Trends in Immunotherapy最新文献_第10页

Sirtuins in wound healing sirtwin有助于伤口愈合

Trends in Immunotherapy Pub Date : 2017-11-20 DOI: 10.24294/TI.V1.I3.122

A. Aioi

引用次数: 3

Potentials of interleukin-27 (IL-27) as an immunotherapeutic cytokine in cancer therapy 白细胞介素-27 (IL-27)作为免疫治疗细胞因子在癌症治疗中的潜力

Trends in Immunotherapy Pub Date : 2017-11-01 DOI: 10.24294/TI.V1.I3.121

W. Yap, Shaktypreya Nadarajah, Nadiah Shidik, N. Alitheen

引用次数: 1

Role of targeting nanoparticles for cancer immunotherapy and imaging 靶向纳米颗粒在癌症免疫治疗和成像中的作用

Trends in Immunotherapy Pub Date : 2017-09-14 DOI: 10.24294/TI.V1.I3.95

Ru Wen, Afoma C. Umeano

引用次数: 5

Mast cells in collagen diseases 胶原蛋白疾病中的肥大细胞

Trends in Immunotherapy Pub Date : 2017-08-28 DOI: 10.24294/TI.V1.I2.96

Naoya Mikita, Y. Inaba, T. Yoshimasu, N. Kanazawa, F. Furukawa

引用次数: 1

Obesity and inflammatory skin diseases 肥胖和炎症性皮肤病

Trends in Immunotherapy Pub Date : 2017-08-23 DOI: 10.24294/TI.V1.I2.98

S. Nakamizo, T. Honda, K. Kabashima

引用次数: 15

Dynamic relationships among tumor, immune response, and microbiota 肿瘤、免疫反应和微生物群之间的动态关系

Trends in Immunotherapy Pub Date : 2017-08-15 DOI: 10.24294/TI.V1.I2.79

T. Tsunoda, K. Shimada, N. Uchida, Shin'ichi Kobayashi, Y. Sasaki

{"title":"Dynamic relationships among tumor, immune response, and microbiota","authors":"T. Tsunoda, K. Shimada, N. Uchida, Shin'ichi Kobayashi, Y. Sasaki","doi":"10.24294/TI.V1.I2.79","DOIUrl":"https://doi.org/10.24294/TI.V1.I2.79","url":null,"abstract":"Recently, the analysis of microbiota has been of interest not only for the clarification of the molecular mechanisms of disease etiology, but also the discovery of novel strategies for treatment. Following the development of \"next-generation\" sequencing, novel areas have been discovered in microbiota; however, in oncology, the relationships between microbiota and cancer have not been fully clarified. In recent literature, surprisingly, detection of gut microbiota in tumor issue itself has been reported. Microbiota might play an important role in carcinogenesis. However, this phenomenon is not well understood, and research in this area has just begun. In the past five years, a paradigm shift has occurred in cancer treatment due to immunotherapy. Immunotherapy has made cure possible even in advanced cancer patients with not only melanoma but also non-small cell lung cancer and others. In this review, we discuss the mechanisms of novel immunotherapies, checkpoint inhibitors, and the relationship between microbiota and immunotherapy. It is of significance to clarify this relationship because it may lead to the discovery of predictive markers for immunotherapy and promote clinical efficacy. Finally, we also mention our activities in the construction of a big database for information on immunotherapy and microbiota, which may lead to excellent possibilities of discovering novel strategies for more effective cancer treatments, and may accelerate the alteration of cancers to the classification of chronic nonfatal disease.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130269855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical experience of combination therapy of infliximab and total glucosides of paeony for severe psoriasis with liver disorder history 英夫利昔单抗联合芍药总苷治疗有肝功能障碍史的重度银屑病的临床体会

Trends in Immunotherapy Pub Date : 2017-06-23 DOI: 10.24294/TI.V1.I2.42

Yu Hu, Lin Lin, P. Cui, X. Yao, C. Luan, Zhimin Hao, Min Chen

{"title":"Clinical experience of combination therapy of infliximab and total glucosides of paeony for severe psoriasis with liver disorder history","authors":"Yu Hu, Lin Lin, P. Cui, X. Yao, C. Luan, Zhimin Hao, Min Chen","doi":"10.24294/TI.V1.I2.42","DOIUrl":"https://doi.org/10.24294/TI.V1.I2.42","url":null,"abstract":"Severe psoriasis patients are reported to have a higher risk of liver abnormalities. Treatment option for severe psoriasis patients with liver disorder history remains a great challenge. Hepatic toxicity and long-term safety are the major concerns. Hence it is necessary to look for safer and more effective treatment for those patients. This retrospective review evaluated the safety and efficacy of combination therapy of infliximab and total glucosides of paeony (TGP) in treating 13 severe psoriasis patients with liver disorder history. Patients with severe psoriasis, comprising eight men and five women with a mean age of 37.3 ± 12.3, were observed. The patients experienced a mean course of psoriasis of 11.2 ± 7.1 years. The mean psoriasis area and severity index (PASI) score was 29.3 ± 12.9. All patients have the history of liver disorder. In our study, these patients were treated with infliximab at a dose of 5 mg/kg and TGP at a dose of 1.8 g/day. No liver test abnormalities were seen during combination therapy. After treatment, 61.5% patients showed PASI 50 response at week 2, and 81.8% patients have PASI 75 response at week 6. The mean time for achieving PASI 75 and PASI 90 improvement was 4.2 weeks and 9.6 weeks, respectively. Our observation demonstrates that combined therapy of infliximab and TGP is effective and safe in the treatment of severe psoriasis, especially for patients with liver disorder history.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124146993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Keigairengyoto, a traditional Japanese medicine, promotes bacterial clearance by activating innate immune cells in mouse cutaneous infection models 在小鼠皮肤感染模型中，一种传统的日本药Keigairengyoto通过激活先天免疫细胞来促进细菌清除

