Polski Merkuriusz Lekarski最新文献

{"title":"The choice of classification to determine the optimal tactics for treatment of the thoracolumbar junction traumatic injuries.","authors":"Oleksii Nekhlopochyn, Vadim Verbov, Iaroslav Tsymbaliuk, Ievgen Cheshuk, Milan Vorodi","doi":"10.36740/Merkur202401116","DOIUrl":"10.36740/Merkur202401116","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the influence of the degree of detail of the nature of the pathomorphological changes in the osteoligamentous structures on the tactics of treating the patients with the traumatic damage to the thoracolumbar junction.</p><p><strong>Patients and methods: </strong>Materials and Methods: A retrospective analysis of the treatment tactics was carried out in 96 patients with a traumatic injury of the thoracolumbar junction, both those who underwent a surgical treatment and those who underwent a conservative therapy. The lesions were classified using F. Magerl and AOSpine classifications; the neurological status was assessed according to the ASIA scale, the nature of the damage was specified using the McCormack criteria. The statistical data processing was performed using the Random Forest machine learning algorithm.</p><p><strong>Results: </strong>Results: The nature of the injury makes it possible to unambiguously determine the optimal method of therapy when using the F. Magerl classification with a probability of 58.33%, while in relation to the AOSpine classification this figure is 55.21%. When building the models that include the nature of the damage, the level of the neurological disorders and the McCormack criteria, it was found that the use of the F. Magerl classification demonstrates an error in unambiguously determining the most effective treatment method at the level of 26.04%, while the use of AOSpine this figure was 21.88%.</p><p><strong>Conclusion: </strong>Conclusions: The application of the AOSpine classification is more promising for the development of a multifactorial algorithm for the treatment of the traumatic injuries of the thoracolumbar junction.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"104-111"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing medication adherence among patients with idiopathic inflammatory bowel disease in Greece and Cyprus: a cross-sectional study.","authors":"Anastasia N Nicolaou, Maria Saridi, Evangelos C Fradelos, Ioannis P Kaimakliotis, Konstantinos Giannakou, Konstantinos H Katsanos, Stavroula A Apostolidou","doi":"10.36740/Merkur202405103","DOIUrl":"https://doi.org/10.36740/Merkur202405103","url":null,"abstract":"<p><strong>Objective: </strong>. Aim: To examine the level of medication adherence among individuals diagnosed with inflammatory bowel disease (IBD) in Greece and Cyprus and assess the demographic, clinical, and psychosocial variables affecting it.</p><p><strong>Patients and methods: </strong>Materials and Methods: An anonymous self-administered questionnaire was administered to adult patients attending hospitals and treatment centers in Greece and Cyprus.</p><p><strong>Results: </strong>Results: From the total of 150 participants, 48.7% of patients took their medication when they had no symptoms, compared to 84% of symptomatic patients. For almost half of the patients, the main reason for non-adherence was daily obligations, while for 40.7% the reported reason was treatment-related side effects. 51.3% of the patients stated that they didn't require any assistance or reminders to improve their adherence. Adherence and reasons for not regularly taking medications were associated with sex, age, type, and duration of the disease as well as the type of treatment received.</p><p><strong>Conclusion: </strong>Conclusions: According to the findings of our study, patients perceived various obstacles, such as daily obligations and the side effects of prescribed drugs, which hindered their adherence to treatment. Adherence levels were found to be associated with demographic, disease-related, and treatment-related factors. These results underscore the importance of implementing timely and targeted interventions to enhance treatment adherence among patients with IBD.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 5","pages":"489-499"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the treatment effectiveness in children with coronavirus infection.","authors":"Olesya M Horlenko, Khrystyna A Hechko, Lyubomyra B Prylypko, Maria A Derbak, Mykhaylo Hechko, Fedir V Horlenko","doi":"10.36740/Merkur202405108","DOIUrl":"https://doi.org/10.36740/Merkur202405108","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study and analyze the treatment effectiveness in children with identified Coronavirus infection..