ACS Applied Electronic Materials最新文献_第9页

New Low-Temperature Collector for Flotation Separation of Quartz and Hematite after Reduction Roasting and Its Mechanism 用于还原焙烧后浮选分离石英和赤铁矿的新型低温捕收剂及其机理

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acs.langmuir.4c0320710.1021/acs.langmuir.4c03207

Chenlu Chen, Xun Wang*, Xian Xie, Xiong Tong, Yuhang Zhu and Ruiqi Xie*,

{"title":"New Low-Temperature Collector for Flotation Separation of Quartz and Hematite after Reduction Roasting and Its Mechanism","authors":"Chenlu Chen, Xun Wang*, Xian Xie, Xiong Tong, Yuhang Zhu and Ruiqi Xie*, ","doi":"10.1021/acs.langmuir.4c0320710.1021/acs.langmuir.4c03207","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c03207https://doi.org/10.1021/acs.langmuir.4c03207","url":null,"abstract":"It is an effective method to separate hematite by converting it to magnetite by reduction roasting and then separating it by magnetite separation. However, quartz will partially remain in the concentrates. Therefore, it is significant to separate quartz from the concentrates to produce high-quality iron concentrates. In this work, N-{3-[(2-propylheptyl)oxy]propyl}propane-1,3-diamine (PPPDA) was synthesized and served as a collector for low-temperature flotation to separate quartz from magnetite that was generated by reduction roasting of hematite. The flotation experiment and principle of the PPPDA collector on quartz and the new generated magnetite surface were studied by flotation experiments, ζ potential measurement, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and density functional theory (DFT) calculations. Flotation data showed that, in the pH range of 5–9, when PPPDA dosage was 15 mg/L and temperature was 10–30 °C, PPPDA has good collecting ability on quartz minerals, which could make the recovery difference between quartz and the new generated magnetite reach more than 95%. Artificial mixed ore experiments at a low temperature of 10 °C yielded a concentrate with an iron grade of 64.41% and an iron recovery of 78.98%. The data of ζ potential, FTIR spectrum, and XPS and DFT calculations confirmed that PPPDA could not be adsorbed on the new generated magnetite, and the adsorption principle between PPPDA and quartz was mainly electrostatic adsorption and hydrogen bond adsorption.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"40 45","pages":"23986–23993 23986–23993"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Role of Strong Metal–Support Interactions in Gold-Catalyzed CO Oxidation on MnO2 Polymorphs 揭示 MnO2 多晶体上金催化一氧化碳氧化过程中强金属-支撑相互作用的作用

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acs.langmuir.4c0264010.1021/acs.langmuir.4c02640

Tiantian Zhang, Jiacheng Xu, Yan Sun, Shiyu Fang, Zuliang Wu, Erhao Gao, Jiali Zhu, Wei Wang, Shuiliang Yao* and Jing Li*,

{"title":"Unveiling the Role of Strong Metal–Support Interactions in Gold-Catalyzed CO Oxidation on MnO2 Polymorphs","authors":"Tiantian Zhang, Jiacheng Xu, Yan Sun, Shiyu Fang, Zuliang Wu, Erhao Gao, Jiali Zhu, Wei Wang, Shuiliang Yao* and Jing Li*, ","doi":"10.1021/acs.langmuir.4c0264010.1021/acs.langmuir.4c02640","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c02640https://doi.org/10.1021/acs.langmuir.4c02640","url":null,"abstract":"The effectiveness of gold (Au)-based catalysts in CO oxidation is significantly influenced by strong metal–support interactions with surface oxygen structures, the mechanisms of which remain elusive. To investigate this property, we selected γ-MnO2, featuring Mn(-O-)2Mn and Mn–O–Mn structural motifs, and β-MnO2, characterized by Mn–O–Mn linkages, as support materials. The CO oxidation process was investigated by fabricating Au nanoparticles supported on these two MnO2 polymorphs. Our findings reveal that Au supported on β-MnO2 substantially enhanced CO oxidation, in stark contrast to the inhibitory effect observed with Au on γ-MnO2. Using operando diffuse reflectance infrared Fourier transform spectroscopy coupled with mass spectrometry, we detected an increase in the production of surface-adsorbed oxygen following Au deposition on β-MnO2. Conversely, Au supported on γ-MnO2 resulted in a diminished capacity for surface oxygen adsorption. The presence of Au+ and Mn2+ ions was identified as pivotal for CO oxidation. Moreover, the engagement of the Mn(-O-)2Mn structure in the reaction was impaired after Au loading on γ-MnO2, and the regeneration of the Mn–O–Mn linkage was similarly hindered. We propose a mechanism for the interactions between Au and the oxygen species associated with Mn(-O-)2Mn and Mn–O–Mn structures on MnO2, offering insights into the divergent catalytic behaviors exhibited by different MnO2 polymorphs.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"40 45","pages":"23739–23753 23739–23753"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Analysis of TPU Microstructure and Performance Optimization across Various Processing Conditions 不同加工条件下热塑性聚氨酯微观结构的定量分析与性能优化

