ACS Applied Electronic Materials最新文献_第8页

Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies 针对糖尿病伤口愈合的炎症调节生物医学干预：临床前和临床研究综述

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsomega.4c0225110.1021/acsomega.4c02251

Nouf N. Mahmoud*, Salma Hamad and Sawsan Shraim,

{"title":"Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies","authors":"Nouf N. Mahmoud*, Salma Hamad and Sawsan Shraim, ","doi":"10.1021/acsomega.4c0225110.1021/acsomega.4c02251","DOIUrl":"https://doi.org/10.1021/acsomega.4c02251https://doi.org/10.1021/acsomega.4c02251","url":null,"abstract":"A diabetic wound exemplifies the challenge of chronic, nonhealing wounds. Elevated blood sugar levels in diabetes profoundly disrupt macrophage function, impairing crucial activities such as phagocytosis, immune response, cell migration, and blood vessel formation, all essential for effective wound healing. Moreover, the persistent presence of pro-inflammatory cytokines and reactive oxygen species, coupled with a decrease in anti-inflammatory factors, exacerbates the delay in wound healing associated with diabetes. This review emphasizes the dysfunctional inflammatory responses underlying diabetic wounds and explores preclinical studies of inflammation-modulating bioactives and biomaterials that show promise in expediting diabetic wound healing. Additionally, this review provides an overview of selected clinical studies employing biomaterials and bioactive molecules, shedding light on the gap between extensive preclinical research and limited clinical studies in this field.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"44860–44875 44860–44875"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c02251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Superhydrophobic and Multifunctional Sponges for Oil/Water Separation and Oil Absorption 制备用于油水分离和吸油的超疏水多功能海绵

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acs.langmuir.4c0303610.1021/acs.langmuir.4c03036

Zhishuang Han, Xinmeng Lv, Yingge Li, Meihuan Gao, Zhenlin Tang, Xinying Su, Ziyang Zhang, Haidi Li, Jing He, Zaihang Zheng* and Yan Liu*,

{"title":"Preparation of Superhydrophobic and Multifunctional Sponges for Oil/Water Separation and Oil Absorption","authors":"Zhishuang Han, Xinmeng Lv, Yingge Li, Meihuan Gao, Zhenlin Tang, Xinying Su, Ziyang Zhang, Haidi Li, Jing He, Zaihang Zheng* and Yan Liu*, ","doi":"10.1021/acs.langmuir.4c0303610.1021/acs.langmuir.4c03036","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c03036https://doi.org/10.1021/acs.langmuir.4c03036","url":null,"abstract":"For settling the recycling problem of waste polyurethane sponges (PU) and environment pollution of oil spills simultaneously, this work exploited the multifunctional superhydrophobic PU materials via the dip-coating method, which were prepared by anchoring modified Fe3O4 and expandable graphite (EG) on PU sponges under the adhesion effect of polydimethylsiloxane (PDMS). The water contact angle and sliding angle of as-prepared PU sponges reached 154.1 ± 1.6 and 8°, respectively. Most importantly, the superhydrophobic PU sponges were endowed with the multipath oil treatment ability, which consisted of magnetically driven, gravity-driven, peristaltic pump-driven, and photothermally driven modes. Besides, the light oil absorption capacity, separation flux, and efficiency for superhydrophobic PU sponges reached 23.9 g/g, 27779 L m–2 h–1, and 99.5%, respectively. Owing to the photothermal conversion ability of Fe3O4 and EG, the temperature of superhydrophobic PU sponges was raised to 71.5 °C within 233 s under 1.2 solar irradiation (1200 W/m2), demonstrating its absorption potential for high-viscosity crude oils. In addition, the prepared sponges exhibited good chemical/mechanical stability, self-cleaning, and flame retardancy. In a nutshell, this article has evolved an environmentally benign and practical method for fabricating the multifunctional materials in oil spill treatment, which will efficiently accomplish the targets of low carbon and environmental management.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"40 45","pages":"23902–23917 23902–23917"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-Promoted La2O2SO4 for High-Temperature Soot Oxidation in Catalyzed Gasoline Particulate Filters 用于催化汽油微粒过滤器高温烟尘氧化的金属促进型 La2O2SO4

