Polski Merkuriusz Lekarski最新文献_第3页

Malignant melanoma of small intestine. 小肠恶性黑色素瘤。

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202603119

Michalina Mikuła, Paulina Suder, Monika Augustyn, Iwon Grys, Bogusław Kopp

{"title":"Malignant melanoma of small intestine.","authors":"Michalina Mikuła, Paulina Suder, Monika Augustyn, Iwon Grys, Bogusław Kopp","doi":"10.36740/Merkur202603119","DOIUrl":"10.36740/Merkur202603119","url":null,"abstract":"The purpose of this article is to present a challenging case of recurrent gastrointestinal bleeding caused by malignant melanoma of the small intestine and to discuss the diagnostic approach, highlighting the role of advanced endoscopic techniques. The patient underwent extensive diagnostic evaluation, including repeated gastroscopies, colonoscopies, two double-balloon enteroscopies, scintigraphy with labeled erythrocytes, and capsule endoscopy. Capsule endoscopy provided a decisive contribution to the diagnostic process, guiding further clinical management including segmental small intestine resection with regional lymphadenectomy. Histopathological examination of the resected tissue revealed malignant melanoma of the spindle cell type, infiltrating the mucosa, submucosa, and part of the muscular layer. No primary cutaneous lesion or distant metastases were detected following comprehensive diagnostic evaluation. In patients with suspected lower gastrointestinal bleeding, when standard endoscopic procedures do not allow to identify the source, location in the small intestine should be considered. In such cases, early implementation of advanced diagnostic techniques, such as capsule endoscopy and double-balloon enteroscopy, is recommended. These methods allow identification of lesions in small intestine segments with limited accessibility. A crucial step in the diagnostic process was capsule endoscopy, which enabled identification of an actively bleeding lesion in the distal segment of the small intestine.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"380-384"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corruption in the healthcare sector during a war: A threat to human rights. 战争期间医疗保健部门的腐败：对人权的威胁。

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202603115

Nataliya Gutorova, Oleksandra Rudnyeva, Tetiana Mykhailichenko

{"title":"Corruption in the healthcare sector during a war: A threat to human rights.","authors":"Nataliya Gutorova, Oleksandra Rudnyeva, Tetiana Mykhailichenko","doi":"10.36740/Merkur202603115","DOIUrl":"https://doi.org/10.36740/Merkur202603115","url":null,"abstract":"Objective: Aim: To show the increase of corruption risks in healthcare during the war, their negative impact on the protection of human rights, and to outline legal ways to minimize these risks.Patients and methods: Materials and Methods: The study was conducted in 2025 and is based on international and humanitarian law, Ukrainian legislation and regulations in the areas of human rights, healthcare, and anti-corruption, interviews with medical professionals and wounded combatants, content analysis of media publications, and Ukrainian judicial practice and statistics. A total of 47 documents were analyzed, and interviews were conducted with three medical professionals and five combatants. The methods used were legal analysis and systemic-structural analysis, interviews, statistical analysis, content analysis of media information, and analytical methods, including induction and deduction. Artificial intelligence was used as an auxiliary tool for information search; Grammarly was used to edit the text.Conclusion: Conclusions: While international law has not yet established a binding norm defining corruption as a human rights violation, corruption in healthcare systems constitutes a significant threat to the realization of human rights. No derogation from commitments to the rights to life and health is legally permissible during wartime. To minimize corruption risks, the healthcare system, including military medicine, must be adequately prepared in advance. Digitalization serves as a crucial tool for transparent assessment of functional/ADL status, and the management of humanitarian aid requires a more effective oversight system.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"355-361"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics in students' psychosomatic health indicators during their distance learning under martial law. 戒严条件下远程学习学生身心健康指标的动态变化

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202603110

Nataliia A Dakal, Oleksandr D Mokhunko, Zoia V Syrovatko, Viktoriia M Yefremenko, Larysa V Anikeienko, Viktor P Bilokon, Valentyna V Zubko

