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Influence of pallet rich plasma, quercetin and their combination on activity of nitric oxide cycle enzymes in nasal mucosa of patients with atrophic rhinitis. 富集托盘血浆、槲皮素及其组合对萎缩性鼻炎患者鼻粘膜一氧化氮循环酶活性的影响
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202401103
Ruslan V Bondarenko, Sergey B Bezshapochnyy, Mychailo I Bezega, Valerii V Loburets, Vitilii O Kostenko, Oleh Ye Akimov, Alevtyna M Bilous
{"title":"Influence of pallet rich plasma, quercetin and their combination on activity of nitric oxide cycle enzymes in nasal mucosa of patients with atrophic rhinitis.","authors":"Ruslan V Bondarenko, Sergey B Bezshapochnyy, Mychailo I Bezega, Valerii V Loburets, Vitilii O Kostenko, Oleh Ye Akimov, Alevtyna M Bilous","doi":"10.36740/Merkur202401103","DOIUrl":"10.36740/Merkur202401103","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To study the general activity of NO synthases (gNOS), the activity of inducible and constitutive isoforms of NO synthase, the activity of arginases, and the concentration of nitrites in the nasal mucosa under the conditions of local treatment of chronic atrophic rhinitis (AR) with quercetin and platelet-rich plasma (PRP therapy)..</p><p><strong>Patients and methods: </strong>Materials and Methods: The study was conducted on 118 patients divided into two groups: control (n=20) and experimental (patients with AR, n=98). Experimental group was divided into 4 subgroups: standard treatment (n=29), PRP therapy (6 injections for 28 day course, n=19), Quercetin (40 mg 3 times a day for 28 days, n=26) and PRP+Quercetin (n=24) groups.</p><p><strong>Results: </strong>Results: Standard therapy of SaR increases gNOS by 278.38% and arginase activity increases by 222.73%. PRP therapy increases gNOS by 211.43% and arginase by 540.91%. Quercetin elevates gNOS by 108.33% and arginase by 250%. PRP therapy and quercetin increases gNOS by 146.15% and arginase by 536.36%.</p><p><strong>Conclusion: </strong>Conclusions: The use of standard therapy of SaR and addition of PRP therapy, quercetin and their combination effectively restores the production of nitric oxide and the arginase activity in the nasal mucosa.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pentose phosphate pathway of glucose-6-phosphate oxidation in the liver of rats with alloxan diabetes on the background of melatonin administrations and variable photoperiod. 在褪黑素给药和光周期变化的背景下,阿脲酮糖尿病大鼠肝脏中葡萄糖-6-磷酸氧化的磷酸五糖途径。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202405109
Oleksandra Yu Kushnir, Iryna Yaremiy, Kyrylo Pantsiuk, Oleksandra Garvasiuk, Volodymyr Vivsyannuk, Kateryna Vlasova, Olena Vlasova
{"title":"Pentose phosphate pathway of glucose-6-phosphate oxidation in the liver of rats with alloxan diabetes on the background of melatonin administrations and variable photoperiod.","authors":"Oleksandra Yu Kushnir, Iryna Yaremiy, Kyrylo Pantsiuk, Oleksandra Garvasiuk, Volodymyr Vivsyannuk, Kateryna Vlasova, Olena Vlasova","doi":"10.36740/Merkur202405109","DOIUrl":"https://doi.org/10.36740/Merkur202405109","url":null,"abstract":"<p><strong>Objective: </strong>. Aim: To find out the influence of melatonin on the enzyme activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and transketolase in the liver of rats with alloxan diabetes under conditions of variable photoperiod.</p><p><strong>Patients and methods: </strong>Materials and Methods: Experiments were conducted on male outbred white rats weighing 180±10 mg. Photoperiodic changes: 1) equinox (light from 8:00 a.m. to 8:00 p.m., 500 lux); 2) light throughout the day and night (500 lux); 3) darkness. Alloxan diabetes was induced by administration of a 5% solution of alloxan monohydrate at a dose of 170 mg/kg once. Groups: 1) control; 2) rats with diabetes mellitus; 3) rats with diabetes mellitus and melatonin injections at the rate of 10 mg/kg of weight for a week daily. Rats were sacrificed on the 12th day in accordance with the ethical principles of experiments on animals. Enzyme activities were determined according to standard methods. Statistical processing was performed according to Statistica 10 StatSoft Inc.</p><p><strong>Results: </strong>Results: In the liver of rats with diabetes mellitus, under the conditions of equinox activities of investigated enzymes decreased by 42, 32 and 40%, while an administration of melatonin let to: 1) an increase in enzyme activities by 40, 31, and 25%, respectively; 2) normalization under conditions of darkness; 3) an increase of the activities by 87, 120, and 60%, respectively in light conditions, compared to the control of equinox.</p><p><strong>Conclusion: </strong>Conclusions: Melatonin contributed to the restoration of the amphibolic and energetic function of the pentose phosphate pathway of glucose-6-phosphate oxidation in liver of rats with alloxan diabetes under condition of variable photoperiod.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 5","pages":"536-540"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational safety of healthcare workers in the terms of the Covid-19 pandemic as the public health aspect. 从公共卫生角度看 Covid-19 大流行中医护人员的职业安全。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202405120
