The Journal of Clinical and Scientific Research最新文献_第10页

Ki-67 proliferation index and clinicopathological patterns in colorectal carcinomas Ki-67增殖指数与结直肠癌的临床病理特征

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.039

A. Bhagyalakshmi, A. Sreelekha, A. Babu, S. V. Kumar, P. Muralikrishna

{"title":"Ki-67 proliferation index and clinicopathological patterns in colorectal carcinomas","authors":"A. Bhagyalakshmi, A. Sreelekha, A. Babu, S. V. Kumar, P. Muralikrishna","doi":"10.15380/2277-5706.JCSR.14.039","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.039","url":null,"abstract":"Background : Tumour, node, metastasis (TNM) staging system provides useful prognostic information in patients with colorectal carcinoma (CRC). An improved prognostication and patient survival may be achieved by employing immunohistochemistry studies with proliferation markers like Ki-67. Material and methods: We prospectively studied 51 patients with CRC and evaluated the clinicopathological patterns of CRC and the relationship of with the clinicopathological variables Results: Their mean age was 48 (range 17-75) years; majority (64.7%) were males. Rectum was the most common subsite affected (45.1%). Histopathologically most of the tumours (86.3%) were usual type adenocarcinomas and were of grade 1 morphology (51%). The Ki-67 proliferation index (PI) ranged from 8.4% to 84.4%. The mean PI was greater in patients aged less than or equal to 50 years than in those aged above 50 years, in males than females, in rectal cancers than colonic cancers. It was greater in mucinous carcinomas than usual type adenocarcinomas, in grade 3 tumours than lower grade tumours (grades 1 and 2) and in T4 than T3 and T2 tumours. There was a significant positive correlation between the PI values and grade of the tumour. Conclusion: We concluded that Ki-67 proliferation marker may be useful as an additional tool to assess the tumour aggressiveness with respect to certain clinicopathological parameters in colorectal carcinomas.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114712278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A rare case of Turcot syndrome 罕见的Turcot综合征病例

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.jcsr.14.028

M. Sriharibabu, Y. Sarma, G. Bhaskararao, D. Chakravarthy

引用次数: 0

Orbital apex syndrome secondary to nasopharyngeal carcinoma 鼻咽癌继发的眶尖综合征

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.036

C. Sandhya, D. Krishna, C. Jagannath, G. Srinivas, K. Radhika

引用次数: 1

Respiratory diseases in pregnancy 妊娠期呼吸系统疾病

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.jcsr.14.048

S. Raghu, S. Pulivarthi

引用次数: 0

Superficial dermatomycoses: a prospective clinico-mycological study 浅表皮肤真菌病:一项前瞻性临床真菌学研究

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.051

A. Surekha, G. Rameshkumar, K. Sridevi, Murthy Ds, G. Usha, G. Bharathi

{"title":"Superficial dermatomycoses: a prospective clinico-mycological study","authors":"A. Surekha, G. Rameshkumar, K. Sridevi, Murthy Ds, G. Usha, G. Bharathi","doi":"10.15380/2277-5706.JCSR.14.051","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.051","url":null,"abstract":"Background: Dermatomycoses are more prevalent in India due to favourable climatic conditions, poverty, poor hygiene and overcrowding. Sparse published data are available regarding superficial dermatomycoses from India. Methods: In this prospective study, demographic characteristics, clinical spectrum and risk factors for the development were studied in 198 patients with superficial dermatomycoses. Results: Their mean age was 34.1 ± 15.3 years; there were 108 (54.5%) males. Majority of the patients (50.5%) belonged to upper-lower socio-economic status (Class IV as per modified Kuppuswamy’s classification). Most of the patients (69.7%) had presented with dermatophytoses. Among superficial dermatomycoses, tinea corporis was the most common (29.3%) clinical type. Potassium hydroxide mount was positive in 77.7% and culture was positive in 30.8%. Trichophyton rubrum was the most common species isolated (64%). Multivariable analysis using logistic regression revealed older age (> 50 years) to be an independent predictor for the development of tinea corporis (p<0.001). Conclusions: Our observations suggest that superficial dermatomycoses are an important cause of morbidity and should be carefully searched for especially in the elderly so that effective curative treatment can be instituted.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133279219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Unusual cause of pyopericardium with tamponade 心包填塞的不寻常原因

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.001

K. Gowrinath, B. Phanikrishna, C. Raghavendra, A. SaiRaviShankar

引用次数: 3

Pseudoneutropenia from cold agglutinin leucoagglutination 由冷凝集素白细胞凝集引起的假中性粒细胞减少症

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.016

M. Momin, Hyderabad Yashoda Hospitals, A. Yashovardhan, A. Quadri, Anamika Aluri, A. Ingle, M. Satyanarayana, R. Agarwal

引用次数: 0

Study of subclinical hypothyroidism among patients with type 2 diabetes mellitus 2型糖尿病患者亚临床甲状腺功能减退的研究

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.071

C. Mallikarjuna, S. Shabnam, P. Pinjar

引用次数: 2

Trends in the presentation of acute exacerbation of chronic obstructive pulmonary disease requiring admission to ICU: Experience at a tertiary care teaching hospital in South India 慢性阻塞性肺疾病急性加重需要入住ICU的趋势:南印度三级护理教学医院的经验

The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.jcsr.15.072

J. Harikrishna, V. Raja, D. Murthy

引用次数: 0