</p><p><strong>Patients and methods: </strong>Materials and Methods: included the treatment and analysis of the study results of of children (n=68, aged 14.36}3.62 years), with confirmed Coronavirus infection, who were observed in outpatient settings and in comparison with the control group (n=28).</p><p><strong>Results: </strong>Results: Positive dynamics after treatment were observed in all parameters of the CBC (р4<0.01-0.03), except in the level of Platelets (р1=0.65; р2=0.3, р3=0.21, р4=0.59) and Eosinophils (p1=0.40, p4=0.06). The levels of vitamin D3 and Zn were below the reference limit at the initial stage of the study and reached the physiological norms (р2=0.14,р2=0.09, respectively). Increasings of Ig M levels in 2.7 times, Ig E - in 10.6 and Ig A -in 3.3 were observed on the starting stage and have positive trend with the normalization of the levels after 6 months, which was confirmed by statistical significance (р4=0 ,06, p4=0.10, p4=0.54, respectively).</p><p><strong>Conclusion: </strong>Conclusions: A level decrease in the the obtained indicators was observed after treatment in the next: IL-1 in 39.3 times, IL-4 in 6.6 times, IL-6 in 14.3 times, TNF-αin 49.2 times, γ-IFN in 11.2 times, D-dimer -in 14.1 times, Neopterin -in 10.1 times, CRP- in 5.4 times and Fibrinogen -1.9 times. The level of Anti IgGSARS-CoV-2S1-RBD exceeded the permissible level in 13.8 times. The levels of Adiponectin, Leptin and C-peptide significantly have decreased after treatment (p1<0.01) and after 6 months.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 5","pages":"529-535"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of university clinics in advancing higher medical education.","authors":"Lidiia V Butska, Viktor A Chernyak, Oksana O Drevitska, Hanna B Varina, Valentyn O Ryzhak, Volodymyr I Bulda, Olena A Mialovytska","doi":"10.36740/Merkur202405116","DOIUrl":"https://doi.org/10.36740/Merkur202405116","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To explore the multifaceted role of university clinics in shaping medical professionals, advancing medical knowledge, and improving healthcare delivery. Special attention is given to their function as primary platforms for practical training, the development of professional competencies, and the implementation of innovative teaching methods in medical education..</p><p><strong>Patients and methods: </strong>Materials and Methods: This article employs an analysis of the organizational structure, educational programs, and research initiatives of university clinics. Case studies, including the experience of the University Clinic of Taras Shevchenko National University of Kyiv, are utilized to provide insights into their operational challenges, successes, and future prospects.</p><p><strong>Conclusion: </strong>Conclusions: University clinics play a crucial role in medical education by fostering professional skills, clinical competencies, and ethical standards in future physicians. They significantly contribute to the evolution of medical education and healthcare improvement through innovative teaching methods and impactful research.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 5","pages":"583-588"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience factors of ukrainian students in the conditions of a war situation.","authors":"Nina V Kolіadenko, Inna V Mykhailyuk, Mykola M Shopsha, Olena L Shopsha, Khrystyna S Zhyvaho, Olena L Turynina, Oksana O Drevitska","doi":"10.36740/Merkur202406113","DOIUrl":"https://doi.org/10.36740/Merkur202406113","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the peculiarities and factors of resilience of students' personalities in the conditions of martial law..</p><p><strong>Patients and methods: </strong>Materials and Methods: A total of 248 students of universities (Kyiv, Ukraine) participated in the study (126 undergraduate students and 122 master's students). The following psychodiagnostic methods were used: Connor-Davidson resilience scale-10; Investigation of the level of reactive and personal anxiety of the Spielberger-Hanin personality; \"Coping behavior in stressful situations\"; Test of emotional intelligence MSCEIT-V 2.0.</p><p><strong>Results: </strong>Results: The results of our study showed that the ability to perceive, evaluate, identify and express emotions in master's students is more developed than in undergraduate students, which determines the choice of more optimal coping strategies and a higher level of individual resilience.