Effect of apelin level in Iraqi diabetic women with hypothyroidism.

Objective: Aim: To determine how Apelin levels and other biochemical markers affect thyroid function of Iraqi diabetic women.

Patients and methods: Materials and Methods: 88 subjects participated in this study, 44 diabetic women with hypothyroidism, whose ages between 40 and 60 years, and 44 healthy as a control group, whose ages between 40 and 55 years, during December 2022 to the end of April 2023. Demographic characters such as age, height, and weight of all participants were noted. Serum thyroxin, triiodothyronine and thyroid stimulating hormone were measured by Minivans with Biomerix Kits. Fasting serum glucose, glycated hemoglobin (HbA1c), lipid profile (total cholesterol, triglyceride, high density lipoprotein, and low-density lipoprotein, and very low-density lipoprotein), blood urea, and serum creatinine were among the tests performed on blood samples for the laboratory research. ELISA kit was used to measure amount of apelin.

Results: Results: A highly significant increase of apelin levels in diabetic women with hypothyroidism when compared with control, a significant positive correlation P <0.05 between Apelin level and each of: weight, body mass index, TSH, glycated hemoglobin (HbA1c), TG and VLDL and shows a highly significant positive correlation P<0.05 between Apelin level vs. TT4, FBS, TC and LDL. A significant negative correlation P<0.05 was found between Apelin levels vs. serum HDL in diabetic women with hypothyroidism.

Conclusion: Conclusions: A significant increase in results of Apelin in women with hypothyroidism and diabetes led to a significant imbalance in lipid metabolism, in the future, this might be an indicator of their risk of heart disease.