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acs.langmuir.4c0309310.1021/acs.langmuir.4c03093

Guangzhi Jin, Yuzhen Gong, Jun Wang, Min Wang, Jiadong Wang, Runguo Wang*, Xuan Qin* and Yonglai Lu*,

{"title":"Quantitative Analysis of TPU Microstructure and Performance Optimization across Various Processing Conditions","authors":"Guangzhi Jin, Yuzhen Gong, Jun Wang, Min Wang, Jiadong Wang, Runguo Wang*, Xuan Qin* and Yonglai Lu*, ","doi":"10.1021/acs.langmuir.4c0309310.1021/acs.langmuir.4c03093","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c03093https://doi.org/10.1021/acs.langmuir.4c03093","url":null,"abstract":"Thermoplastic polyurethane (TPU) is essential in resource exploration, healthcare, automotive, and high-end recreational sports. Despite extensive research on TPU’s microstructures and their macroscopic properties, the impact of processing conditions like compression and injection molding remains underexplored. This study investigates the influence of processing conditions on TPU by preparing samples with varying hard segment contents using compression molding at 205 °C and injection molding at melt temperatures of 205, 210, 215, and 220 °C, followed by heat treatment at 120 °C for 12 h. Results indicate that injection-molded TPU at 205 °C exhibits lower hydrogen bonding, crystallinity, long period, interfacial thickness, and lamella thickness than compression-molded TPU, leading to higher Young’s modulus but lower elongation at break. As melt temperatures increase, these microstructural parameters decrease, reducing Young’s modulus and increasing elongation at break. Post heat treatment, microstructural parameters increase, aligning Young’s modulus with that of compression-molded samples, while elongation at break surpasses them. This suggests that heat treatment enhances microphase separation by rearranging hard and soft segments. our research reveals a consistent pattern across TPUs with varying hard segment contents, indicating that adjusting processing parameters can effectively regulate microstructure and performance, offering valuable insights for developing high-performance polyurethanes.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"40 45","pages":"23939–23950 23939–23950"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promising Proteolysis-Targeting Chimera for Mutant p53-R175H 针对突变 p53-R175H 的蛋白水解嵌合体前景看好

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsomega.4c0617710.1021/acsomega.4c06177

Xinzhe Zhuang, Yidan Guo, Xiaozi Sun, Jie Chen, Songbo Xie, Fengtang Yang* and Jingrui Li*,

