Polski Merkuriusz Lekarski最新文献_第5页

Peculiarities of students' mental functions development under the influence of different physical activities. 不同体育活动影响下学生心理机能发展的特殊性。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202403109

Grygoriy Griban, Mykhailo F Khoroshukha, Natalia A Lyakhova, Viktoriia V Biletska, Pavlo B Yefimenko, Oksana P Kanishcheva, Tetiana M Zhlobo

{"title":"Peculiarities of students' mental functions development under the influence of different physical activities.","authors":"Grygoriy Griban, Mykhailo F Khoroshukha, Natalia A Lyakhova, Viktoriia V Biletska, Pavlo B Yefimenko, Oksana P Kanishcheva, Tetiana M Zhlobo","doi":"10.36740/Merkur202403109","DOIUrl":"https://doi.org/10.36740/Merkur202403109","url":null,"abstract":"Objective: Aim: The aim is to study the influence of the training activities of different orientations on the attention development of student specializing in different sports.Patients and methods: Materials and Methods: The study involved 127 students, who were divided into three groups: group A (n=68) was engaged in speed and power sports, group B (n=59) was engaged in endurance sports, the control group (n=83) included peer students who did not do sports during their studies. The research on students' attention was carried out according to Anfimov's test using a table with letters.Results: Results: It was revealed that speed and power activities increase the integrated indicator of attention (the coefficient of work performance) based only on the speed of viewing characters with unreliable changes in the correctness of the work indicators. Under the influence of endurance training, the coefficient of efficiency is increased based on both an increase in the speed of viewing characters and the correctness of the work indicators. The students of the control group were found to have insignificant changes in the studied indicators of attention.Conclusion: Conclusions: This suggests that endurance training promotes the development of students' attention more ef f ectively. It is set, that specifics of the training process, its orientation equally specifically specialize the peculiarities of the attention development of students.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 3","pages":"326-331"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pityriasis Rubra Pilaris - a difficult path to optimal treatment. Case report. 红斑狼疮--通往最佳治疗的艰难之路。病例报告。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202403114

Jakub Smyk, Alicja Kamińska, Przemysław Borowy, Patrycja Major, Katarzyna Gołojuch, Bogdan Batko

引用次数: 0

Music therapy and psychotherapy - complementarity or antagonism in the treatment of patients with mental disorders. 音乐疗法和心理疗法--在治疗精神障碍患者方面是互补还是对立。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202404111

Andrzej Witusik, Anna Mosiołek, Tadeusz Pietras

引用次数: 0

Immunohistochemical study of CD74 biomarker in normal and malignant breast tissues. 正常和恶性乳腺组织中 CD74 生物标记物的免疫组化研究

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202402113

Hayder Neamah Hassan, Rouaida Kadhim A Al-Hussein, Asmehan Adnan Al-Naqeeb

{"title":"Immunohistochemical study of CD74 biomarker in normal and malignant breast tissues.","authors":"Hayder Neamah Hassan, Rouaida Kadhim A Al-Hussein, Asmehan Adnan Al-Naqeeb","doi":"10.36740/Merkur202402113","DOIUrl":"https://doi.org/10.36740/Merkur202402113","url":null,"abstract":"Objective: Aim: To detect the role of CD74 expression in breast carcinoma as a predictive marker for identifying the biological behavior of malignancy in Iraqi women..Patients and methods: Materials and Methods: The study used technique of immunohistochemistry for detection CD74 protein role in breast cancer, and its expression in breast cancer tissue samples. Samples were collected in Al-Najaf city in Iraq, from Al-Forat Al-Awsat Oncology Center. The study was achieved at the Laboratories of the Faculty of Science in the University of Kufa. Fifty samples of breast cancer tissue, and twenty controls benign tissue were included in the study. The study has investigated relationship between expression of biomarker with grade, age of patient and tumor size.Results: Results: The study showed that the cytoplasmic expression of CD74 with more clear and intensive staining in the cytoplasm, and reported that CD74 positivity rate was 52%. A significant association between CD74 expression and grade and size of tumor, so CD74 can be considered as a biomarker for prediction of breast cancer in women. No association was found between CD74 expression and each of patients' age and node metastasis.Conclusion: Conclusions: The study represents an important step in our region because there are a few studies about this topic; more efforts are required to approve the function of this biomarker.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 2","pages":"233-239"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of indicators of caries of permanent teeth in children according to the endemic features of the Poltava region, Ukraine. 根据乌克兰波尔塔瓦州的地方特点分析儿童恒牙龋齿指标。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202401117

