Vladyslav O Bardash, Tetiana A Maksymets, Olha O Bondarenko, Halyna I Kovalchuk, Zoryana M Kit, Natalia V Karpyshyn, Eugen Ya Sklyarov
{"title":"Hepcidin as a marker of iron status in patients with chronic kidney disease.","authors":"Vladyslav O Bardash, Tetiana A Maksymets, Olha O Bondarenko, Halyna I Kovalchuk, Zoryana M Kit, Natalia V Karpyshyn, Eugen Ya Sklyarov","doi":"10.36740/Merkur202503113","DOIUrl":"https://doi.org/10.36740/Merkur202503113","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate hepcidin as a marker of iron status in chronic kidney disease (CKD) patients (stage 5 vs. stage 3), and to assess its association with iron injection status within the maintenance hemodialysis group.</p><p><strong>Patients and methods: </strong>Materials and Methods: This cross-sectional study compared 69 hemodialysis (stage 5 CKD [G1]) and 19 non-dialysis (stage 3 CKD [G2]) patients, assessing hepcidin, ferritin and hemoglobin. As a part of their standard anemia management, patients requiring iron administration received scheduled injections of ferric carboxymaltose.</p><p><strong>Results: </strong>Results: Hemodialysis patients (G1) had significantly lower hemoglobin and higher anemia prevalence than non-dialysis patients (G2), while baseline hepcidin and ferritin levels were comparable. Importantly, hepcidin levels were above the normal range in 85,5% and 84,2% of G1 and G2 patients, respectively. Hepcidin correlated positively with ferritin in both groups (G1: ρ=0,66, p<0,001; G2: ρ=0,87, p<0,001). Within G1, recent iron injections, administered in 24 patients, were significantly associated with higher hepcidin and ferritin, but not hemoglobin, as compared to patients without additional ferric therapy (n=45) (effect size: r=0,09 [by hemoglobin], r=0,80 [by hepcidin] and r=0,58 [by ferritin]).</p><p><strong>Conclusion: </strong>Conclusions: Significant iron metabolism impairment, marked by high hepcidin and ferritin prevalence, exists in both CKD stages studied. Although hemodialysis patients had lower hemoglobin, baseline hepcidin/ferritin levels were similar between groups. Within the hemodialysis group, recent iron injections were associated with increased hepcidin/ferritin but not hemoglobin. Findings suggest hepcidin may be a crucial indicator of functional iron availability in CKD, potentially offering more insight than ferritin, particularly reflecting acute changes following iron administration in hemodialysis patients.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 3","pages":"384-388"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piotr Czapski, Wiktoria Niegowska, Jan Domański, Aleksandra Witkowska, Jakub Wirkijowski, Paulina Woźniak, Katarzyna Januszewska, Małgorzta Kupisz-Urbańska, Ada Sawicka, Piotr Jankowski
{"title":"Statin use and muscle strength in older patients with heart failure.","authors":"Piotr Czapski, Wiktoria Niegowska, Jan Domański, Aleksandra Witkowska, Jakub Wirkijowski, Paulina Woźniak, Katarzyna Januszewska, Małgorzta Kupisz-Urbańska, Ada Sawicka, Piotr Jankowski","doi":"10.36740/Merkur202503101","DOIUrl":"https://doi.org/10.36740/Merkur202503101","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the association between statin use and muscle strength in older adults with heart failure (HF).</p><p><strong>Patients and methods: </strong>Materials and Methods: Hospitalized, older adults with HF were divided into two subgroups: use statin (US) and not use statin (N-US). Muscle strength was measured using a hand-held dynamometer and HF was assessed based on the New York Heart Association NYHA functional classification.</p><p><strong>Results: </strong>Results: 194 patients (median age 82 [78-86] years), 90 patients in US and 104 in N-US group. Muscle strength didn't differ significantly in US vs N-US group, 19.74kg (15.48-27.18) vs 17.58kg (12.73-25.66), p=0.098. In a multivariate analysis age, sex, NYHA class, hemoglobin concentration, presence of atrial fibrillation, and hypothyroidism were found to be independent factors of muscle strength (p<0.001, p<0.001, p<0.01, p<0.001, p=0.02, p=0.04 respectively).</p><p><strong>Conclusion: </strong>Conclusions: statin use is not related to decreased muscle strength in older adults with HF.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 3","pages":"295-301"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karol Batko, Aleksander Stefanik, Andrzej Witusik, Kasper Sipowicz, Tadeusz Pietras
{"title":"The influence of student classes in psychiatry on the perception of people with intellectual disabilities.","authors":"Karol Batko, Aleksander Stefanik, Andrzej Witusik, Kasper Sipowicz, Tadeusz Pietras","doi":"10.36740/Merkur202501110","DOIUrl":"10.36740/Merkur202501110","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To gain knowledge about the attitudes of medical students towards people with intellectual disabilities and the impact of psychiatry teaching on changing these attitudes..</p><p><strong>Patients and methods: </strong>Materials and Methods: The study involved 106 students of medical faculties who had not yet taken a course in psychiatry and 104 who had completed the course and passed the exam. The interviewers who conducted the research were the students themselves. The tool used in the study was a questionnaire of own design designed by a special educator and a psychiatrist. The questionnaire included questions about age and gender, as well as 5 statements of a discriminatory (rejecting) nature and 5 affirmative (accepting) statements indicating full acceptance of people with intellectual disabilities.