{"title":"Promising Proteolysis-Targeting Chimera for Mutant p53-R175H","authors":"Xinzhe Zhuang, Yidan Guo, Xiaozi Sun, Jie Chen, Songbo Xie, Fengtang Yang* and Jingrui Li*, ","doi":"10.1021/acsomega.4c0617710.1021/acsomega.4c06177","DOIUrl":"https://doi.org/10.1021/acsomega.4c06177https://doi.org/10.1021/acsomega.4c06177","url":null,"abstract":"The tumor suppressor protein p53 is among the most commonly mutated proteins across a variety of cancer types. Notably, the p53 R175H mutation ranks as one of the most prevalent hotspot mutations. Proteolysis-targeting chimeras (PROTACs) represent a class of bifunctional molecules capable of harnessing the cellular ubiquitin-proteasome pathway to facilitate targeted protein degradation. Despite the potential of PROTACs, limited research has been directed toward the degradation of the p53-R175H mutant protein. In this study, we developed a series of peptide-based PROTACs, leveraging known peptide ligands for both the p53-R175H mutation and the E3 ubiquitin ligase VHL. Our findings indicate that one of these peptide-based PROTACs is capable of directing the p53-R175H protein to the proteasome for degradation within a recombinant expression system. Moreover, by synthesizing a fusion peptide PROTAC molecule that incorporates a membrane-penetrating peptide, we have demonstrated its ability to traverse cellular membranes and subsequently reduce the levels of the p53-R175H mutant protein. Importantly, the degradation of p53-R175H was found to mitigate the cellular migration and invasion. In summary, our study introduces a novel class of protein degraders and establishes a foundational framework for the therapeutic management of cancers associated with p53 mutations.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45138–45146 45138–45146"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conception and Optimization of Extraction-Free Loop-Mediated Isothermal Amplification Detection of Dry Rot Fungus Serpula lacrymans 干腐菌 Serpula lacrymans 的无萃取环介导等温扩增检测方法的构思与优化

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsomega.4c0550910.1021/acsomega.4c05509

Vanessa Lapointe, Myriam Roy, Stéphanie Rose, Yvan Boutin and Frédéric Couture*,

{"title":"Conception and Optimization of Extraction-Free Loop-Mediated Isothermal Amplification Detection of Dry Rot Fungus Serpula lacrymans","authors":"Vanessa Lapointe, Myriam Roy, Stéphanie Rose, Yvan Boutin and Frédéric Couture*, ","doi":"10.1021/acsomega.4c0550910.1021/acsomega.4c05509","DOIUrl":"https://doi.org/10.1021/acsomega.4c05509https://doi.org/10.1021/acsomega.4c05509","url":null,"abstract":"The use of nucleic acid-based detection tools for microorganisms and fungi has become a gold standard. This is particularly the case for wood-decaying fungi like Serpula lacrymans, which are hard to discriminate based on macroscopic and microscopic observations. This dry rot is important to detect as it is particularly destructive in an infested building, which requires immediate action to prevent spreading and significant damage to structural elements. Through the development and optimization of loop-mediated isothermal amplification against S. lacrymans-specific rDNA internal transcribed spacer region, we demonstrate that it is possible to achieve rapid and specific amplification without nonspecific self-amplification in a similar range as real-time quantitative PCR without any necessary DNA isolation using a colorimetric detection assay. Through a combined set of self-amplification minimization along with hand-held sample homogenization, the LAMP assay was optimized to provide a femtogram-range assay capable of confirming identification in a real field sample either predominantly composed of S. lacrymans or containing the fungus while remaining negative when tested on different types of fungi found in basement-collected samples.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45080–45089 45080–45089"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c05509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weyl Characteristics Induced an Anomalous Hall Effect in Double Half-Heusler Alloy Cr2FeCoAs2: A Density-Functional Study 双半赫斯勒合金 Cr2FeCoAs2 中韦尔特性诱发的反常霍尔效应：密度函数研究

IF 4.3 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsaelm.4c0153210.1021/acsaelm.4c01532

Gang Bahadur Acharya, Bishnu Karki, Madhav Prasad Ghimire and Bhuvanesh Srinivasan*,