Lyudmila I Amosova, Lyudmyla F Kaskova, Oksana S Pavlenkova, Olena V Khmil, Svitlana Ch Novikova, Larysa P Ulasevych

{"title":"Analysis of indicators of caries of permanent teeth in children according to the endemic features of the Poltava region, Ukraine.","authors":"Lyudmila I Amosova, Lyudmyla F Kaskova, Oksana S Pavlenkova, Olena V Khmil, Svitlana Ch Novikova, Larysa P Ulasevych","doi":"10.36740/Merkur202401117","DOIUrl":"10.36740/Merkur202401117","url":null,"abstract":"Objective: Aim: This research is focused at analyzing the indicators and substantiating the peculiarities of caries prevention in permanent teeth in schoolchildren of Poltava region, taking into account the endemic features of the Poltava region.Patients and methods: Materials and Methods: A comparative study was conducted among 608 pupils of secondary schools in Kremenchuk, who consumed drinking water with fluoride concentrations in the lower limits of the norm, and 1214 pupils of secondary schools in Poltava, who consumed drinking water with fluoride concentrations in the optimal upper limits of the norm.Results: Results: The rates of caries in permanent teeth in children living in a region with fluoride concentrations in drinking water in the optimal-upper normal range are several times lower than in children of the same age living in a region with fluoride concentrations in drinking water in the lower normal range, and a significant increase in the prevalence and intensity of caries is observed from 7 to 9 to 12 years of age, as teeth after eruption are most vulnerable to caries. In a region where the fluoride concentration in drinking water is in the optimal-upper range of the norm, children with early forms of fluorosis have the lowest prevalence and intensity of caries.Conclusion: Conclusions: Endemic features of the region directly affect the prevalence and intensity of the caries process. In regions with a fluoride concentration in drinking water within the optimal upper limits of the norm, prevention of caries in permanent teeth in children should be carried out taking into account the presence of fluorosis.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"112-116"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the indicators of stiffness and remodeling of magistral arteries in young patients at the early stage of essential hypertension under conditions of syntropy with obesity. 在肥胖综合征的条件下，处于原发性高血压早期阶段的年轻患者肱动脉僵硬度和重塑指标的变化。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202401105

Tatiana A Ivanytska, Yurii M Kazakov, Yevhen Ye Petrov, Yuriі H Burmak, Ihor V Ivanytskyi, Nataliia I Chekalina, Svitlana V Shut

{"title":"Changes in the indicators of stiffness and remodeling of magistral arteries in young patients at the early stage of essential hypertension under conditions of syntropy with obesity.","authors":"Tatiana A Ivanytska, Yurii M Kazakov, Yevhen Ye Petrov, Yuriі H Burmak, Ihor V Ivanytskyi, Nataliia I Chekalina, Svitlana V Shut","doi":"10.36740/Merkur202401105","DOIUrl":"10.36740/Merkur202401105","url":null,"abstract":"Objective: Aim: The study and analysis of indicators of remodeling and rigidity of magistral vessels in young essential hypertension patients with abdominal obesity and determination of the detected changes as a possible criterion for their remodeling..Patients and methods: Materials and Methods: 98 young people with essential hypertension and obesity were included in the study. The structure of the carotid artery and its stiffness were assessed using the ultrasound method, and the level of abdominal fat was determined using dual-energy X-ray absorptiometry.Results: Results: Carotid Intima-Media Thickness in patients with essential hypertension reliably exceeded the corresponding indicator of the control group. We observed a significant increase in arterial stiffness indicators, which is explained by the increased stiffness of blood vessels in patients with obesity. During the correlation analysis, it was established that the relationship between the level of abdominal fat and the elasticity of the vascular wall was positive and strong, which indicated the dominant role of the abdominal type of obesity in the remodeling of the vascular wall in young patients with essential hypertension in combination with obesity.Conclusion: Conclusions: In young patients at the early stage of the formation of essential hypertension, there are signs of a decrease in resilient-elastic properties and remodeling of magistral vessels, whose severity is significantly stronger in combination with abdominal obesity.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"30-35"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tranexamic acid versus adrenaline-soaked pledgets for the reduction of intraoperative bleeding in functional endoscopic sinus surgery. 氨甲环酸与肾上腺素浸泡敷料在减少功能性内窥镜鼻窦手术术中出血方面的比较。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202401106

