. Sarma, M. Nagaraj, L. Srikant, B. Vasavi, P. Chandramouli, U. Kalawat

{"title":"Burden of hepatitis C virus infection and its genotypes among the blood donors at Tirupati, Andhra Pradesh","authors":"Anju Verma, S. Jothibai, P. Sarma, M. Nagaraj, L. Srikant, B. Vasavi, P. Chandramouli, U. Kalawat","doi":"10.15380/2277-5706.JCSR.14.066","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.066","url":null,"abstract":"Background: Safe blood donation remains a challenge in resource limited countries. False positive serological tests lead to wastage of large number of blood units. Nucleic acid amplification test (NAAT) technology has greatly enhanced the accuracy in identification of transfusions transmitted infections. \u0000Methods: The present study was undertaken to study the seroprevalence of hepatitis C virus (HCV) and asses the concordance between seropositivity with the presence of HCV ribonucleic acid (RNA) and to know the distribution pattern of HCV genotypes in healthy blood donors. \u0000Results: Among the 9287 donors screened (88.3% males), 7153 (77%) were voluntary donors while 2134 (23%) were replacement donors. Among blood donors, 27 (0.3%) samples tested HCV seropositive. Among 27 anti-HCV positive samples only 11 (41%) were found positive for HCV RNA. Among the 5 samples subjected to sequencing, three were found to be genotype 1a while two were genotype 3a. \u0000Conclusions: Our observations suggest that implementing NAAT test for HCV screening will be helpful in minimizingfalse-positive test results in the Indian setting.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134112543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ageing and kidney: A primer 衰老与肾脏:底漆

The Journal of Clinical and Scientific Research Pub Date : 2015-10-01 DOI: 10.15380/2277-5706.JCSR.15.073

P. Suneetha, V. Raja, V. Sivakumar

引用次数: 0

Abdominal cocoon: A rare cause of acute intestinal obstruction 腹部茧:一种罕见的急性肠梗阻的原因

The Journal of Clinical and Scientific Research Pub Date : 2015-10-01 DOI: 10.15380/2277-5706.JCSR.14.068

S. Kadiyala, S. Gavini, R. Patnayak, B. Devi, S. Sarala, A. Lakshmi

{"title":"Abdominal cocoon: A rare cause of acute intestinal obstruction","authors":"S. Kadiyala, S. Gavini, R. Patnayak, B. Devi, S. Sarala, A. Lakshmi","doi":"10.15380/2277-5706.JCSR.14.068","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.068","url":null,"abstract":"Sclerosing encapsulating peritonitis (SEP) is a relatively rare cause of intestinal obstruction resulting from encasement of variable lengths of bowel by dense fibro-collagenous membrane. The idiopathic cases of SEP, which lack any identifiable cause from clinical, radiological and histopathological findings, are also reported under the descriptive term “abdominal cocoon syndrome”. Patient with SEP present with intestinal obstruction. Persistent untreated SEP may advance to bowel gangrene or intestinal perforation, which are life threatening conditions. \u0000We report the rare occurrence of SEP in a 45-year-old male presenting with signs of intestinal obstruction. Imaging findings revealed abdominal cocoon with bowel gangrene leading to perforation and the same was confirmed at surgery. Surgical excision of the fibrotic sac encasing the bowel, resection of gangrenous bowel segment and end ileostomy were performed. Histopathology of the excised membrane confirmed the diagnosis of SEP. Radiologists should be aware of this relatively rare cause of intestinal obstruction, its imaging findings and complications, as an accurate preoperative diagnosis will prevent diagnostic delay and aid the surgeon in planning treatment.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125454809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embolization of uterine artery as an emergency treatment for vaginal bleeding due to ectopic cervical pregnancy 子宫动脉栓塞术作为子宫异位妊娠阴道出血的紧急治疗

The Journal of Clinical and Scientific Research Pub Date : 2015-10-01 DOI: 10.15380/2277-5706.JCSR.15.007

Anupama Hari, B. Indira, J. Venkateswarlu, G. Sravanthi

引用次数: 0