Open Biomarkers Journal最新文献

{"title":"Plasma Fibrinogen as a Biomarker of Stable and Exacerbated Chronic Obstructive Pulmonary Disease","authors":"Kashifa Ehsan, S. Zulfiqar, Amber Hassan, H. Waseem","doi":"10.2174/1875318302111010048","DOIUrl":"https://doi.org/10.2174/1875318302111010048","url":null,"abstract":"Background: Chronic Obstructive Pulmonary Disease (COPD) is a preventable and treatable disease, but is a partially reversible chronic inflammatory condition characterized by airway obstruction. COPD remains under-diagnosed and under-treated because the only available diagnostic method at present is testing lung functions by spirometry which is not helpful to determine the severity and clinical outcomes of the disease. Circulating biomarkers are under consideration for various diseases worldwide. Plasma fibrinogen is emerging as one of the most promising biomarkers of COPD in smokers.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"11 1","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42723402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hidden Danger of Environmental Chemicals during the “Windows of Susceptibility” in a Woman’s Life – How can we use Intermediate Biomarkers to Improve Breast Cancer Prevention?","authors":"K. Rygiel","doi":"10.2174/1875318302111010054","DOIUrl":"https://doi.org/10.2174/1875318302111010054","url":null,"abstract":"Usually, there is a long interval of time between the exposure to EDC and BC incidence, and this often represents a serious obstacle for effective BC prophylaxis. Notably, during certain periods of a woman’s life cycle, the BC risk is particularly elevated due to increased susceptibility to some EDC. These windows of susceptibility (WOS) include prenatal, puberty, pregnancy, and menopausal transition stages of a female’s life course.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"11 1","pages":"54-62"},"PeriodicalIF":0.0,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47853123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of Carbohydrate Antigen 19-9 as a biomarker in Hepatocellular Carcinoma and Cholangiocarcinoma","authors":"Badawy A. Abdulaziz, W. Agawy, M. Ibrahim, M. Khalil, W. A. Halim","doi":"10.2174/1875318302111010039","DOIUrl":"https://doi.org/10.2174/1875318302111010039","url":null,"abstract":"Background & Aims: Combined hepatocellular cholangiocarcinomas (cHCC-CCs) are rare malignancies representing less than 1% of all primary liver cancers. Correct preoperative diagnosis is desirable because the frequency of lymph node metastasis in ICC and cHCC-CC, making lymph node dissection a necessity if curative resection to be attempted. This study aimed to investigate the significance of elevated CA19-9 in suspecting a diagnosis of Intrahepatic Cholangiocarcinoma (ICC) “non-invasively” in patients with typical radiological features of HCC.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"11 1","pages":"39-47"},"PeriodicalIF":0.0,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46316692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of MicroRNAs (miRNA 155, miRNA-146b) and Procalcitonin as Novel Markers for the Diagnosis of Spontaneous Bacterial Peritonitis","authors":"D. M. A. El-Hassib, D. Abo-Elmatty, N. Mesbah, S. Abd-Elsalam, Shorouk A. Bastawisy, Doaa E., Ayat Mahmoud Hassan, F. Zahran, Reda S. Abdelghany, R. Siddik, A. Abdel-Hamed","doi":"10.2174/1875318302111010028","DOIUrl":"https://doi.org/10.2174/1875318302111010028","url":null,"abstract":"Department of Clinical and Chemical Pathology, Benha Faculty of Medicine, Benha University, Egypt Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt Department of Tropical Medicine, Tanta University, Tanta, Egypt Department of Biochemistry, Misr University for Science and Technology, Giza, Egypt Department of Electron Microscopy, Theodor Bilharz Research Institute, Giza, Egypt Department of Internal Medicine, Faculty of Medicine (Girls), Al -Azhar University, Cairo, Egypt Department of Tropical Medicine, Ahmed Maher Teaching Hospital, Cairo, Egypt Department of Internal Medicine, National Research Center, Cairo, Egypt","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"11 