Trends in Immunotherapy Pub Date : 2017-05-18 DOI: 10.24294/TI.V1.I1.31

J. Koseki, A. Kaneko, Yosuke Matsubara, K. Sekiguchi, S. Ebihara, S. Aiba, K. Yamasaki

{"title":"Keigairengyoto, a traditional Japanese medicine, promotes bacterial clearance by activating innate immune cells in mouse cutaneous infection models","authors":"J. Koseki, A. Kaneko, Yosuke Matsubara, K. Sekiguchi, S. Ebihara, S. Aiba, K. Yamasaki","doi":"10.24294/TI.V1.I1.31","DOIUrl":"https://doi.org/10.24294/TI.V1.I1.31","url":null,"abstract":"Prompt elimination of pathogens including bacteria and dead cells prevents the expansion of secondary and prolonged inflammations and tissue damage. Keigairengyoto (KRT) is a traditional Japanese medicine prescribed for dermatoses such as purulent inflammations. Our aim is to clarify the actions of KRT in bacterial clearance and to examine the cell-kinetic profiles of phagocytes. In a mouse cutaneous infection model using living Staphylococcus aureus, KRT drastically reduced the number of bacteria in the infection sites. To evaluate the bacterial clearance, pseudo-infection was induced in mouse ears by intradermal injection of FITC-conjugated dead S. aureus. Biochemical and histological examinations revealed that KRT promoted bacterial clearance at 6 and 24 h post-injection. The numbers and phagocytic activities of neutrophils and macrophages in the ears were evaluated histologically using anti-Ly6G and F4/80 antibodies. KRT reduced bacterial deposition and increased the accumulation of F4/80+ resident macrophages around the lesion site. FACS analysis was performed on single cell suspensions dispersed enzymatically from skin lesions, followed by an investigation of CD11b+Ly6G+ (neutrophils) and CD11b+Ly6G– (monocytes/macrophages) cells. KRT increased the mean fluorescent intensity of FITC in CD11b+Ly6G–cells and the number of FITC-positive CD11b+Ly6G+ cells, while KRT did not change the numbers of these cells. To investigate the active constituents of KRT, phagocytosis assay using macrophages was performed, resulting in that some flavonoid glucuronides of KRT derivatives augmented phagocytosis. Collectively, KRT promoted bacterial clearance by enhancing the phagocytic capability of neutrophils and macrophages. KRT may exert unique properties in preventive and therapeutic strategies for skin infectious inflammation.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125275513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Head-out immersion in hot water does not increase serum CXCL1 in healthy men 在健康男性中，头部浸在热水中不会增加血清CXCL1

Trends in Immunotherapy Pub Date : 2017-05-15 DOI: 10.24294/TI.V1.I1.37

Yuta Sakurai, Y. Umemoto, T. Kawasaki, D. Kojima, T. Kinoshita, Mami Yamashiro, M. Banno, H. Arakawa, F. Tajima

引用次数: 1

Acute-phase effects of single-time topical or systemic corticosteroid application immediately after hot water-induced burn injury of various grades 不同程度的热水烧伤后立即单次局部或全身应用皮质类固醇的急性期效应

Trends in Immunotherapy Pub Date : 2017-03-21 DOI: 10.24294/TI.V1.I1.14

Naotaka Doi, Y. Nakatani, Y. Inaba, T. Kondo, F. Furukawa, N. Kanazawa

{"title":"Acute-phase effects of single-time topical or systemic corticosteroid application immediately after hot water-induced burn injury of various grades","authors":"Naotaka Doi, Y. Nakatani, Y. Inaba, T. Kondo, F. Furukawa, N. Kanazawa","doi":"10.24294/TI.V1.I1.14","DOIUrl":"https://doi.org/10.24294/TI.V1.I1.14","url":null,"abstract":"The aim of this study is to evaluate the effects of corticosteroid application on each grade of burn, and to clarify the underlying mechanisms of the effects, especially in its acute inflammatory phase. To generate three-graded burn models (epidermal burn, or EB; dermal burn, or DB; and subcutaneous burn, or SB), hot water was applied on the back skin of Hos:HR-1 mice. Strongest-class (or high-potent) corticosteroid ointment (DD group) or petrolatum (control group) was applied on the back immediately after the hot water application on mice. Prednisolone sodium succinate (PDN group), 1 mg/kg was orally applied immediately after the hot water application on mice. The mice were sacrificed 1–3 days after hot water application, and the lesional skin samples were provided for histological assessment to enumerate the number of infiltrating inflammatory cells. The mRNA expression levels of inflammatory cytokines (IL-1b, TNFa, IL-6 and IFNg) in the lesional skin were also investigated. As a result, corticosteroid application suppressed the number of infiltrating inflammatory cells in the DD group of EB and SB at the early phase, and in DB at all time-points. However, the number of infiltrating inflammatory cells increased in EB on day 3. Expression of cytokines was generally suppressed in the PDN group of SB. In the cases of EB and DB, some cytokines had decreased but many of the others showed increased expression. In conclusion, the anti-inflammatory effects of corticosteroids are not simple inhibitory effects on inflammatory cell infiltration and cytokine production, but exert more complicated effects in vivo.","PeriodicalId":401129,"journal":{"name":"Trends in Immunotherapy","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115980899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0