Neurochemistry international最新文献_第4页

Unraveling the role of cholecystokinin in epilepsy: Mechanistic insight into neuroplasticity 揭示胆囊收缩素在癫痫中的作用：神经可塑性的机制启示。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-28 DOI: 10.1016/j.neuint.2024.105870

Muhammad Asim , Gao Qianqian , Abdul Waris , Huajie Wang , Yuanying Lai , Xi Chen

{"title":"Unraveling the role of cholecystokinin in epilepsy: Mechanistic insight into neuroplasticity","authors":"Muhammad Asim , Gao Qianqian , Abdul Waris , Huajie Wang , Yuanying Lai , Xi Chen","doi":"10.1016/j.neuint.2024.105870","DOIUrl":"10.1016/j.neuint.2024.105870","url":null,"abstract":"<div><div>Epilepsy is a disorder characterized by an imbalance between excitability and inhibition, leading to uncontrolled hyperexcitability of neurons in the central nervous system. Despite the prevalence of epileptic seizures, the underlying mechanisms driving this hyperexcitability remain poorly understood. This review article aims to enhance our understanding of the mechanisms of epilepsy, with a specific focus on the role of cholecystokinin (CCK) in this debilitating disease. We will begin with an introduction to the topic, followed by an examination of the role of GABAergic neurons and the synaptic plasticity mechanisms associated with seizures. As we delve deeper, we will elucidate how CCK and its receptors contribute to seizure behavior. Finally, we will discuss the CCK-dependent synaptic plasticity mechanisms and highlight their potential implications in seizure activity. Through a comprehensive examination of these aspects, this review provides valuable insights into the involvement of CCK and its receptors in epilepsy. By improving our understanding of the mechanisms underlying this condition, particularly the role of CCK, we aim to contribute to the development of more effective treatment strategies.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105870"},"PeriodicalIF":4.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of Withania somnifera on ischemic stroke are mediated via anti-inflammatory response and modulation of neurotransmitter levels 睡茄对缺血性中风的神经保护作用是通过抗炎反应和调节神经递质水平来实现的。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-28 DOI: 10.1016/j.neuint.2024.105867

Abhilasha Sood , Arpit Mehrotra , Devinder K. Dhawan , Rajat Sandhir

{"title":"Neuroprotective effects of Withania somnifera on ischemic stroke are mediated via anti-inflammatory response and modulation of neurotransmitter levels","authors":"Abhilasha Sood , Arpit Mehrotra , Devinder K. Dhawan , Rajat Sandhir","doi":"10.1016/j.neuint.2024.105867","DOIUrl":"10.1016/j.neuint.2024.105867","url":null,"abstract":"<div><div>The present study was designed to evaluate the beneficial effects of hydroalcoholic root extract of <em>Withania somnifera</em> (WS) on ischemia-reperfusion injury (IRI) induced by Middle Cerebral Artery Occlusion (MCAO). MCAO animals showed increase in IL-6, TNF-α and MCP-1 levels in terms of mRNA and protein levels. Concomitantly, mRNA and protein levels for astrocyte and microglial activation markers; GFAP and IBA-1, were increased in MCAO animals. COX-2 and NF-kβ protein levels were also increased in the brains of MCAO animals. The levels of neurotransmitters; glutamate and GABA were increased in the MCAO animals. On the contrary, levels of catecholamines; dopamine, norepinephrine and serotonin were reduced in the MCAO animals. Additionally, MCAO animals showed reduced locomotor activity. However, pre-supplementation with WS hydro-alcoholic root extract at a dose of 300 mg/kg, body weight to MCAO animals reduced the expression of IL-6, TNF-α and MCP-1. In addition, WS also reduced the number of GFAP and Iba-1 positive cells in comparison to MCAO animals. WS pre-supplementation was also observed to inhibit MCAO induced increase in COX-2; NF-kβ proteins and reduce the glutamate levels. The levels of GABA, dopamine, norepinephrine and serotonin were increased in WS pre-supplemented MCAO animals. WS pre-supplementation also prevented motor deficits in the MCAO animals. Taken together, these findings suggest that WS is effective in attenuating IRI induced neuroinflammation, neurochemical alterations and motor deficits in MCAO model of ischemic stroke thereby suggesting its ameliorative role in ischemia-reperfusion injury.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105867"},"PeriodicalIF":4.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyto-nanotechnology: A novel beneficial strategy for Alzheimer's disease therapy 植物纳米技术：一种治疗阿尔茨海默病的新型有益策略。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-25 DOI: 10.1016/j.neuint.2024.105868

