Oleksandr M Shevchuk, Oksana O Volodina, Yevhen V Povzyk, Valeriia V Klimova
{"title":"Legal qualification of collaborationism in healthcare.","authors":"Oleksandr M Shevchuk, Oksana O Volodina, Yevhen V Povzyk, Valeriia V Klimova","doi":"10.36740/Merkur202601115","DOIUrl":"https://doi.org/10.36740/Merkur202601115","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate approaches to the criminal legal qualification of collaborationism in the field of healthcare, taking into account the norms of international humanitarian law.</p><p><strong>Patients and methods: </strong>Materials and Methods: The research methodology involves an analysis of current legislative documents on the qualification of criminal liability for collaborative activities, as well as regulatory legal acts in the healthcare field, and documents of international humanitarian law. The data analysis was conducted using open sources, mainly for the period 2013-2025, with an emphasis on the period of the active phase of the war in Ukraine. The main search keywords were \"human rights\", \"collaborationism\", \"criminal liability\", \"crimes against the foundations of national security\", \"medical immunity in international humanitarian law\", and \"healthcare\". The initial database consisted of 70 sources, of which 34 were included in the final analysis. The materials of the publication form the basis for the systematization of criminal legislation on the problems of protecting the rights of persons accused of collaborative activities in the field of healthcare, the key ones being the Constitution of Ukraine, the Criminal Code of Ukraine, and the European Convention on Human Rights.</p><p><strong>Conclusion: </strong>Conclusions: The study emphasizes the need to improve the approach to the criminal legal qualification of collaborationism in the health sector, which covers both legal and organizational components, as well as mandatory compliance with the norms of international humanitarian law. The social danger of this phenomenon lies not only in the fact that it encroaches on the defense capability and foundations of national security, but also in the fact that it poses a threat to other objects of criminal law protection.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 1","pages":"95-99"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Volodymyr I Ostrianko, Inessa I Yakubova, Victor Y Dosenko, Roman I Andriiashyk
{"title":"Biomarkers of cellular senescence in bone tissue.","authors":"Volodymyr I Ostrianko, Inessa I Yakubova, Victor Y Dosenko, Roman I Andriiashyk","doi":"10.36740/Merkur202601108","DOIUrl":"https://doi.org/10.36740/Merkur202601108","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To summarize the biomarkers of cellular senescence in bone tissue and discuss their potential relevance for clinical risk stratification and outcomes related to bone remodeling and implant osseointegration.</p><p><strong>Patients and methods: </strong>Materials and Methods: A narrative literature review was performed using PubMed and Google Scholar searches focused on osteoblast, osteocyte and mesenchymal stem cell senescence, DNA damage response, senescence-associated secretory phenotype, oxidative stress, and epigenetic regulation in bone. Eligible peer-reviewed publications were screened for evidence on established and emerging senescence biomarkers, detection methods (histochemical, immunohistochemical, molecular, and secretory profiling), and mechanistic links to impaired osteogenesis and enhanced osteoclastogenesis. Findings were synthesized into practical biomarker categories (molecular, cellular/tissue, and functional) with emphasis on translational implications for dental implant planning and peri-implant bone stability.</p><p><strong>Conclusion: </strong>Conclusions: Bone cellular senescence is characterized by increased SA-β-gal activity, upregulation of cell-cycle inhibitors (p16INK4a, p21CIP1/WAF1, p53-related pathways), persistent DNA damage signaling, and a proinflammatory secretory phenotype that promotes osteoclast activation and suppresses osteogenesis. Tissue-level changes include reduced osteoblast function, osteocyte loss, and a shift toward resorptive remodeling reflected by an elevated RANKL/OPG ratio. Emerging signals (e.g., selected long non-coding RNAs and innate immune sensors such as TLR9) may complement classic markers in future panels. Integrating senescence-related biomarkers into clinical assessment may support individualized protocols for patients with biologically compromised bone and inform targeted preventive strategies.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 1","pages":"54-59"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Igor S Brodetskyi, Nataliia M Savielieva, Mykhailo S Myroshnychenko, Shaker J Tarawneh, Liudmyla O Brodetska, Yevheniia A Hromko, Sergey B Brodetskyi, Andrii A Boiko, Yaroslava А Kulbashna, Larysa V Natrus, Yuliia G Klys, Olha I Koval
