Polski Merkuriusz Lekarski最新文献

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Morphological features of the dermis collagen fibers and regenerate filling the experimental skin wound cavity during its closure in different ways. 实验皮肤创面闭合过程中真皮胶原纤维的形态特征及再生填充方式的不同。
Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI: 10.36740/Merkur202501101
Halyna V Zhurakovska, Vladyslav O Malanchuk, Oksana S Volovar, Mykola V Oblap, Mykhailo S Myroshnychenko, Yevheniia A Hromko
{"title":"Morphological features of the dermis collagen fibers and regenerate filling the experimental skin wound cavity during its closure in different ways.","authors":"Halyna V Zhurakovska, Vladyslav O Malanchuk, Oksana S Volovar, Mykola V Oblap, Mykhailo S Myroshnychenko, Yevheniia A Hromko","doi":"10.36740/Merkur202501101","DOIUrl":"10.36740/Merkur202501101","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The purpose was to determine the morphological features of collagen fibers of the dermis and regenerate filling the cavity of the experimental skin wound during its closure by different methods..</p><p><strong>Patients and methods: </strong>Materials and Methods: The experimental study was conducted on 60 rats of the WAG population weighing 250-300 grams. Five groups were formed (12 rats in each group). Rats of groups 1-4 underwent a 1.5 cm long skin incision on the lateral surface of the neck. The formed defect in rats of group 1 was sutured with an interrupted suture, in group 2 it was sutured with an intradermal suture, in group 3 it was closed with skin glue based on 2-octyl cyanoacrylate, in group 4 it was welded with an electrocoagulator PATONMED EKVZ-300 (Ukraine). Group 5 included intact rats that did not undergo any manipulations. On the 7th and 14th day, 6 animals were removed from the experiment in groups 1-4. In group 5, all animals were removed from the experiment on the 7th day. The material for morphological study was a skin sample from the lateral surface of the neck. Histological, histochemical, morphometric and statistical research methods were used.</p><p><strong>Results: </strong>Results: In survey microscopy, collagen fibers located in the regenerate and surrounding dermis, in cases of experimental wound closure with nodal or intradermal sutures, had different directions of location, mostly looked thickened, and were interconnected, which led to the disappearance of intercellular spaces. In cases of wound closure with 2-octyl cyanoacrylate-based skin glue or by welding with the PATONMED EKVZ-300 electrocoagulator, collagen fibers looked mostly thinned, chaotically arranged in a dense intertwining network. The density of collagen fibers in the regenerate and the surrounding dermis did not differ depending on the different methods of wound closure. The collagen content in the collagen fibers of the regenerate increased on day 14 compared to day 7 for all methods of experimental wound closure. In cases of wound closure using a nodal or intradermal suture, the collagen content was higher compared to cases when the wound was closed with 2-octyl cyanoacrylate-based skin glue or by welding with the PATONMED EKVZ-300 electrocoagulator. In the collagen fibers of the dermis surrounding the wound, the collagen content was higher in cases of wound closure with a nodal or intradermal suture. In cases of wound closure using 2-octyl cyanoacrylate-based skin glue or by welding with the PATONMED EKVZ-300 electrocoagulator, the collagen content in the dermis surrounding the regenerated tissue corresponded to the control value.</p><p><strong>Conclusion: </strong>Conclusions: Closing the surgical wound with a nodular or intradermal suture is likely to lead to the formation of skin scars in the future. In cases of wound closure using 2-octyl cyanoacrylate-based skin glue or by welding with the PATONMED EKVZ-300","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of sodium bicarbonate in the treatment of patients with urolithiasis. 碳酸氢钠在尿石症治疗中的应用。
Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI: 10.36740/Merkur202501118
Reza Fathi
{"title":"The use of sodium bicarbonate in the treatment of patients with urolithiasis.","authors":"Reza Fathi","doi":"10.36740/Merkur202501118","DOIUrl":"10.36740/Merkur202501118","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aims to evaluate the efficacy and safety of sodium bicarbonate for the conservative treatment of urolithiasis, which may offer a meaningful alternative to conventional treatments for the disease, reduce the incidence of surgery and improve the quality of life of patients suffering from this condition..</p><p><strong>Patients and methods: </strong>Materials and Methods: A number of scientific methods such as analysis, including comparative, categorization, induction, synthesis, abstraction and bibliographic method were used in the execution of this study.