Trends in Immunotherapy最新文献_第4页

Summary of COVID-19 vaccine-related erythema multiforme at Kindai University Hospital, Japan 日本近畿大学医院COVID-19疫苗相关多形性红斑报告综述

Trends in Immunotherapy Pub Date : 2022-12-14 DOI: 10.24294/ti.v6.i2.1653

Keiko Watanabe, C. Nakashima, A. Matsuo, Maiko Kato, S. Yanagihara, N. Oiso, A. Otsuka

引用次数: 0

Harnessing the crosstalk of adipocytes, autophagy, and immune cells for immunotherapy in obesity 利用脂肪细胞、自噬和免疫细胞的串扰进行肥胖的免疫治疗

Trends in Immunotherapy Pub Date : 2022-11-18 DOI: 10.24294/ti.v6.i2.1654

G. Guerrero M

引用次数: 0

Autoinflammatory disease, Nakajo-Nishimura syndrome and further perspective 自体炎症性疾病、中乔-西村综合征及其进一步的观点

Trends in Immunotherapy Pub Date : 2022-10-13 DOI: 10.24294/ti.v6.i2.1710

Fukumi Furukawa

引用次数: 0

The concise review of etiology, pathology, and treatment strategy of polyarteritis nodosa 结节性多动脉炎的病因、病理及治疗策略综述

Trends in Immunotherapy Pub Date : 2022-09-06 DOI: 10.24294/ti.v6.i2.1452

T. Ikeda

引用次数: 0

Antioxidants: The counterstriking immunomodulators in therapeutics of oral lesions 抗氧化剂:口腔病变治疗中的对抗免疫调节剂

Trends in Immunotherapy Pub Date : 2022-07-28 DOI: 10.24294/ti.v6.i2.1438

Bharani Krishna Takkella, Mulagolla Sirisha, C. Sunil, Tejaswin Polepalle, Katravath MadhuKiran Naik, Chaitanya Krishna Thakkella, V. Sujana, Bhavya Sri Sai Kandi

{"title":"Antioxidants: The counterstriking immunomodulators in therapeutics of oral lesions","authors":"Bharani Krishna Takkella, Mulagolla Sirisha, C. Sunil, Tejaswin Polepalle, Katravath MadhuKiran Naik, Chaitanya Krishna Thakkella, V. Sujana, Bhavya Sri Sai Kandi","doi":"10.24294/ti.v6.i2.1438","DOIUrl":"https://doi.org/10.24294/ti.v6.i2.1438","url":null,"abstract":"Antioxidants are a group of natural phytochemicals found in dietary ingredients that can be utilised to treat oral lesions and diseases. They are employed as chemical compound alternatives since they have less adverse effects. The dietary antioxidants found in fruits and vegetables reduce the damage by modulating detoxification enzymes, increasing immune system, and hormone metabolism. Scientists were drawn to antioxidants because of their ability to modify cell cycle controls, apoptosis, invasion, angiogenesis, and metastasis. They have demonstrated significant success as single treatments or in combination with chemo-preventive medicines for oral lesions.Inside this article, we will look at the immuno-modulating effects of antioxidants, which aid in the treatments and even sometimes avoidance of numerous oral and maxillofacial conditions that contribute to morbidity, such as autoimmune lesions, and death, such as oral cancer. Antioxidants are chemicals that considerably impede or decrease the degradation of a living matter and defend the organism from oxidative harm. As a result, the sickness will be significantly reduced.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115478829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peristomal pyoderma gangrenosum successfully treated with cyclo-sporine 环孢菌素成功治疗表皮脓皮坏疽

Trends in Immunotherapy Pub Date : 2022-07-27 DOI: 10.24294/ti.v6.i2.1474

Shoko Urano, Jinnroh Abe, H. Kikuchi

引用次数: 1

Successful combined treatment with omalizumab and tocilizumab in a case of chronic spontaneous urticaria and rheumatoid arthritis: A case report and literature review omalizumab和tocilizumab联合治疗慢性自发性荨麻疹和类风湿关节炎1例:1例报告和文献综述

Trends in Immunotherapy Pub Date : 2022-06-27 DOI: 10.24294/ti.v6.i2.1443

N. Takeuchi, Ayumi Yamanishi, Y. Kumagai, T. Yokoyama

引用次数: 0

Activation of proteinase-activated receptor-2 (PAR-2) simultaneously induces interleukin 8 (IL-8) and suppresses monocyte chemoattractant protein-1 (MCP-1) in HaCaT cells 在HaCaT细胞中，蛋白酶活化受体-2 (PAR-2)的激活可同时诱导白细胞介素8 (IL-8)和抑制单核细胞趋化蛋白-1 (MCP-1)

