Polski Merkuriusz Lekarski最新文献

{"title":"The role of oxidative disorders in the pathogenesis of kidney damage in type 1 diabetes mellitus and diabetic nephropathy in children: xanthine oxidase as a trigger.","authors":"Ievgeniia A Burlaka, Ihor V Kovalchuk, Inga O Mityuryayeva-Kornijko","doi":"10.36740/Merkur202501115","DOIUrl":"https://doi.org/10.36740/Merkur202501115","url":null,"abstract":"<p><strong>Objective: </strong>. Aim: This review aims to analyze scientific articles and publications on the role of oxidative stress and xanthine oxidase in the pathogenesis of type 1 diabetes mellitus and diabetic nephropathy in order to update the theories underlying its development and progression.</p><p><strong>Patients and methods: </strong>Materials and Methods: The literature analysis used peer-reviewed articles, reviews, and descriptions of experimental studies from 2021-2024. The study describes the role of oxidative damage in the pathogenesis of diabetic nephropathy and the function of xanthine oxidase as a trigger.</p><p><strong>Conclusion: </strong>Conclusions: The study of the molecular mechanisms of the cytoprotective and renoprotective effects of xanthine oxidase inhibition confirms its leading role in the pathogenesis of diabetic nephropathy and opens up new prospects for the development of biomarkers, and therefore new approaches in the diagnosis, treatment, and prevention of diabetes and its dangerous complications.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"108-114"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subspecies typing on the example of klebsiella pneumoniae isolated from patients with pulmonary tuberculosis.","authors":"Nurlan Tabriz, Zhanara Nurtazina, Alyona Lavrinenko, Zhumat Mutayhan, Altynay Taishykova","doi":"10.36740/Merkur202501109","DOIUrl":"https://doi.org/10.36740/Merkur202501109","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The purpose of this study was to evaluate sub-species typing by matrix-activated laser desorption/ionisation mass spectrometry on the example of Klebsiella pneumoniae isolated from patients with pulmonary tuberculosis in Karaganda region..</p><p><strong>Patients and methods: </strong>Materials and Methods: This study evaluated the potential of MALDI-TOF MS for epidemiological identification of Klebsiella pneumoniae isolated from pulmonary tuberculosis patients in Karaganda region. A total of 47 strains of Klebsiella pneumoniae obtained between 2015 and 2019 were typed. Mass spectra were taken using Microflex LT MALDI-TOF (Bruker) according to standard procedure.</p><p><strong>Results: </strong>Results: As a result, MALDI-TOF evaluation of subspecies typing on the example of Klebsiella pneumoniae isolated from patients with pulmonary tuberculosis in Karaganda region, predominantly showed the diversity of isolates, indicating their out-of-hospital nature. Based on all available information, including facts, sources, and experimental results, it can be reasonably concluded that the current study of Klebsiella pneumoniae does not provide a complete picture of the epidemiology of this microorganism.</p><p><strong>Conclusion: </strong>Conclusions: The current study provided a limited opportunity to investigate the genetic structure and diversity of Klebsiella pneumoniae subspecies more accurately. The findings suggest that the time-of-flight laser-ionisation ablation mass spectrometry method with magnetic focusing is more likely to detect differences in external characteristics between individual specimens of the same species than internal genetic variation in the microorganisms under study. The practical relevance of this study is to inform the development of more effective infection control strategies in clinical practice and infection control.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prediction power of thymidine phosphorylase and IL-6 in the relapse of breast cancer.","authors":"Ahmed Hussein Zwamel, Hind Mizhir Mousa, Bushra A M Abdul Azeez, Ali A Al-Fahham","doi":"10.36740/Merkur202501112","DOIUrl":"https://doi.org/10.36740/Merkur202501112","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the role of thymidine phosphate and IL-6 in the pathogenesis and survival rate in women with breast cancer..</p><p><strong>Patients and methods: </strong>Materials and Methods: Sixty women diagnosed with breast cancer (with age ranging between 25-65 years) were included in the current study. Of these, 40 women relapse after 6 months of follow up, while 40 patients were non-relapsed.</p><p><strong>Results: </strong>Results: Statistical analysis pointed out that thymidine phosphorylase may be significantly increased in relapsed women comparing to non-relapsed women (4.48±0.24 ng/ml and 1.12±0.18 ng/ml respectively, p value <0.0001). Regarding IL-6, the current study also found that IL-6 tends to be increased in relapse BC comparing to non-relapsed BC (8.6±0.92 pg/ml vs. 6.82±1.14 pg/ml respectively, p-value<0.0001. There was a high significant positive correlation between thymidine phosphorylase and IL-6 (r=0.368; p-value <0.01). The sensitivity and specificity in predicting relapse in breast cancer were 0.83 and 0.64 for TP and 0.78, and 0.65 respectively.