Neurochemistry international最新文献_第5页

Corrigendum to “HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway’[Neurochemistry International 99 (2016) 239–251] HPOB，一种HDAC6抑制剂，通过抑制线粒体GR转位和内在凋亡途径减轻皮质酮诱导的大鼠肾上腺嗜铬细胞瘤PC12细胞损伤'[Neurohemistry International 99 (2016) 239-251]的更正。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-14 DOI: 10.1016/j.neuint.2024.105856

Zong-yang Li , Qing-zhong Li , Lei Chen , Bao-dong Chen , Ce Zhang , Xiang Wang , Wei-ping Li

引用次数: 0

Soy lysolecithin prevents hypertension and cognitive impairment induced in mice by high salt intake by inhibiting intestinal inflammation 大豆卵磷脂通过抑制肠道炎症预防高盐摄入诱发的小鼠高血压和认知障碍

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-12 DOI: 10.1016/j.neuint.2024.105858

Hisayoshi Kubota , Kazuo Kunisawa , Masaya Hasegawa , Hitomi Kurahashi , Kazuhiro Kagotani , Yuki Fujimoto , Akihito Hayashi , Ryoji Sono , Takehiko Tsuji , Kuniaki Saito , Toshitaka Nabeshima , Akihiro Mouri

{"title":"Soy lysolecithin prevents hypertension and cognitive impairment induced in mice by high salt intake by inhibiting intestinal inflammation","authors":"Hisayoshi Kubota , Kazuo Kunisawa , Masaya Hasegawa , Hitomi Kurahashi , Kazuhiro Kagotani , Yuki Fujimoto , Akihito Hayashi , Ryoji Sono , Takehiko Tsuji , Kuniaki Saito , Toshitaka Nabeshima , Akihiro Mouri","doi":"10.1016/j.neuint.2024.105858","DOIUrl":"10.1016/j.neuint.2024.105858","url":null,"abstract":"<div><p>High salt (HS) intake induces hypertension and cognitive impairment. Preventive strategies include against dietary supplements. Soybean lecithin is a widely used phospholipid supplement. Lysolecithin is important in cell signaling, digestion, and absorption. This study aimed to investigate the effects of lysophosphatidylcholine containing >70% of the total phospholipids (LPC70), on hypertension and cognitive impairment induced in mice by HS intake. Mice were provided with HS solution (2% NaCl in drinking water) with or without LPC70 for 12 weeks. Blood pressure, cognitive function, and inflammatory response of intestine were determined. Hypertension and impaired object recognition memory induced by HS intake were implicated with increased inducible nitric oxide synthase in the small intestine and tau hyperphosphorylation in the prefrontal cortex. LPC70 treatment prevented cognitive impairment by suppressing inducible nitric oxide synthase and tau hyperphosphorylation. LPC70 may be valuable as a functional food component in preventing HS-induced cognitive impairment.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105858"},"PeriodicalIF":4.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical appraisal of geroprotective activities of flavonoids in terms of their bio-accessibility and polypharmacology 从生物可及性和多药理角度对黄酮类化合物的老年保护活性进行严格评估

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-10 DOI: 10.1016/j.neuint.2024.105859

Roumi Naskar , Anirrban Ghosh , Raja Bhattacharya , Sandipan Chakraborty

{"title":"A critical appraisal of geroprotective activities of flavonoids in terms of their bio-accessibility and polypharmacology","authors":"Roumi Naskar , Anirrban Ghosh , Raja Bhattacharya , Sandipan Chakraborty","doi":"10.1016/j.neuint.2024.105859","DOIUrl":"10.1016/j.neuint.2024.105859","url":null,"abstract":"<div><p>Flavonoids, a commonly consumed natural product, elicit health-benefits such as antioxidant, anti-inflammatory, antiviral, anti-allergic, hepatoprotective, anti-carcinogenic and neuroprotective activities. Several studies have reported the beneficial role of flavonoids in improving memory, learning, and cognition in clinical settings. Their mechanism of action is mediated through the modulation of multiple signalling cascades. This polypharmacology makes them an attractive natural scaffold for designing and developing new effective therapeutics for complex neurological disorders like Alzheimer's disease and Parkinson's disease. Flavonoids are shown to inhibit crucial targets related to neurodegenerative disorders (NDDs), including acetylcholinesterase, butyrylcholinesterase, β-secretase, γ-secretase, α-synuclein, Aβ protein aggregation and neurofibrillary tangles formation. Conserved neuro-signalling pathways related to neurotransmitter biogenesis and inactivation, ease of genetic manipulation and tractability, cost-effectiveness, and their short lifespan make <em>Caenorhabditis elegans</em> one of the most frequently used models in neuroscience research and high-throughput drug screening for neurodegenerative disorders. Here, we critically appraise the neuroprotective activities of different flavonoids based on clinical trials and epidemiological data. This review provides critical insights into the absorption, metabolism, and tissue distribution of various classes of flavonoids, as well as detailed mechanisms of the observed neuroprotective activities at the molecular level, to rationalize the clinical data. We further extend the review to critically evaluate the scope of flavonoids in the disease management of neurodegenerative disorders and review the suitability of C. <em>elegans</em> as a model organism to study the neuroprotective efficacy of flavonoids and natural products.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105859"},"PeriodicalIF":4.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity-based anorexia (ABA) model: Effects on brain neuroinflammation, redox balance and neuroplasticity during the acute phase 基于活动的厌食症（ABA）模型：对急性期大脑神经炎症、氧化还原平衡和神经可塑性的影响。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-06 DOI: 10.1016/j.neuint.2024.105842

