Polski Merkuriusz Lekarski最新文献

{"title":"Effectiveness and safety of antiestrogens in the treatment of functional hypogonadism in men with obesity.","authors":"Marcin Rabijewski, Jakub Wydra, Grzegorz Kapuściński, Michał Rabijewski","doi":"10.36740/Merkur202602119","DOIUrl":"10.36740/Merkur202602119","url":null,"abstract":"<p><p>Functional hypogonadism in men is a syndrome characterized by low testosterone levels and clinical signs of hypogonadism without organic disease of the hypothalamus-pituitary-gonadal axis. It is most often caused by obesity, diabetes type 2, exogenous steroid abuse, excessive physical exercise, opioid use, co-occurring diseases, and is most prevalent among middle-aged and older men as so-called late-onset hypogonadism. It seems that the most important epidemiological factor causing functional hypogonadism is excess adipose tissue. Obesity is currently one of the most important public health problems and its prevalence is higher in men than in women. Complications of obesity include not only cardiovascular diseases or type 2 diabetes mellitus, but also lead to decreased testosterone levels, reduced libido and erectile dysfunctions, and impaired fertility in men. These disorders in men with obesity are associated with decreased gonadotropins and testosterone secretion due to hyperinsulinemia, hyperleptinemia, chronic inflammation and oxidative stress. Currently, it seems that an important complication of obesity is the deterioration of semen parameters (sperm concentration, motility, and morphology) and reduced fertility. Theoretically, obesity-related functional hypogonadism in men is reversible, so the basis of initial treatment is primarily lifestyle modification and effective treatment of chronic diseases but primarily reducing body fat mass (physical exercise and low-caloric diet). Unfortunately, lifestyle changes are often insufficient to significantly increase testosterone levels and resolve the clinical symptoms of hypogonadism. Because in men seeking fertility conventional testosterone replacement therapy is contraindicated, alternative pharmacological methods, such antiestrogens (selective estrogen receptor modulators and aromatase inhibitors) are often used.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 2","pages":"229-235"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical analysis and distribution of lymphocytes and Kupffer cells in the liver of rats with long-term experimental use of hemp seed oil.","authors":"Mykola M Shevchuk, Liliya I Volos, Oksana R Kovalska","doi":"10.36740/Merkur202602106","DOIUrl":"10.36740/Merkur202602106","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To conduct histological and immunohistochemical analysis and distribution of lymphocytes and Kupffer cells in the liver of rats with long-term experimental use of hemp seed oil (HSO).</p><p><strong>Patients and methods: </strong>Materials and Methods: 26 sexually mature male rats (180-230 g, 5-7 months old) were divided into three groups: experimental (n=14, 0.5 ml/kg/day HSO orally for 10 weeks), control (n=6, 0.1 ml/kg/day HSO orally for 10 weeks), and intact (n=6). Histological and immunohistochemical (CD3, CD20, CD56, CD68) studies, alongside quantitative analysis of lymphocyte and macrophage distribution in hepatic lobules, were performed. Statistical significance was assessed using Mann-Whitney and Pearson tests, with p<0.05 considered significant.</p><p><strong>Results: </strong>Results: After 10 weeks of 0.5 ml/kg/day HSO, 71.43% of experimental rats developed mild fatty liver disease (Kleiner grade S1 steatosis), a significant difference from the control group (p<0.0001). No histological inflammation or necrotic changes in hepatocytes were observed. Small numbers of CD3 lymphocytes were present in portal tracts, without extending into or damaging the adjacent parenchyma. CD20 and NK resident lymphocytes were sparse. Aggregates of CD68-positive Kupffer cells were most common near liver lobule triads. The average number of Kupffer cells (5.79±0.06 per 0.01 mm2) in the experimental group significantly (p<0.001) exceeded the control by 1.49 times, suggesting hyperplasia of specialized macrophages and their increased role in liver immune function.</p><p><strong>Conclusion: </strong>Conclusions: Ten weeks of experimental use indicates that hemp seed oil is safe to consume at a dose of 0.5 ml/kg/day.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 2","pages":"137-143"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural changes in the testes during ethanol intoxication following modulation of testicular blood flow.","authors":"Mykhailo B Pastukh, Andrii O Yurakh, Oksana H Popadynets, Nadiia S Tokaruk, Romaniia R Barchuk, Larysa Ya Fedoniuk, Tariel R Kerimov","doi":"10.36740/Merkur202603120","DOIUrl":"https://doi.org/10.36740/Merkur202603120","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To examine the structural changes in the testes during various stages of alcohol intoxication and after alcohol cessation; to assess the potential for regenerative processes following surgically improved testicular blood supply.