Open Biomarkers Journal最新文献_第2页

Role of Serum Cystatin C as a Diagnostic Tool for Renal Function in Cirrhotic Patients 血清半胱氨酸蛋白酶抑制剂C作为肝硬化患者肾功能诊断工具的作用

Open Biomarkers Journal Pub Date : 2022-04-08 DOI: 10.2174/18753183-v12-e2203210

Fathia Asal, M. Yousef, H. Abdraboh, S. Abd-Elsalam, Ahmed Abdelaziz Abdelaziz Shama, M. Elbahnasawy, M. Elnaggar, Hesham Ahmed Alsrogy, Heba Elashry

引用次数: 0

Combination of Albumin-Bilirubin Grade and Platelet Count as a Predictor of Esophageal Varices’ Presence and Grading in Egyptian Patients with HCV Related Cirrhosis 白蛋白-胆红素分级和血小板计数联合预测埃及HCV相关肝硬化患者食管静脉曲张的存在和分级

Open Biomarkers Journal Pub Date : 2022-02-07 DOI: 10.2174/18753183-v12-2112230

Amera Esam AbdElmoneim Moharm, F. El-Kalla, A. Kobtan, W. ElKhalawany

{"title":"Combination of Albumin-Bilirubin Grade and Platelet Count as a Predictor of Esophageal Varices’ Presence and Grading in Egyptian Patients with HCV Related Cirrhosis","authors":"Amera Esam AbdElmoneim Moharm, F. El-Kalla, A. Kobtan, W. ElKhalawany","doi":"10.2174/18753183-v12-2112230","DOIUrl":"https://doi.org/10.2174/18753183-v12-2112230","url":null,"abstract":"\u0000 \u0000 Screening guidelines recommend that all patients who are newly diagnosed with cirrhosis should be screened for esophageal varices (EV). This study aimed at predicting the presence of esophageal varices among Egyptian hepatitis C cirrhotic patients by a combination of albumin-bilirubin grade and platelet count score (ALBI-Platelet score).\u0000 \u0000 \u0000 \u0000 This study was performed on 150 cirrhotic patients. Eighty- seven patients with hepatitis C virus (HCV) related cirrhosis and esophageal varices formed Group (A), while Group (B) consisted of sixty-three patients with HCV related cirrhosis and no esophageal varices. Full metabolic profile, Complete blood count (CBC), ultrasonography, and endoscopy were done.\u0000 \u0000 \u0000 \u0000 There was a significant difference between studied groups regarding serum bilirubin, serum albumin and platelet count. The cutoff point of platelets count as a predictor for esophageal varices among studied groups was <154.5. The cutoff value for albumin-bilirubin (ALBI) score as a predictor for esophageal varices of any size was -1.67 with 52.9% sensitivity, 59.6% specificity, 47% negative predictive value (NPV) and 64% positive predictive value (PPV). The ALBI-Plt score >3 had 42.5%, specificity 63.5%, negative predictive value 40% and positive predictive value 65%. The cutoff value for the ALBI score representing large-sized esophageal varices was -1.27. The ALBI-Plt score >4 for large-sized varices had sensitivity 61.9%, specificity 55%, negative predictive value 59%, positive predictive value 50%.\u0000 \u0000 \u0000 \u0000 ALBI-Platelet score is a non-costly, readily available and reliable new non-invasive predictor of the presence of EV that could easily be used in screening for the presence of esophageal varices and risky large-sized esophageal varices in cases of hepatitis C Virus related hepatic cirrhosis, lessening the need for endoscopic screening.\u0000","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41662798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Phage Therapy in the Treatment of Infectious Diseases: An Overview 噬菌体疗法在感染性疾病治疗中的应用综述