{"title":"Significance of Epstein-Barr Virus and Human Papillomavirus type 16 in the development of pleomorphic adenomas of the salivary glands.","authors":"Igor S Brodetskyi, Nataliia M Savielieva, Mykhailo S Myroshnychenko, Shaker J Tarawneh, Liudmyla O Brodetska, Yevheniia A Hromko, Sergey B Brodetskyi, Andrii A Boiko, Yaroslava А Kulbashna, Larysa V Natrus, Yuliia G Klys, Olha I Koval","doi":"10.36740/Merkur202603103","DOIUrl":"https://doi.org/10.36740/Merkur202603103","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of the study was to determine the role of Epstein-Barr virus and human papillomavirus (HPV) type 16 in the development of pleomorphic adenoma of the salivary gland by identifying the viruses in tumor tissue, oral mucosal epithelium, oral fluid, and blood.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 30 patients with a morphologically confirmed diagnosis of pleomorphic adenoma of the parotid salivary glands, who were assigned to group 1. The control group (group 2) consisted of 10 patients who had no tumor or non-tumor salivary gland pathology either during life or at autopsy examination. To identify Epstein-Barr virus and HPV type 16, an immunohistochemical examination of tumor tissue fragments in group 1 and salivary gland tissue fragments in group 2 was performed, as well as polymerase chain reaction (PCR) analysis of blood, buccal scraping, and oral fluid. Statistical analysis of the obtained data was performed using the PAST software (version 4.15, Natural History Museum, University of Oslo, Norway). Mean values of indicators were compared using the Mann-Whitney U test.</p><p><strong>Results: </strong>Results: The immunohistochemical reaction with mouse monoclonal antibody (MMA) to HPV type 16 was positive in a significantly greater (p<0.05) number of cases in group 1 (26 cases, 86.7%) compared with group 2 (3 cases, 42.9%). The number of cases with a positive immunohistochemical reaction with MMA to anti-Epstein-Barr virus was significantly higher (p<0.05) in group 1 (8 cases, 26.7%) compared with group 2 (1 case, 14.3%). PCR study of buccal scraping, blood and oral fluid samples from patients in group 1 revealed a lower number of cases with a positive reaction compared with the immunohistochemical examination of tumor tissue. In group 2, this analysis did not detect any positive cases at all. In group 1 PCR enabled the detection of Epstein-Barr virus DNA in buccal scraping in 2 cases, accounting for 6.7%; in oral fluid samples in 4 patients (13.3%); in blood samples in 4 patients (13.3%). The study of buccal scraping, oral fluid and blood by PCR in patients from group 1 enabled the detection of HPV type 16 DNA, respectively, in 1 case (3.3%), 2 cases (6.7%), 2 cases (6.7%).</p><p><strong>Conclusion: </strong>Conclusions: HPV type 16 appears to play a greater role in the genesis of pleomorphic adenomas of the parotid salivary glands compared with Epstein-Barr virus. Immunohistochemical examination of tumor tissue is an effective method for demonstrating the role of HPV type 16 and Epstein-Barr virus in the development of pleomorphic adenomas of the salivary glands. PCR analysis of oral fluid, blood, and buccal scraping is not a sufficiently sensitive or reliable method for identifying the investigated viruses in patients with pleomorphic adenomas.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"259-264"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eleni Albani, Aikaterini Toska, Olympia Perivolari, Constantinos Togas, Ioanna Dimitriadou, Evangelos C Fradelos, Ioannis Moisoglou, Kyriakos Souliotis, Maria Saridi
{"title":"Investigating the psychosocial and financial burden and perceived social support of parents with hospitalized children in Greece.","authors":"Eleni Albani, Aikaterini Toska, Olympia Perivolari, Constantinos Togas, Ioanna Dimitriadou, Evangelos C Fradelos, Ioannis Moisoglou, Kyriakos Souliotis, Maria Saridi","doi":"10.36740/Merkur202603105","DOIUrl":"https://doi.org/10.36740/Merkur202603105","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The present cross-sectional study aimed to investigate the psychosocial and financial burden, as well as the perceived social support experienced by parents of hospitalized children in Greece.</p><p><strong>Patients and methods: </strong>Materials and Methods: The sample consisted of 100 parents or legal guardians of children hospitalized in various departments of the General Hospital of Corinth, using a convenience sampling method. The Bakas Care Outcomes Scale (BCOS), the Multidimensional Scale of Perceived Social Support (MSPSS), and the Index of Personal Economic Distress (IPED) were used as measurement tools (pp. 4-6). Data analysis was performed using descriptive statistics and Spearman's rho correlation coefficient.