</p><p><strong>Conclusion: </strong>Conclusions: Thus, the result of the study was a comprehensive review of current literature sources on the subject of modern ideas about urolithiasis, its structure and pathogenesis, ways of conservative treatment, including oral haemolysis and metaphylaxis with the main emphasis on the prospects of application in this context of sodium bicarbonate. This study has important practical implications for healthcare professionals as it offers an effective and affordable approach to the treatment and prevention of urolithiasis, which may reduce the need for invasive procedures and improve the quality of life of patients, thereby reducing overall healthcare costs and improving patient outcomes.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"126-133"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in mineral metabolism in blood and periodontium in animals with modelled peri-implantitis under the influence of a therapeutic and prophylactic complex. 在治疗和预防复合物的影响下,模拟种植周炎动物血液和牙周组织中矿物质代谢的变化。
Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI: 10.36740/Merkur202501103
Galyna F Biloklytska, Edhar O Petrosian, Iryna K Novytska, Olena V Tretiakova
{"title":"Changes in mineral metabolism in blood and periodontium in animals with modelled peri-implantitis under the influence of a therapeutic and prophylactic complex.","authors":"Galyna F Biloklytska, Edhar O Petrosian, Iryna K Novytska, Olena V Tretiakova","doi":"10.36740/Merkur202501103","DOIUrl":"10.36740/Merkur202501103","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the effectiveness of a therapeutic and prophylactic complex based on mineral metabolism markers in a peri-implantitis model under calcium deficiency conditions..</p><p><strong>Patients and methods: </strong>Materials and Methods: A peri-implantitis under calcium deficiency was modeled in experimental animals. The study evaluated the effects of a therapeutic and prophylactic complex, consisting of the oral gel \"Perioimplantgel\" and the dietary supplement \"Minerol,\" on markers of mineral metabolism in the blood and periodontal tissues of rats.</p><p><strong>Results: </strong>Results: Modeling peri-implantitis in experimental animals with calcium deficiency caused a significant decrease in magnesium, calcium, and phosphorus levels in the blood and periodontal tissues, accompanied by increased osteoresorption and alkaline phosphatase activation. The oral gel \"Perioimplantgel\" significantly reduced enzyme activity, while the combination with the dietary supplement \"Minerol\" stabilized all mineral metabolism markers, returning tchem to levels comparable to intact animals. These effects were more pronounced with prolonged use of the complex before and after implantation, suggesting its high osteoregenerative properties and the need for extended use.</p><p><strong>Conclusion: </strong>Conclusions: The applied experimental model of peri-implantitis in the conditions of calcium deficiency allowed for revealing the positive effect of the oral gel \"Perioimplantgel\" on the state of periodontal tissues during the installation of dental implants, as well as determining the indicators of mineral metabolism for its greatest effectiveness when used in combination with the dietary supplement \"Minerol\".</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 1","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Odontogenic infections in pregnant women. 孕妇的牙源性感染。
Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI: 10.36740/Merkur202503116
Katarzyna Grudnik, Małgorzata Grudnik, Julia Smyczek, Maciej Słomian, Monika Prokurat, Mateusz Jagielski, Karolina Lau, Janusz Kasperczyk
{"title":"Odontogenic infections in pregnant women.","authors":"Katarzyna Grudnik, Małgorzata Grudnik, Julia Smyczek, Maciej Słomian, Monika Prokurat, Mateusz Jagielski, Karolina Lau, Janusz Kasperczyk","doi":"10.36740/Merkur202503116","DOIUrl":"https://doi.org/10.36740/Merkur202503116","url":null,"abstract":"<p><p>Odontogenic infections in pregnant women pose a threat to the health of both the mother and her unborn child. Adjusting diagnostics and treatment for this group of patients presents numerous challenges for dental practitioners. The National Health Fund in Poland provides additional dental services for pregnant and also postpartum women. Access to these services is critical for the well-being of pregnant women and their future children, on condition of providing safe treatment. Despite the reduction in the risk of dental complications, there is concern that some patients may delay treatment until pregnancy. Therefore, a key aspect is educating the public on the risks of untreated oral pathologies, promoting oral hygiene, and encouraging regular dental check-ups. This article analyzes the key aspects related to the dangers of untreated dental infections, presents the mechanisms of the most common diseases, and outlines basic forms of treatment, diagnostic and therapeutic limitations due to pregnancy, as well as the influence of the legal system in Poland on the potential decisions of pregnant women to undergo treatment.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 3","pages":"403-408"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protection of the rights of drug addicts and the right to a fair trial: Practice of the European court of human rights. 保护吸毒者的权利和获得公平审判的权利:欧洲人权法院的实践。
Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI: 10.36740/Merkur202504114
Oleksandr M Shevchuk, Oleksandr M Drozdov, Oleksandra V Babaieva, Inna L Bespalko, Alisa V Panova
{"title":"Protection of the rights of drug addicts and the right to a fair trial: Practice of the European court of human rights.","authors":"Oleksandr M Shevchuk, Oleksandr M Drozdov, Oleksandra V Babaieva, Inna L Bespalko, Alisa V Panova","doi":"10.36740/Merkur202504114","DOIUrl":"https://doi.org/10.36740/Merkur202504114","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To identify violations of the rights of persons who use psychoactive substances through the analysis of decisions of the European Court of Human Rights within the framework of the implementation of the right to a fair trial in cases related to illicit drug trafficking, and to propose directions for reducing their negative impact on public health..</p><p><strong>Patients and methods: </strong>Materials and Methods: The methodological basis of the article is a set of methods and techniques of scientific knowledge.</p><p><strong>Conclusion: </strong>Conclusions: Respect for the rights of persons who use psychoactive substances, including their full exercise of the right to a fair trial, remains a key element of the rule of law, particularly in the context of protecting their lives and public health, and is an obligation of the state.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 4","pages":"529-533"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of melatonin on antioxidant defense indicators in the blood of rats with insulin resistance. 褪黑素对胰岛素抵抗大鼠血液中抗氧化防御指标的影响。
Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI: 10.36740/Merkur202505112
Oleksandra Yu Kushnir, Iryna Yaremii, Kyrylo Pantsiuk, Volodymyr Vivsyannuk, Inna Buzdugan, Olga Bukach, Georgiy Prodanchuk
{"title":"The effect of melatonin on antioxidant defense indicators in the blood of rats with insulin resistance.","authors":"Oleksandra Yu Kushnir, Iryna Yaremii, Kyrylo Pantsiuk, Volodymyr Vivsyannuk, Inna Buzdugan, Olga Bukach, Georgiy Prodanchuk","doi":"10.36740/Merkur202505112","DOIUrl":"https://doi.org/10.36740/Merkur202505112","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine the effect of melatonin on the activities of glucose-6-phosphate dehydrogenase, glutathione reductase, glutathione peroxidase and the content of reduced glutathione, glucose and insulin levels in the blood of rats with insulin resistance.</p><p><strong>Patients and methods: </strong>Materials and Methods: Research performed in compliance with the Rules of the work using experimental animals (1977) and the Council of Europe Convention on the Protection of Vertebrate Animals used in experiments (Strasbourg, 1986). Sexually mature 18-month-old outbred white male rats were divided into groups: 1) control, 2) insulin resistant rats (dexamethasone at a dose of 0.125 mg/kg for 13 days daily), 3) insulin resistant rats ingested with metformin (200 mg/kg) daily, 4) insulin resistant rats were orally administered melatonin at a dose of 10 mg/kg daily. Measurement of fasting glucose content in the blood from the tail vein (One Touch, USA) and insulin in the blood serum (immunochemiluminescent analyzer Snibe Co., Ltd, the Maglumi test kit, China) was performer on the 14th day. Blood was taken to determine the parameters of glutathione system by using standard methods. Statistical processing was performed using the IBM SPSS Statistics 21 program. Differences were considered statistically significant at p≤0.05.</p><p><strong>Results: </strong>Results: Melatonin ingestion as well as metformin were helpful in normalization of insulin level on the background of glucose level restoration and antioxidant system activation.</p><p><strong>Conclusion: </strong>Conclusions: We have established the hypoglycemic and antioxidant effects of melatonin on the background of dexamethasone-induced insulin resistance.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 5","pages":"641-647"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of ophthalmologists' opinions on the influence of current conditions in Ukraine on the organization of medical care for glaucoma patients. 眼科医生对乌克兰现状对青光眼患者医疗护理组织的影响的意见研究。
Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI: 10.36740/Merkur202505117
Volodymyr O Melnyk, Kateryna O Bobkovych, Maryna O Pavlovska, Borys I Palamar