Open Biomarkers Journal Pub Date : 2021-12-23 DOI: 10.2174/1875318302111010126

Mahsa Jalili, N. Ansari, S. Bakhtiari, F. Jalilian

引用次数: 0

COL1A1 Gene Expression in Hepatitis B Virus (HBV) Related Hepatocellular Carcinoma (HCC) Egyptian's Patients COL1A1基因在乙型肝炎病毒(HBV)相关肝细胞癌(HCC)埃及患者中的表达

Open Biomarkers Journal Pub Date : 2021-12-20 DOI: 10.2174/1875318302111010108

A. Mohamed, Y. Abo-Amer, Amyan Aalkhalegy, L. Fathalla, Mostafa Bedair Elmaghraby, M. M. Elhoseeny, S. M. Mostafa, Mohamed El-Abgeegy, R. Khattab, D. El-damasy, Wafaa Salah, A. M. Salem, W. Elmashad, M. Elbahnasawy, S. Abd-Elsalam

{"title":"COL1A1 Gene Expression in Hepatitis B Virus (HBV) Related Hepatocellular Carcinoma (HCC) Egyptian's Patients","authors":"A. Mohamed, Y. Abo-Amer, Amyan Aalkhalegy, L. Fathalla, Mostafa Bedair Elmaghraby, M. M. Elhoseeny, S. M. Mostafa, Mohamed El-Abgeegy, R. Khattab, D. El-damasy, Wafaa Salah, A. M. Salem, W. Elmashad, M. Elbahnasawy, S. Abd-Elsalam","doi":"10.2174/1875318302111010108","DOIUrl":"https://doi.org/10.2174/1875318302111010108","url":null,"abstract":"\u0000 \u0000 Collagens are the most abundant proteins in the human body, accounting for one-third of total proteins. Over the last few years, accumulated evidence have indicated that some collagens are differentially expressed in cancer. The aim of the study was to assess COL1A1 gene expression as a novel marker for the progression of hepatitis B cirrhosis into hepatocellular carcinoma.\u0000 \u0000 \u0000 \u0000 This cohort study included 348 subjects and was conducted between May 2018 and June 2019. Subjects were divided into 4 groups: group1 included HBV positive hepatocellular carcinoma patients “HCC” (n= 87), group II included HBV positive patients with liver cirrhosis “LC” (n = 87), group III included chronic hepatitis B patients with neither HCC nor cirrhosis “ C-HBV” (n = 87) and group IV consisted of healthy volunteers as controls (n = 87). Fasting venous blood samples (10 ml) were collected from each participant in this study and were used for assessment of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, albumin and alfa-fetoprotein (AFP). Another portion of blood was collected in 2 vacutainer tubes containing EDTA, one for Complete blood count and the other for gene expression of COL1A1.\u0000 \u0000 \u0000 \u0000 The gene expression of collagen was 6.9 ± 8.8 in group 1 (HBV positive hepatocellular carcinoma patients) and this was a significant increase in comparison with the other groups. In group 2 (HBV positive patients with liver cirrhosis), the gene expression (collagen) was 3.7±1.5 and it was significantly increased when compared with group 4 (healthy volunteers).\u0000 \u0000 \u0000 \u0000 COL1A1 gene expression can be used as an indicator of the progression of hepatitis B cirrhosis into hepatocellular carcinoma.\u0000","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44517829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prognostic Value of Long Non-coding RNAs in Urological Malignancies: A Systematic Review, and Meta-Analysis 泌尿系恶性肿瘤中长非编码RNA的预后价值：系统综述和荟萃分析