1","pages":"28-38"},"PeriodicalIF":0.0,"publicationDate":"2021-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45243000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-targeted Serum Metabolomics Identifies Candidate Biomarkers Panels Associated with Nonalcoholic Fatty Liver Disease: A Pilot Study in Russian Male Patients","authors":"E. Demyanova, E. Shcherbakova, Tatyana S. Sall, I. Bakulin, T. Vakhitov, Stanislav Sitkin","doi":"10.2174/1875318302111010017","DOIUrl":"https://doi.org/10.2174/1875318302111010017","url":null,"abstract":"RESEARCH ARTICLE Non-targeted Serum Metabolomics Identifies Candidate Biomarkers Panels Associated with Nonalcoholic Fatty Liver Disease: A Pilot Study in Russian Male Patients Elena V. Demyanova, Elena S. Shcherbakova, Tatyana S. Sall, Igor G. Bakulin, Timur Ya. Vakhitov and Stanislav I. Sitkin Department of Microbiology, State Research Institute of Highly Pure Biopreparations, St. Petersburg, Russia Department of Internal Diseases, Gastroenterology and Dietetics, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"11 1","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"2021-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41358431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrected ESR/Albumin Ratio as a Simple, Practical Marker Predicts the Severity in Egyptian Ulcerative Colitis Patients","authors":"S. E. Sharawy, H. El-Horany, I. Amer","doi":"10.2174/1875318302111010008","DOIUrl":"https://doi.org/10.2174/1875318302111010008","url":null,"abstract":"RESEARCH ARTICLE Corrected ESR/Albumin Ratio as a Simple, Practical Marker Predicts the Severity in Egyptian Ulcerative Colitis Patients Shimaa El Sharawy, Hemat El-Horany and Ibrahim Amer Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt Department of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Kafr El Sheikh University, Kafr Elsheikh, Egypt","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"11 1","pages":"8-16"},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45656711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Growth Factor-1 as a Predictor for the Progression of Hepatic Disease in Chronic Hepatitis B Virus Infection","authors":"A. Mohamed, S. Abd-Elsalam, M. El-Daly, Noha Kamal, S. Saed, Seham Mohamoud, H. Abed, Reda S. Abdelghany, Shereen Ahmed","doi":"10.2174/1875318302111010001","DOIUrl":"https://doi.org/10.2174/1875318302111010001","url":null,"abstract":"Department of Biochemistry, National Hepatology and Tropical Medicine Research Institution, Cairo, Egypt Department of Tropical Medicine , Tanta University, Tanta, Egypt Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia Department of Molecular Biology , National Liver Institute, Menoufia University, Shebin El-Kom, Egypt Theodor Bilharz Research Institute (TBRI), Ministry of Scientific Research and Higher Education Department of Clinical and Chemical Pathology , Faculty of Medicine, Cairo University, Cairo, Egypt Department of Tropical Medicine , El Sahel teaching hospital, Cairo, Egypt Department of Public Health, Faculty of Medicine, Benha University, Banha, Egypt Department of Tropical Medicine , Ahmed Maher Teaching Hospital, Cairo, Egypt Department of Medical Microbiology and Immunology , Faculty of Medicine, Benha University, Banha, Egypt","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"11 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45079615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Markers as a Predictor of Hepatic Fibrosis Compared to Fibroscan in chronic hepatitis B Infected Egyptian patients: A Cross-sectional Study","authors":"R. Badawi, Hanan H Soliman, D. Ziada, M. Elhendawy, S. Abd-Elsalam, M. Salama, S. Soliman, Reham M. Gameaa, N. Hawash","doi":"10.2174/1875318302010010069","DOIUrl":"https://doi.org/10.2174/1875318302010010069","url":null,"abstract":"The gamma-glutamyl transpeptidase (GGT) to platelet ratio (GPR), the gamma-glutamyl transpeptidase to albumin (GAR) and S-index are novel biomarkers suggested to assess liver fibrosis. The aim of the work was to assess the correlation between GGT and other related markers as GAR and GPR among other previous documented markers and the degree of fibrosis and steatosis in chronic HBV Egyptian patients as measured by fibroscan.