{"title":"Study of ophthalmologists' opinions on the influence of current conditions in Ukraine on the organization of medical care for glaucoma patients.","authors":"Volodymyr O Melnyk, Kateryna O Bobkovych, Maryna O Pavlovska, Borys I Palamar","doi":"10.36740/Merkur202505117","DOIUrl":"https://doi.org/10.36740/Merkur202505117","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the professional opinions of ophthalmologists who provide medical care to glaucoma patients in current conditions in Ukraine, particularly regarding the impact of Russia's full-scale invasion of Ukraine on the organization, quality, and timeliness of medical care for these patients.</p><p><strong>Patients and methods: </strong>Materials and Methods: The research materials were data from a voluntary anonymous questionnaire survey of 322 ophthalmologists from various regions of Ukraine who work in public and private medical institutions. Data from the Kyiv City Information and Analytical Center of Medical Statistics were also analyzed.</p><p><strong>Results: </strong>Results: According to the ophthalmologists, the proportion of patients with secondary glaucoma (62,9±3,5%) and open-angle glaucoma (34,4±3,5%) has increased, as well as the proportion of patients with stage III glaucoma (61,6±3,4%). Since the onset of the full-scale invasion, the number of glaucoma patients seeking ophthalmological help late (74,8±2,4%) or irregularly (83,5±2,1%) has increased. A total of 62,7±2,7% of ophthalmologists report that glaucoma patients are effectively refusing surgical treatment, mostly due to a lack of financial resources to undergo the operation (82,7±2,7%).</p><p><strong>Conclusion: </strong>Conclusions: The war has had a negative impact on the ability to provide quality ophthalmologic care, particularly to patients with open-angle glaucoma. The findings may be used to identify opportunities and strategies for improving the quality of ophthalmologic care.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 5","pages":"676-682"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building a child-centred, multilayered MHPSS eco-system for conflict-affected children (Ukraine). 为受冲突影响的儿童建立以儿童为中心的多层次MHPSS生态系统(乌克兰)。
Polski Merkuriusz Lekarski Pub Date : 2025-01-01 DOI: 10.36740/Merkur202505105
Viktor Vus, Oleksii Nalyvaiko, Liliya Zotova, Natalia Kostruba, Evangelos Fradelos, Ioanna V Papathanasiou
{"title":"Building a child-centred, multilayered MHPSS eco-system for conflict-affected children (Ukraine).","authors":"Viktor Vus, Oleksii Nalyvaiko, Liliya Zotova, Natalia Kostruba, Evangelos Fradelos, Ioanna V Papathanasiou","doi":"10.36740/Merkur202505105","DOIUrl":"https://doi.org/10.36740/Merkur202505105","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This article aims to propose a multilayered, child-centred Mental Health and Psychosocial Support (MHPSS) ecosystem model tailored for conflict-affected children (on example of Ukraine). The model integrates evidence-based interventions, multisectoral collaboration, and cultural adaptation to address acute psychosocial distress and foster long-term resilience, offering a replicable blueprint for humanitarian contexts.</p><p><strong>Patients and methods: </strong>Materials and Methods: The development of the MHPSS ecosystem model was informed by a comprehensive review of theoretical frameworks, peerreviewed literature, international reports, and successful MHPSS interventions in humanitarian settings. The model synthesizes the Inter-Agency Standing Committee (IASC) pyramid of psychosocial intervention and Bronfenbrenner's ecological systems theory, contextualized through analysis of UNICEF and WHO reports, Ukraine's National the Action Plan for 2024-2026 and Target Model of the MHPSS System, and global best practices. An 11-stage implementation plan was formulated, incorporating adaptation, governance, capacity building, database/certification, supervision, quality assurance, and policy integration, guided by implementation science frameworks.</p><p><strong>Results: </strong>Results: The proposed model operationalizes a coordinated, scalable MHPSS ecosystem centred on children, layered across family, school, service infrastructure, and policy. Through localization, community-driven delivery, and multisectoral governance, the model enhances cultural fit, professionalizes the MHPSS workforce, and embeds continuous quality improvement. Integration with Community Resilience Centres (CRCs) strengthens local service delivery and sustainability. The staged implementation plan provides a universal roadmap for bridging immediate psychosocial needs and long-term systemic resilience.</p><p><strong>Conclusion: </strong>Conclusions: The multilayered MHPSS ecosystem represents a paradigm shift in addressing the psychosocial impact of conflict on children. By embedding evidence-based, contextually adapted supports within a sustainable multisectoral framework, the model offers significant potential to mitigate distress and promote resilience, serving as a foundation for future research and global replication.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"53 5","pages":"592-599"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of enterosgel on the activity of energy supply processes in rats at the same time affected by malathion and tetrachlormethane. 肠溶凝胶对同时受马拉硫磷和四氯甲烷影响的大鼠能量供应过程活性的影响