</p><p><strong>Results: </strong>Results: The mean score on the BCOS was 51.34 (SD=5.79), indicating a moderate to negative perception of the caregiving experience. On the IPED scale, the mean score was 17.67 (SD=2.17), with 82% of participants experiencing severe financial hardship (score >15). The mean MSPSS score was 4.24 (SD=0.39), indicating moderate to high perceived social support =1. A significant positive correlation was observed between perceived social support and financial hardship (p=0.324, p=0.001), suggesting that those experiencing greater financial hardship received more support.</p><p><strong>Conclusion: </strong>Conclusions: The findings highlight the need for comprehensive, family-centered interventions within the hospital setting. Provision of psychosocial support, financial assistance, and accommodation facilities is imperative to alleviate the significant burden faced by caregivers and improve the overall hospital experience for families.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"272-280"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Halyna V Bilavych, Andrii B Savchuk, Oksana V Vintoniak, Iryna V Komar, Nadiya O Fedchyshyn, Nataliia I Yelahina
{"title":"Support for the physical and mental health of Ukrainian youth during the war.","authors":"Halyna V Bilavych, Andrii B Savchuk, Oksana V Vintoniak, Iryna V Komar, Nadiya O Fedchyshyn, Nataliia I Yelahina","doi":"10.36740/Merkur202603121","DOIUrl":"10.36740/Merkur202603121","url":null,"abstract":"<p><strong>Objective: </strong>Aim: to highlight the role of health-preserving technologies in supporting the physical and mental health of Ukrainian youth during the war.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study employs a comprehensive set of research methods: theoretical (search-targeted analysis, comparison, and generalization of literature to systematize key concepts; structural-functional analysis of university activities); practical (observation of the psycho-emotional state of young people; a survey of 200 students from Vasyl Stefanyk Carpathian National University (СNU) and I. Horbachevsky Ternopil National Medical University (TNMU) interviewing); and methods of mathematical data processing.</p><p><strong>Results: </strong>Results: The research results confirm that under conditions of Russian aggression, Ukrainian youth face challenges that affect not only the educational process, but also their psycho-emotional state. The war has caused increased levels of stress, instability, and psychological pressure on young Ukrainians who are forced to study under constant threat. In the fourth year of the war, about 60% of young people report a deterioration in their emotional state; none indicated an improvement. Anxiety has risen (59% of respondents experience it, compared to 52% previously). The number of young people who feel depressed has tripled compared to 2022 (59% now, previously 20%). An even larger share feel sadness (about 60%), whereas earlier this figure was significantly lower - up to 13%. The percentage of young people who express joy and describe their emotional state as positive has increased slightly (up to 8%, compared to 5%). In this context, innovative health-preserving technologies - which help maintain the physical and mental health of Ukrainian youth during wartime - are becoming especially relevant.</p><p><strong>Conclusion: </strong>Conclusions: Supporting an individual's mental health is one of the priority tasks of state policy. Higher education institutions emphasize innovative healthpreserving methods and technologies that allow Ukrainian youth to adapt to wartime conditions, care for their mental health, maintain their well-being, and strengthen their resilience.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"344-354"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Children on the brink: Mental health, long-term social consequences, and psychosocial support for Ukrainian children in war.","authors":"Viktor Vus, Mariana Shkoliar, Galina Itskovich","doi":"10.36740/Merkur202604119","DOIUrl":"https://doi.org/10.36740/Merkur202604119","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To systematically analyse empirical data on the mental health of Ukrainian children in the context of armed conflict; to conduct a comparative analysis with research on the consequences of the Second World War; to examine long-term social consequences; and to analyse the state of the psychosocial support system, with particular attention to the trauma-informed approach as its methodological foundation.</p><p><strong>Patients and methods: </strong>Materials and Methods: Narrative review with elements of comparative analysis. Databases searched: PubMed/MEDLINE, Scopus, Web of Science, PsycINFO. Included: empirical studies and systematic reviews/meta-analyses (2022-2026) on children and adolescents (0-18 years) in war or post-conflict settings with measurable mental health, behavioural, or developmental outcomes; comparative studies on children from the Second World War era, with no time restrictions. Supplemented by institutional reports and national Ukrainian research.