Open Biomarkers Journal Pub Date : 2021-12-20 DOI: 10.2174/1875318302111010115

Z. Bagheri, Mohammad-Hassan Arjmand

{"title":"Prognostic Value of Long Non-coding RNAs in Urological Malignancies: A Systematic Review, and Meta-Analysis","authors":"Z. Bagheri, Mohammad-Hassan Arjmand","doi":"10.2174/1875318302111010115","DOIUrl":"https://doi.org/10.2174/1875318302111010115","url":null,"abstract":"\u0000 \u0000 Many studies have explored the potential roles of long non-coding RNAs (lncRNAs) in urological cancer (UC) progression. The clinical outcome and prognosis of UCs remain weak. Therefore, finding clinical prognostic markers is needed to improve therapeutic potential. The aim of this study was to consider the possible association between the lncRNAs expression with the survival time and clinical outcomes in patients with UC.\u0000 \u0000 \u0000 \u0000 A literature search was performed in several related databases to find eligible English papers published before 9 February 2021. Hazard ratios (HRs) with 95% CI were calculated to investigate the association between lncRNAs expression and overall survival in patients with UC.\u0000 \u0000 \u0000 \u0000 A total of 46 studies, including 39 lncRNAs were identified. Results indicated that lncRNAs expression was significantly correlated with poor overall survival (OS) outcome in patients with UCs (HR: 1.923, 95% CI: 1.448-2.554, P<0.001). Also, we divided included studies into up-regulated and down-regulated subgroups according to lncRNAs expression. The results indicated a significant association with poor OS outcomes in both up-regulated (HR=2.546, 95% CI: 1.896-3.41, P<0.001) and down-regulated (HR=0.33, 95% CI: 0.22-0.49, P<0.001). Moreover, expression of lncRNAs was significantly associated with lymph node metastasis (LNM) (OR=0.25, 95% CI: 0.13-0.47, P<0.001)\u0000 \u0000 \u0000 \u0000 Abnormal expression of various lncRNAs is a potential novel marker for predicting the clinical outcomes of urological tumors.\u0000","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49516484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Serological Testing for Managing the COVID-19 Pandemic: A Review 快速血清学检测用于管理COVID-19大流行:综述

Open Biomarkers Journal Pub Date : 2021-12-16 DOI: 10.2174/1875318302111010099

S. M. Faheem, Jancie D’Mello, S. Kaleem, B. Prasad, K. Siddiqui

引用次数: 0

Lipid Profiles as Markers for the Severity of Liver Diseases in Cirrhotic Patients 作为肝硬化患者肝脏疾病严重程度标志的脂质图谱

Open Biomarkers Journal Pub Date : 2021-11-17 DOI: 10.2174/1875318302111010093

R. Badawi, Mohamed Zakaria Abu Rahma, H. Ramadan, S. Soliman, D. Mohareb, N. Hawash, R. Elkafoury, S. Abd-Elsalam

{"title":"Lipid Profiles as Markers for the Severity of Liver Diseases in Cirrhotic Patients","authors":"R. Badawi, Mohamed Zakaria Abu Rahma, H. Ramadan, S. Soliman, D. Mohareb, N. Hawash, R. Elkafoury, S. Abd-Elsalam","doi":"10.2174/1875318302111010093","DOIUrl":"https://doi.org/10.2174/1875318302111010093","url":null,"abstract":"\u0000 \u0000 Liver cirrhosis is a diffuse process in which the anatomical structure and function of the liver are disturbed. Lipid metabolism occurs mainly in the hepatocytes. In liver cirrhosis, it is expected to detect abnormal lipid profile and abnormal neutrophil to lymphocyte ratio due to necro-inflammation and hepatocyte dysfunction. This study aimed to estimate the lipid profile in patients with liver cirrhosis and to assess its relation to the severity of the liver disease based on Child-Pugh Turcotte score and Neutrophil to Lymphocyte Ratio (NLR).\u0000 \u0000 \u0000 \u0000 This study included 500 cirrhotic patients. All patients are subjected to history taking, clinical examination, liver and renal function tests, lipid profile, and also abdomino-pelvic ultrasound. Child -Pugh score, fibrosis-4 score (FIB4), and neutrophil and platelet lymphocyte ratio were calculated.\u0000 \u0000 \u0000 \u0000 A total of 500 patients were enrolled in this study; 12 patients were excluded (two patients were on the immunosuppressive drug, three patients had body mass index (BMI) >30, and seven patients took lipid-lowering drugs). Cholesterol level was significantly higher in patients with Child- Score A than B and C. Cholesterol, Low-Density Lipoprotein (LDL), and very-low-density lipoprotein (VLDL) cholesterol were significantly higher in Child B than C. A significant negative correlation was found between cholesterol level and each of FIB4 and NLR ratios.\u0000 \u0000 \u0000 \u0000 There was a significant negative correlation between the severity of liver cirrhosis and lipid profiles (except triglyceride), FIB4 and NLR ratio.\u0000","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44471813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of a Predictive Model of Pre-eclampsia from a Cohort Study in Pregnant Women 孕妇队列研究中先兆子痫预测模型的验证