IF 3.8 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acs.iecr.4c0286910.1021/acs.iecr.4c02869

Elisabetta Maria Cepollaro, Stefano Cimino, Maria Rosaria Infante and Luciana Lisi*,

引用次数: 0

A Strategy for Fabricating Microscale Freestanding Single-Crystalline Complex Oxide Device Arrays 制造微米级独立单晶复合氧化物器件阵列的策略

IF 4.3 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsaelm.4c0148010.1021/acsaelm.4c01480

Huandong Chen, Yang Liu, Harish Kumarasubramanian, Mythili Surendran and Jayakanth Ravichandran*,

引用次数: 0

Formation and Dynamics of Imidazole Supramolecular Chains Investigated by Deep Potential Molecular Dynamics Simulation 利用深电位分子动力学模拟研究咪唑超分子链的形成和动力学特性

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acs.langmuir.4c0288810.1021/acs.langmuir.4c02888

Jianwei Zhang, Jinyu Lei, Pu Feng, Wenduo Chen, Jiajia Zhou* and Guangzhao Zhang*,

{"title":"Formation and Dynamics of Imidazole Supramolecular Chains Investigated by Deep Potential Molecular Dynamics Simulation","authors":"Jianwei Zhang, Jinyu Lei, Pu Feng, Wenduo Chen, Jiajia Zhou* and Guangzhao Zhang*, ","doi":"10.1021/acs.langmuir.4c0288810.1021/acs.langmuir.4c02888","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c02888https://doi.org/10.1021/acs.langmuir.4c02888","url":null,"abstract":"Imidazole-based materials have attracted considerable attention due to their promising potential for facilitating anhydrous proton transport at high temperatures. Herein, a machine learning-based deep potential (DP) model for bulk imidazole with first-principles accuracy is developed. The trained model exhibits remarkable accuracy in predicting energies and forces, with minor errors of 4.71 × 10–4 eV/atom and 3.23 × 10–2 eV/Å, respectively. Utilizing DP molecular dynamics simulations, we have systematically investigated the temperature-dependent formation and dynamics of imidazole supramolecular chains through the partial radial distribution function, quantification of hydrogen bond numbers, incoherent intermediate scattering function, and diffusion coefficient. The findings reveal the influence of temperature on the proton transport path following either the “Grotthuss” and “vehicle” mechanism.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"40 45","pages":"23864–23871 23864–23871"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Hypertension: The Role of AT1 Receptors, Sartans, and Lipid Bilayers 探索高血压：AT1 受体、沙坦类药物和脂质双层膜的作用

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsomega.4c0635110.1021/acsomega.4c06351

Nikitas Georgiou, Eleni Chontzopoulou, Efthymios Alexandros Routsi, Irene Georgia Stavrakaki, Errikos Petsas, Nikoletta Zoupanou, Margarita Georgia Kakava, Demeter Tzeli, Thomas Mavromoustakos and Sofia Kiriakidi*,