</p><p><strong>Conclusion: </strong>Conclusions: Ukraine is facing a psychiatric and social crisis of historic proportions for European children. An effective response requires long-term systemic investment in psychosocial support grounded in the trauma-informed approach, with priority for underserved groups (the youngest children, orphans, children of the mobilised), deinstitutionalisation, anti-stigma education, and urgent funding for longitudinal research.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"517-525"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Altered glutamatergic neurotransmission in the development and maintenance of PTSD.","authors":"Ewa Alicja Ogłodek","doi":"10.36740/Merkur202604120","DOIUrl":"https://doi.org/10.36740/Merkur202604120","url":null,"abstract":"<p><p>Post-traumatic stress disorder (PTSD) is a multifactorial neuropsychiatric condition characterized by persistent disturbances in fear processing, emotional regulation, and memory. Increasing evidence indicates that dysregulation of glutamatergic neurotransmission plays a crucial role in both the development and persistence of PTSD. Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), is essential for synaptic plasticity and the formation of traumarelated memories. The aim of this study was to provide an integrated and critical synthesis of current knowledge on glutamatergic dysfunction in PTSD, with particular emphasis on its neurobiological, clinical, and therapeutic implications. This article is a narrative review of the literature published between 2017 and 2025 was conducted. Databases such as PubMed, Scopus, and Web of Science were searched for experimental, clinical, and neuroimaging studies investigating glutamatergic signaling in PTSD. The reviewed studies indicate that chronic stress disrupts glutamate homeostasis, leading to increased extracellular glutamate concentrations and impaired synaptic clearance. These alterations result in excessive activation of ionotropic receptors, particularly N-methyl-D-aspartate (NMDA) receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, promoting calcium influx and neuronal dysfunction. Such processes affect key brain regions, including the amygdala, hippocampus, and prefrontal cortex, contributing to impaired fear extinction and heightened emotional reactivity. Importantly, glutamatergic dysregulation does not occur in isolation but interacts dynamically with neuroinflammatory pathways, altered inhibitory transmission, and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. In conclusion, altered glutamatergic neurotransmission represents a central mechanism in PTSD pathophysiology. Its role in synaptic plasticity, neuronal vulnerability, and network dysregulation highlights its potential relevance as a diagnostic and therapeutic target. Future research should focus on integrating glutamate-related biomarkers with mechanism-based therapeutic interventions in order to improve diagnostic precision and treatment outcomes in PTSD.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"526-535"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olena G Babchuk, Olha M Pasko, Tetyana V Matiienko, Maksym M Isaienko, Inha A Serednytska, Natalia T Zhuk, Ivan M Okhrimenko
{"title":"Dynamics of psychosomatic health indicators in future law enforcement officers under the influence of high-intensity loads.","authors":"Olena G Babchuk, Olha M Pasko, Tetyana V Matiienko, Maksym M Isaienko, Inha A Serednytska, Natalia T Zhuk, Ivan M Okhrimenko","doi":"10.36740/Merkur202601105","DOIUrl":"https://doi.org/10.36740/Merkur202601105","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To investigate the impact of high-intensity interval training (HIIT) on cadets' somatic and mental health indicators during their academic training under martial law.</p><p><strong>Patients and methods: </strong>Materials and Methods: The research involved 98 male cadets, who were divided into three groups: group No. 1 (n=21), whose cadets engaged in HIIT; Group No. 2 (n=53), whose cadets were involved in other sports; Group No. 3 (n=24), whose cadets did not engage in additional sports. Research methods: theoretical analysis and generalization of literature, biomedical methods, psychological methods, statistical methods.</p><p><strong>Results: </strong>Results: In most tests, cadets in Group No. 1 had significantly better somatic and mental health indicators during their senior training years than those in Group No. 3, indicating a more pronounced effect of HIIT on the morphofunctional and psycho-emotional state of cadets during their academic training. At the same time, no significant difference was found between the indicators of cadets in Group No. 1 and Group No. 2, which indicates the effectiveness of additional motor activity and sports training sessions in improving the psychosomatic health of cadets.