Bara'a Mahir Aziz, Islam Al-Talibi, Shalan Mufleh Darak, Ali Abdulmuttalib Mohammed, Haitham Alnori

{"title":"Tranexamic acid versus adrenaline-soaked pledgets for the reduction of intraoperative bleeding in functional endoscopic sinus surgery.","authors":"Bara'a Mahir Aziz, Islam Al-Talibi, Shalan Mufleh Darak, Ali Abdulmuttalib Mohammed, Haitham Alnori","doi":"10.36740/Merkur202401106","DOIUrl":"10.36740/Merkur202401106","url":null,"abstract":"Objective: Aim: To examine the impact of locally applied tranexamic acid and adrenaline, separately and in combination, on intraoperative blood loss and surgical field quality during functional endoscopic sinus surgery.Patients and methods: Materials and Methods: The study involved 40 patients with chronic rhinosinusitis. They were divided into two groups. Group I received adrenaline alone in one side and a mixture of adrenaline and tranexamic acid in the other side. Group II received adrenaline alone in one side and tranexamic acid in the otherside. Parameters like surgery time, blood loss, and surgical field quality were studied.Results: Results: In Group I, the combination of adrenaline and tranexamic acid significantly reduced blood loss and enhanced surgical field quality compared to adrenaline alone. In Group II, adrenaline outperformed tranexamic acid in shortening surgery duration and improving surgical field quality. However, there was no significant difference in blood loss reduction between adrenaline and tranexamic acid.Conclusion: Conclusions: The study concluded that tranexamic acid is less effective than adrenaline when introduced as topical intranasal pledgets in both decreasing the time needed for the surgery and improving the subjective satisfaction of the surgeon while there is no significant difference regarding decreasing intraoperative blood loss. The mixture of adrenaline and tranexamic acid pledgets are more effective than adrenaline-only pledgets in terms of decreasing the intraoperative blood loss and improving the surgeon's satisfaction with no significant difference regarding the time needed for the surgery.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"36-41"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, insilco study and biological evaluation of new isatin-sulfonamide derivatives by using mono amide linker as possible as histone deacetylase inhibitors. 使用单酰胺连接物作为组蛋白去乙酰化酶抑制剂的新异atin-磺酰胺衍生物的设计、合成、insilco 研究和生物学评价。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202402106

Ammar Abdul Aziz Alibeg, Mohammed Hassan Mohammed

{"title":"Design, synthesis, insilco study and biological evaluation of new isatin-sulfonamide derivatives by using mono amide linker as possible as histone deacetylase inhibitors.","authors":"Ammar Abdul Aziz Alibeg, Mohammed Hassan Mohammed","doi":"10.36740/Merkur202402106","DOIUrl":"https://doi.org/10.36740/Merkur202402106","url":null,"abstract":"Objective: Aim: To evaluate the cytotoxic activity of newly synthesized a series of novel HDAC inhibitors comprising sulfonamide as zinc binding group and Isatin derivatives as cap group joined by mono amide linker as required to act as HDAC inhibitors.Patients and methods: Materials and Methods: The utilization of sulfonamide as zinc binding group joined by N-alkylation reaction with ethyl-bromo hexanoate as linker group that joined by amide reaction with Isatin derivatives as cap groups which known to possess antitumor activity in the designed of new histone deacetylase inhibitors and using the docking and MTT assay to evaluate the compounds.Results: Results: Four compounds have been synthesized and characterized successfully by ART-FTIR, NMR and ESI-Ms. the compounds were synthesized and characterized by successfully by ART-FTIR, NMR and ESI- Ms. Assessed for their cytotoxic activity against human colon adenocarcinoma MCF-7 (IC50, I=105.15, II=60.00, III=54.11, IV=56.57, vorinostat=28.41) and hepatoblastoma HepG2 (IC50, I=63.91, II=135.18, III=118.85, IV=51.46, vorinostat=37.50). Most of them exhibited potent HDAC inhibitory activity and significant cytotoxicity.Conclusion: Conclusions: The synthesized compounds (I, II, III and IV) showed cytotoxicity toward MCF-7 and HepG2 cancer cell lines and their docking analysis provided a preliminary indication that they are viable [HDAC6] candidates.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 2","pages":"178-188"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on the current approaches and perspectives of Covid-19 treatment. 综述当前治疗 Covid-19 的方法和前景。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202403111

