Polski Merkuriusz Lekarski最新文献

{"title":"Dynamics of the size ratio between the cerebellar vermis and the fourth ventricle of the human brain during the fetal period of ontogenesis.","authors":"Olexandr V Tsyhykalo, Nataliia B Kuzniak, Larysa Ya Fedoniuk, Roman R Dmytrenko, Halyna M Chernikova, Haliia B Kulynych","doi":"10.36740/Merkur202502106","DOIUrl":"https://doi.org/10.36740/Merkur202502106","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine the patterns of change in the cross-sectional area of the cerebellar vermis and the fourth ventricle during the fetal period of human ontogenesis and to analyze the dynamics of their interrelationship.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study was conducted using magnetic resonance imaging (MRI) scans of the human fetal brain obtained from open-access databases. Generalized images from the \"Fetal Brain Atlas\" (21-38 weeks of gestation) and MRI scans from the \"Fetal Brain MRI from Stanford Lucile Packard Children's Hospital\" database (20-39 weeks of gestation, n=20) were used. Morphometric analysis of mid-sagittal sections was performed using the Image Tool software. The cross-sectional areas of the cerebellar vermis and the fourth ventricle were measured, along with their relative values and ratios.</p><p><strong>Results: </strong>Results: Between 21 and 38 weeks of gestation, the cross-sectional area of the cerebellar vermis increased steadily, whereas the fourth ventricle exhibited a biphasic growth pattern: relatively slow expansion until 30 weeks, followed by accelerated growth. The analysis of relative areas revealed that the growth rate of the cerebellum exceeded that of the fourth ventricle until 30-32 weeks, after which the fourth ventricle underwent rapid expansion, leading to an alignment of their relative values. The ratio of the fourth ventricle's area to that of the cerebellum ranged from 4.8% to 9.8%, showing minimal values at 25-28 weeks and rapid growth between 28 and 34 weeks of gestation.</p><p><strong>Conclusion: </strong>Conclusions: The obtained data indicate changes in the proportional relationship between the cerebellum and the fourth ventricle throughout the fetal period of ontogenesis, reflecting the specific features of their morphogenesis. The proposed approach for assessing the interrelationship between these structures may be useful for analyzing both normal and abnormal hindbrain development during the prenatal period.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"184-190"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forensic medical and legal analysis of cases of improper performance of professional duties by medical employees, including incorrect prescription of medical products Anzhela B. Berzina, Alina O. Pletenetska BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE KEY WO RDS.","authors":"","doi":"10.36740/Merkur202501113","DOIUrl":"10.36740/Merkur202501113","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To conduct a forensic medical and legal analysis of cases of improper performance of professional duties by medical employees, including incorrect prescription of medical products..</p><p><strong>Patients and methods: </strong>Materials and Methods: The article is based on the analysis of defects in the performance of professional duties by medical employees, particularly according to data from commission forensic medical examinations, as well as an analysis of international and national legal acts and national judicial practices of Ukraine. Dialectical, hermeneutic, comparative, analytical, synthetic, and system analysis research methods were used.</p><p><strong>Results: </strong>Results: Although the total number of forensic medical examinations tends to decrease, these examinations remain the focus of attention in cases of improper performance of professional duties by medical employees. A more detailed analysis of cases involving violations of treatment strategies revealed instances of incorrect treatment method selection (whether conservative or surgical), along with cases of improper or unjustified prescription of medicinal products. Incorrect prescription of medical products is one significant way medical employees fail in their professional duties.</p><p><strong>Conclusion: </strong>Conclusions: Understanding the general dynamics of forensic medical examinations is important, as it helps establish practical cause-and-effect relationships between the performance of professional duties by medical employees and adverse consequences for patients (including cases involving incorrect prescription of medical products).</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"94-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The right to privacy in medical legal relations in the practice of the European court of human rights: Experience for Ukraine.","authors":"Oleksandr M Shevchuk, Iryna V Borodina, Оlena V Verhoglyad-Gerasymenko, Oleksii I Marochkin, Oleksandr V Lysodyed","doi":"10.36740/Merkur202503118","DOIUrl":"https://doi.org/10.36740/Merkur202503118","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyse the problems of implementing an individual's right to privacy in medical legal relations and to characterise the practice of the European Court of Human Rights (ECtHR).</p><p><strong>Patients and methods: </strong>Materials and Methods: The methodological basis of the article is a set of methods and techniques of scientific knowledge. Methods of theoretical analysis, system-analytical and comparative-legal methods made it possible to characterise the problems of protecting the right of an individual to privacy in medical legal relations, taking into account the practice of the ECtHR.