</p><p><strong>Conclusion: </strong>Conclusions: The positive effect of HIIT on indicators of psychosomatic health among future law enforcement officers has been demonstrated. This underscores the advisability of the broader implementation of HIIT in the physical training of future law enforcement officers during their academic training at higher educational institutions with a specific learning environment, to improve their psychosomatic health and, accordingly, increase the effectiveness of their future service activities.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 1","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of correlation of GDF11 and atherogenic factors in patients with diabetic dyslipidemia.","authors":"Nagham Yahya Ghafil, Sura Hadi Ibraheim Abd Ali","doi":"10.36740/Merkur202602107","DOIUrl":"10.36740/Merkur202602107","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To explore link between circulating Growth Differentiation Factor 11 (GDF11) levels and atherogenic lipid parameters in individuals with diabetic dyslipidemia, and to evaluate whether GDF11 may serve as a potential biomarker to minimize atherosclerosis in this population.</p><p><strong>Patients and methods: </strong>Materials and methods: A cross-sectional study was conducted at AL-Hassn Metabolism, Endocrine, and Diabetes Center in Kerbala, Iraq, February-April, 2025. A 172 participants with either type 1 or type 2 diabetes mellitus. Diabetic patients with dyslipidemia (n=90, 52 male and 38 female), with 4 having type 1 diabetes, 86 having type 2 diabetes, and without dyslipidemia (n=86: 36 male and 46 female), with 28 having type 1 diabetes and 54 having type 2 diabetes. Ages 20-70 years, serum level of GDF11 was determined using ELISA method. Atherogenic marker measures include midkine, NLRP3 inflammasome, PPARy and oxidative stress. Additional data obtained included age, BMI, duration of diabetes, fasting glucose, and liver enzyme (ALT). Link between GDF11 and atherogenic markers was assessed using Spearman's correlation analysis to assess independent connections, multivariate regression analysis was performed, with adjustments for age, BMI, and glycemic control.</p><p><strong>Results: </strong>Results: diabetic individuals with dyslipidemia had considerably greater levels of all biomarkers tested (GDF11, SOD, NLRP3, MIDKINE, and PPARy) than with diabetes alone. Diabetes and dyslipidemia are linked to increased oxidative stress (SOD), heightened inflammation (NLRP3, Midkine), and altered metabolic regulation (GDF11, ppary).</p><p><strong>Conclusion: </strong>Conclusions: Diabetes with dyslipidemia linked to elevated levels of GDF11, SOD, NLRP3, midkine and PPARy, indicating increased oxidative stress, inflammation, and metabolic dysregulation.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 2","pages":"144-150"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stress, resilience and job satisfaction among emergency department healthcare workers in Greece.","authors":"Zoi Karimali, Eleni Karimali, Effie Mitsopoulou, Georgios Charalambous","doi":"10.36740/Merkur202602105","DOIUrl":"10.36740/Merkur202602105","url":null,"abstract":"<p><strong>Objective: </strong>Aim: This study aimed to assess levels of perceived stress, psychological resilience and job satisfaction among Emergency Department (ED) healthcare professionals in Attica, Greece, and examine the correlations among them.</p><p><strong>Patients and methods: </strong>Materials and Methods: A cross-sectional study was conducted in 12 public hospitals in Attica, Greece, using self-administered questionnaires: Perceived Stress Scale (PSS-10), Connor-Davidson Resilience Scale (CD-RISC-10), and Job Satisfaction Survey (JSS). Descriptive statistics, Pearson correlations, and multiple linear regression analyses were performed using SPSS v30.</p><p><strong>Results: </strong>Results: Participants reported moderate levels of perceived stress (M=17.72, SD=6.30) and psychological resilience (M=27.18, SD=6.01), while job satisfaction appeared variable, with an overall mean score indicating low to moderate satisfaction (M=113.10, SD=23.41). A significant negative correlation was found between perceived stress and job satisfaction (r=-0.36, p < .001), as well as between stress and resilience (r=-0.53, p < .001). A positive but weaker correlation was observed between resilience and job satisfaction (r=0.14, p < .001).</p><p><strong>Conclusion: </strong>Conclusions: Psychological resilience plays a critical protective role against stress and positively influences job satisfaction among ED healthcare professionals. Resilience-enhancing interventions may reduce stress and improve satisfaction among ED staff.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 2","pages":"131-136"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}