Indian Journal of Tuberculosis最新文献

{"title":"An investigation of knowledge, attitude and practice towards tuberculosis among denizen of Sikkim","authors":"Jiwan Gurung,&nbsp;Sonam Tashi Bhutia,&nbsp;Prashanti Pradhan","doi":"10.1016/j.ijtb.2024.01.012","DOIUrl":"10.1016/j.ijtb.2024.01.012","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis (TB) is a significant global health problem caused by Mycobacterium tuberculosis<span>, leading to high mortality rates in developing countries. India bears the highest burden of TB, yet there is a lack of studies on public understanding and preventive practices related to TB. Further, Sikkim, with limited healthcare access, lacks research on its population's TB awareness.</span></div></div><div><h3>Aim</h3><div>An online survey was conducted in Sikkim to assess people's knowledge, attitudes, and prevention practices regarding TB.</div></div><div><h3>Materials</h3><div>A cross-section study was conducted among 250 denizen of Sikkim. The data was collected through online survey link (Google Forms) through social media (Facebook, Messenger, WhatsApp, and Electronic Email). A total of 38-item questionnaire was administered for this present study.</div></div><div><h3>Results</h3><div>Most respondents were young, female and postgraduate students. The questionnaire had high reliability (0.86) and showed high awareness of TB (94.29 %) and its curability (90.00 %). However, misconceptions persisted, including beliefs about transmission through food, utensils, and mosquito bites. A significant portion considered TB serious (39.05 %) and believed in their susceptibility (82.86 %). Many were compassionate (53.81 %) and willing to help TB patients. Despite being aware, a considerable number of respondents had not undergone TB screening (83.33 %) and had no health education (70.00 %). Many preferred modern medications for treatment (80.00 %) and would visit health facilities if symptoms occurred (71.90 %). However, stigmatization was evident, with over half believing the community avoids TB patients (54.56 %).</div></div><div><h3>Conclusion</h3><div>The study shows a commendable level of knowledge among participants about various aspects of TB, TB might contribute to high suicide rate. People undergoing TB treatment need counseling. It is noteworthy that possessing a solid foundation of knowledge, coupled with a positive attitude and sound practices, plays a pivotal role in the timely detection and eventual eradication of TB.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 220-225"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139638668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss to follow-up: Understand its determinants among tuberculosis patients, in Coimbra District (2005–2017)","authors":"Ricardo Eufrásio ,&nbsp;Maria Celeste Alcobia ,&nbsp;Carlos Robalo Cordeiro ,&nbsp;Henriqueta Coimbra Silva","doi":"10.1016/j.ijtb.2024.02.003","DOIUrl":"10.1016/j.ijtb.2024.02.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Tuberculosis patients who abscond from treatment are more likely to contribute to ongoing transmission. This growing concern has led to the development of this study in order to assess risk factors among Tuberculosis patients lost to follow up (LTFU) notified in the Coimbra District between 2005 and 2017.</div></div><div><h3>Material and methods</h3><div>A case-control study was designed to compare Tuberculosis patients LTFU (cases) to those successfully treated (controls). Forty-two LTFU cases were compared to 712 controls. Social and demographic data, co-morbidities, disease location, previous treatment history, drug resistance pattern and time period related to economic crisis were analyzed. In order to determine independent risk factors, numeric data was compared by one sample <em>t</em><span>-test; categorical data compared by the chi-square test or the fisher exact test<span>, and included in a logistic regression analysis, in order to analyze their association to LTFU as a dependent variable.