</p><p><strong>Conclusion: </strong>Conclusions: It is suggested that thymidine phosphate activity and IL-6 serum levels after six months of follow up, have a dual synergistic impact on the pathogenesis of relapse for BC. These biomarkers can also be used in the prediction of relapse rate in women diagnosed with BC.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive approach to the rehabilitation of professionals with high levels of psychophysical stress, pain syndromes and type 2 diabetes mellitus during the war Lidiia V. Butska1,2,3, Oksana O. Drevitska1,2,3, Sergei V. Dybkalyuk4, Valentyn O. Ryzhak 5 1TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV, KYIV, UKRAINE 2INTERREGIONAL ACADEMY OF PERSONNEL MANAGEMENT, KYIV, UKRAINE 3STATE INSTITUTION «KUNDIIEV INSTITUTE OF OCCUPATIONAL HEALTH OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE», KYIV, UKRAINE 4SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE 5OPTIMUM MEDIA UKRAINE, KYIV, UKRAINE.","authors":"","doi":"10.36740/Merkur202501105","DOIUrl":"https://doi.org/10.36740/Merkur202501105","url":null,"abstract":"<p><strong>Objective: </strong>. Aim: To evaluate the effectiveness of a multilevel rehabilitation program integrating physiotherapy (PT), transcranial electrical stimulation (TES), and endonasal breathing of a singlet-oxygen mixture (EBSO) on pain syndromes (PS), quality of life (QL), and levels of depression in professionals with type 2 diabetes mellitus (T2DM) and high psychophysical stress.</p><p><strong>Patients and methods: </strong>Materials and Methods: Sixty professionals with high psychophysical stress were randomly divided into three groups (n=20 each). Group 1 received standard rehabilitation. Group 2 underwent targeted PT, including ultrasound therapy for the pancreas projection and magneto-laser therapy for the liver projection and Th5-Th7 zones. Group 3 received the same PT as Group 2, supplemented with TES (alpha rhythm frequency) and EBSO. The rehabilitation program lasted two weeks, comprising 10 sessions. Outcomes were assessed using the QL questionnaire - SF-36 and Beck Depression Inventory-II (BDI-II).</p><p><strong>Results: </strong>Results: Group 3 demonstrated significant improvements in QL by SF-36 score, particularly in Physical Functioning (from 49,2 ± 2,6 to 70,3 ± 3,8), Bodily Pain (from 48,1 ± 2,6 to 69,3 ± 3,1), and Mental Health (from 38,0 ± 3,3 to 59,3 ± 3,6; p < 0,01). Depression score decreased from 30,6 ± 2,1 to 18,2 ± 2,0 (p < 0,01), with notable improvements in cognitive-affective and somatic subscales. Group 2 showed moderate improvements, while Group 1 exhibited minimal changes.</p><p><strong>Conclusion: </strong>Conclusions: Combining targeted PT with TES and EBSO significantly improves somatic and psychological outcomes in T2DM patients compared to standard rehabilitation or PT alone.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"34-39"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of parathyroid hormone, vitamin D3, calcium, phosphate, and RFT in patients with chronic renal failure: A three-year follow-up study.","authors":"Hamid K Al-Tameemi, Noor Ibrahim, Dina A A Abdullah, Noor Nayyef Oddah","doi":"10.36740/Merkur202501106","DOIUrl":"https://doi.org/10.36740/Merkur202501106","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aimed to evaluate the serum levels of key biomarkers, including parathyroid hormone (PTH), vitamin D3, calcium, phosphate, and renal function tests (RFTS), in patients with chronic renal failure over three years..</p><p><strong>Patients and methods: </strong>Materials and Methods: A cohort of 83 patients with chronic renal failure and 70 healthy controls were followed, with data collected at one, two, and three years.</p><p><strong>Results: </strong>Results: Significant differences were observed in the levels of creatinine, urea, phosphate, calcium, vitamin D, and parathyroid hormone between patients and controls. the study found a progressive increase in phosphate and parathyroid hormone levels, alongside a decrease in calcium and vitamin D levels in patients over time. strong correlations were observed between these biomarkers, highlighting the complex interplay between mineral metabolism and renal function in chronic renal failure.</p><p><strong>Conclusion: </strong>Conclusions: These findings confirm the need for integrated management strategies to address these biochemical disturbances and improve the life quality of patients with chronic renal failure.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of the anatomical variations of pancreatic blood vessels and occurrence of diseases of pancreas.","authors":"Anastasiya Spaska","doi":"10.36740/Merkur202501114","DOIUrl":"https://doi.org/10.36740/Merkur202501114","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The research aims to confirm or reject the hypothesis on the possible relationship between the influence of changes in pancreatic vascular variations on the mechanisms of occurrence of pancreatic diseases based on the collected scientific literature..