</p><p><strong>Results: </strong>Results: The right to privacy in medical legal relations is a fundamental principle of the legal systems of the states parties to the European Convention. The right to privacy in medical legal relations is complex and forms part of the right to health. The ECtHR, in many of its decisions in the field of healthcare, has emphasised the existence of both negative and positive obligations of the state to ensure the right to respect for the private and family life of patients. States parties to the European Convention must not only refrain from unlawful interference, but also create mechanisms for the effective protection of patients'privacy, including the protection of confidential data.</p><p><strong>Conclusion: </strong>Conclusions: The practice of the ECtHR in implementing an individual's right to privacy in medical legal relations is a dynamic source of law and contributes to the formation of uniform judicial practice in the context of protecting the rights, freedoms and interests of individuals in the field of healthcare.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 3","pages":"418-422"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotypes of Candida albicans and its cooperative interaction with Streptococci isolated from throat infections.","authors":"Janan Majeed Al-Akeedi, Haider Hamid Khudiar, Seenaa Taqi Mansour Al Muhtaser, Ali A Al-Fahham","doi":"10.36740/Merkur202503112","DOIUrl":"https://doi.org/10.36740/Merkur202503112","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study was aimed to detect and determine genotypes of Candida albicans and its cooperative interaction with streptococci isolated from throat infections.</p><p><strong>Patients and methods: </strong>Materials and Methods: This survey was carried out during November 2023 and March 2024 to collect a total of 80 throat swab samples from patients in in Al-Sadr Medical City in Najaf during. Candida was isolated from culturing throat swab samples on Sabouraud agar, and Blood agar. Each isolate (Candida & Streptococci) enhanced in monoculture using enrichment media; Potato Dextrose broth. Molecular assay included detecting three of biofilm forming genes; Als1, Als2, Als3.</p><p><strong>Results: </strong>Results: Twelve out of fifteen Candida isolates showed increase in number after mixing with Streptococci and incubation. In contrast, three isolates showed no change or decrease after mixing in co-culture media. Five Candida isolates (out of 15 isolates) were positive in gel electrophoresis to three biofilm genes classified as first genotype (CALSG1). Four Candida isolates were negative in gel electrophoresis to three biofilm genes, classified as second genotype (CALSG2). Other Candida isolates were positive to one or two of three biofilm genes, classified with genotypes (CALSG3, CALSG4, CALSG5 and CALSG6).</p><p><strong>Conclusion: </strong>Conclusions: Candida albicans has biofilm formation genes (Als), which attract other organisms, like streptococci resulting in synergistic interaction. Despite the presence of some Als genes, it's not necessary to found strong biofilm results as Als genes may not be translated to form biofilm.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 3","pages":"378-383"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of oxidative disorders in the pathogenesis of kidney damage in type 1 diabetes mellitus and diabetic nephropathy in children: xanthine oxidase as a trigger.","authors":"Ievgeniia A Burlaka, Ihor V Kovalchuk, Inga O Mityuryayeva-Kornijko","doi":"10.36740/Merkur202501115","DOIUrl":"10.36740/Merkur202501115","url":null,"abstract":"<p><strong>Objective: </strong>. Aim: This review aims to analyze scientific articles and publications on the role of oxidative stress and xanthine oxidase in the pathogenesis of type 1 diabetes mellitus and diabetic nephropathy in order to update the theories underlying its development and progression.</p><p><strong>Patients and methods: </strong>Materials and Methods: The literature analysis used peer-reviewed articles, reviews, and descriptions of experimental studies from 2021-2024. The study describes the role of oxidative damage in the pathogenesis of diabetic nephropathy and the function of xanthine oxidase as a trigger.</p><p><strong>Conclusion: </strong>Conclusions: The study of the molecular mechanisms of the cytoprotective and renoprotective effects of xanthine oxidase inhibition confirms its leading role in the pathogenesis of diabetic nephropathy and opens up new prospects for the development of biomarkers, and therefore new approaches in the diagnosis, treatment, and prevention of diabetes and its dangerous complications.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"108-114"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of implementing and collecting data on somatic methods during wartime Donbas, Ukraine.","authors":"Katja Kolcio, Marta Pyvovarenko, Jennifer Rose, Vitaliy Kharechko, Volodymyr Shevchyk","doi":"10.36740/Merkur202501108","DOIUrl":"10.36740/Merkur202501108","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study explores the feasibility and psychosocial outcomes of using somatic methods as a mental and psychosocial health intervention in the context of active violent conflict..