Denys V Varyvonchyk, Оleksandr P Yavorovskyi, Oksana S Petrovska, Liudmyla A Ustinova, Andriy A Kalashnikov, Natalia V Kurdil, Borys I Palamar
{"title":"Occupational safety of healthcare workers in the terms of the Covid-19 pandemic as the public health aspect.","authors":"Denys V Varyvonchyk, Оleksandr P Yavorovskyi, Oksana S Petrovska, Liudmyla A Ustinova, Andriy A Kalashnikov, Natalia V Kurdil, Borys I Palamar","doi":"10.36740/Merkur202405120","DOIUrl":"10.36740/Merkur202405120","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To assess the level of occupational safety, health and hygiene of healthcare workers in the terms of the COVID-19 pandemic..</p><p><strong>Patients and methods: </strong>Materials and Methods: bibliosemantic, bibliographic, analytical, statistical methods as well as a systemic approach have been used in the research. The data of the Cabinet of Ministers of Ukraine, the Ministry of Health of Ukraine, the State Labour Service and the scientific research findings from open sources have been analyzed.</p><p><strong>Conclusion: </strong>Conclusions: The safety of healthcare workers with regard to infection is essential for a secure hospital environment. From an infection prevention perspective, PPE and sanitary requirements are fundamental to ensuring a safe environment for healthcare workers. The analysis revealed inadequate provision of PPE for healthcare workers during the pandemic, with levels ranging from 61,25% to 63,63%. The risk of contracting the novel coronavirus among healthcare personel during the pandemic was 12 times higher than in the general population. The risk of developing an occupational disease among those who treated patients infected with SARS-CoV-2 was 58,1 times higher. The analysis revealed that the provision of personal protective equipment (PPE) to healthcare workers during the study period was only two-thirds of the required amount, which consequently elevated the risk and incidence of morbidity among healthcare workers.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 5","pages":"604-609"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of dentistry in forensic medicine: the process of human remains identification. 牙科在法医学中的作用:遗骸鉴定过程。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202404114
Monika Prokurat, Maciej Słomian, Katarzyna Elżbieta Grudnik, Małgorzata Grudnik, Mateusz Jagielski, Maciej Budzik, Karolina Lau, Janusz Kasperczyk
{"title":"The role of dentistry in forensic medicine: the process of human remains identification.","authors":"Monika Prokurat, Maciej Słomian, Katarzyna Elżbieta Grudnik, Małgorzata Grudnik, Mateusz Jagielski, Maciej Budzik, Karolina Lau, Janusz Kasperczyk","doi":"10.36740/Merkur202404114","DOIUrl":"10.36740/Merkur202404114","url":null,"abstract":"<p><p>The use of dentistry in forensic medicine has gradually become an indispensable tool in the process of identifying human remains. In recent years, there has been a significant increase in the importance of this field in the identification of victims in mass disasters, criminal investigations, ethnic research, and the identification of decomposed and distorted bodies, such as drowning, fire and car accident victims. Dental examinations allow for precise determination of individual identities based on unique dental features. Various methods applied in forensic medicine in the realm of dentistry include dental impressions, radiographs, photographic examinations, rugoscopy, cheiloscopy, and molecular methods. Advanced dental analysis techniques make it possible to restore identities even in the most challenging cases. Equally important is the integration of knowledge and methods of forensic dentistry with other forensic disciplines such as molecular genetics and anthropology. Further research and development in this branch of science are crucial for improving investigative processes and ensuring the dignity of mass disaster victims. The aim of this work is to present methods using teeth for the identification of human remains along with the latest advancements in forensic DNA technology, which utilizes dental evidence to aid in the identification of human remains.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 4","pages":"466-471"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of exercise training after acute coronary syndromes in octogenarians - prospective 12-month evaluation. 八旬老人急性冠状动脉综合征后运动训练的效果--为期 12 个月的前瞻性评估。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202402102