{"title":"Dynamics in students' psychosomatic health indicators during their distance learning under martial law.","authors":"Nataliia A Dakal, Oleksandr D Mokhunko, Zoia V Syrovatko, Viktoriia M Yefremenko, Larysa V Anikeienko, Viktor P Bilokon, Valentyna V Zubko","doi":"10.36740/Merkur202603110","DOIUrl":"https://doi.org/10.36740/Merkur202603110","url":null,"abstract":"Objective: Aim: To investigate the impact of motor activity on the dynamics of students' psychosomatic health indicators during their distance learning under martial law.Patients and methods: Materials and Methods: The research involved 252 female students aged 17-20. Depending on the level of their motor activities, three groups were formed: female students in group a (n=75) engaged in physical exercise 3 or more times a week; female students in group b (n=95) exercised 1-2 times per week; female students in group c (n=82) did not engage in physical exercise. Research methods: theoretical methods, questionnaire, psychodiagnostics methods, statistical methods.Results: Results: It was found that among female students of group a, psychosomatic health indicators significantly improved (p<0.05). In contrast, group b and group c deteriorated. The most pronounced negative changes in group c were observed in indicators of stress levels, neuropsychological tension, and the emotional state of the female students. At the end of the research, all subgroups of group a exhibited statistically similar indicators of psychosomatic health (p>0.05), regardless of the focus of the physical exercise sessions.Conclusion: Conclusions: The results demonstrate the effectiveness and appropriateness of incorporating a reasonable amount of physical activity to maintain and improve students' psychosomatic health indicators during distance learning under martial law. At the same time, physical exercise of any type helps reduce stress and neuropsychological tension, strengthen health, improve students' well-being and mood, increase their work capacity, and, consequently, their academic performance during wartime.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"306-313"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD38 genotype-dependent regulation of CD44 and TP53 links genetic variation to aggressive phenotype in chronic lymphocytic leukemia. CD38基因型依赖性的CD44和TP53调控将慢性淋巴细胞白血病的遗传变异与侵袭性表型联系起来。

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202602101

Maryam A Hussain, Maggie E Amer, Shaimaa El-Ashwah, Motaz ElKosairy, Yasser M El-Sherbini, Mohamed Mabed, Mohamed E Abdraboh

{"title":"CD38 genotype-dependent regulation of CD44 and TP53 links genetic variation to aggressive phenotype in chronic lymphocytic leukemia.","authors":"Maryam A Hussain, Maggie E Amer, Shaimaa El-Ashwah, Motaz ElKosairy, Yasser M El-Sherbini, Mohamed Mabed, Mohamed E Abdraboh","doi":"10.36740/Merkur202602101","DOIUrl":"10.36740/Merkur202602101","url":null,"abstract":"Objective: Aim: To estimate role of CD38 rs6449182 polymorphism in CLL risk and its effect on the expression of critical tumor suppressor TP53, the promoter of cell adhesion and migration, CD44, and the immune checkpoint molecule PD-L1.Patients and methods: Materials and Methods: This case-control study included 50 CLL patients and 50 healthy individuals, age- and sex-matched. CLL diagnosed by flow cytometry (CD5+/CD19+/CD23+) based on WHO criteria. Genotyping of the CD38 rs6449182 polymorphism was detected through TaqMan SNP Assay. mRNA expression levels of TP53, CD44, and PD-L1 were quantified using real-time RT-PCR .Results: Results: Mutant G-allele was more frequent in CLL patients than in controls (19.0% vs. 10.0%), although this difference was only marginally significant P=0.075. No statistically significant association was observed between specific CD38 genotypes and the regulatory status (upregulation/downregulation) of the target genes P>0.05, while individuals with GG genotype exhibited higher median fold changes for TP53 (FC=2.97) and CD44 (FC=2.00) than the wild-type, the presence of significant inter-individual variance and broad confidence intervals indicates that these genetic variants do not serve as definitive independent predictors of gene expression in this cohort.Conclusion: Conclusions: results suggest that the CD38 rs6449182 polymorphism may, at least in part, be involved in CLL risk but that it does not lead to a significant genotype-specific regulatory effect on the fold change of CD44, TP53, or PD-L1 expression. Although CD38 remains an important prognostic biomarker, the absence of a genetic-phenotypic relationship found in this study illustrates the complexity of molecular regulation by CLL. Larger studies are needed to confirm these findings.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 2","pages":"120-126"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased cellular stress responses, neuroinflammation, and altered neuronal signaling in the pathophysiology of PTSD. 增加细胞应激反应，神经炎症，改变神经信号在创伤后应激障碍的病理生理。