Shayeri Chatterjee Ganguly , Sk Sangram , Sayani Paul , Moumita Kundu

{"title":"Phyto-nanotechnology: A novel beneficial strategy for Alzheimer's disease therapy","authors":"Shayeri Chatterjee Ganguly , Sk Sangram , Sayani Paul , Moumita Kundu","doi":"10.1016/j.neuint.2024.105868","DOIUrl":"10.1016/j.neuint.2024.105868","url":null,"abstract":"<div><div>Alzheimer's disease, a neurodegenerative condition, is characterized by the slow and progressive deterioration of the cognitive functions of geriatric patients. It occurs due to exacerbation of neurons in the brain, indicated by loss of memory, mood instability, and even death. The aggregation of amyloid β protein and neurofibrillary tangles-atypical forms of tau protein is the major cause of this disease. Phytoconstituents have been frequently employed in treating Alzheimer's disease. These natural compounds act through different molecular mechanisms to treat the disease. However, their potential in Alzheimer's disease therapy may be limited due to poor blood-brain barrier permeability, off-target effects, low bioavailability, etc. In recent times, nanotechnology has gained attraction to overcome these challenges. This article focuses on the potential phytoconstituents for Alzheimer's disease treatment and the associated limitations. Moreover, it highlights various nanoformulation strategies employed to penetrate the blood-brain barrier effectively, avoid side effects, improve bioavailability, and target specificity in treating Alzheimer's disease. The integration of nanotechnology with plant-derived compounds has the potential to revolutionize the therapeutic landscape for Alzheimer's disease.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105868"},"PeriodicalIF":4.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effect of vitamin B12 supplementation on cognitive functions and neuronal morphology at different time intervals after traumatic brain injury in male Swiss albino mice 补充维生素 B12 对雄性瑞士白化小鼠脑外伤后不同时间间隔认知功能和神经元形态的神经保护作用

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-25 DOI: 10.1016/j.neuint.2024.105869

Priyanka Yadav, Farheen Nasir, Thamil Mani Sivanandam

{"title":"Neuroprotective effect of vitamin B12 supplementation on cognitive functions and neuronal morphology at different time intervals after traumatic brain injury in male Swiss albino mice","authors":"Priyanka Yadav, Farheen Nasir, Thamil Mani Sivanandam","doi":"10.1016/j.neuint.2024.105869","DOIUrl":"10.1016/j.neuint.2024.105869","url":null,"abstract":"<div><div>Traumatic brain injury is a highly irreversible process that consists of primary as well as secondary injury which develops and progresses over months to years, leading to cognitive dysfunctions. Vitamin B<sub>12</sub> received considerable interest due to its potential therapeutic properties. The pathways of vitamin B<sub>12</sub> are closely related to neuronal survival but its effects on the pathophysiology of injury with respect to cognition is a relatively unexplored area of research. In this study, we investigated, the effect of vitamin B<sub>12</sub> and its involvement in neuroprotection on TBI-induced pathophysiology in male Swiss albino mice. Our findings suggested that vitamin B<sub>12</sub> supplementation improves TBI-mediated neurological impairments, spatial and recognition memory, and anxiety-like behavior. Furthermore, the oxidative stress was reduced by declined homocysteine level with vitamin B<sub>12</sub> supplementation validating declined expression of astrocytes and TBI biomarkers. The studies on neuronal morphology revealed that vitamin B<sub>12</sub> supplementation increases the dendritic arborization and density of mushroom and filopodia-shaped spines and further increases the expression of synaptic plasticity-related genes and proteins. Taken together, our findings reveal that, supplementation of vitamin B<sub>12</sub> restored the TBI-induced downregulation of dendritic arborization, and spine density which ultimately increases synaptic plasticity, cell survival, and recovery of cognitive dysfunctions.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105869"},"PeriodicalIF":4.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statins ameliorate oxaliplatin- and paclitaxel-induced peripheral neuropathy via glutathione S-transferase 他汀类药物通过谷胱甘肽-S-转移酶改善奥沙利铂和紫杉醇诱发的周围神经病变