Hanna Rymuza, Justyna Mączyńska, Natasza Krauze, Ilona Kowalik, Edyta Smolis-Bąk, Andrzej Ciszewski, Hanna Szwed, Rafał Dąbrowski
{"title":"Effects of exercise training after acute coronary syndromes in octogenarians - prospective 12-month evaluation.","authors":"Hanna Rymuza, Justyna Mączyńska, Natasza Krauze, Ilona Kowalik, Edyta Smolis-Bąk, Andrzej Ciszewski, Hanna Szwed, Rafał Dąbrowski","doi":"10.36740/Merkur202402102","DOIUrl":"https://doi.org/10.36740/Merkur202402102","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To demonstrate the impact of individual exercise training on the course of the disease, exercise tolerance and quality of life (QoL) in patients over 75 years after acute coronary syndrome (ACS).</p><p><strong>Patients and methods: </strong>Materials and methods: Study included octogenarians after ACS randomly assigned into two groups: a training group (ExT) subjected to individualized physical training and a control group (CG) with standard recommendations for activity. Patients underwent exercise tolerance test (ETT), 6-minute walk test (6-MWT), NHP and QoL questionnaires evaluation, lab tests, ECG, echocardiographic examination at the beginning and after 2, 6 and 12 months.</p><p><strong>Results: </strong>Results: Study included 51 patients, mean age 80 years, 50% men, all patients completed the study. Initial physical capacity was comparable in both groups. After 2-month training the average ETT exercise time increased by 12.5% (p=0.0004), the load increased by 13% (p=0.0005) and the 6-MWT results improved by 8.3% (p=0.0114). Among CG these changes were not significant. But 6 and 12 months after training cessation 6-MWT results returned to the initial values (p=0.069, p=0.062 respecitvely). Average ETT exercise time and average load decreased significantly after 12 months (p=0.0009, p=0.0006). Level of pain was significantly lower at the end of the training in ExT group (p=0.007), but it returned to initial 12 months later (p=0.48). QoL deteriorated significantly in the ExT group 12 months after training cessation (p=0.04).</p><p><strong>Conclusion: </strong>Conclusions: Cardiac rehabilitation in octogenarians after ACS was safe and improved physical performance in a short period of time. Cessation of training resulted in a loss of achieved effects and deterioration of the QoL.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 2","pages":"145-152"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of the spread of medicinal herbs use among patients suffering from chronic diseases in Iraq. 关于伊拉克慢性病患者使用药草情况的研究。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202401112
Qayssar Joudah Fadheel, Rusul Ahmed Mohammed
{"title":"Study of the spread of medicinal herbs use among patients suffering from chronic diseases in Iraq.","authors":"Qayssar Joudah Fadheel, Rusul Ahmed Mohammed","doi":"10.36740/Merkur202401112","DOIUrl":"10.36740/Merkur202401112","url":null,"abstract":"<p><strong>Objective: </strong>Aim: To assess the prevalence of medicinal plants, use among Iraqi patients with chronic disease and compare it with another study in same or different countries.</p><p><strong>Patients and methods: </strong>Materials and Methods: A randomized Internet and social media questionnaire was used. In this cross-sectional study, peoples with chronic diseases from different age group were recruited. Participants had an internet questionnaire to answer. This questionnaire embraced age, gender, occupation, marital status, education level and some lifestyle details as demographic data, a large proportion of the questionnaire was related to herbs, both prescribed and OTC ones.</p><p><strong>Results: </strong>Results: Gender distribution: about 70% of patients were female and 30% male. Education level: uneducated - 35%, primary school - 30%, secondary school - 25%, academic - 10%. Place of residence: 30% lived in urban and 70% in rural areas. Diseases distribution: 30% hypertension, 20% diabetes, 10% asthma, 10% migraine, 15% hyperlipidemia and 15% rheumatoid arthritis. Medicinal plants: 10% green tea, 5%fish oil, 15% anise 25% castor oil and 15% spirulina.</p><p><strong>Conclusion: </strong>Conclusions: The study reported a high prevalence of medicinal herbs use among patients with chronic disease in Iraq. Several factors (rural residence, education, age, multiple chronic conditions and low quality of life) associated with medicinal herbs use. This knowledge will help policy makers and health care providers for decision making on the safe use of herbal medicine.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronavirus infection and systemic inflammatory reaction syndrome. 冠状病毒感染和全身炎症反应综合征。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202401110
Bauyrzhan Sarsembayev, Valentin Madyarov, Marat Kuzikeev, Edil Kurakbayev, Timur Utegaliev