</p><p><strong>Patients and methods: </strong>Materials and Methods: Project leaders taught an 8-day program in somatic methods to local mental health care providers in the Donbas region of Ukraine. In the following seven months, 20 mental health care providers applied the somatic methods in their work with clients. The progress of clients participating in the study was tracked utilizing a software designed for the project. Longitudinal data was collected from 460 clients between December 2020 and May 2021 and was analyzed using mixed linear models to estimate changes in outcomes of depression, functionality, anxiety and alcohol problems.</p><p><strong>Results: </strong>Results: The program was successfully implemented despite the challenges posed by the ongoing conflict. Demographic data on participants and survey results were successfully collected and analyzed. Data demonstrated significant declines over time for depression and anxiety as well as a significant increase in daily functioning.</p><p><strong>Conclusion: </strong>Conclusions: The results of this pilot study support the feasibility of developing a subsequent randomized controlled trial study to further assess the impact of somatic methods on psycho-social wellness in Ukraine.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"56-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological effectiveness of platelet-rich plasma application in the experimental treatment of post immobilization extra-articular contractures of the mandible.","authors":"Sergiy M Grigorov, Arsenii V Tretiakov, Mykhailo S Myroshnychenko, Yevheniia A Hromko, Alina O Grygorova, Alina S Poliashenko, Nataliia V Kapustnyk, Oleksandr V Arseniev, Maryna O Kucheriavchenko","doi":"10.36740/Merkur202502102","DOIUrl":"https://doi.org/10.36740/Merkur202502102","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Aim: The purpose of the study was to prove the effectiveness of platelet-rich plasma (PRP) application in the treatment of post-immobilization extra-articular contractures of the mandible by modeling the specified pathology and conducting morphological analysis of experimental material.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients and methods: &lt;/strong&gt;Materials and Methods: The study involved an experiment conducted on 60 male WAG rats aged 9-11 months. Four groups were formed. Group 1 included 6 intact rats that were not subjected to any interventions and were withdrawn from the experiment one month after its initiation. Group 2 included 18 rats with a mandibular fracture in the angle region which was treated over the course of one month using an immobilizing muzzle. After removal of the muzzle, extra-articular mandibular contracture was diagnosed. All rats were withdrawn from the experiment one month after its initiation. Group 3 included 18 rats with mandibular fractures that were treated over the course of one month using an immobilizing muzzle. After removal of the muzzle, post-immobilization extra-articular mandibular contracture was diagnosed. Following this diagnosis, 6 rats were withdrawn from the experiment. The other rats received PRP injections into the contracture area every three days for 15 days. After completion of the treatment, these rats were also withdrawn from the experiment. Group 4 included 18 rats with a mandibular fracture. After modeling a mandibular fracture, PRP was injected into the soft tissues surrounding the fracture through the available holes in the immobilizing muzzle every five days for one month. After a month, the immobilizing muzzle was removed from the rats, among which 6 rats were randomly selected and withdrawn from the experiment. The other rats continued to be injected with PRP every three days for 15 days, after which the animals were withdrawn from the experiment. The material for morphological examination consisted of masseter muscle samples. Histological, histochemical, immunohistochemical, morphometric and statistical methods were used.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Results: The comprehensive morphological study showed that PRP in the masseter muscle had antifibrotic and anti-inflammatory effects, reduced the severity of alterative changes in muscle fibers and increased their regenerative potential, reduced the severity of hemodynamic disorders, and increased the number of vessels. The therapeutic effect of PRP was more pronounced in cases where it was applied both during the treatment of mandibular fracture using an immobilizing muzzle for one month and for an additional 15 days after its removal, compared to animals in which PRP was applied only during the 15 days following muzzle removal.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Conclusions: The comprehensive morphological study of experimental material conducted by the authors confirmed the effectiveness of platelet-rich plasma in the tre","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"157-165"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dehumanization and attitudes toward LGBTQ individuals among primary healthcare nurses: The role of personality traits and LGBTQ health knowledge.","authors":"Vissarion Bakalis, Aikaterini Toska, Stella Zetta, Foteini Malli, Maria Saridi, Sofia Zyga, Krysatlia Gkouletsa, Evangelos C Fradelos","doi":"10.36740/Merkur202502112","DOIUrl":"https://doi.org/10.36740/Merkur202502112","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study investigates dehumanization and attitudes toward LGBTQ+ individuals among primary healthcare nurses in Greece, exploring the influence of personality traits, empathy, and LGBTQ+ health knowledge.