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-21 DOI: 10.1016/j.neuint.2024.105863

Fuka Aizawa , Haruna Kajimoto , Ami Okabayashi , Daishi Moriyama , Kenta Yagi , Shimon Takahashi , Yuhei Sonoda , Takahiro Shibata , Mitsuhiro Goda , Takahiro Niimura , Yuki Izawa-Ishizawa , Hirofumi Hamano , Kei Kawada , Yoshito Zamami , Keisuke Ishizawa

{"title":"Statins ameliorate oxaliplatin- and paclitaxel-induced peripheral neuropathy via glutathione S-transferase","authors":"Fuka Aizawa , Haruna Kajimoto , Ami Okabayashi , Daishi Moriyama , Kenta Yagi , Shimon Takahashi , Yuhei Sonoda , Takahiro Shibata , Mitsuhiro Goda , Takahiro Niimura , Yuki Izawa-Ishizawa , Hirofumi Hamano , Kei Kawada , Yoshito Zamami , Keisuke Ishizawa","doi":"10.1016/j.neuint.2024.105863","DOIUrl":"10.1016/j.neuint.2024.105863","url":null,"abstract":"<div><div>Some therapeutic agents have been found to have effects beyond their primary indications. Peripheral neuropathy, a common side effect of chemotherapy, remains inadequately treated. Identifying additional properties of existing medications could thus uncover novel therapeutic avenues. Previous studies have identified an additional effect of simvastatin in reducing neuropathy; however, the mechanism underlying this effect remains unclear. We investigated the novel effects of statins on chemotherapy-induced peripheral neuropathy in mice. Mice treated with oxaliplatin or paclitaxel did not show exacerbation or improvement in cold sensations upon acetone testing with statin administration. However, concurrent oral statin treatment mitigated the nociceptive response to mechanical stimuli induced by each anti-tumor agent. Co-administration of a glutathione S-transferase inhibitor, which modulates redox reactions, abolished the ameliorative effect of statins on mechanical nociceptive behavior. Additionally, the glutathione S-transferase inhibitor did not affect normal sensory perception or impair the anti-tumor effect of chemotherapy agents. A search for GST-associated molecules and pathways using artificial intelligence revealed that GST regulates inflammatory cytokines as a regulatory or causative gene. Our findings suggest that statins have class effects that ameliorate cytotoxic anti-cancer drug-induced mechanical allodynia via GST pathway activation.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105863"},"PeriodicalIF":4.4,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Mandukparni (Centella asiatica Linn Urban) in neurological disorders: Evidence from ethnopharmacology and clinical studies to network enrichment analysis Mandukparni (Centella asiatica Linn Urban) 在神经系统疾病中的作用：从民族药理学和临床研究到网络富集分析的证据。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-20 DOI: 10.1016/j.neuint.2024.105865