</p><p><strong>Patients and methods: </strong>Materials and Methods: The experiment was conducted on 60 adult male outbred albino rats, allocated into three experimental groups, the intact group, and the control group. The effects of alcohol were studied at the light-microscopic and ultrastructural levels, followed by statistical analysis. Alcohol was administered for one, two, three, or four weeks. Tissue samples were collected immediately after each exposure period, as well as 30 days after one-, two-, three-, and four-week exposure durations. In addition, in animals exposed to alcohol for four weeks, tissue samples were collected on postoperative days 14 and 30 following ligation of the caudal epigastric arteries above the origin of the cremasteric arteries.</p><p><strong>Results: </strong>Results: Chronic alcohol intoxication adversely affected the testes of outbred albino rats, inducing destructive changes in the arterial system, the microvasculature, the blood-testis barrier, and the spermatogenic epithelium. The severity of morphological changes in the testes of rats exposed to chronic alcohol intake correlated with the duration of exposure to the damaging agent. Spermatocytes, i.e., cells at more advanced stages of differentiation, were most sensitive to alcohol-induced damage. Recovery processes in the testes of rats exposed to chronic alcohol intake occurred after short-term intoxication (one to two weeks) but were absent following four weeks of alcohol exposure. Targeted enhancement of testicular blood supply by ligation of the caudal epigastric arteries above the origin of the cremasteric arteries promoted more intensive reparative processes and restoration of the testicular morphological structure.</p><p><strong>Conclusion: </strong>Conclusions: Alcohol intoxication induces significant hemodynamic changes, which underlie the maladaptive responses and degenerative processes in the testes. After cessation of alcohol exposure, regenerative and adaptive processes proceed slowly. Enhancing testicular blood flow surgically via collateral vessels improves microcirculation and stimulates regenerative processes within the testicular parenchyma.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"337-343"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of 755 nm Alexandrite laser in the treatment of hirsutism.","authors":"Nadia Sahib, Fatin Ahmed, Mohammed Alhattab, Mohammed Sameir","doi":"10.36740/Merkur202603106","DOIUrl":"https://doi.org/10.36740/Merkur202603106","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluate the efficacy and safety of the 755 nm Alexandrite laser in the treatment of facial hirsutism.</p><p><strong>Patients and methods: </strong>Materials and Methods: 50 patients with facial hirsutism underwent 4 to 6 treatment sessions using the 755 nm Alexandrite laser, spaced three to four weeks apart. Clinical assessment was performed using the Ferriman-Gallwey scoring system prior to treatment. Patient response was assessed by their self-reported reduction in hair growth at the end of the protocol.</p><p><strong>Results: </strong>Results: Most of the patients experienced excessive hair growth on the cheeks, chin, and upper lip. Following treatment, 50% of patients reported a 50-75% reduction in hair growth, 30% reported a reduction greater than 75%, 10% reported a 25-50% reduction, and 10% reported a reduction of less than 25%. Mild erythema and slight discomfort were observed in a few patients.</p><p><strong>Conclusion: </strong>Conclusions: The 755 nm Alexandrite laser appears to be a safe and effective option for long-term facial hair reduction in suitable patients. However, further studies are recommended.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"281-285"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspects of the use of artificial intelligence in medical education: Results of a cross-sectional survey conducted at Bogomolets national medical university.","authors":"Inna I Kucherenko, Andrii O Burdeinyi, Lesya V Lymar, Anna V Blagaia, Ievgeniia A Burlaka, Dmytro V Zolotov, Oksana V Vygovska","doi":"10.36740/Merkur202603109","DOIUrl":"https://doi.org/10.36740/Merkur202603109","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To analyze the key aspects of artificial intelligence (AI) application in medical education and to assess related psychological attitudes among students and academic staff.</p><p><strong>Patients and methods: </strong>Materials and Methods: A cross-sectional study was conducted using an anonymous online survey. A total of 727 respondents participated, the majority of whom were involved in medical education. The questionnaire included demographic items, questions on frequency and purposes of AI use, self-assessment of AI proficiency, and a 40-item scale evaluating psychological attitudes. Data were analyzed using descriptive statistics and presented as relative frequencies (%).</p><p><strong>Results: </strong>Results: The findings demonstrated significant integration of АІ into the medical education environment: 41.4% of respondents reported daily use, while 46.6% reported using these tools several times per week. Primary applications included learning support (79.6%), self-education (78%), and preparation of educational materials (30.1%). While 61.8% of participants rated their proficiency as high, the study raised concerns about the rapid pace of technological development and potential cognitive dependence.</p><p><strong>Conclusion: </strong>Conclusions: The normalisation of АІ in academic practice indicates its role as a cognitive extension. While it enhances efficiency and creativity, the risk of reduced autonomy and ethical challenges necessitates the development of structured educational strategies and methodological guidelines for its responsible use in medical training.