</p><p><strong>Patients and methods: </strong>Materials and Methods: A cross-sectional design was used with 114 public-sector primary healthcare nurses completing self-report questionnaires between July and October 2023. Instruments included a culturally adapted dehumanization scale, the Ten-Item Personality Inventory, and the Toronto Empathy Questionnaire. Statistical analysis included Mann-Whitney and Kruskal-Wallis tests, Spearman's correlations, and linear regression.</p><p><strong>Results: </strong>Results: The sample was predominantly female (74.6%), heterosexual (93.9%), and Christian Orthodox (93%). Only 8.8% had attended LGBTQ+ healthcare courses, and 33.3% had cared for LGBTQ+ patients. Mechanistic dehumanization showed limited associations with personality traits, while animalistic dehumanization was negatively correlated with willingness to care (r = -0.441, p < 0.001) and comfort with LGBTQ+ care (r = -0.391, p < 0.001). Empathy and openness to experience influenced attitudes and willingness to care. Higher empathy unexpectedly reduced willingness to care, while emotional stability and conscientiousness predicted dehumanization.</p><p><strong>Conclusion: </strong>Conclusions: Findings highlight a moderate dehumanization trend among nurses, affecting LGBTQ+ patients' care quality. Educational initiatives targeting LGBTQ+ health knowledge, empathy training, and the influence of personality traits are critical to fostering inclusive care and reducing dehumanization in healthcare settings.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"229-238"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of apelin level in Iraqi diabetic women with hypothyroidism.","authors":"Maryam Qusay Isaa, Noor Thair Tahir","doi":"10.36740/Merkur202502110","DOIUrl":"https://doi.org/10.36740/Merkur202502110","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine how Apelin levels and other biochemical markers affect thyroid function of Iraqi diabetic women.</p><p><strong>Patients and methods: </strong>Materials and Methods: 88 subjects participated in this study, 44 diabetic women with hypothyroidism, whose ages between 40 and 60 years, and 44 healthy as a control group, whose ages between 40 and 55 years, during December 2022 to the end of April 2023. Demographic characters such as age, height, and weight of all participants were noted. Serum thyroxin, triiodothyronine and thyroid stimulating hormone were measured by Minivans with Biomerix Kits. Fasting serum glucose, glycated hemoglobin (HbA1c), lipid profile (total cholesterol, triglyceride, high density lipoprotein, and low-density lipoprotein, and very low-density lipoprotein), blood urea, and serum creatinine were among the tests performed on blood samples for the laboratory research. ELISA kit was used to measure amount of apelin.</p><p><strong>Results: </strong>Results: A highly significant increase of apelin levels in diabetic women with hypothyroidism when compared with control, a significant positive correlation P <0.05 between Apelin level and each of: weight, body mass index, TSH, glycated hemoglobin (HbA1c), TG and VLDL and shows a highly significant positive correlation P<0.05 between Apelin level vs. TT4, FBS, TC and LDL. A significant negative correlation P<0.05 was found between Apelin levels vs. serum HDL in diabetic women with hypothyroidism.</p><p><strong>Conclusion: </strong>Conclusions: A significant increase in results of Apelin in women with hypothyroidism and diabetes led to a significant imbalance in lipid metabolism, in the future, this might be an indicator of their risk of heart disease.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"218-221"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of plasma TGF-β1 after intra-articular platelet rich plasma injection in-patient with anterior disc displacement with intermittent locking of TMJ disorder.","authors":"Karar Abdulzahra Mahdi, Muhassad H Al-Mudhafar, Dunya Malhan Hanweet","doi":"10.36740/Merkur202502101","DOIUrl":"https://doi.org/10.36740/Merkur202502101","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate plasma levels of TGF-β1 and the clinical impact of platelet-rich plasma injections on mandibular opening and pain in patients with anterior disc displacement and intermittent locking.</p><p><strong>Patients and methods: </strong>Materials and Methods: Twenty-seven temporomandibular disorder patients, diagnosed by oral medicine specialists, received three intra-articular PRP injections over three months, with evaluations conducted two weeks after the final injection. Plasma TGF-β1 levels were measured before and after treatment, with visual analog scale pain scores and mouth opening measurements.</p><p><strong>Results: </strong>Results: Results showed that the mean plasma TGF-β1 level in temporomandibular disorder patients increased significantly from (312.6 pg/ml ± 67.96) before PRP injection to (400.4 pg/ml± 108.51) after PRP injection. Platelet-rich plasma-treated patients also experienced a significant reduction in Visual Analogue Scale scores, which decreased from (6.21 ± 0.95) to (0.78 ± 0.79), with improved range of mouth opening after PRP injection.</p><p><strong>Conclusion: </strong>Conclusions: Intra-articular platelet-rich plasma injections effectively increased plasma TGF-β1 levels, reduced pain intensity, and improved mandibular opening range in temporomandibular disorder patients.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"179-183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}