</p><p><strong>Conclusion: </strong>Conclusions: It has been established that the long-term stressogenic influence of martial law causes a decrease in the level of resilience of students, insufficient compliance of their coping strategies and non-constructive coping behavior, an increase in the level of reactive anxiety and tension and exhaustion of adaptation resources, which justifies the need for appropriate psycho-corrective and psycho-prophylactic measures. The results of the study can be used to increase the resilience of students as a factor of ensuring the effectiveness of the educational process in the conditions of martial law.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 6","pages":"706-710"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of apoptotic and proliferative processes in experimental infected radiation-induced skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma.","authors":"Olena S Pushkar, Mykhailo S Myroshnychenko, Oleh M Koliada","doi":"10.36740/Merkur202401109","DOIUrl":"10.36740/Merkur202401109","url":null,"abstract":"<p><strong>Objective: </strong>. Aim: The purpose of the study was to identify the features of apoptotic and proliferative processes in experimental Staphylococcus aureus-infected radiation skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma.</p><p><strong>Patients and methods: </strong>Materials and Methods: An experimental study was conducted on 95 six-month-old male rats of the WAG population, which were divided into three groups. Group 1 included 25 animals that were simulated a radiation ulcer of the skin in the thigh area with subsequent application to its surface on the 7th day after irradiation with 0.2 ml of a suspension of the Staphylococcus aureus (ATCC 25923) reference strain (0.5 million microbial cells/cm2). Group 2 included 25 animals with Staphylococcus aureus-infected radiation skin ulcer, which were subjected to photodynamic therapy a day after infection. Group 3 included 45 animals with Staphylococcus aureus-infected radiation skin ulcers, which, 1 day after infection, received photodynamic therapy in the first half of the day, and in the second half of the day the periphery of the wound defect was injected with platelet-rich plasma. The material for the study was skin with underlying soft tissues from the area of radiation exposure. Histological, immunohistochemical, morphometric and statistical methods were used.</p><p><strong>Results: </strong>Results: In cases of simultaneous use of photodynamic therapy and platelet-rich plasma, compared with photodynamic therapy alone, the processes ofapoptosis and proliferation were more balanced, active, with a shift in the proliferative-apoptotic ratio towards proliferation processes and met the needs of the regenerative process. From the 10th to the 22nd day of the experiment these processes increased, which indicated active healing processes, that, during survey microscopy on the 22nd day, were manifested by the complete filling of the wound cavity with granulation and connective tissues with the presence of an epithelial layer on the surface of the regenerate. From the 22nd to the 45th day of the experiment, a decrease in the rate of regeneration was recorded, as evidenced by a decrease in the intensity of apoptotic and proliferative processes. The intensity of the latter was sufficient, which led to the healing of Staphylococcus aureus-infected radiation skin ulcer on the 45th day with complete restoration of the original structure of the skin.</p><p><strong>Conclusion: </strong>Conclusions: Photodynamic therapy in combination with the use of platelet-rich plasma balancedly activates apoptotic and proliferative processes with a predominance of the latter in granulation and connective tissues filling the lumen of Staphylococcus aureus-infected radiation skin ulcer, which on the 45th day of the experiment leads to wound healing with complete restoration of the original structure of the skin.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"54-59"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficiency and stability of surface-modified implants: acid modification versus photoactivation.","authors":"Serhii S Terekhov, Andriy M Proshchenko, Nina S Proshchenko, Dina V Shorikova","doi":"10.36740/Merkur202401107","DOIUrl":"10.36740/Merkur202401107","url":null,"abstract":"<p><strong>Objective: </strong>. Aim: To study the stability of surface-modified dental implants, with the usage of sandblasting/acid modification vs. photoactivation.