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202604118

Ewa Alicja Ogłodek

{"title":"Increased cellular stress responses, neuroinflammation, and altered neuronal signaling in the pathophysiology of PTSD.","authors":"Ewa Alicja Ogłodek","doi":"10.36740/Merkur202604118","DOIUrl":"https://doi.org/10.36740/Merkur202604118","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is associated with persistent dysregulation of cellular stress pathways and altered neuronal signaling within limbic and prefrontal circuits. Increasing evidence indicates that activation of endoplasmic reticulum stress responses, oxidative imbalance, and inflammasome signaling contribute to sustained neurobiological alterations underlying PTSD symptomatology. Stress-induced activation of inositol-requiring enzyme 1 (IRE1) and activating transcription factor 6 (ATF6) interacts with inflammatory mediators such as interleukin-18 (IL-18) and interleukin-1β (IL-1β), amplifying neuroimmune responses. Activation of the NOD-like receptor family pyrin domain containing 3 inflammasome (NLRP3 inflammasome) and caspase-1 promotes cytokine maturation and microglial activation, leading to impaired synaptic plasticity. These mechanisms are accompanied by alterations in glutamatergic and gammaaminobutyric acid (GABA) signaling, oxidative stress imbalance, and dysregulation of the hypothalamic-pituitary-adrenal axis. Neuroimaging data demonstrate volumetric and microstructural changes in the hippocampus, amygdala, and prefrontal cortex in chronic PTSD, suggesting structural correlates of prolonged inflammatory and stress-related activity. Biomarker studies further indicate associations between inflammatory mediators, coping strategies, sleep disturbances, and illness duration. These findings support the concept that increased cellular stress responses and altered neuronal signaling are central components of PTSDpathophysiology rather than secondary epiphenomena. Understanding the interaction between endoplasmic reticulum stress, inflammasome activation, oxidative imbalance, and neurotransmitter dysregulation may improve biomarker-based diagnostics and facilitate development of targeted therapeutic interventions.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"508-516"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Training of nursing personnel for the public health system. 为公共卫生系统培训护理人员。

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202604121

Nataliia V Hrechyshkina, Inessa G Bibyk, Kateryna O Bobkovych, Borys I Palamar

{"title":"Training of nursing personnel for the public health system.","authors":"Nataliia V Hrechyshkina, Inessa G Bibyk, Kateryna O Bobkovych, Borys I Palamar","doi":"10.36740/Merkur202604121","DOIUrl":"10.36740/Merkur202604121","url":null,"abstract":"Objective: Aim: To analyse contemporary global approaches to training nursing personnel for the public health sector, focusing on the integration of competency-based, interprofessional, and practice-oriented models, and to evaluate their strategic relevance to the transformation of national health systems.Patients and methods: Materials and Methods: A systematic literature review and narrative synthesis were conducted using international scientific databases (PubMed/Medline, Scopus, Web of Science) covering 2010-2026, with an analytical focus on publications from 2021-2026. The search strategy was guided by Boolean logic and targeted MeSH terms. Of the 120 records initially identified, 35 core sources, including global strategic guidelines from the WHO and ICN, met the strict inclusion and exclusion criteria and were selected for final qualitative analysis.Conclusion: Conclusions: Transitioning from traditional clinical education to integrated instructional models (CBE, IPE, and the ADDIE framework) is crucial for developing a resilient workforce. For transforming national systems, such as Ukraine's, managing this transition through adaptive, asynchronous e-learning under emergency conditions ensures the attainment of critical population-based competencies, with a focus on epidemiological surveillance and community-based preventive care.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"536-540"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective interventions used by preschool teachers to develop executive functions in preschoolers with attention difficulties. 幼儿教师对发展学龄前注意困难儿童执行功能的有效干预。