</p><p><strong>Patients and methods: </strong>Materials and Methods: The bibliosemantic, bibliographic, statistical research methods were used in the research. Scientometric databases Web of Science, Scopus, PubMed, and archives of scientific papers such as Google Scholar and Research Gate for the last 6 years (2018-2023) were used to form a study basis.</p><p><strong>Conclusion: </strong>Conclusions: Based on the analyzed sources, blood supply variants to the pancreas do not influence the development of pathological processes. However, vein and artery features impact treatment choices and surgical outcomes. Main and additional pancreatic ducts, and the common bile duct, may be linked to diseases. Atypical pancreatic artery branching affects surgical tactics and increases bleeding risk.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"100-107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current priorities in research on metabolic-associated fatty liver disease based on the results of EASL - 2024.","authors":"Leonid L Pinsky, Mykola V Khaitovych, Olga A Golubovska, Irina P Ryzhova","doi":"10.36740/Merkur202501117","DOIUrl":"https://doi.org/10.36740/Merkur202501117","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To systematize and comprehensively analyze scientific sources and studies on metabolic-associated steatotic liver disease (MASLD) based on materials from the European Congress of the European Association for the Study of the Liver (EASL - 2024)..</p><p><strong>Patients and methods: </strong>Materials and Methods: This paper analyzes the current scientific research on the prevalence, pathogenesis, diagnostic methods, prognosis, and pharmacotherapy of MASLD presented at the EASL 2024 Congress. The following methods were used in the preparation of the work: a systematic approach and bibliosemantic analysis.</p><p><strong>Conclusion: </strong>Conclusions: Studies on the pathogenesis of MASLD progression confirm the significant role of insulin resistance and hyperinsulinemia in increasing hepatocyte cytolysis activity, raising the concentration of cytokeratin CK-18, HbA1c, low-density lipoproteins, triglycerides, and the severity of fibrosis (FIB-4). EASL 2024 studies evaluated the diagnostic efficiency of non-invasive methods for assessing steatosis and liver fibrosis severity in MASLD (FIB-4, FibroScan®, Enhanced Liver Fibrosis (ELF), Vibration Controlled Transient Elastography (VCTE), LiverPRO, etc.). Due to the high prevalence of steatotic liver disease, comorbidities such as chronic viral hepatitis C, autoimmune hepatitis, and alcoholic liver disease - contributing to liver fibrosis progression and hepatocellular carcinoma - are significant. Promising drugs for MASLD treatment include resmethyrom, fibroblast growth factor 21 analogs (including pegosafermin), and pemvidutide, a long-acting, balanced GLP-1/glucagon dual receptor agonist.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"120-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological features of the dermis collagen fibers and regenerate filling the experimental skin wound cavity during its closure in different ways.","authors":"Halyna V Zhurakovska, Vladyslav O Malanchuk, Oksana S Volovar, Mykola V Oblap, Mykhailo S Myroshnychenko, Yevheniia A Hromko","doi":"10.36740/Merkur202501101","DOIUrl":"https://doi.org/10.36740/Merkur202501101","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Aim: The purpose was to determine the morphological features of collagen fibers of the dermis and regenerate filling the cavity of the experimental skin wound during its closure by different methods..&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients and methods: &lt;/strong&gt;Materials and Methods: The experimental study was conducted on 60 rats of the WAG population weighing 250-300 grams. Five groups were formed (12 rats in each group). Rats of groups 1-4 underwent a 1.5 cm long skin incision on the lateral surface of the neck. The formed defect in rats of group 1 was sutured with an interrupted suture, in group 2 it was sutured with an intradermal suture, in group 3 it was closed with skin glue based on 2-octyl cyanoacrylate, in group 4 it was welded with an electrocoagulator PATONMED EKVZ-300 (Ukraine). Group 5 included intact rats that did not undergo any manipulations. On the 7th and 14th day, 6 animals were removed from the experiment in groups 1-4. In group 5, all animals were removed from the experiment on the 7th day. The material for morphological study was a skin sample from the lateral surface of the neck. Histological, histochemical, morphometric and statistical research methods were used.