Trends in Immunotherapy Pub Date : 2022-06-09 DOI: 10.24294/ti.v6.i1.1472

Y. Murakami, S. Azuma, K. Baba, M. Taniguchi, Fukumi Furukawa

{"title":"Activation of proteinase-activated receptor-2 (PAR-2) simultaneously induces interleukin 8 (IL-8) and suppresses monocyte chemoattractant protein-1 (MCP-1) in HaCaT cells","authors":"Y. Murakami, S. Azuma, K. Baba, M. Taniguchi, Fukumi Furukawa","doi":"10.24294/ti.v6.i1.1472","DOIUrl":"https://doi.org/10.24294/ti.v6.i1.1472","url":null,"abstract":"Allergic diseases are currently considered diseases of excessive type 2 inflammation created by orchestration between the innate and acquired immune systems. Since pattern recognition receptors (PRRs) are present in epidermal keratinocytes, it is noteworthy that aggravating factors of allergic diseases act directly on keratinocytes via PRRs. To investigate the relationship between the activation of PRRs and inflammation, we stimulated a keratinocyte cell line (HaCaT cells) with agonists against proteinase-activated receptor-2 (PAR-2), Toll-like receptor (TLR)2, and TLR4, alone or in combination, and we evaluated the changes in inflammatory cytokines and chemokines. Activation of TLR2 or TLR4 alone induced interleukin 6 (IL-6), IL-8, and monocyte chemoattractant protein-1 (MCP-1) in an agonist concentration-dependent manner. Simultaneous activation of TLR2 and TLR4 induced IL-8 synergistically, MCP-1 in an additive trend, and IL-6 weakly but synergistically. PAR-2 activation of HaCaT cells induced IL-6 and IL-8 but suppressed MCP-1 in an agonist concentration-dependent manner. The enhancement of IL-8 and the suppression of MCP-1 by PAR-2 activation were both neutralized by the PAR-2 antagonist AZ3451, supporting the possibility that PAR-2 activation simultaneously induces the following opposing effects in inflammation: enhancement of IL-8 and suppression of MCP-1. The nuclear factor-κB (NF-κB) pathway inhibitor BAY 11-7082 neutralized the induction of IL-8 but not the suppression of MCP-1 by PAR-2 activation, indicating that PAR-2 activation induces activation of the NF-κB pathway, and that the suppression of MCP-1 by PAR-2 activation is not related to the NF-κB pathway.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130062343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular pathogenesis of fibrosis in systemic sclerosis 系统性硬化症纤维化的分子发病机制

Trends in Immunotherapy Pub Date : 2022-05-26 DOI: 10.24294/ti.v6.i1.1453

M. Jinnin

引用次数: 1

IL-27 regulates cytokine production as a double-edged sword in keratinocytes 在角质形成细胞中，IL-27调控细胞因子的产生是一把双刃剑

Trends in Immunotherapy Pub Date : 2022-05-12 DOI: 10.24294/ti.v6.i1.1436

A. Aioi, T. Imamichi

{"title":"IL-27 regulates cytokine production as a double-edged sword in keratinocytes","authors":"A. Aioi, T. Imamichi","doi":"10.24294/ti.v6.i1.1436","DOIUrl":"https://doi.org/10.24294/ti.v6.i1.1436","url":null,"abstract":"Inflammaging is a subject of considerable attention, because aging is characterized by low-grade, chronic, and asymptomatic inflammation, concomitant with increased blood levels of senescence-associated secretory phenotype (SASP) factors, including IL-1, IL-6, IL-8, IL-18, and tumor necrosis factor-α (TNF-α). However, IL-27 is currently not categorized as a SASP factor, although it is known to play pleiotropic roles in inflammation. In this study, we evaluated the interaction between TNF-α and IL-27 in context of low-grade inflammation using HaCaT cells. TNF-α induced significant upregulation of the mRNA levels of IL-6 and IL-8 at the experimental concentration (~10ng/ml), while the mRNA levels of IL-1RA, IL-10, and IL-18BP were unchanged. After confirming the expression of functional IL-27 receptors in HaCaT cells, we examined the effects of IL-27 alone on cytokine expression. IL-27 alone significantly upregulated the mRNA levels of IL-10, IL-18BP and IL-6 by 1.61-fold, 1.46-fold, and 2.32-fold, respectively. In the presence of 100 ng/ml of IL-27, the mRNA levels of the anti-inflammatory cytokines IL-1RA, IL-10 and IL-18BP, were significantly upregulated upon treatment with TNF-α at the physiological concentration (1 ng/ml). Taken together, this study indicates that a high concentration of IL-27 exhibits anti-inflammatory effects in the presence of a low concentration of TNF-α, in keratinocytes, suggesting that the anti-inflammatory role of IL-27 in inflammaging may be regulated by TNF-α concentration.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125624734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2