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202602109

Theoni Kyriakou, Ilias Vasileiou, Dimitra V Katsarou

{"title":"Effective interventions used by preschool teachers to develop executive functions in preschoolers with attention difficulties.","authors":"Theoni Kyriakou, Ilias Vasileiou, Dimitra V Katsarou","doi":"10.36740/Merkur202602109","DOIUrl":"10.36740/Merkur202602109","url":null,"abstract":"Objective: Aim: This study explores the interventions used by preschool teachers to develop executive functions in preschoolers with attention difficulties. It aims to provide a comprehensive understanding of effective interventions for fostering executive function development, as viewed from the perspectives of preschool teachers.Patients and methods: Materials and Methods: A qualitative study was conducted through semi-structured interviews with thirty preschool teachers. Thematic analysis was employed to examine the interventions proposed by teachers for enhancing executive functions in preschoolers with concentration difficulties. The results were subsequently discussed in relation to the existing literature.Results: Results: The results indicate that motor games and interest-driven activities are the most effective in developing executive functions in children with attention difficulties. Teachers suggested that successful interventions often incorporate rhythm and movement, aligning with children's interests.Conclusion: Conclusions: Early and effective interventions aimed at developing executive functions in preschoolers at risk of ADHD can delay the onset of symptoms and enhance academic success. Teachers emphasise that motor games and activities based on children's interests are key strategies for improving concentration and self-regulation; however, further research is required to validate these findings.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 2","pages":"158-162"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing cognitive engagement in medical students through problem-based histology instruction: implications for competency-oriented physician training. 通过以问题为基础的组织学教学增强医学生的认知参与：对以能力为导向的医师培训的启示。

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202602112

Nataliia M Dymar, Tetiana D Reva, Ihor M Drapei, Lylia M Yaremenko

{"title":"Enhancing cognitive engagement in medical students through problem-based histology instruction: implications for competency-oriented physician training.","authors":"Nataliia M Dymar, Tetiana D Reva, Ihor M Drapei, Lylia M Yaremenko","doi":"10.36740/Merkur202602112","DOIUrl":"10.36740/Merkur202602112","url":null,"abstract":"Objective: Aim: This study aimed to verify experimentally the effectiveness of a problem-search approach for teaching Histology in enhancing the level of cognitive engagement among first-year medical students enrolled in specialty I2 \"Medicine,\" as well as to substantiate the feasibility of its implementation in the educational process of future physician training.Patients and methods: Materials and Methods: The study was conducted during the 2024-2025 academic year and consisted of three stages (summative, formative, and final) using a pedagogical quasi-experimental design. A total of 756 undergraduate students enrolled in specialty I2 \"Medicine\" participated and were divided into a control group (n=352) and an experimental group (n=354). The level of cognitive engagement was assessed before and after the formative stage using B. K. Pashnev's questionnaire. The experimental group was taught using a combination of problem-based learning, the case method, heuristic dialogue, smallgroup work, project-based learning, and digital interactive technologies.Results: Results: At the summative stage, no statistically significant differences between the groups were identified. After the implementation of the problem-inquiry teaching methodology, the experimental group demonstrated a significant increase in the proportion of medical students with an advanced level of cognitive engagement (from 32.5% to 70.1%) compared with the control group (χ2=38.369; p<0.05).Conclusion: Conclusions: The proposed methodology for teaching Histology to future physicians, grounded in a problem-search approach, is an effective means of enhancing medical students' cognitive engagement and may be recommended for implementation in higher medical education practice.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 2","pages":"176-182"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol improves cognitive function and quality of life in postmenopausal women. 白藜芦醇可改善绝经后妇女的认知功能和生活质量。