{"title":"Exploring Hypertension: The Role of AT1 Receptors, Sartans, and Lipid Bilayers","authors":"Nikitas Georgiou, Eleni Chontzopoulou, Efthymios Alexandros Routsi, Irene Georgia Stavrakaki, Errikos Petsas, Nikoletta Zoupanou, Margarita Georgia Kakava, Demeter Tzeli, Thomas Mavromoustakos and Sofia Kiriakidi*, ","doi":"10.1021/acsomega.4c0635110.1021/acsomega.4c06351","DOIUrl":"https://doi.org/10.1021/acsomega.4c06351https://doi.org/10.1021/acsomega.4c06351","url":null,"abstract":"The rational design of AT1 receptor antagonists represents a pivotal approach in the development of therapeutic agents targeting cardiovascular pathophysiology. Sartans, a class of compounds engineered to inhibit the binding and activation of Angiotensin II on the AT1 receptor, have demonstrated significant clinical efficacy. This review explores the multifaceted role of sartans in mitigating hypertension and related complications. We highlight the integration of crystallography, computational simulations, and NMR spectroscopy to elucidate sartan-AT1 receptor interactions, providing a foundation for the next-generation antagonist design. The review also delves into the challenges posed by the high lipophilicity and suboptimal bioavailability of sartans, emphasizing advancements in nanotechnology and novel drug delivery systems. Additionally, we discuss the impact of lipid bilayers on the AT1 receptor conformation and drug binding, underscoring the importance of the lipidic environment in receptor-drug interactions. We suggest that optimizing drug design to account for these factors could enhance the therapeutic potential of AT1 receptor antagonists, paving the way for improved cardiovascular health outcomes.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"44876–44890 44876–44890"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melamine-Derived Mesoporous Carbon for Efficient and Selective Removal of Trace Hg(II) from Honeysuckle Decoction 三聚氰胺衍生介孔碳用于高效、选择性地去除金银花煎剂中的痕量汞（II）

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsomega.4c0326910.1021/acsomega.4c03269

Qing He, Kun Pang, Lin Tian, Yiqian Ma, Xiang Guo, Jianyong Zhang* and Ming Yu*,

{"title":"Melamine-Derived Mesoporous Carbon for Efficient and Selective Removal of Trace Hg(II) from Honeysuckle Decoction","authors":"Qing He, Kun Pang, Lin Tian, Yiqian Ma, Xiang Guo, Jianyong Zhang* and Ming Yu*, ","doi":"10.1021/acsomega.4c0326910.1021/acsomega.4c03269","DOIUrl":"https://doi.org/10.1021/acsomega.4c03269https://doi.org/10.1021/acsomega.4c03269","url":null,"abstract":"Melamine-derived mesoporous carbon, which was obtained from pyrolysis of modified melamine, was employed for the purpose of eliminating trace amounts of Hg(II) from honeysuckle decoction. The specific surface area of the mesoporous carbons with N-functional (MCN1) was 648.372 m2·g–1. The chemical composition and morphology of MCN1 were thoroughly examined, and a comprehensive analysis led to the identification of its formation mechanism. A noteworthy association has been identified between the adsorption efficacy and the chemical composition of MCN1. In the elimination of trace mercury in aqueous solutions over a broad pH range (pH 2–9), MCN1 demonstrates high effectiveness, approaching 100%. Adsorption kinetics and isotherm results indicate that a more accurate representation of Hg(II) adsorption on MCN1 is provided by pseudo-second-order kinetics and Freundlich models, with chemical adsorption being the dominant mechanism. This study further examined the removal of chlorogenic acid, a bioactive component, by MCN1. The findings imply that MCN1 has a noteworthy 80% efficacy in removing mercury from honeysuckle decoction while maintaining the purity of its medicinal ingredients, particularly chlorogenic acid. As a result, utilizing MCN1 for the adsorption of Hg(II) in honeysuckle decoction appears to be a reasonable approach.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"44931–44941 44931–44941"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c03269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brief Report: Learning About Autism: Is the Source of Autism Knowledge Associated with Differences in Autism Knowledge, Autism Identity, and Experiences of Stigma. 简要报告：学习自闭症：自闭症知识的来源是否与自闭症知识、自闭症身份和耻辱感经历的差异有关。

IF 3.2 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 Epub Date: 2022-11-28 DOI: 10.1007/s10803-022-05823-5

Simon M Bury, Alex Haschek, Michael Wenzel, Jennifer R Spoor, Darren Hedley

引用次数: 0

Construction of Nonclassical Type-I Heterojunction for Efficient Photodegrading Tetracycline 构建用于高效光降解四环素的非经典 I 型异质结

IF 3.8 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acs.iecr.4c0322910.1021/acs.iecr.4c03229

Huan Yan, Xinhui Lu, Guoqiang Shen, Yangrui Xu, Xinping Zhang, Qinlan Luo*, Guosheng Zhou, Ziyang Lu*, Yangqiang Huang, Xiao Luo and Hao Chen*,