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 3","pages":"300-305"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detoxification of some heavy metals by GST level and null genotypes of GST (GSTM1 and GSTT1) in car repairing workshops workers.","authors":"Noora M Hameed, Tabark Fakhri Hashim, Ahmed M Amshawee, Zainab Ali Hussein, Maryam A Hussain, Islam K Alazzawi, Mona N Al-Terehi, Ahmed Flayyih Hasan","doi":"10.36740/Merkur202604113","DOIUrl":"https://doi.org/10.36740/Merkur202604113","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To evaluated efficiency of heavy metals detoxification by GST level and null genotypes of GST in car repairing workshops workers.</p><p><strong>Patients and methods: </strong>Materials and methods: Samples included 32 male workers with an average age 34 year. Level of heavy metals (Cd and Pb) and GST were measured, GSTT1 and GSTM1 null genotyping were determined by PCR.</p><p><strong>Results: </strong>Results: significant association were found between socidemographic variables. Significant higher concentration of Pb, Cd and GST in case group compared to control group p<0.05, no-significant effect of disease present or smoking in Pb, Cd and GST levels, in the case group, significant inverse correlation in age with Cd. A Significant inverse association between Cd and Pb in case group but in control group, no significant correlation among other variables. Linear regression of GST level on Pb and Cd showed non-sig effect (b=0.041, p=0.884 of Cd and b=-0.957, p=0.973 of Pb) in case group, significant association of GSTT1 null genotyping (OR=34.7561, CI95%=1.9448 to 621.1255 at p=0.0159) with risk of toxicity, the null of GSTT1 also showed sig significant impact on Pb and Cd levels in the case group (p= 0.000 and 0.006 respectively), while GSTM1 showed non -significant.</p><p><strong>Conclusion: </strong>Conclusions: Results suggested elevation of heavy metals PB, Cd levels and GST activity in case group may be significantly influence by the GSTT1 null genotyping, indicating a potential role in reduce detoxification capacity and increase health risk in exposed worker.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"464-471"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forensic medical assessment of thoracic and lumbar traumatic spinal cord injury in percutaneous and open transpedicular fixation.","authors":"Ivan V Varnakov, Volodymyr V Medvediev, Alina O Pletenetska","doi":"10.36740/Merkur202604112","DOIUrl":"https://doi.org/10.36740/Merkur202604112","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To conduct a forensic medical evaluation of the severity of bodily injuries in thoracic and lumbar traumatic spinal cord injury; to assess surgical care quality indicators in percutaneous and open transpedicular fixation in the context of iatrogenic risk and prevention of medical care deficiencies; to analyse whether the surgical stabilisation method may influence parameters of forensic significance for evaluating injury outcomes.</p><p><strong>Patients and methods: </strong>Materials and Methods: A retrospective study of 269 patients: open fixation (215), percutaneous fluoroscopy-guided fixation (54). Assessed: Frankel scale, pelvic dysfunction, blood loss, duration of surgery and anesthesia, fentanyl dose, hyperthermia, and implant quality.</p><p><strong>Results: </strong>Results: Severe bodily injury (life-threatening) was established in 27.9% (Group 1) vs 7.4% (Group 2) (p=0.001); by ≥33% permanent disability - 22.3% vs 7.4% (p=0.012). Mean permanent disability: 30.1±24.2% vs 17.8±7.9% (p<0.001). Neurological deficit (Frankel A-D) at admission: 32.4% vs 7.7%. Moderate injuries: 63.3% vs 88.9%; no mild injuries. Percutaneous technique resulted in 16.3-fold lower blood loss (20 vs 325 mL; p<0.001), lower fentanyl dose, and shorter anesthesia (p<0.001); implant quality did not differ (p>0.05).</p><p><strong>Conclusion: </strong>Conclusions: Injury severity is a fixed legal fact determined by the primary trauma. Surgery may affect legal qualification via: change in outcome at reassessment; qualification of care defects as independent injuries. Percutaneous fixation significantly reduces iatrogenic risk. Documentation gaps complicate forensic evaluation of care quality.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"458-463"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glioblastoma mimicking acute stroke: A case report and diagnostic challenges.","authors":"Gabriela Chlebowska, Krystian Kansik, Inga Atamaniuk, Marta Czerwiec, Marta Czerwińska-Suszniak, Anna Bieniasiewicz, Krzysztof Kandziora, Beata Łabuz-Roszak","doi":"10.36740/Merkur202604122","DOIUrl":"https://doi.org/10.36740/Merkur202604122","url":null,"abstract":"<p><p>Glioblastoma is the most common malignant primary brain tumor in adults. Gliomas infiltrate and destroy surrounding brain tissue, leading to neurological deficits such as speech and visual disturbances, hemiparesis, cranial nerve palsies, personality changes, and impaired consciousness. These symptoms may mimic acute stroke; however, 20-40% of patients initially diagnosed with stroke in the emergency department (ED) are later found not to have experienced an acute cerebrovascular event. Brain tumors account for