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202601103

Viktoriia Myhal, Yurii Kazakov, Svitlana Shut, Tetiana Tribrat, Yevhen Petrov, Tetiana Ivanytska, Nataliia Chekalina

{"title":"Resveratrol improves cognitive function and quality of life in postmenopausal women.","authors":"Viktoriia Myhal, Yurii Kazakov, Svitlana Shut, Tetiana Tribrat, Yevhen Petrov, Tetiana Ivanytska, Nataliia Chekalina","doi":"10.36740/Merkur202601103","DOIUrl":"https://doi.org/10.36740/Merkur202601103","url":null,"abstract":"Objective: Aim: To evaluate the effect of trans-resveratrol on cognitive function and quality of life in postmenopausal women.Patients and methods: Materials and Methods: A prospective controlled clinical study involved 88 women aged 52.1±2.5 years, postmenopausal for 2.3±1.2 years, who were randomized into two groups: study (n=55) and comparison (n=33). All patients underwent laboratory and psychometric examinations.Results: Results: Compared with the control group, resveratrol intake was associated with an increase in serum magnesium levels (p 0.05). Resveratrol administration in the study group resulted in positive changes in cognitive function (P<0.001), unlike in the control group, where no significant changes were observed (P>0.05). Improvements in quality of life according to the EQ-5D-3L scale occurred in both groups, but with an advantage in the study group (p 0.05).Conclusion: Conclusions: The results of the study indicate a significant positive effect of resveratrol on cognitive functioning, as confirmed by an increase in MoCA scores, as well as an improvement in quality-of-life parameters according to the EQ-5D-3L and MENQOL questionnaires. The data obtained provide grounds for asserting that resveratrol can help slow age-related cognitive decline in postmenopausal women.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of IFNG rs2069709 on the severity of varicella in children. IFNG rs2069709对儿童水痘严重程度的影响

Polski Merkuriusz Lekarski Pub Date : 2026-01-01 DOI: 10.36740/Merkur202604106

Zarina Alshimbayeva, Rozaliya Begaydarova, Nigina Khodzhayeva, Gulsharbat Alshynbekova, Gulmira Nasakayeva, Gulim Omarova

{"title":"Influence of IFNG rs2069709 on the severity of varicella in children.","authors":"Zarina Alshimbayeva, Rozaliya Begaydarova, Nigina Khodzhayeva, Gulsharbat Alshynbekova, Gulmira Nasakayeva, Gulim Omarova","doi":"10.36740/Merkur202604106","DOIUrl":"https://doi.org/10.36740/Merkur202604106","url":null,"abstract":"Objective: Aim: To assess the association between IFNG rs2069709 genotypes (CC, AC), as well as demographic factors such as sex and age, with the risk of complicated varicella in children.Patients and methods: Materials and Methods: The study included 132 children with confirmed varicella. Genotyping was performed using PCR with the TaqMan Genotyping Assay. Statistical analysis comprised the χ2 test, allele frequency evaluation, and logistic regression to determine the effects of genotype, sex, and age on disease severity.Results: Results: The AC genotype was detected in 67.2% of children, while the CC genotype accounted for 20.3%; samples lacking genotype data (12.5%) were excluded from analysis. The C allele predominated in the uncomplicated group (64.2%), whereas the A allele was more frequent among children with complicated varicella (41.3%). Logistic regression demonstrated a tendency toward increased risk of complicated disease in AC carriers (OR=2.05; p=0.10). Sex and age showed no significant association with disease severity (p>0.05). Although statistical significance was not reached, the findings indicate that variability in the IFNG locus may influence individual immune responses to varicella-zoster virus.Conclusion: Conclusions: The IFNG rs2069709 C allele may act as a protective factor against severe varicella, while the A allele may increase susceptibility to complications. The observed trend for the AC genotype highlights the potential role of genetic markers in predicting disease course. Larger studies are required to confirm these associations and clarify their underlying mechanisms.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"421-426"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0