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"10 1","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"2020-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43519131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Cotinine as a Biomarker of Cigarette Smoke Exposure: A Method to Differentiate Among Active, Second-Hand, and Non-Smoker Circumstances","authors":"A. Fernandes, L. Santos, G. Pinheiro, Diego da Silva Vasconcellos, Sérgio Telles de Oliva, Bruno José Dumêt Fernandes, R. Couto","doi":"10.2174/1875318302010010060","DOIUrl":"https://doi.org/10.2174/1875318302010010060","url":null,"abstract":"Program for Asthma Control in Bahia (ProAR) and Graduate Studies in Medicine and Health, Bahia Medical School , Federal University of Bahia UFBA, Salvador, Bahia, Brazil The Graduate Program in Immunology, Institute of Health Sciences, Federal University of Bahia UFBA, Salvador, Bahia, Brazil Environmental Analytical Chemistry Laboratory, Department of Analytical Chemistry, Institute of Chemistry, Federal University of Bahia UFBA, Salvador, Bahia, Brazil. Graduate Program in Pharmacy (PPGFAR-UFBA), Clinical Biochemistry and Lipid Metabolism Laboratory, Department of Clinical Chemistry and Toxicological Analyses, Faculty of Pharmacy, Federal University of Bahia UFBA. Barão de Jeremoabo, Salvador, Bahia, Brazil","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"10 1","pages":"60-68"},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47752432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Human Leukocyte Antigen-DQ Polymorphisms and Treatment Response in Chronic Hepatitis B Egyptian Population: A Prospective Study","authors":"A. Mohamed, S. Abd-Elsalam, M. Zaghloul, Mohamed A. Attala, R. Khattab, A. Khater, D. El-damasy, Eman F El-Sayed, S. Hassanin, N. Hawash, Mohmoud R. Mohamed","doi":"10.2174/1875318302010010055","DOIUrl":"https://doi.org/10.2174/1875318302010010055","url":null,"abstract":"\u0000 \u0000 Several studies, in different populations, have focused on the role of HLA-DQ gene polymorphism in the pathogenesis of HBV infection. However, these findings are still controversial. This study aimed to determine HLA-DQ polymorphism in Chronic HBV patients and its impact on the response to antiviral therapy.\u0000 \u0000 \u0000 \u0000 This study was carried out on a total number of 188 participants, they were subdivided as follows: Group I (patients’ group): included 97 patients with chronic hepatitis B viral infection that was further subdivided according to response to treatment into responder and non-responder subgroups, Group II (Control group): included 91 normal healthy subjects who were matched to the patient group by sex and age. PCR (Polymerase Chain Reaction) testing, for HBV-DNA, was done for all participants enrolled in the study to measure the viral virus load before and after treatment. HLA- DQ polymorphism allelic discrimination assay was assayed using the Real-time equipment.\u0000 \u0000 \u0000 \u0000 In a general analysis for the SNP rs7453920, the overall genotypes frequencies were 37% for A/A, 60.6% for A/G, and 37% for G/G. The G alleles of HLA-DQ rs7453920 were significantly increased in chronic HBV infection patients. A total of 77 (79.4%) patients were responders. Among this group, 72.7% were male, and the average age was 38.59 ±9.15 years. On evaluation of the association between polymorphisms in HLA-DQ gene and treatment response, the results indicated that response to treatment declined when patients were carrying the more unfavorable rs 7453920 GG with a response rate of 64%. Patients carrying the mutant allele AG, or the wild type allele AA were more likely to achieve a higher rate of response (84.8% and 83.3%, respectively).\u0000 \u0000 \u0000 \u0000 The presence of HLA-DQB2 rs 7453920-G serves as a risk factor for chronic HBV infection and treatment failure in the Egyptian population.\u0000","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43336043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}