</p><p><strong>Results: </strong>Results: Most of the people surveyed presented positive attitudes towards people with intellectual disabilities (approx. 88%). Approximately 12% of the respondents presented negative attitudes reflecting social stereotypes. The groups of students before and after completion of the classes in this subject did not differ in the frequency of the 10 selected attitudes studied.</p><p><strong>Conclusion: </strong>Conclusions: The vast majority of medical students surveyed present positive attitudes (judgments) regarding people with intellectual disability. Approximately 12% of the surveyed medical students present negative attitudes (judgments) towards persons with intellectual disability. There is no correlation between the completion of psychiatry classes and the frequency of negative attitudes (judgments) towards persons with intellectual disability among the surveyed medical students.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despoina Iordanidou, Ioannis Kouroutzis, Aristomenis Kotsakis, Vasileios Tzenetidis, Pavlos Sarafis, Maria Malliarou
{"title":"Psychosocial risks and musculoskeletal disorders (MSD's) nurses face in the hospital working environment.","authors":"Despoina Iordanidou, Ioannis Kouroutzis, Aristomenis Kotsakis, Vasileios Tzenetidis, Pavlos Sarafis, Maria Malliarou","doi":"10.36740/Merkur202501102","DOIUrl":"10.36740/Merkur202501102","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of this study was to investigate and correlate psychosocial risks and musculoskeletal disorders (MSDs) faced by nurses in the hospital work environment..</p><p><strong>Patients and methods: </strong>Materials and Methods: A cross-sectional study was conducted among 90 nurses (response rate: 56%) working in a General Hospital of Central Greece, from January to March 2023. A self-administered questionnaire was used for data collection, which included demographic information, characteristics of the nursing unit, the Copenhagen Psychosocial Questionnaire Version III (COPSOQ III), and the Nordic Musculoskeletal Questionnaire.</p><p><strong>Results: </strong>Results: No statistically significant differences were found between individual factors and the COPSOQ scales under examination, except for gender. Professional characteristics, however, were associated with psychosocial risks. For example, an increase in the number of nurses was positively associated with work demands. Conversely, night shifts were negatively associated with freedom of movement, as was the length of employment with opportunities for career development and the assessment of leadership quality. No statistically significant differences were found between MSDs and individual factors. Regarding the correlation between psychosocial risks and MSDs, the study revealed several associations among COPSOQ scales, such as work demands, work-life balance, freedom of movement, social support from colleagues and supervisors, job insecurity and satisfaction, interactions with others, health assessment, and mental exhaustion, with the occurrence of MSDs in body areas such as the neck, shoulders, elbows, wrists, hips, upper back, and ankles.</p><p><strong>Conclusion: </strong>Conclusions: The hospital work environment entails numerous psychosocial risk factors, and ensuring its safety requires their identification and evaluation. Interventions such as ergonomics training, acquiring ergonomic equipment, avoiding manual lifting, and training on the use of patient handling devices can increase risk awareness, reducing the frequency and intensity of musculoskeletal pain.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"12-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aigerim Sadyrbekova, Gulnara Svyatova, Galina Berezina, Roza Suleimenova, Alexandra Murtazaliyeva
{"title":"Study of abortion material in idiopathic habitual miscarriage of pregnancy: Literature review.","authors":"Aigerim Sadyrbekova, Gulnara Svyatova, Galina Berezina, Roza Suleimenova, Alexandra Murtazaliyeva","doi":"10.36740/Merkur202503117","DOIUrl":"https://doi.org/10.36740/Merkur202503117","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The study aims to review current scientific publications on the genetic study of foetal material in habitual miscarriage with an emphasis on a comparative analysis of the methods used traditional karyotyping and chromosomal microarray analysis. The material in this paper is based on an analysis of scientific publications covering the issues under study over the past five years.</p><p><strong>Patients and methods: </strong>Materials and Methods: This study reviewed cytogenetic diagnostic methods for detecting genetic abnormalities in foetal material from recurrent miscarriages. A comparative analysis of the widely used methods, karyotyping and chromosomal microarray analysis (CMA), was conducted to assess their strengths and limitations.</p><p><strong>Conclusion: </strong>Conclusions: Given its superior diagnostic capabilities, CMA should be adopted as the first-line method for investigating genetic abnormalities in cases of habitual miscarriage. Its ability to detect a wider range of chromosomal abnormalities allows for more accurate diagnosis and better-informed clinical decisions. The use of CMA in routine practice can significantly improve the management of future pregnancies, offering couples a greater chance of successful outcomes and providing reproductive health specialists with a more reliable tool for evaluating repeated pregnancy loss.