Vittoria Spero , Maria Scherma , Sabrina D'Amelio , Roberto Collu , Simona Dedoni , Chiara Camoglio , Carlotta Siddi , Walter Fratta , Raffaella Molteni , Paola Fadda

{"title":"Activity-based anorexia (ABA) model: Effects on brain neuroinflammation, redox balance and neuroplasticity during the acute phase","authors":"Vittoria Spero , Maria Scherma , Sabrina D'Amelio , Roberto Collu , Simona Dedoni , Chiara Camoglio , Carlotta Siddi , Walter Fratta , Raffaella Molteni , Paola Fadda","doi":"10.1016/j.neuint.2024.105842","DOIUrl":"10.1016/j.neuint.2024.105842","url":null,"abstract":"<div><p>Several evidences suggest that immuno-inflammatory responses are involved in the pathogenesis of anorexia nervosa (AN). Herein we investigate the possible alteration of key mediators of inflammation, redox balance, and neuroplasticity in the brain of rats showing an anorexic-like phenotype. We modeled AN in adolescent female rats using the activity-based anorexia (ABA) paradigm and measured gene expression levels of targets of interest in the prefrontal cortex (PFC) and dorsal hippocampus (DH). We observed reduced mRNA levels of pro-inflammatory cytokines IL-1β and TNF-α, the inflammasome NLRP3, and the microglial marker CD11b in both PFC and DH of ABA animals. Conversely, the mRNA of IL-6, which acts as both a pro-inflammatory and anti-inflammatory cytokine, was increased. Moreover, we observed an overall upregulation of different antioxidant enzymes in PFC, while their profile was not affected or opposite in the DH, with the exception of MT1α. Interestingly, ABA animals showed elevated levels of the neuroplasticity marker BDNF in both PFC and DH. Our data indicate that ABA induction is associated with anatomical-specific cerebral alteration of mediators of neuroinflammation, oxidative balance and neuroplasticity. Although more research should be conducted, these results add important information about the role of these systems in the complex AN etiopathogenesis.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105842"},"PeriodicalIF":4.4,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells-a prospect for the development of herbal nutraceuticals 传统食用药用植物可防止鱼藤酮诱导的 SH-SY5Y 细胞毒性--中草药保健品的开发前景广阔。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-06 DOI: 10.1016/j.neuint.2024.105855

Aruna Chanu Hijam , Yaiphabi Chanu Tongbram , Pooja Devi Nongthombam , Heikrujam Nilkanta Meitei , Arunkumar Singh Koijam , Yallapa Rajashekar , Reena Haobam