Ruchi Sharma , Subhadip Banerjee , Rohit Sharma

{"title":"Role of Mandukparni (Centella asiatica Linn Urban) in neurological disorders: Evidence from ethnopharmacology and clinical studies to network enrichment analysis","authors":"Ruchi Sharma , Subhadip Banerjee , Rohit Sharma","doi":"10.1016/j.neuint.2024.105865","DOIUrl":"10.1016/j.neuint.2024.105865","url":null,"abstract":"<div><div><em>Centella asiatica Linn</em> Urban (<em>C. asiatica</em>), aka <em>Mandukparni</em>, is one of the flagship herbs used in traditional medicines to effectively manage neurological problems. Although this plant has a wealth of comprehensive preclinical pharmacological profiles, further clinical research and execution of its molecular mode of action are still required. We searched electronic databases (Google Scholar, SciFinder, MEDLINE, Scopus, EMBASE, Science Direct, and PubMed) using relevant key words to retrieve information pertaining to <em>C. asiatica</em> till June 2023 and performed network pharmacology to understand the mechanism related to their neurobiological roles. This study extensively analyses its pharmacological properties, nutritional profile, ethnomedical uses, safety, and mechanistic role in treating neurological and neurodegenerative disorders. Additionally, a network pharmacology study was performed which suggests that its phytomolecules are involved in different neuroactive ligand-receptor pathways, glial cell differentiation, gliogenesis, and astrocyte differentiation. Hopefully, this report will lead to a paradigm shift in medical practice, research, and the creation of phytopharmaceuticals derived from <em>C. asiatica</em> that target the central nervous system.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105865"},"PeriodicalIF":4.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation 环亮氨酸会降低 Pax3 的表达，并损害早期神经形成过程中增殖和凋亡的平衡，从而诱发神经管缺陷。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-20 DOI: 10.1016/j.neuint.2024.105861

Li Zhang , Dandan Li , Yurong Liu , Xiaona Zhang , Kaixin Wei , Xiaorong Zhao , Huijing Ma , Bo Niu , Rui Cao , Xiuwei Wang

{"title":"Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation","authors":"Li Zhang , Dandan Li , Yurong Liu , Xiaona Zhang , Kaixin Wei , Xiaorong Zhao , Huijing Ma , Bo Niu , Rui Cao , Xiuwei Wang","doi":"10.1016/j.neuint.2024.105861","DOIUrl":"10.1016/j.neuint.2024.105861","url":null,"abstract":"<div><div>S-adenosylmethionine (SAM) plays a critical role in the development of neural tube defects (NTDs). Studies have shown that the paired box 3 (<em>Pax3</em>) gene is involved in neural tube closure. However, the exact mechanism between <em>Pax3</em> and NTDs induced by SAM deficiency remains unclear. Here, The NTD mouse model was induced using cycloleucine (CL), an inhibitor of SAM biosynthesis, to determine the effect of <em>Pax3</em> on NTDs. The effect of CL on NTD occurrence was assessed by 5-ethynyl-2′-deoxyuridine (EdU) staining, immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), and Western blot in NTD embryonic brain tissues and immortalized hippocampal neuron cells (HT-22). A high incidence of NTDs was observed when CL was administered at a dose of 200 mg/kg body weight. The levels of SAM and <em>Pax3</em> were significantly reduced in NTD embryonic brain tissues and HT-22 cells after CL exposure. Decreased proliferation and excessive apoptosis were observed in neuroepithelial cells of NTD embryos and HT-22 cells under SAM deficiency, but these effects were reversed by overexpression of <em>Pax3</em>. These results suggest that decreased expression of <em>Pax3</em> impairs the dynamic balance between cellular proliferation and apoptosis, contributing to NTDs induced by SAM deficiency, which would provide new insights for clarifying the underlying mechanism of NTDs.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105861"},"PeriodicalIF":4.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shh regulates M2 microglial polarization and fibrotic scar formation after ischemic stroke Shh 可调节缺血性中风后 M2 小胶质细胞的极化和纤维化瘢痕的形成。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-20 DOI: 10.1016/j.neuint.2024.105862

Qinghuan Yang, Peiran Jiang, Hao Tang, Jun Wen, Li Zhou, Yong Zhao, Ling Wang, Jiani Wang, Qin Yang