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 3","pages":"409-417"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The influence of the mastoid air cell system buffer function on the appearance of a spontaneous perilymphatic fistula development.","authors":"Olga V Sherbul-Trokhymenko, Ilona A Srebniak","doi":"10.36740/Merkur202502109","DOIUrl":"https://doi.org/10.36740/Merkur202502109","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To examine mastoid pneumatisation in patients with perilymphatic fistula (PLF) and determine the influence of its buffering function on the onset and prognosis of the disease.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 37 patients with PLF and labyrinthine window ruptures, experiencing unilateral hearing loss on the affected side. Mastoid process length, the volume of the mastoid, the planimetric size of the mastoid, and the area of the mastoid air-containing cells were measured. The assessment was made by temporal bone computed tomography.</p><p><strong>Results: </strong>Results: Thirty-two patients had signs of impaired ventilation of the middle ear and mastoid due to Eustachian tube (ET) dysfunction. The length of the mastoid process and its planimetric size in patients with hypopneumatized mastoids were significantly lower than in patients with non-hypopneumatized mastoids (which included 4 cases of normal pneumatisation and 1 case of hyperpneumatised mastoid process). The area of air-containing cells of the mastoid, its volume, and the average length were significantly lower when compared to the corresponding indicators on the conditionally healthy ear side. The obtained data may indicate a disruption of the protective buffering function on the affected ear side and can be considered as one of the possible causes of PLF with labyrinthine window ruptures.</p><p><strong>Conclusion: </strong>Conclusions: Thus, when mastoid pneumatisation decreases, its buffering function is compromised, posing a risk of damage to the middle and inner ear with the potential occurrence of PLF and labyrinthine window ruptures. The effectiveness of treatment for these patients depends on a comprehensive approach.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"212-217"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piotr Kuzaka, Sharma Sumit, Bolesław Kuzaka, Piotr Radziszewski
{"title":"Schistosomiasis in urology. Outline of the problem.","authors":"Piotr Kuzaka, Sharma Sumit, Bolesław Kuzaka, Piotr Radziszewski","doi":"10.36740/Merkur202502115","DOIUrl":"https://doi.org/10.36740/Merkur202502115","url":null,"abstract":"<p><p>Schistosomiasis very often illness in endemic countries caused by schistosoma haematobium and very rare disease, in Poland caused especially by birds flukes, and in travellers and refugees from endemic countries. It is important for urologist to keep in mind in differential diagnosis also this disease. Symptoms of the disease are primarily due to the body's reaction to the parasite's eggs and dead flukes forms, which cause inflammatory infiltrates. In the early stages, these are reversible and curable, but in later stages, they lead to recidivans haematurie, fibrosis and calcification of the affected organ, resulting in subsequent changes, bladder neck strictures, ureteral strictures, vesico-ureteral reflux, calculi in the urinary tract, squamous cell carcinoma of the urinary bladder, renal failure, and others. In neglected cases, bilharziasis manifestations are fistulas on the scrotum with pseudo-elephantiasis changes.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"256-266"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tadeusz Pietras, Kasper Sipowicz, Andrzej Witusik, Anna Mosiołek, Karol Batko, Aleksander Stefanik
{"title":"Special pedagogy of people with intellectual disability and contemporary psychiatry in poland - mutual complementarity or lack of understanding?","authors":"Tadeusz Pietras, Kasper Sipowicz, Andrzej Witusik, Anna Mosiołek, Karol Batko, Aleksander Stefanik","doi":"10.36740/Merkur202502118","DOIUrl":"https://doi.org/10.36740/Merkur202502118","url":null,"abstract":"<p><p>Intellectual disability is the subject of interest of psychiatry and special education. Both sciences in Poland adopt an inclusive model of care for people with disabilities. The path of each of them from a directive model to an inclusive model has been different. The aim of the study is to compare the attitude towards people with intellectual disabilities and the evolution of changes that have taken place in Polish special education and in Polish psychiatry in the last few decades. The comparison was carried out using the narrative method through a review of key publications on the understanding of the intellectual disability phenomenon by special education in Poland and by psychiatry. In 1989, Polish special education departed from dialectical materialism as a binding doctrine in the social sciences. A postmodern understanding of the phenomenon of disability, culminating in the formulation of a humanistic paradigm of special education consisting of four microparadigms, developed instead. Special education moved away from quantitative research in favor of qualitative research, negating the biomedical aspects of disability. Qualitative and conceptual research studies carried out in Poland have not entered the global circulation of scientific information and are known locally in Poland. Polish psychiatry has undergone a less revolutionary path of change than special education. The development of community psychiatry in Western Europe slowly began to be implemented in Poland. It has been implemented in