{"title":"Weyl Characteristics Induced an Anomalous Hall Effect in Double Half-Heusler Alloy Cr2FeCoAs2: A Density-Functional Study","authors":"Gang Bahadur Acharya, Bishnu Karki, Madhav Prasad Ghimire and Bhuvanesh Srinivasan*, ","doi":"10.1021/acsaelm.4c0153210.1021/acsaelm.4c01532","DOIUrl":"https://doi.org/10.1021/acsaelm.4c01532https://doi.org/10.1021/acsaelm.4c01532","url":null,"abstract":"Magnetic Weyl semimetals can exhibit a significant electronic transport behavior known as the anomalous Hall effect caused by the inherent Berry curvature generated by Weyl fermions. This study presents the result of density-functional theory analysis focusing on the magnetic ground state, electronic properties, topological Weyl properties, nontrivial surface state, and anomalous Hall effect of the double half-Heusler compound Cr2FeCoAs2. We determined that Cr2FeCoAs2 acts as a ferrimagnetic half-metal with a total spin magnetic moment of 6 μB per unit cell. This system is particularly interesting as it features one insulating and one metallic topological channel. The minority-spin insulating channel shows an energy band gap of 1.26 eV. The majority spin channel consists of several sets of low-energy Weyl points. Among them, four exactly lie at the Fermi level. The chiral Weyl nodes, breaking time-reversal symmetry and protected by mirror symmetry, act as the monopole source and sink of the Berry curvature and provide a large intrinsic anomalous Hall conductivity approaching −190 Ω–1 cm–1 at the Fermi level and −370 Ω–1 cm–1 at 170 meV, which is comparable to those of topological magnetic materials. Additionally, nontrivial surface states are clearly present in Cr2FeCoAs2. Our work will support future experimental investigations into the previously unexplored topological phenomena of Cr2FeCoAs2.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"6 11","pages":"8260–8268 8260–8268"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Monolithically Integrated GaN-Based Light Emitting Transistor with a High On/Off Ratio and Low Gate Leakage Current 具有高通断比和低栅极泄漏电流的单片集成氮化镓基发光晶体管

IF 4.3 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsaelm.4c0123910.1021/acsaelm.4c01239

Jae Hun Kim, and , Ilgu Yun*,

{"title":"A Monolithically Integrated GaN-Based Light Emitting Transistor with a High On/Off Ratio and Low Gate Leakage Current","authors":"Jae Hun Kim,  and , Ilgu Yun*, ","doi":"10.1021/acsaelm.4c0123910.1021/acsaelm.4c01239","DOIUrl":"https://doi.org/10.1021/acsaelm.4c01239https://doi.org/10.1021/acsaelm.4c01239","url":null,"abstract":"This study presents a trench structured gallium nitride (GaN)-based light emitting transistor (LET) that integrates the functionalities of both a transistor and a light emitting diode into a single compact unit. Utilizing the superior material properties of GaN, these items surpass the performance of their silicon- or organic-based counterparts. However, due to polarization effects caused by the wurtzite crystal structure of GaN, the LET operates in depletion mode (D-mode). A metal-insulator-semiconductor gate was employed in the deep trench to mitigate prevalent issues such as poor gate controllability and high off-current in GaN-based devices. This work outlines the integrated device concept, operational mechanism, and fabrication process details and discusses the results of the characteristic assessment. The epitaxial wafer structure was optimized to enhance light emission, yielding a device capable of switching with an on/off ratio of approximately 107 and emitting visible blue light through a multi-quantum well layer, fabricated using state-of-the-art semiconductor fabrication technology.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"6 11","pages":"7876–7882 7876–7882"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ignition Delay Time Measurements of Substituted Phenol Additives in a Toluene Reference Fuel 在甲苯标准燃料中测量取代苯酚添加剂的点火延迟时间

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsomega.4c0698510.1021/acsomega.4c06985