{"title":"Shh regulates M2 microglial polarization and fibrotic scar formation after ischemic stroke","authors":"Qinghuan Yang, Peiran Jiang, Hao Tang, Jun Wen, Li Zhou, Yong Zhao, Ling Wang, Jiani Wang, Qin Yang","doi":"10.1016/j.neuint.2024.105862","DOIUrl":"10.1016/j.neuint.2024.105862","url":null,"abstract":"<div><h3>Background</h3><div>Fibrotic scar formation is a critical pathological change impacting tissue reconstruction and functional recovery after ischemic stroke. The regulatory mechanisms behind fibrotic scarring in the central nervous system (CNS) remain largely unknown. While macrophages are known to play a role in fibrotic scar formation in peripheral tissues, the involvement of microglia, the resident immune cells of the CNS, in CNS fibrosis requires further exploration. The Sonic Hedgehog (Shh) signaling pathway, pivotal in embryonic development and tissue regeneration, is also crucial in modulating fibrosis in peripheral tissues. However, the impact and regulatory mechanisms of Shh on fibrotic scar formation post-ischemic stroke have not been thoroughly investigated.</div></div><div><h3>Methods</h3><div>This study explores whether Shh can regulate fibrotic scar formation post-ischemic stroke and its underlying mechanisms through in vivo and in vitro manipulation of Shh expression.</div></div><div><h3>Results</h3><div>Our results showed that Shh expression was upregulated in the serum of acute ischemic stroke patients, as well as in the serum, CSF, and ischemic regions of MCAO/R mice. Moreover, the upregulation of Shh expression was positively correlated with fibrotic scar formation and M2 microglial polarization. Shh knockdown inhibited fibrotic scar formation and M2 microglial polarization while aggravating neurological deficits in MCAO/R mice. In vitro, adenoviral knockdown or Smoothened Agonist (SAG) activation of Shh expression in BV2 cells following OGD/R regulated their polarization and influenced the expression of TGFβ1 and PDGFA, subsequently affecting fibroblast activation.</div></div><div><h3>Conclusion</h3><div>These results suggest that Shh regulates M2 microglial polarization and fibrotic scar formation after cerebral ischemia.</div></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105862"},"PeriodicalIF":4.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GABA, epigallocatechin gallate, tea, and the gut-brain axis GABA、表没食子儿茶素没食子酸酯、茶和肠脑轴。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-18 DOI: 10.1016/j.neuint.2024.105860

Tina Hinton, Graham A.R. Johnston

引用次数: 0

Carotenoids modulate antioxidant pathways in In vitro models of Parkinson's disease: A comprehensive scoping review 类胡萝卜素调节帕金森病体外模型中的抗氧化途径：综合范围综述

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-16 DOI: 10.1016/j.neuint.2024.105857

Han Ting Guo , Zi Xin Lee , Kasthuri Bai Magalingam , Ammu Kutty Radhakrishnan , Saatheeyavaane Bhuvanendran

{"title":"Carotenoids modulate antioxidant pathways in In vitro models of Parkinson's disease: A comprehensive scoping review","authors":"Han Ting Guo , Zi Xin Lee , Kasthuri Bai Magalingam , Ammu Kutty Radhakrishnan , Saatheeyavaane Bhuvanendran","doi":"10.1016/j.neuint.2024.105857","DOIUrl":"10.1016/j.neuint.2024.105857","url":null,"abstract":"<div><p>Parkinson's disease (PD) is the second most common neurodegenerative disease, and it has affected the living quality of elderly people significantly. PD is characterised by the accumulation of α-Synuclein and progressive loss of dopaminergic neurons at the substantia nigra pars compacta. In the pathogenesis of Parkinson's disease, α-Synuclein, oxidative stress, and electron transport chain (ETC) are the three main factors that contribute to the production of reactive oxygen species (ROS). Currently, there is no commercial disease-modifying agent available for PD; the first-line treatment, Levodopa (<span>l</span>-DOPA), could only relieve the symptoms of PD, with many side effects. Carotenoids, which encompass red, orange, and yellow pigments found in nature and contribute to the colouration of plants, have been associated with various health benefits, including anti-cancer and neuroprotective effects due to their antioxidant properties. This scoping review delves into the impact and underlying mechanisms of carotenoids on cell-based models of neurodegenerative diseases.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105857"},"PeriodicalIF":4.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197018624001840/pdfft?md5=0d1cbc28753d75c4219ae493cc311ee9&pid=1-s2.0-S0197018624001840-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0