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Role of adipokines in the pathogenesis of nonalcoholic fatty liver disease 脂肪因子在非酒精性脂肪肝发病机制中的作用
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.072
M. Pallavi, M. Suchitra, S. Pvln
{"title":"Role of adipokines in the pathogenesis of nonalcoholic fatty liver disease","authors":"M. Pallavi, M. Suchitra, S. Pvln","doi":"10.15380/2277-5706.JCSR.14.072","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.072","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. The increased prevalence of obesity, diabetes, hypertension, hypertriglyceridaemia and hypercholesterolemia are considered to be the potential causative factors for NAFLD. NAFLD is emerging as a major clinical problem worldwide. Recently much attention has been focused in India as the prevalence of obesity and diabetes is rising. NAFLD is responsible for unexplained raise in transaminases, and an important cause of cryptogenic cirrhosis and cryptogenic hepatocellular carcinoma in India. NAFLD is a spectrum of disease ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), potentially leading to fibrosis and cirrhosis. Studies have suggested that the adipokines are involved in the pathogenesis of NAFLD and its progression to NASH, through their metabolic and pro- or anti-inflammatory activity. Adipokines in particular tumor necrosis factor-α and interleukin-6 are believed to mediate the shift in pathology from steatosis to steatohepatitis. In addition, other adipokines such as adiponectin, leptin and resistin also play a crucial role in the development and progression of NAFLD through their metabolic and pro-or anti-inflammatory activity. This suggests that imbalance between pro-inflammatory and anti-inflammatory cytokines may have a role in the development of liver damage in NAFLD. Understanding the relationship between adipokines and NAFLD may play an important role in the early identification/diagnosis, treatment and also help in preventing disease progression.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124307299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Serum lipoprotein(a) and lipid profile in polycystic ovarian syndrome 多囊卵巢综合征的血清脂蛋白(a)和脂质谱
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.007
R. Swetha, Ravich Bv, Nalini Ks
{"title":"Serum lipoprotein(a) and lipid profile in polycystic ovarian syndrome","authors":"R. Swetha, Ravich Bv, Nalini Ks","doi":"10.15380/2277-5706.JCSR.14.007","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.007","url":null,"abstract":"Background: Polycystic ovarian syndrome (PCOS) is associated with dyslipidaemia and may render the affected women “at risk” of developing cardiovascular disease. Lipoprotein(a) [Lp(a)] is an independent risk factor for development of atherosclerosis and along with dyslipidaemia may add to cardiovascular risk. In this background the levels of Lp(a) and lipid profile are assessed in PCOS patients. Material and Methods: The study was carried out on 30 newly diagnosed PCOS subjects aged 18-35 years and 30 age-matched healthy women. Blood samples were collected in a fasting state and serum Lp(a), lipid parameters were estimated. Results: The lipid profile parameters were comparable between patients and control subjects. There was no statistically significant difference in the median [interquartile range (IQR)] Lp(a) levels between patients with PCOS and normal controls. However, the proportion of subjects with elevated (> 30 mg/dL) Lp(a) levels were significantly higher in patients with PCOS compared to control subjects.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127161357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Familial Kikuchi-Fujimoto disease 家族性菊chi-藤本病
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.13.077
J. Krishnappa, D. BharathReddy, Harsha Pj, Prasad Csb
{"title":"Familial Kikuchi-Fujimoto disease","authors":"J. Krishnappa, D. BharathReddy, Harsha Pj, Prasad Csb","doi":"10.15380/2277-5706.JCSR.13.077","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.13.077","url":null,"abstract":"Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disease of unknown aetiology presenting with cervical lymphadenopathy, fever, vomiting, weight loss, night sweats and chills. Familial occurrence of KFD is reported very rarely in literature. We report two cases from the same family presenting with KFD. The two non-twin sisters presented with symptoms of fever, cervical lymphadenopathy, weight loss, nausea, vomiting, night sweats and chills 6 months apart. The elder sibling with KFD also manifested mononeuritis multiplex. Laboratory evaluation revealed raised erythrocyte sedimentation rate, C-reactive protein levels and leucopenia. Anti-nuclear antibody and anti-double stranded deoxyribonucleic acid antibody were negative. Histopathological findings were suggestive of Kikuchi -Fujimoto’s disease. The patients responded well to oral corticosteroid treatment.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126979386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Ulcerative erythema nodosum: a rare entity 溃疡性结节性红斑:一种罕见的疾病
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.002
K. S. Dhillon, D. Sharma, M. S. Umar, T. Singh, Tanu Gupta, K. Varshney, P. Shukla