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202404107
Larysa Boiko, Oksana Kachur, Petro Lykhatskyi, Dmytro Fira, Liudmyla Fira
{"title":"The effect of enterosgel on the activity of energy supply processes in rats at the same time affected by malathion and tetrachlormethane.","authors":"Larysa Boiko, Oksana Kachur, Petro Lykhatskyi, Dmytro Fira, Liudmyla Fira","doi":"10.36740/Merkur202404107","DOIUrl":"https://doi.org/10.36740/Merkur202404107","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of the study was to investigate the activity of bioenergetic processes in rats under conditions of simultaneous exposure to malathion and carbon tetrachloride and after the use of enterosgel.</p><p><strong>Patients and methods: </strong>Materials and Methods: Experiments were conducted on rats. The rats were divided into nine groups.Malathion was administered daily (for 30 days) at a dose of 20 mg / kg body weight of the animal. Tetrachloromethane was administered twice (every other day) as a 50% oil solution at a dose of 1.0 ml / kg body weight. The intensity of energy supply processes was assessed by the activity of succinate dehydrogenase and cytochrome oxidase, impaired carbohydrate metabolism in terms of glucose and glycogen.</p><p><strong>Results: </strong>Results: It was noted that succinate dehydrogenase activity in the liver decreased 2 times, in the myocardium - 1.6 times. On the thirty and seventh day of administration of toxicants after enterosorbent use, succinate dehydrogenase activity increased in the liver by 20%, cytochrome oxidase by 27%, in the myocardium - by 31% and 23%, respectively. The content of glucose in the serum after exposure to toxicants increased maximally (2.4 times) at the end of the study. In contrast, the glycogen content in the liver decreased by 48%, in the myocardium by 13%. The use of enterosgel resulted in a decrease in serum glucose.</p><p><strong>Conclusion: </strong>Conclusions: The use of enterosgel leads to the restoration of energy processes in the body of affected rats, which is confirmed by increased activity of mitochondrial enzymes, lowering glucose and increasing glycogen in the studied organs.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 4","pages":"427-432"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing precision and safety in dental surgery - the advantages of piezosurgery. 提高牙科手术的精确性和安全性--压电手术的优势。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202404113
Agnieszka Rolek
{"title":"Enhancing precision and safety in dental surgery - the advantages of piezosurgery.","authors":"Agnieszka Rolek","doi":"10.36740/Merkur202404113","DOIUrl":"https://doi.org/10.36740/Merkur202404113","url":null,"abstract":"<p><p>Piezosurgery in dentistry is an innovative surgical technique utilizing ultrasonic vibrations to precisely cut bone tissue while minimizing damage to surrounding soft tissues. This method is particularly advantageous for delicate procedures in oral and maxillofacial surgery, including bone graft harvesting, sinus lifts, and tooth extractions. Piezosurgery operates on the principle of piezoelectricity, discovered by Jacques and Pierre Curie in the 19th century, where a piezoelectric crystal converts oscillating electric fields into mechanical vibrations. Devices used in piezosurgery generate ultrasonic frequencies (25-30 kHz) that enable linear vibrations and controlled cutting, selective for mineralized tissues.The technology offers significant benefits over conventional surgical methods, including improved visibility, precise and smooth cuts, and a reduced risk of soft tissue damage. Clinical applications of piezosurgery demonstrate its effectiveness in preserving vital cells such as osteoblasts and osteocytes, promoting faster healing, and better osseointegration of implants. Specialized inserts and operating modes enhance its versatility for various surgical needs. Piezosurgery has shown to lower postoperative complications and enhance patient safety in complex procedures like sinus lifts and bone splitting. This advanced surgical technique represents a significant improvement in dental and oral surgery, offering enhanced precision, safety, and clinical outcomes, ultimately improving the standard of care and patient satisfaction.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 4","pages":"462-465"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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