Grace Trombley*, and , Elisa Toulson,

{"title":"Ignition Delay Time Measurements of Substituted Phenol Additives in a Toluene Reference Fuel","authors":"Grace Trombley*,  and , Elisa Toulson, ","doi":"10.1021/acsomega.4c0698510.1021/acsomega.4c06985","DOIUrl":"https://doi.org/10.1021/acsomega.4c06985https://doi.org/10.1021/acsomega.4c06985","url":null,"abstract":"Using a rapid compression machine, fuel autoignition resistance can be quantified by the ignition delay time measurements of homogeneous mixtures. As the occurrence and intensity of knock in spark ignition engines are related to autoignition resistance, ignition delay time measurements give valuable insight into fundamental fuel combustion properties that can be used to predict undesirable combustion behavior. Therefore, the work presented in this paper aims to understand the autoignition resistance of a gasoline surrogate fuel and how it is affected by the addition of substituted phenol additives from ignition delay time measurements in a rapid compression machine. Six substituted phenols were tested: p-cresol, 2,4-xylenol, 2,5-xylenol, 2,6-xylenol, 3,4-xylenol, and 3,5-xylenol. Lean and stoichiometric mixtures, as well as stoichiometric mixtures with N2 dilution, were studied at engine-relevant conditions of 20 bar between 700 and 950 K. It was found that most additives were able to lengthen the base fuel ignition delay time at high and low temperatures, but that the most effective had two methyl groups located adjacent to each other.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45319–45327 45319–45327"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06985","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of Polyphenol Oxidase Activity by Mesoporous Silica Nanoparticles and Multiwalled Carbon Nanotubes Modified with Surfactants 用表面活性剂修饰的介孔二氧化硅纳米颗粒和多壁碳纳米管对多酚氧化酶活性的抑制作用

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acs.langmuir.4c0385010.1021/acs.langmuir.4c03850

Xiaonan Fan, Xin Xu, Shuhuai Xia, Yanrong Cheng* and Xia Guo*,

引用次数: 0

Study of Hydrolysis Kinetics and Synthesis of Single Isomer of Phosphoramidate ProTide-Acyclovir 水解动力学研究和磷酰胺丙肽-阿昔洛韦单一异构体的合成

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsomega.4c0664510.1021/acsomega.4c06645

Thitiphong Khamkhenshorngphanuch, Pitchayathida Mee-udorn, Maleeruk Utsintong, Chutima Thepparit, Nitipol Srimongkolpithak and Sewan Theeramunkong*,

{"title":"Study of Hydrolysis Kinetics and Synthesis of Single Isomer of Phosphoramidate ProTide-Acyclovir","authors":"Thitiphong Khamkhenshorngphanuch, Pitchayathida Mee-udorn, Maleeruk Utsintong, Chutima Thepparit, Nitipol Srimongkolpithak and Sewan Theeramunkong*, ","doi":"10.1021/acsomega.4c0664510.1021/acsomega.4c06645","DOIUrl":"https://doi.org/10.1021/acsomega.4c06645https://doi.org/10.1021/acsomega.4c06645","url":null,"abstract":"Acyclovir (ACV) is a vital treatment for herpes simplex (HSV) and varicella-zoster virus (VZV) infections that inhibit viral DNA polymerase. Phosphoramidate ProTides-ACV, a promising technology, circumvents the reliance on thymidine kinase (TK) for activation. Twelve novel single isomers of phosphoramidate ProTide-ACV were synthesized. Successful isomer separation was achieved, emphasizing the importance of single isomers in medical advancements. The enzymatic hydrolysis kinetics of the synthesized compounds were investigated by using carboxypeptidase Y (CPY). The results revealed a faster conversion for the isomer Rp- than for the Sp-diastereomer. Hydrolysis experiments confirmed steric hindrance effects, particularly with the tert-butyl and isopropyl groups. Molecular modeling elucidated the mechanisms of hydrolysis, supporting the results of the experiments. This research sheds light on the potential of phosphoramidate ProTides-ACV, bridging the gap in understanding their biological and metabolic properties, while supporting future investigations into anti-HSV activity. Preliminary screening revealed that three of the four single isomers demonstrated superior antiviral efficacy against wild-type HSV-1 compared to acyclovir, with isomer 24a ultimately reducing the viral yield at 200 μM. These findings emphasize the importance of isolating racemic ACV-ProTides as pure single isomers for future drug development.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45221–45231 45221–45231"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0