{"title":"Coronavirus infection and systemic inflammatory reaction syndrome.","authors":"Bauyrzhan Sarsembayev, Valentin Madyarov, Marat Kuzikeev, Edil Kurakbayev, Timur Utegaliev","doi":"10.36740/Merkur202401110","DOIUrl":"10.36740/Merkur202401110","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The purpose of this study was a clinical approbation of the Kometad drug (international non-proprietary name sodium colistimethate), an antibiotic from the polymyxin group in patients with severe course of confirmed сoronavirus infection in the intensive care unit of the Branch of the I. Zhekenova Municipal Clinical Infectious Diseases Hospital..</p><p><strong>Patients and methods: </strong>Materials and Methods: The methodology is based on both theoretical and empirical methods of scientific cognition. During the study, the features of the Coronavirus infection and the inflammatory reaction syndrome were considered, which became quite a big problem during the pandemic.</p><p><strong>Results: </strong>Results: The main indications for the tested drug and the consequences of its use for one age group were also determined.</p><p><strong>Conclusion: </strong>Conclusions: The conclusion was made about the positive dynamics of the patients' health status, and recommendations were given for further research in this area. The practical significance of this study lies in the first clinical approbation of the Kometad drug, which can be used in medicine to reduce the severity of the systemic inflammatory reaction syndrome and improve the patient's health as a result of the disease of Coronavirus infection, after further clinical trials of the drug with different age groups of patients.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological parameters and monitoring of analysis of treatment of children and adolescents with type 1 diabetes mellitus in insulin pump therapy with modified educational program. 1 型糖尿病儿童和青少年胰岛素泵治疗的流行病学参数和监测分析与修改后的教育计划。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202401104
Akmaral Tashmanova, Salim Berkinbayev, Gulnara Rakhimova, Madina Mansurova, Gulnur Tyulepberdinova
{"title":"Epidemiological parameters and monitoring of analysis of treatment of children and adolescents with type 1 diabetes mellitus in insulin pump therapy with modified educational program.","authors":"Akmaral Tashmanova, Salim Berkinbayev, Gulnara Rakhimova, Madina Mansurova, Gulnur Tyulepberdinova","doi":"10.36740/Merkur202401104","DOIUrl":"10.36740/Merkur202401104","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of the present published work is efficacy evaluation of the modified educational program in achieving the target levels of glycemia in children and adolescents with type 1 diabetes mellitus in pump insulin therapy in Almaty..</p><p><strong>Patients and methods: </strong>Materials and Methods: This study involved 125 children and adolescents with type 1 DM and evaluated the effectiveness of a modified educational program at the School of Type 1 Diabetes Mellitus. Participants were divided into subgroups based on their method of glycemia evaluation. The program's effectiveness was assessed through pre-and post-training questionnaires and measurement of glycohemoglobin levels. Statistical analysis was conducted using the Statistica application.</p><p><strong>Results: </strong>Results: The study evaluated the effectiveness of a modified educational program for children and adolescents with type 1 DM. The results indicated that those who participated in the modified program demonstrated significant improvements in their knowledge and ability to manage their diabetes. They were able to correctly answer 80-90% of the questionnaire questions six months to a year after the training. Additionally, those in the modified program exhibited better carbohydrate metabolism rates and achieved higher rates of their individual treatment goals, especially when using the FreeStyle Libre system for continuous monitoring of blood glucose levels. These findings suggest that a modified educational approach can significantly enhance diabetes management and treatment outcomes in children and adolescents.</p><p><strong>Conclusion: </strong>Conclusions: The study concluded that a modified educational program leads to better target therapy levels in children and adolescents with type 1 diabetes mellitus, highlighting the importance of motivated parents and frequent blood glycemia measurements.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of reparative processes of chronic wounds using photobiomodulation therapy (experimental study). 利用光生物调节疗法激活慢性伤口的修复过程(实验研究)。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202403101
Sergey Pavlov, Nataliia Babenko, Marina Kumetchko, Olga Litvinova, Iegor Komarchuk