{"title":"Traditionally used edible medicinal plants protect against rotenone induced toxicity in SH-SY5Y cells-a prospect for the development of herbal nutraceuticals","authors":"Aruna Chanu Hijam , Yaiphabi Chanu Tongbram , Pooja Devi Nongthombam , Heikrujam Nilkanta Meitei , Arunkumar Singh Koijam , Yallapa Rajashekar , Reena Haobam","doi":"10.1016/j.neuint.2024.105855","DOIUrl":"10.1016/j.neuint.2024.105855","url":null,"abstract":"<div><p>Plants are good sources of pharmacologically active compounds. The present study aimed to examine the neuroprotective potentials of the methanol extracts of <em>Salix tetrasperma</em> Roxb. leaf (STME) and <em>Plantago asiatica</em> L. (PAME), two edibles medicinal plants of Manipur, India against neurotoxicity induced by rotenone in SH-SY5Y cells. Free radical quenching activities were evaluated by ABTS and DPPH assays. The cytotoxicity of rotenone and the neuronal survival were assessed by MTT assay and MAP2 expression analysis. DCF-DA, Rhodamine 123 (Rh-123), and DAPI measured the intracellular reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), and apoptotic nuclei, respectively. Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities were also assessed. LC-QTOF-MS analysis was performed for the identification of the compounds present in STME and PAME. The study showed that both the plant extracts (STME and PAME) showed antioxidant and neuroprotective capabilities in rotenone-induced neurotoxicity by preventing oxidative stress through the reduction of intracellular ROS levels and reversing the activities of GPx, SOD, and CAT caused by rotenone. Further, both plants prevented apoptotic cell death by normalizing the steady state of MMP and protecting nuclear DNA condensation. LC-QTOF-MS analysis shows the presence of known neuroprotective compounds like uridine and gabapentin in STME and PAME respectively. The two plants might be an important source of natural antioxidants and nutraceuticals with neuroprotective abilities. This could be investigated further to formulate herbal nutraceuticals for the treatment of neurodegenerative disease like Parkinson's disease.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105855"},"PeriodicalIF":4.4,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation and characterization of cortical organoids from iPSC-derived dental pulp stem cells using traditional and innovative approaches 利用传统和创新方法从 iPSC 衍生的牙髓干细胞中生成皮质类器官并确定其特征。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-04 DOI: 10.1016/j.neuint.2024.105854

André Luíz Teles e Silva , Bruno Yukio Yokota-Moreno , Mariana Silva Branquinho , Geisa Rodrigues Salles , Thiago Cattuzo de Souza , Ronald Almeida de Carvalho , Gabriel Batista , Elisa Varella Branco , Karina Griesi-Oliveira , Maria Rita Passos Bueno , Marimélia Aparecida Porcionatto , Roberto Hirochi Herai , Lionel Fernel Gamarra , Andrea Laurato Sertié

{"title":"Generation and characterization of cortical organoids from iPSC-derived dental pulp stem cells using traditional and innovative approaches","authors":"André Luíz Teles e Silva , Bruno Yukio Yokota-Moreno , Mariana Silva Branquinho , Geisa Rodrigues Salles , Thiago Cattuzo de Souza , Ronald Almeida de Carvalho , Gabriel Batista , Elisa Varella Branco , Karina Griesi-Oliveira , Maria Rita Passos Bueno , Marimélia Aparecida Porcionatto , Roberto Hirochi Herai , Lionel Fernel Gamarra , Andrea Laurato Sertié","doi":"10.1016/j.neuint.2024.105854","DOIUrl":"10.1016/j.neuint.2024.105854","url":null,"abstract":"<div><p>Cortical organoids derived from human induced pluripotent stem cells (hiPSCs) represent a powerful <em>in vitro</em> experimental system to investigate human brain development and disease, often inaccessible to direct experimentation. However, despite steady progress in organoid technology, several limitations remain, including high cost and variability, use of hiPSCs derived from tissues harvested invasively, unexplored three-dimensional (3D) structural features and neuronal connectivity. Here, using a cost-effective and reproducible protocol as well as conventional two-dimensional (2D) immunostaining, we show that cortical organoids generated from hiPSCs obtained by reprogramming stem cells from human exfoliated deciduous teeth (SHED) recapitulate key aspects of human corticogenesis, such as polarized organization of neural progenitor zones with the presence of outer radial glial stem cells, and differentiation of superficial- and deep-layer cortical neurons and glial cells. We also show that 3D bioprinting and magnetic resonance imaging of intact cortical organoids are alternative and complementary approaches to unravel critical features of the 3D architecture of organoids. Finally, extracellular electrical recordings in whole organoids showed functional neuronal networks. Together, our findings suggest that SHED-derived cortical organoids constitute an attractive model of human neurodevelopment, and support the notion that a combination of 2D and 3D techniques to analyze organoid structure and function may help improve this promising technology.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105854"},"PeriodicalIF":4.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer 解密 FAM72 基因家族的分子景观：对干细胞生物学和癌症的影响

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-09-03 DOI: 10.1016/j.neuint.2024.105853

Janani Ramesh , Raja Mohan Gopalakrishnan , Tuan Hoang Anh Nguyen , Soak-Kuan Lai , Hoi-Yeung Li , Pok-Son Kim , Arne Kutzner , Noriko Inoue , Klaus Heese

引用次数: 0

Pentylenetetrazole: A review 戊烯四唑：综述。

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-08-28 DOI: 10.1016/j.neuint.2024.105841

Álefe Brito Monteiro, Alan Ferreira Alves, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Mayara Pessoa de Melo, Nayana Maria Medeiros Vilar Barbosa, Cícero Francisco Bezerra Felipe