Open Biomarkers Journal Pub Date : 2021-11-10 DOI: 10.2174/1875318302111010086

H. C. Vadell, R. Barroso, A. C. Diéguez, Adrian M. Pujals, Eloy D. Á. Guerra

{"title":"Validation of a Predictive Model of Pre-eclampsia from a Cohort Study in Pregnant Women","authors":"H. C. Vadell, R. Barroso, A. C. Diéguez, Adrian M. Pujals, Eloy D. Á. Guerra","doi":"10.2174/1875318302111010086","DOIUrl":"https://doi.org/10.2174/1875318302111010086","url":null,"abstract":"\u0000 \u0000 To validate a predictive model of pre-eclampsia for classifying pregnant women into pre-eclamptic and healthy groups.\u0000 \u0000 \u0000 \u0000 A cohort study was carried out in a total of 132 pregnant women, including biochemical and clinical parameters for assessing the classification performed by a predictive model of pre-eclampsia from a 10-fold cross-validation method and the experts’ criteria.\u0000 \u0000 \u0000 \u0000 A highly predictive value was obtained from the set of biochemical parameters included in the proposed model. Wilks’ Lambda, eigenvalues, canonical correlation, and distances between centroids of the groups point to the high classificatory power of the discriminant function. Risk indexes, computed from the centroids, provided a measure of different risk levels for this condition. The analysis of these indexes in a prospective study allowed assessing the effect of the parameters. The new ten models obtained from a 10-fold cross-validation achieved a 100% of correct classification (AUC:1.00; CI:0.00-1.00; p=0.00). The sensitivity and specificity of the model, obtained from ROC curves, showed the consistency of the model, even though there were only four clinical manifestations of the entity. Moreover, the risk indexes were assessed from the experts’ criteria in the cohort study, showing an AUC of 100% in the 3rd trimester of pregnancy.\u0000 \u0000 \u0000 \u0000 The model and proposed pre-eclampsia risk indexes could constitute an accurate diagnostic tool, employing markers of oxidative stress as a significant element in the prediction of this entity.\u0000","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48537420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Genomic Predictive Biomarkers for Early-Stage Lung Cancer Patients 早期癌症患者的预后基因组预测生物标志物