approximately 5% of such stroke mimics. The aim of the study was to present a clinical case of brain tumor mimicking stroke. We present a 71-year-old woman admitted with suspected stroke due to impaired verbal communication, confusion, disorientation, and transient mild rightsided weakness. Symptoms had progressed over one week. Brain computed tomography revealed a hypodense lesion in the medial left temporal lobe, and magnetic resonance imaging suggested a high-grade glioma infiltrating deep structures. Intravenous dexamethasone was initiated. Navigated biopsy confirmed glioblastoma on histopathological examination. The patient was not eligible for oncological treatment and underwent supportive care, including rehabilitation. At discharge, she was ambulatory with caregiver assistance and remained on long-term dexamethasone with proton pump inhibitor (PPI) prophylaxis. Despite advances in therapy, glioblastoma carries a poor prognosis, with approximately 10% five-year survival.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"541-546"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of biochemical factors and microalbuminuria among type 2 diabetes mellitus patients.","authors":"Ruqaya M Hassan, Mawj N Modher, Shahad M Hussain, Baneen S Rasool, Yousif Sh Raheem, Ahmed Flayyih Hasan","doi":"10.36740/Merkur202604101","DOIUrl":"https://doi.org/10.36740/Merkur202604101","url":null,"abstract":"<p><strong>Objective: </strong>Aim: Progression of type 2 diabetes produces capillary and macrovascular problems, including microalbuminuria, an early renal impairment marker. This study examines biochemical factors associated to microalbuminuria in T2DM patients of varying durations.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 90 healthy controls, patients with type 2 diabetes mellitus (T2DM) for less than five years, and those with the illness for more than five years. Fasting blood glucose, HbA1c, lipid profile (HDL, LDL, vLDL, TC), serum albumin, globulins, creatinine, and urine microalbumin were tested. To compare groups, ANOVA and independent t-tests were utilized.</p><p><strong>Results: </strong>Results: Patients with long-term illness showed higher fasting glucose (210.17±5.98 mg/dL), HbA1c (8.94±0.51%), serum creatinine (122.01±0.28 μmol/L), and reduced albumin (33.42±3.61 g/L Diabetics often had greater LDL, vLDL, and TC levels than controls (p<0.001). Microalbuminuria is connected to renal and metabolic dysfunction.</p><p><strong>Conclusion: </strong>Conclusions: These findings suggest biochemical markers and microalbuminuria may predict T2DM. Early detection of these indications may help doctors prevent chronic kidney disease and cardiovascular issues.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"404-409"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial model of inflammatory bowel diseases: The impact of multisystem comorbidity and mental health on patients' quality of life.","authors":"Iryna Romash, Ivan Romash, Vitalii Yatsynovych, Tetiana Dzvonkovska, Uliana Reinert","doi":"10.36740/Merkur202604115","DOIUrl":"https://doi.org/10.36740/Merkur202604115","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To determine the association between the presence of comorbid pathology, the frequency and nature of extraintestinal manifestations, and changes in different health-related quality-of-life domains in patients with inflammatory bowel diseases.</p><p><strong>Patients and methods: </strong>Materials and Methods: A total of 248 patients with inflammatory bowel disease were examined, including 117 with Crohn's disease (Group I) and 131 with ulcerative colitis (Group II). The control group consisted of 82 apparently healthy individuals. Patients received inpatient treatment at healthcare institutions in Ivano-Frankivsk. The diagnosis was established in accordance with current clinical guidelines. Quality of life was assessed using the IBDQ questionnaire, while comorbidity was evaluated using the Cumulative Illness Rating Scale (CIRS) and the Charlson Comorbidity Index.</p><p><strong>Results: </strong>Results: Patients with IBD demonstrated a statistically significant decrease in the overall IBDQ quality-of-life index compared with the control group (119.3±10.48 in Crohn's disease and 127.4±8.3 in ulcerative colitis versus 198.5±12.6; p<0.001), corresponding to a reduction of 39.9% and 35.9%, respectively. The most pronounced impairments were observed in the systemic and social domains, particularly in patients with Crohn's disease. A high prevalence of comorbid pathology was identified (73% in Crohn's disease and 82% in ulcerative colitis), along with a substantial burden of extraintestinal manifestations, characterized by predominant multisystem involvement in Crohn's disease and mental and vascular disorders in ulcerative colitis. The Charlson Comorbidity Index was higher in Crohn's disease (3.14±0.27) compared with ulcerative colitis (2.93±0.14; p≤0.005), indicating a less favorable prognosis in this patient group.</p><p><strong>Conclusion: </strong>Conclusions: Inflammatory bowel diseases are associated with a marked deterioration in quality of life and a high comorbid burden, substantiating the need for a comprehensive multidisciplinary approach to the management of such patients.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"54 4","pages":"478-487"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}