{"title":"Construction of Nonclassical Type-I Heterojunction for Efficient Photodegrading Tetracycline","authors":"Huan Yan, Xinhui Lu, Guoqiang Shen, Yangrui Xu, Xinping Zhang, Qinlan Luo*, Guosheng Zhou, Ziyang Lu*, Yangqiang Huang, Xiao Luo and Hao Chen*, ","doi":"10.1021/acs.iecr.4c0322910.1021/acs.iecr.4c03229","DOIUrl":"https://doi.org/10.1021/acs.iecr.4c03229https://doi.org/10.1021/acs.iecr.4c03229","url":null,"abstract":"Traditional Type-I heterojunctions, the combination of large- and narrow-bandgap semiconductors, possess a long electron transmission path and an electron–hole confinement region, making them not conducive to improving catalytic performance. Hence, few studies about the heterostructure combined with large and narrow bandgap in chemocatalysis were invested, especially in terms of reaction mechanism. Herein, a narrow bandgap (CdS) and a large bandgap (hexagonal boron nitride, h-BN) were selected as the research objects to fabricate h-BN/CdS heterojunction by Joule heating by an ultrafast heating procedure. Density functional theory (DFT) calculations were performed and showed that in the h-BN/CdS heterojunctions photogenerated electrons (e–) transferred from h-BN to CdS, while the photogenerated holes (h+) moved conversely, which is completely different from that of classical Type-I heterojunctions. Thus, a nonclassical Type-I h-BN/CdS heterojunction was successfully constructed, as proved by DFT calculations and experimental verification, which revealed excellent visible light response and photocatalytic degradation ability of tetracycline (TC). The optimized h-BN/CdS heterojunction exhibited a high degradation rate of 84.78% under visible light irradiation. Additionally, the applicability of h-BN/CdS heterojunction was expanded to photodegradation of different water environments. A nonclassical Type-I heterojunction that combined large- and narrow-bandgap materials was proposed, which opened up a new path for efficient photocatalysis in antibiotic wastewater degradation.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"63 45","pages":"19589–19599 19589–19599"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidation on the In Vivo Activity of the Bivalent Opioid Peptide MACE2 against Several Types of Chronic Pain 阐明二价阿片肽 MACE2 对几种慢性疼痛的体内活性

IF 3.7 3区材料科学

ACS Applied Electronic Materials Pub Date : 2024-11-01 DOI: 10.1021/acsomega.4c0644910.1021/acsomega.4c06449

Azzurra Stefanucci*, Lorenza Marinaccio, Stefano Pieretti, Joseph A. Mancuso, Carrie Stine, John M. Streicher and Adriano Mollica,

{"title":"Elucidation on the In Vivo Activity of the Bivalent Opioid Peptide MACE2 against Several Types of Chronic Pain","authors":"Azzurra Stefanucci*, Lorenza Marinaccio, Stefano Pieretti, Joseph A. Mancuso, Carrie Stine, John M. Streicher and Adriano Mollica, ","doi":"10.1021/acsomega.4c0644910.1021/acsomega.4c06449","DOIUrl":"https://doi.org/10.1021/acsomega.4c06449https://doi.org/10.1021/acsomega.4c06449","url":null,"abstract":"Biphalin is a bivalent μ/δ opioid receptor agonist showing a promising therapeutic profile with reduced side effects, but as a peptide is limited by poor metabolic stability and blood-brain barrier penetration. To improve these features, we developed the ligand MACE2 and showed initial in vivo efficacy. To further explore the druggability of this ligand, in this report, we tested MACE2 metabolic stability in human plasma, receptor engagement by 3 different routes of administration using the tail-flick test, and MACE2 efficacy in 2 different pathological and chronic pain models. We found that MACE2 had high stability in plasma and could produce target engagement and a tail flick response. We also showed that MACE2 had high analgesic efficacy in CIPN but no efficacy in paw incision. Together, these findings suggest that MACE2 has improved metabolic stability and brain penetration in vivo, prompting further development in clinical testing.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"9 45","pages":"45214–45220 45214–45220"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142608466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0