{"title":"Activation of reparative processes of chronic wounds using photobiomodulation therapy (experimental study).","authors":"Sergey Pavlov, Nataliia Babenko, Marina Kumetchko, Olga Litvinova, Iegor Komarchuk","doi":"10.36740/Merkur202403101","DOIUrl":"https://doi.org/10.36740/Merkur202403101","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim of the work was to study the ef f ect of photobiomodulation therapy on the regulation of disorders in the healing of chronic wounds at the remodeling stage using indicators of platelet aggregation activity, reactive oxygen species, platelet-derived growth factor, and interleukin-1β.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study included 3 groups of Wistar rats: intact animals and animals of the control and experimental groups, for which chronic wounds were simulated. Rats in the experimental group received photobiomodulation therapy once a day for 5 days. Wound defects of animals in the control group were fictitiously irradiated. The levels of reactive oxygen species, platelet-derived growth factor, and interleukin-1β in the blood serum of animals were studied by enzyme immunoassay. The functional activity of platelets was measured on a computerized platelet aggregation analyzer using the turbidimetric method. Histological studies were carried out.</p><p><strong>Results: </strong>Results: Changes in the expression of the studied indicators were found in the blood serum of animals with chronic wounds when using photobiomodulation therapy: an increase in platelet-derived growth factor concentrations, the levels of reactive oxygen species and interleukin-1β did not have statistically signif i cant differences compared to the corresponding indicators of animals in the control group. There were no significant differences in the indicators of platelet aggregation activity in the control and experimental groups of animals.</p><p><strong>Conclusion: </strong>Conclusions: The findings suggest that photobiomodulation therapy may promote wound healing by increasing platelet-derived growth factor levels. Histological studies have shown that using photobiomodulation therapy helps reduce inflammation and better organization of collagen fibers in animals of the experimental group.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 3","pages":"261-267"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peculiarities of students' mental functions development under the influence of different physical activities. 不同体育活动影响下学生心理机能发展的特殊性。
Polski Merkuriusz Lekarski Pub Date : 2024-01-01 DOI: 10.36740/Merkur202403109
Grygoriy Griban, Mykhailo F Khoroshukha, Natalia A Lyakhova, Viktoriia V Biletska, Pavlo B Yefimenko, Oksana P Kanishcheva, Tetiana M Zhlobo
{"title":"Peculiarities of students' mental functions development under the influence of different physical activities.","authors":"Grygoriy Griban, Mykhailo F Khoroshukha, Natalia A Lyakhova, Viktoriia V Biletska, Pavlo B Yefimenko, Oksana P Kanishcheva, Tetiana M Zhlobo","doi":"10.36740/Merkur202403109","DOIUrl":"https://doi.org/10.36740/Merkur202403109","url":null,"abstract":"<p><strong>Objective: </strong>Aim: The aim is to study the influence of the training activities of different orientations on the attention development of student specializing in different sports.</p><p><strong>Patients and methods: </strong>Materials and Methods: The study involved 127 students, who were divided into three groups: group A (n=68) was engaged in speed and power sports, group B (n=59) was engaged in endurance sports, the control group (n=83) included peer students who did not do sports during their studies. The research on students' attention was carried out according to Anfimov's test using a table with letters.</p><p><strong>Results: </strong>Results: It was revealed that speed and power activities increase the integrated indicator of attention (the coefficient of work performance) based only on the speed of viewing characters with unreliable changes in the correctness of the work indicators. Under the influence of endurance training, the coefficient of efficiency is increased based on both an increase in the speed of viewing characters and the correctness of the work indicators. The students of the control group were found to have insignificant changes in the studied indicators of attention.</p><p><strong>Conclusion: </strong>Conclusions: This suggests that endurance training promotes the development of students' attention more ef f ectively. It is set, that specifics of the training process, its orientation equally specifically specialize the peculiarities of the attention development of students.</p>","PeriodicalId":39518,"journal":{"name":"Polski Merkuriusz Lekarski","volume":"52 3","pages":"326-331"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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