Łukasz Dobrek

{"title":"A review on the current approaches and perspectives of Covid-19 treatment.","authors":"Łukasz Dobrek","doi":"10.36740/Merkur202403111","DOIUrl":"https://doi.org/10.36740/Merkur202403111","url":null,"abstract":"At the beginning of 2020, the world was faced with the challenge of the coronavirus disease 2019 (COVID-19) pandemic announced by the WHO on March 11, caused by the betacoronavirus type 2 of the severe acute respiratory syndrome (SARS-CoV-2), which had profound health, sociological and even economic consequences. The quickly implemented and large-scale research resulted in the introduction of widely available vaccines that reduced the further development of the pandemic and antivirals against SARS-CoV-2. Currently, 11 antiviral drugs (Tixagevimab/Cilgavimab, Regdanvimab, Casirivimab/Imdevimab, Sotrovimab, Nirmatrelvir/Ritonavir, Remdesivir, Molnupiravir, Baricitinib, Anakinra, Tocilizumab, Vilobelimab) have been approved or conditionally approved by the European Medicines Agency and/or by the Food and Drug Administration and are available on the pharmaceutical market. The progress in the pathophysiological description of the SARS-CoV-2 infection has allowed the identif i cation of potential targets for drugs against SARS-CoV-2: inhibitors of intracellular entry of the virus (the interaction between the viral spike (S) protein and the cellular angiotensin converting enzyme-2; ACE2 receptor), inhibitors of viral and cellular proteases, and immunomodulatory drugs (antagonists of pro-inf l ammatory cytokines or complement components). Novel agents against SARS-CoV-2 are also sought among the previously routinely used drugs as their repositioning and among plant-derived compounds. It is expected that ongoing research should result in the introduction of new drugs used in COVID-19 in the near future. The article brief l y describes the current epidemiological situation regarding COVID-19 and the currently used vaccines. Moreover, the paper outlines currently used and researched potential drugs in the pharmacotherapy of this disease.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 3","pages":"337-346"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet-Rich Plasma - a remedy present in every human being. History, functioning, and the benefits of therapy using it. 富血小板血浆--一种存在于每个人体内的疗法。使用它进行治疗的历史、功能和益处。

Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202402114

Monika Prokurat, Katarzyna Grudnik, Wojciech Niemczyk, Stanisław Niemczyk, Mateusz Migas, Karolina Wągrowska, Karolina Lau, Janusz Kasperczyk

{"title":"Platelet-Rich Plasma - a remedy present in every human being. History, functioning, and the benefits of therapy using it.","authors":"Monika Prokurat, Katarzyna Grudnik, Wojciech Niemczyk, Stanisław Niemczyk, Mateusz Migas, Karolina Wągrowska, Karolina Lau, Janusz Kasperczyk","doi":"10.36740/Merkur202402114","DOIUrl":"https://doi.org/10.36740/Merkur202402114","url":null,"abstract":"Platelet-rich plasma is an autologous product used in restorative medicine. It contains a high concentration of platelets, which are rich in growth factors and other biologically active substances known for their ability to stimulate regenerative processes in the body. Currently, research is being conducted into the use of platelet-rich plasma in many areas of medicine. This publication provides information on the nature, mechanism of action, therapeutic properties and application of autologous platelet-rich plasma in medicine. Furthermore, ongoing investigations explore its potential in wound healing, orthopedics, dermatology, and even in dentistry, showcasing its versatility and promising outcomes across various medical disciplines. Additionally, the safety and efficacy of platelet-rich plasma therapies are subjects of continual scrutiny, aiming to refine protocols and expand its clinical utility with robust scientific evidence. The growing interest in this regenerative approach underscores its potential as a valuable tool in modern medical practice. Platelet-rich plasma therapy represents a promising avenue for personalized medicine, offering tailored treatment approaches that capitalize on the body's own healing mechanisms to promote tissue repair and regeneration.","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 2","pages":"240-245"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0