Open Biomarkers Journal Pub Date : 2021-09-17 DOI: 10.2174/1875318302111010069

H. Moon, A. Nguyen, Evan Lee

{"title":"Prognostic Genomic Predictive Biomarkers for Early-Stage Lung Cancer Patients","authors":"H. Moon, A. Nguyen, Evan Lee","doi":"10.2174/1875318302111010069","DOIUrl":"https://doi.org/10.2174/1875318302111010069","url":null,"abstract":"\u0000 \u0000 Our goal is to find predictive genomic biomarkers in order to identify subgroups of early-stage lung cancer patients that are most likely to benefit from adjuvant chemotherapy with surgery (ACT).\u0000 \u0000 \u0000 \u0000 Receiving ACT appears to have a better prognosis for more severe early-stage non-small cell lung cancer patients than surgical resection only. However, not all patients benefit from chemotherapy.\u0000 \u0000 \u0000 \u0000 Preliminary studies suggest that the application of ACT is associated with a better prognosis for more severe NSCLC patients compared to those who only underwent surgical resection. Given the immense personal and financial costs associated with ACT, finding the patients who are most likely to benefit from ACT is paramount. Thus, the purpose of this research is to utilize gene expression and clinical data from lung cancer patients to find treatment-associated genomic biomarkers.\u0000 \u0000 \u0000 \u0000 To investigate the treatment effect, a modified-covariate regularized Cox regression model with lasso penalty is implemented using National Cancer Institute gene expression data to find genomic biomarkers.\u0000 \u0000 \u0000 \u0000 This research utilized an independent validation dataset involving 318 lung cancer patients to validate the models. In the validation set with 318 patients, the modified covariate Cox model with lasso penalty were able to show patients who followed their predicted recommendation (either ACT for low-risk group or OBS for the high-risk group, n = 171) have higher survival benefits than 147 patients who did not follow the recommendations (p < .0001).\u0000 \u0000 \u0000 \u0000 Based on validation data, patients who follow our predicted recommendation by genomic biomarkers selected from the proposed model will likely benefit from ACT.\u0000","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41577218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidermal Growth Factor rs4444903 A>G Gene Polymorphism Association with Chronic Hepatitis B Liver Disease Progression among Egyptian Children: A Multicenter Study 表皮生长因子rs4444903A>G基因多态性与埃及儿童慢性乙型肝炎肝病进展的多中心研究

Open Biomarkers Journal Pub Date : 2021-07-12 DOI: 10.2174/1875318302111010063

A. Mohamed, G. A. Hakeem, Gihan M. Babrs, Laila E. Abolfotoh, N. Shehata, S. Maher, Suzan M. Mousa, A. Ismail, D. Ezzat, Ahmed G. K. Habib, D. Ghaith, Naglaa Fawazy, R. Khattab, Eman S. Habib, D. M. A. El-Hassib, S. Abd-Elsalam, D. El-damasy

{"title":"Epidermal Growth Factor rs4444903 A>G Gene Polymorphism Association with Chronic Hepatitis B Liver Disease Progression among Egyptian Children: A Multicenter Study","authors":"A. Mohamed, G. A. Hakeem, Gihan M. Babrs, Laila E. Abolfotoh, N. Shehata, S. Maher, Suzan M. Mousa, A. Ismail, D. Ezzat, Ahmed G. K. Habib, D. Ghaith, Naglaa Fawazy, R. Khattab, Eman S. Habib, D. M. A. El-Hassib, S. Abd-Elsalam, D. El-damasy","doi":"10.2174/1875318302111010063","DOIUrl":"https://doi.org/10.2174/1875318302111010063","url":null,"abstract":"Polymorphisms of genes encoding the pro-inflammatory and anti-inflammatory cytokines can affect the clinical presentation of the infection. We aimed to assess the role of EGF gene single-nucleotide polymorphism in the outcome of chronic hepatitis B virus (HBV) infection in children. One hundred HBV-infected children and 75 healthy matched controls were enrolled in this prospective study. Patients included 18 chronic inactive and 82 chronic active carriers. EGF rs4444903 A>G genotypes were determined using allele-specific amplification. Significant differences regarding EGF genotypic frequency (p=0.001) in patients compared to controls (p=0.001). Eighteen percent were inactive, and 82% were active carriers. AA, AG and GG genotypic frequency were 66.7%, 33.3%, 0% and were 3.7%, 37.8% and 58.5% in the inactive and active carriers, respectively, with significant differences regarding AA, AG, GG genotypic frequency (p=0.001 for all). EGF AA, AG, GG genotypes frequency were 1.9%, 33.3%, and 64.8%, respectively, with significant differences between cirrhotic and non-cirrhotic patients regarding AA, AG, GG genotypic frequency (p=0.001 for all). Increased G allele frequency in EGF rs4444903 A > G polymorphism in HBV- Egyptian children is associated with worse outcomes.","PeriodicalId":39398,"journal":{"name":"Open Biomarkers Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47783975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0