Primary vaginal Ewing’s sarcoma/primitive neuroectodermal tumour: diagnostic and treatment challenges

Abstract

Extra osseous Ewing’s sarcoma/primitive neuroectodermal tumour (PNET) of the genital tract of women is scarcely described in the literature and involvement of the vagina is even rarer with a very few cases reported so far. We present 50-year-old-woman who presented with a vaginal mass that was diagnosed to be a malignant round cell tumour which later was confirmed to be primary vaginal Ewing’s sarcoma/PNET on light microscopy and immunohistochemical staining. She was then treated with induction chemotherapy followed by local radiotherapy and further maintenance chemotherapy. This rare case of primary vaginal Ewing’s sarcoma/PNET emphasizes the need for combining morphological features with immunohistochemistry with a panel of antibodies in establishing the diagnosis of Ewing’s sarcoma/PNET at an uncommon site. Further, the case also highlights the use of induction chemotherapy followed by radiation therapy and subsequent maintenance chemotherapy as a treatment modality. Das P, Gunaseelan K, Basu D, Ananthakrishnan R, Reddy KS. A rare case of primary vaginal ewing’s sarcoma/ primitiveneuroectodermal tumour : diagnostic and treatment challenges. J Clin Sci Res 2014;3:145-9. DOI: http://dx.doi.org/ 10.15380/2277-5706.JCSR.13.033. Corresponding author: Dr Pranabandhu Das, Assistant Professor, Department of Radiation Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India. e-mail: daspranabandhu@gmail.com Received: 01 June, 2013. Vaginal Ewing's sarcoma/PNET Das et al