{"title":"Ulcerative erythema nodosum: a rare entity","authors":"K. S. Dhillon, D. Sharma, M. S. Umar, T. Singh, Tanu Gupta, K. Varshney, P. Shukla","doi":"10.15380/2277-5706.JCSR.14.002","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.002","url":null,"abstract":"We report an 18-year-old girl who presented with multiple recurrent nodulo-ulcerativelesions over arms and painful reddish nodular lesions over both legs and abdomen of 7 months duration. She was diagnosed to have Crohn’s disease on the basis of clinical presentation and colonoscopy findings. Skin biopsy from lesion on shin showed septal panniculitis. She was diagnosed to have ulcerative erythema nodosum. Erythema Nodosum is an acute, tender, erythematous, subcutaneous nodular eruption that is typically located symmetrically on the extensor aspects of the lower extremities. Chronic or recurrent erythema nodosum is rare but may occur.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129438944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Illusion and reality: Correlative neurophilosophy 幻觉与现实:相关神经哲学
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.15.035
I. Dinakar
{"title":"Illusion and reality: Correlative neurophilosophy","authors":"I. Dinakar","doi":"10.15380/2277-5706.JCSR.15.035","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.15.035","url":null,"abstract":"","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123278426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A seizure with a spot: A study of patients with mesial temporal lobe epilepsy 有斑点的癫痫发作:对内侧颞叶癫痫患者的研究
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.jcsr.14.075
N. Sundarachary, A. Sridhar
{"title":"A seizure with a spot: A study of patients with mesial temporal lobe epilepsy","authors":"N. Sundarachary, A. Sridhar","doi":"10.15380/2277-5706.jcsr.14.075","DOIUrl":"https://doi.org/10.15380/2277-5706.jcsr.14.075","url":null,"abstract":"One of the convulsive disorders, presenting to physicians with complex and bizarre behaviour is Mesial temporal lobe epilepsy MTLE.1 Refractory seizures especially complex partial seizures (CPS) should make the physician think of this possibility. Early specific investigations for the disorder therefore can prevent the delay and its consequences to of this treatable condition. MTLE is associated with focal seizures and dyscognitive features. It is generally refractory to treatment with anticonvulsants but responds extremely well to surgical intervention. There is a paucity of data regarding the disease in the state of Andhra Pradesh. We studied the 20 cases with mesial temporal epilepsy admitted to the tertiary care Government general hospital, Guntur during the period 2010 to April 2012.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121968277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Broad ligament ectopic pregnancy 阔韧带异位妊娠
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.013
C. Rama, G. Lepakshi, Raju Sn
{"title":"Broad ligament ectopic pregnancy","authors":"C. Rama, G. Lepakshi, Raju Sn","doi":"10.15380/2277-5706.JCSR.14.013","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.013","url":null,"abstract":"","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115335081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Institution building - Organizational structure and function 制度建设——组织结构和功能
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.jcsr.13.076
Sridhar
{"title":"Institution building - Organizational structure and function","authors":"Sridhar","doi":"10.15380/2277-5706.jcsr.13.076","DOIUrl":"https://doi.org/10.15380/2277-5706.jcsr.13.076","url":null,"abstract":"","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115885816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cysticercosis of breast: A rare encounter 乳房囊虫病:罕见的遭遇
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.14.050
B. Anuradha, S. Bodhireddy, Sharrif, Bharathisree Moode, Chandrakala Kasetty, Jyothi Brahmaiah
{"title":"Cysticercosis of breast: A rare encounter","authors":"B. Anuradha, S. Bodhireddy, Sharrif, Bharathisree Moode, Chandrakala Kasetty, Jyothi Brahmaiah","doi":"10.15380/2277-5706.JCSR.14.050","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.050","url":null,"abstract":"","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130025720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Diuretic intervention improves accuracy of 18F-fluorodeoxyglucose PET-CT in bladder malignancies 利尿剂干预可提高18f -氟脱氧葡萄糖PET-CT在膀胱恶性肿瘤中的准确性
The Journal of Clinical and Scientific Research Pub Date : 1900-01-01 DOI: 10.15380/2277-5706.JCSR.13.071
T. Kalawat, M. Ranadheer, S. Sarala, R. Narayan, A. Tyagi
{"title":"Diuretic intervention improves accuracy of 18F-fluorodeoxyglucose PET-CT in bladder malignancies","authors":"T. Kalawat, M. Ranadheer, S. Sarala, R. Narayan, A. Tyagi","doi":"10.15380/2277-5706.JCSR.13.071","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.13.071","url":null,"abstract":"18F Fluorodeoxyglucose 18F-FDG, positron emission tomography computed tomography (PET-CT) is a relatively new imaging modality which is increasingly being used in the diagnosis and management of patients suffering with different types of cancer in body. 18FDG tracer molecule, clears from body through urinary tract. Physiological presence of tracer activity in urinary bladder (UB) at the time of scanning may be a limitation for appropriate evaluation of patients suffering with UB cancer.1 To overcome this limitation some investigators suggested the utility of a delayed scan after diuretic intervention to improve the diagnostic sensitivity of the test in this group of patients.2,3","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133754724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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