</p><p><strong>Patients and methods: </strong>Materials and Methods: In the observation were included 164 patients with dental defects. All patients had digital impressions taken by scanning the oral cavity with an intraoral scanner 3Shape TRIOSR. Group A (80 subjects) included implants whose surface was modified with a combination of sandblasting and acid. Group B (84 subjects) - implants after modification with photoactivation. The implant stability quotient was recorded using an Osstell MentorTM device.</p><p><strong>Results: </strong>Results: The reliable effectiveness of the photoactivation method in complex treatment of the surface of dental implants in improving the stability of fixed dentures in the short and long-term periods of observation was proven. When assessing immediate clinical outcomes, there was no significant difference in the frequency of hyperemia, algesia, hyperthermia, soft tissue edema, regional lymphadenitis, depending on the classical method of treating the implant surface and the complex method with photoactivation. Of the long-term clinical outcomes with classical surface treatment, the absolute risk of implant failure was 1.2%, relative risk - 0,99 [CI%0,96-1,0]. The average value of the implant stability coefficient (ISQ) and the data of the Periotest study at the time of surgery probably did not differ in the observation groups, after 3 months, a higher index was proven in the treatment of the surface by the method of photoactivation and greater stability of the mandibular implants. At the time of implantation, there were no statistically significant differences in implant fixation between the groups, however, during prospective observation in group A, secondary stability indicators based on periotestometry results were significantly lower.</p><p><strong>Conclusion: </strong>Conclusions: It was proved the reliable effectiveness of the photoactivation-method for surface modification in the short and long-term periods of observation for improving the results of orthodontically treatment.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"42-48"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the influence of the shapes and dimensions of dental arches on the morphotopogeometric characteristics of the facial area.","authors":"Anatoliy Potapchuk, Vasyl Almashi, Arsenii Horzov, Svitlana Kostenko","doi":"10.36740/Merkur202403113","DOIUrl":"10.36740/Merkur202403113","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of the article is a comparative analysis of the main aspects of existing medical and diagnostic measures in patients with abnormal types of occlusal relationships and methods of mathematical and graphic reproduction of the shape of the dental arches, taking into account the individual characteristics of the maxillofacial area.</p><p><strong>Patients and methods: </strong>Materials and Methods: The search for relevant publications related to the objective topic was carried out through scientific databases: Scopus, PubMed, BVS and Scielo.</p><p><strong>Conclusion: </strong>Conclusions: The analysis of regression models of the reproduction of individual characteristics of the dental arch of the jaws will avoid errors that occur when comparing the actual sizes with their statistical norm, which will allow to correctly determine the proportionality and ratio of dif f erent departments of the dental and jaw system, the necessary amount of orthodontic measures in the treatment of anomalies of the dental arches.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 3","pages":"356-362"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of modulators of nitric oxide synthesis on the level of cytokines in bronchoalveolar lavage in experimental antiphospholipid syndrome.","authors":"Nataliia Mekhno, Nelia Hlyvka, Olha Furka, Olena Ruzhytska, Mariia Kulitska, Iryna Kuzmak, Olha Yaremchuk","doi":"10.36740/Merkur202403110","DOIUrl":"https://doi.org/10.36740/Merkur202403110","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of the research is to study the cytokine prof i le (IL-1β, IL 6, TNF-α, IL-4, IL-10) in bronchoalveolar lavage of lungs in experimental APS and its correction with L-arginine and aminoguanidine.</p><p><strong>Patients and methods: </strong>Materials and Methods: Antiphospholipid syndrome was modeled on white female BALB/c mice. L-arginine (25 mg/kg) and aminoguanidine (10 mg/kg) were used for its correction. The concentration of cytokines in bronchoalveolar lavage from the lungs was assessed using the ELISA test.