{"title":"Pentylenetetrazole: A review","authors":"Álefe Brito Monteiro, Alan Ferreira Alves, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Mayara Pessoa de Melo, Nayana Maria Medeiros Vilar Barbosa, Cícero Francisco Bezerra Felipe","doi":"10.1016/j.neuint.2024.105841","DOIUrl":"10.1016/j.neuint.2024.105841","url":null,"abstract":"<div><p>Pentylenetetrazole (PTZ), a tetrazole derivative, is commonly used as a chemical agent to induce neurological disorders and replicate the characteristics of human epileptic seizures in animal models. This review offers a comprehensive analysis of the behavioral, neurophysiological, and neurochemical changes induced by PTZ. The epileptogenic and neurotoxic mechanisms of PTZ are associated with an imbalance between the GABAergic and glutamatergic systems. At doses exceeding 60 mg/kg, PTZ exerts its epileptic effects by non-competitively antagonizing GABA<sub>A</sub> receptors and activating NMDA receptors, resulting in an increased influx of cations such as Na<sup>+</sup> and Ca<sup>2+</sup>. Additionally, PTZ promotes oxidative stress, microglial activation, and the synthesis of pro-inflammatory mediators, all of which are features characteristic of glutamatergic excitotoxicity. These mechanisms ultimately lead to epileptic seizures and neuronal cell death, which depend on the dosage and method of administration. The behavioral, electroencephalographic, and histological changes associated with PTZ further establish it as a valuable preclinical model for the study of epileptic seizures, owing to its simplicity, cost-effectiveness, and reproducibility.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105841"},"PeriodicalIF":4.4,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-stroke whole body vibration therapy alters the cerebral transcriptome to promote ischemic tolerance in middle-aged female rats 中风后全身振动疗法改变大脑转录组，促进中年雌性大鼠的缺血耐受性

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-08-28 DOI: 10.1016/j.neuint.2024.105843

Shahil H. Patel , Helen M. Bramlett , Ami P. Raval

{"title":"Post-stroke whole body vibration therapy alters the cerebral transcriptome to promote ischemic tolerance in middle-aged female rats","authors":"Shahil H. Patel , Helen M. Bramlett , Ami P. Raval","doi":"10.1016/j.neuint.2024.105843","DOIUrl":"10.1016/j.neuint.2024.105843","url":null,"abstract":"<div><p>Low-frequency whole body vibration (WBV; 40 Hz) therapy after stroke reduces ischemic brain damage, motor, and cognitive deficits in middle-aged rats of both sexes. However, the underlying mechanisms responsible for WBV induced ischemic protections remain elusive. In the current study, we hypothesize that post-stroke WBV initiates transcriptional reprogramming in the cortex of middle-aged female rats which is responsible for the observed reduced stroke consequences. Middle-aged female Sprague-Dawley rats that remained in constant diestrus (reproductively senescent) were randomized to either sham or transient middle cerebral artery occlusion (tMCAO; 90 min) surgery. A day after induction of tMCAO, animals received either WBV or no-WBV treatment for 15 min twice a day for five days for a week. Post-treatment, cortical tissue was analyzed for gene expression using RNA sequencing (RNAseq) and gene enrichment analysis via Enrichr. The RNAseq data analysis revealed significant changes in gene expression due to WBV therapy and the differentially expressed genes are involved in variety of biological processes like neurogenesis, angiogenesis, excitotoxicity, and cell death. Specifically, observed significant up-regulation of 116 and down-regulation of 258 genes after WBV in tMCAO exposed rats as compared to the no-WBV group. The observed transcriptional reprogramming will identify the possible mechanism(s) responsible for post-stroke WBV conferred ischemic protection and future studies will be needed to confirm the role of the genes identified in the current study.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":"180 ","pages":"Article 105843"},"PeriodicalIF":4.4,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Pharmacological inhibition of cGAS ameliorates postoperative cognitive dysfunction by suppressing caspase-3/GSDME-dependent pyroptosis” [Neurochem. Int. 178 (2024) 105788] 更正："药理抑制 cGAS 可通过抑制 caspase-3/GSDME 依赖性脓毒症改善术后认知功能障碍" [Neurochem.

IF 4.4 3区医学

Neurochemistry international Pub Date : 2024-08-25 DOI: 10.1016/j.neuint.2024.105838

Xueshan Bu , Ping Gong , Lei Zhang , Wenqin Song , Jiabao Hou , Qingwen Li , Wei Wang , Zhongyuan Xia

引用次数: 0