血清半胱氨酸蛋白酶抑制剂C作为肝硬化患者肾功能诊断工具的作用

Q3 Medicine

Open Biomarkers Journal Pub Date : 2022-04-08 DOI:10.2174/18753183-v12-e2203210

Fathia Asal, M. Yousef, H. Abdraboh, S. Abd-Elsalam, Ahmed Abdelaziz Abdelaziz Shama, M. Elbahnasawy, M. Elnaggar, Hesham Ahmed Alsrogy, Heba Elashry

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引用次数: 0

摘要

胱抑素C水平的评估在早期检测肾功能障碍中可能有价值，因为随着肾小球滤过率的降低，胱抑素C的增加速度快于肌酐水平。这项工作的目的是评估血清胱抑素C作为诊断肝硬化伴或不伴肝肾综合征（HRS）患者肾功能障碍的工具。这项病例对照研究是对坦塔大学医院热带医学部的60名患者和10名健康对照志愿者进行的。测定三组血清胱抑素C。三组之间存在显著差异，因为HRS患者的胱抑素C高于肝硬化组和健康对照组。血清胱抑素C是肝肾综合征的良好预测指标，与血清肌酐、血尿素、肾小球滤过率和肌酐清除率有良好相关性。

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Role of Serum Cystatin C as a Diagnostic Tool for Renal Function in Cirrhotic Patients

Assessment of cystatin C levels could be valuable in the early detection of renal dysfunction because they increase faster than the creatinine levels as the GFR decreases. The aim of this work was to evaluate serum cystatin C as a diagnostic tool for renal dysfunction in cirrhotic patients with and without hepatorenal syndrome (HRS). This case-control study was conducted on 60 patients from the Tropical Medicine Department of Tanta University Hospitals and 10 people served as healthy control volunteers. Serum cystatin C was measured in the three groups. A significant difference was observed among the three groups as cystatin C was higher in patients with HRS compared to the cirrhotic group and healthy controls. Serum cystatin C is a good predictor for hepatorenal syndrome with a good correlation with serum creatinine, blood urea, GFR, and creatinine clearance.

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来源期刊

Open Biomarkers Journal Medicine-Medicine (miscellaneous)

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Open Biomarkers Journal is an Open Access online journal, which publishes original full-length, short research articles and reviews on biomarkers in clinical, medical and pharmaceutical research. The coverage includes biomarkers of disease, new biomarkers, exposure to drugs, genetic effects, and applications of biomarkers. The Open Biomarkers Journal, a peer reviewed journal, aims to provide the most complete and reliable source of information on current developments in the field. The emphasis will be on publishing quality articles rapidly and freely available to researchers worldwide.