</p><p><strong>Results: </strong>Results: It was established that in cases of APS the concentration of proinf l ammatory cytokines IL-1β, IL-6 and TNF-a increased in 1.9, 2.3 and 6.6 times, respectively, compare to the control. At the same time a decrease of the IL-4 in 1.7 and IL-10 in 1.8 times was found in the APS group compare to the control. L-arginine reduced the level of proinf l ammatory cytokines IL-1β by 22%, IL-6 - by 36%, and TNF-α - by 23% compare to the animals with APS. At the same time, the level of anti-inf l ammatory cytokines increased: IL-4 - by 46%, IL-10 - by 57% compare to the APS animal group. Aminoguanidine, a selective iNOS inhibitor, did not cause any signif i cant decrease in pro-inf l ammatory cytokines but the level of anti-inf l ammatory cytokines IL-4 increased by 44% and IL-10 - by 49%.</p><p><strong>Conclusion: </strong>Conclusions: The precursor of the NO synthesis L-arginine leads to a decrease in the concentrations of IL-1β, IL-6, TNF-a and an increase of IL-4 and IL-10 compare to the group of BALB/c mice with APS.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 3","pages":"332-336"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex features of the development of oxidative stress in high and low hypoxic resistancy rats, which experienced repeated stressful episodes of immobilization.","authors":"Olha V Denefil, Viktoria A Miroshnyk, Olena P Venher, Ruslan S Usynskyi, Olha O Liuta, Larysa Ya Fedoniuk","doi":"10.36740/Merkur202405102","DOIUrl":"https://doi.org/10.36740/Merkur202405102","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Aim: of the study was to find out the sexual characteristics of the development of oxidative stress in rats with high and low resistance to hypoxic hypoxia (HRH, LRH) during repeated stressful episodes of immobilization..&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients and methods: &lt;/strong&gt;Materials and Methods: The study was performed on 96 white HRH, LRH male and female Wistar rats. The animals were divided into eight groups: 1 - control (HRH, LRH) males and females, 2 - immobilization (HRH, LRH) males and females. Immobilization stress was induced by gently restraining the animals four Times by all paws and maxillary central incisors dorsally for 1 hour at an interval of 72 hours. The concentration of diene and triene conjugates (DC, TC), Schiff's bases (SB), TBA-active products (TBA-ap), activity of superoxide dismutase (SOD) and catalase (CAT), reduced glutathione (GSH), activity of glutathione peroxidase (GP) and glutathione reductase (GR) were determined in the homogenate of heart. A morphological study of heart preparations stained with hematoxilin and eosin was carried out. All studies were performed in control, after 24 hours after last immobilization.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Results: In control HRH, compared to LRH males, the values of TBA-ap were found to be lower. Under stress, an increase of LPO was noted in HRH and LRH males, only SB decreased. Higher level of LPO products noted in LRH rats compared to HRH. In control HRH females, compared to LRH, the content of DC, SB were higher and TBA-ap - lower. In HRH females, compared to HRH males, TC was higher and SB - lower. Under stress, in HRH females DC and TBA-ap were increased, TC and Sb - decreased. In LRH females all indicators increased. Lower TC and TBA-ap values were noted in HRH compared to LRH females rats. In control HRH males, compared to females, lower TC and higher values of SB were found. In LRH males, compared to females, the values of DC, TC, SB were higher. During stress, a more intensive course of LPO was noted in males. SOD in control HRH males, compared to LRH, was higher; CAT was not statistically different. Under stress, SOD decreased, CAT - increased. In HRH males, compared to LRH, in this group SOD was higher CAT - lower. In the control, HRH females, compared to LRH, had higher SOD, lower - CAT. Under stress, CAT increased in HRH females; in LRH females CAT decreased and SOD - increased. In HRH females, compared to LRH, CAT was higher. In control males, compared to females, SOD and CAT was higher. Under stress higher SOD was in females, and CAT - in males. GSH and GP were higher in control HRH compared to LRH males and females. Under stress, in males the GSH increased, GR decreased; GP in HRH decreased, in LRH it increased. HRH males, compared to LRH, GSH and GR were higher, GP - lower. Under stress, in females GSH, GP, GR in females decreased; HRH, compared to LRH, had higher GP and GH. In intact HRH males, compared to females, was higher GR and ","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 5","pages":"480-488"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}