recent years in the form of mental health centers. Since the beginning of the political transformation, Polish psychiatry has been present in international journals in published English with the Impact Factor. Despite the postmodern, inclusive understanding of mental disorders, but in contrast to Polish special education, Polish psychiatry is based on quantitative research studies. Their results are published in international journals. Polish special pedagogy of people with intellectual disabilities, as well as Polish psychiatry, have undergone a significant paradigmatic reconstruction in the last few decades. Both sciences adopted an inclusive model of understanding intellectual disability. The different ways of development of the two sciences are reflected in publications and scientific research, as well as in certain terminological differences.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"277-283"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jakub Sadowski, Mateusz Roszak, Lech Kipiński, Krzysztof Kandziora, Aleksandra Szczerbaniewicz, Ina Żabicka, Beata Łabuz-Roszak
{"title":"Painful swelling of the skull as the first symptom of multiple myeloma - a case report.","authors":"Jakub Sadowski, Mateusz Roszak, Lech Kipiński, Krzysztof Kandziora, Aleksandra Szczerbaniewicz, Ina Żabicka, Beata Łabuz-Roszak","doi":"10.36740/Merkur202502119","DOIUrl":"10.36740/Merkur202502119","url":null,"abstract":"<p><p>This article presents the case of a 53-year-old patient who reported to the neurology emergency room because of painful swelling of the left side of the forehead, temple and parietal region that had been persisting for 4 days. In the interview, the patient is under constant cardiology care due to pharmacologically treated hypertension, additionally diagnosed with nephrolithiasis and left intercostal neuralgia as a result of chronic cough that had been persisting for 2 months. Neurological physical examination revealed slight facial asymmetry, with the left eyeball set deeper and the zygomatic bone less prominent on the left side. Noteworthy was the swelling of the soft tissues of the left side of the head, covering half of the forehead, temple and parietal region, without involvement of the back of the head or the right side. The patient underwent an imaging examination of the head using computed tomography (CT). Due to ambiguous changes in the bones of the skull cap, an extension of the diagnostics was ordered with magnetic resonance imaging (MRI). Very numerous osteolytic foci were found, which enhanced after contrast administration, scattered throughout the skull bone, and at least one foci in the spine - in the apex of the dentary tooth. The most probable origin of the changes was indicated as multiple myeloma, for differential diagnosis with other metastatic changes. The patient underwent a hematological consultation, during which a bone marrow aspirate and protein tests were taken. The histopathological result revealed numerous plasma cells and a monoclonal protein peak (M). A date was set for the patient to be admitted to the Hematology Department for further treatment.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 2","pages":"284-288"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olha Prykhodko, Olga Avilova, Serhii Dmytruk, Olha Yarmolenko, Alina Ponyrko
{"title":"The thymus structural organization in severe extracellular dehydration and during readaptation.","authors":"Olha Prykhodko, Olga Avilova, Serhii Dmytruk, Olha Yarmolenko, Alina Ponyrko","doi":"10.36740/Merkur202503107","DOIUrl":"https://doi.org/10.36740/Merkur202503107","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the changes of the thymus structure under extracellular dehydration and after rehydration in model experiment.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study was conducted on 40 white male rats, divided into 4 groups of 10 animals each. 2 experimental groups were subjected to extracellular dehydration during 90 days. Following this period, one group was removed from the experiment and other one was switched to the vivarium's standard ration for 30 days (rehydration). The control groups of animals received the vivarium's standard ration throughout the 90 days and the 120 days respectively. The morphometric analysis, histological examination, immunohistochemical analysis were used.</p><p><strong>Results: </strong>Results: 90 days extracellular dehydration leads to deformation of the thymocytes nuclei of rats, vacuolation or organelle destruction in cytoplasm, apoptosis and necrosis activation. The signs of stasis and thrombosis are present in thymic vessels. Functional thymus tissues replaced with connective and adipose tissues almost completely. After 30 days of rehydration reveals partial thymus restoration with lymphoid cell density increasing, with preserved morphological signs of cellular stress and structural remodelling, vascular abnormalities and incomplete restoration of thymus mass.</p><p><strong>Conclusion: </strong>Conclusions: In the context of severe extracellular dehydration, profound the depletion of functional thymus tissue, its substitution with connective and adipose tissue, and the occlusion of blood vessels. The morphological structure of the thymus doesn't complete recover during 30 days readaptation period. This suggest the need for prolonged rehydration periods or more effective interventions to fully restore thymic structure and function.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 3","pages":"340-346"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}