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Results: In survey microscopy, collagen fibers located in the regenerate and surrounding dermis, in cases of experimental wound closure with nodal or intradermal sutures, had different directions of location, mostly looked thickened, and were interconnected, which led to the disappearance of intercellular spaces. In cases of wound closure with 2-octyl cyanoacrylate-based skin glue or by welding with the PATONMED EKVZ-300 electrocoagulator, collagen fibers looked mostly thinned, chaotically arranged in a dense intertwining network. The density of collagen fibers in the regenerate and the surrounding dermis did not differ depending on the different methods of wound closure. The collagen content in the collagen fibers of the regenerate increased on day 14 compared to day 7 for all methods of experimental wound closure. In cases of wound closure using a nodal or intradermal suture, the collagen content was higher compared to cases when the wound was closed with 2-octyl cyanoacrylate-based skin glue or by welding with the PATONMED EKVZ-300 electrocoagulator. In the collagen fibers of the dermis surrounding the wound, the collagen content was higher in cases of wound closure with a nodal or intradermal suture. In cases of wound closure using 2-octyl cyanoacrylate-based skin glue or by welding with the PATONMED EKVZ-300 electrocoagulator, the collagen content in the dermis surrounding the regenerated tissue corresponded to the control value.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Conclusions: Closing the surgical wound with a nodular or intradermal suture is likely to lead to the formation of skin scars in the future. In cases of wound closure using 2-octyl cyanoacrylate-based skin glue or by welding with the PATONMED EKVZ-300","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of sodium bicarbonate in the treatment of patients with urolithiasis.","authors":"Reza Fathi","doi":"10.36740/Merkur202501118","DOIUrl":"https://doi.org/10.36740/Merkur202501118","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aims to evaluate the efficacy and safety of sodium bicarbonate for the conservative treatment of urolithiasis, which may offer a meaningful alternative to conventional treatments for the disease, reduce the incidence of surgery and improve the quality of life of patients suffering from this condition..</p><p><strong>Patients and methods: </strong>Materials and Methods: A number of scientific methods such as analysis, including comparative, categorization, induction, synthesis, abstraction and bibliographic method were used in the execution of this study.</p><p><strong>Conclusion: </strong>Conclusions: Thus, the result of the study was a comprehensive review of current literature sources on the subject of modern ideas about urolithiasis, its structure and pathogenesis, ways of conservative treatment, including oral haemolysis and metaphylaxis with the main emphasis on the prospects of application in this context of sodium bicarbonate. This study has important practical implications for healthcare professionals as it offers an effective and affordable approach to the treatment and prevention of urolithiasis, which may reduce the need for invasive procedures and improve the quality of life of patients, thereby reducing overall healthcare costs and improving patient outcomes.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"126-133"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in mineral metabolism in blood and periodontium in animals with modelled peri-implantitis under the influence of a therapeutic and prophylactic complex.","authors":"Galyna F Biloklytska, Edhar O Petrosian, Iryna K Novytska, Olena V Tretiakova","doi":"10.36740/Merkur202501103","DOIUrl":"https://doi.org/10.36740/Merkur202501103","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the effectiveness of a therapeutic and prophylactic complex based on mineral metabolism markers in a peri-implantitis model under calcium deficiency conditions..</p><p><strong>Patients and methods: </strong>Materials and Methods: A peri-implantitis under calcium deficiency was modeled in experimental animals. The study evaluated the effects of a therapeutic and prophylactic complex, consisting of the oral gel \"Perioimplantgel\" and the dietary supplement \"Minerol,\" on markers of mineral metabolism in the blood and periodontal tissues of rats.</p><p><strong>Results: </strong>Results: Modeling peri-implantitis in experimental animals with calcium deficiency caused a significant decrease in magnesium, calcium, and phosphorus levels in the blood and periodontal tissues, accompanied by increased osteoresorption and alkaline phosphatase activation. The oral gel \"Perioimplantgel\" significantly reduced enzyme activity, while the combination with the dietary supplement \"Minerol\" stabilized all mineral metabolism markers, returning tchem to levels comparable to intact animals. These effects were more pronounced with prolonged use of the complex before and after implantation, suggesting its high osteoregenerative properties and the need for extended use.</p><p><strong>Conclusion: </strong>Conclusions: The applied experimental model of peri-implantitis in the conditions of calcium deficiency allowed for revealing the positive effect of the oral gel \"Perioimplantgel\" on the state of periodontal tissues during the installation of dental implants, as well as determining the indicators of mineral metabolism for its greatest effectiveness when used in combination with the dietary supplement \"Minerol\".</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}