</span></span></div></div><div><h3>Results</h3><div><span>Bivariate analysis found that LTFU patients were more likely to be immigrants (OR:2,54; 95%CI,1,36-4,75;</span><em>p</em> &lt; <em>0,01</em>); unemployed (OR:1,99; 95%CI, 1,08-3,69;<em>p</em> = <em>0,03</em>); civil construction workers (OR:2,53; 95%CI,1,22-5,27;<em>p</em> = <em>0,01</em>), have a history of drug (OR:3,29; 95%CI,1,57-6,91;<em>p</em> &lt; <em>0,01</em>), alcohol (OR:2,16; 95%CI,1,41-3,32; <em>p</em> &lt; <em>0,01</em>), and tobacco abuse (OR:1,60; 95%CI,1,12-2,30; <em>p</em>=<em>0,02</em>), HIV (OR:4,15; 95%CI,2,12-8,13; <em>p</em> &lt; <em>0,01</em>), Hepatitis C (OR:4,51; 95%CI,1,95-10,45; <em>p</em> &lt; <em>0,01</em>) and Hepatitis B (OR:12,97; 95%CI,3,00–56,02; <em>p</em> &lt; <em>0,01</em><span>) virus infection. Multivariate analysis found immigrants (aOR:3,08; 95% CI, 1,20-7,93; </span><em>p</em> = <em>0,02</em>) and alcohol abuse (aOR:2,81; 95% CI, 1,22-6,47; <em>p</em> = <em>0,01</em>) to be the strongest LTFU predictor.</div></div><div><h3>Conclusions</h3><div>LTFU likelihood was strongly associated to addictive behaviours and immigrants. It is important that the medical teams prioritize these patients for intensive follow-up care. It is recommended stronger coordination with other support services such as mental health and substance abuse programs. Multidrug-resistant tuberculosis makes necessary to highlight all of the strategies available to its prevention and management; those, should include legislative responses towards recalcitrant patients, particularly when all other less restrictive measures fail.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 226-232"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140282319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of tuberculosis among patients with rheumatic diseases – A systematic review and meta-analysis","authors":"Karthikeyan Sundaram ,&nbsp;Leela Kagithakara Vajravelu ,&nbsp;Ravichandiran Velayutham ,&nbsp;Utpal Mohan","doi":"10.1016/j.ijtb.2023.07.001","DOIUrl":"10.1016/j.ijtb.2023.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis is a contagious disease that ranks among the top ten killers of humans worldwide. <span><span>Mycobacterium tuberculosis</span></span> is an etiological agent of tuberculosis. The prognosis of tuberculosis in patients with autoimmune diseases is high due to treatment with <em>anti</em>-TNF-alpha therapy.</div></div><div><h3>Methods and materials</h3><div>We analyzed the studies based on the Preferred Reporting Items and Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Methods of eligibility criteria, search criteria and critical analyses, biased and challenges, and intervention.</div></div><div><h3>Results</h3><div><span><span>We observed the tuberculosis incidence of 595 (3.25%; 95% CI- 2.9 – 3.5) cases in systemic lupus erythematosus, 332 (4.54%; 95% CI - 4.07 - 5.01) in </span>rheumatoid arthritis, and 25 (1.9%; 95% CI - 1.16 – 2.64) in </span>multiple sclerosis out of 26,870 study populations in the various studies, and a total of 93 (7.2%; 95% CI - 5.8 – 8.6) cases in MS, and 10 (0.05%; 95% CI - 0.02 – 0.08) in SLE reported of TB indeterminate results.</div></div><div><h3>Conclusion</h3><div><span>This systematic review comprehensively analyzed the recent studies of the disease progression of latent </span>tuberculosis infection<span> to active tuberculosis is high in treatments with glucocorticoid<span><span>, azathioprine, </span>prednisone<span>, and leflunomide among patients with autoimmune diseases.</span></span></span></div></div><div><h3>Key findings</h3><div><span>We summarized recent studies emphasizing the risk factors of tuberculosis to be found the disease-modifying anti-rheumatic drug (DMARD), immunosuppressive treatments given to biologic-naive patients as the dominant factor associated with the risk of TB and treatment with a </span>tumor necrosis factor inhibitor.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 174-182"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46015503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis and co-morbidities: Multidisciplinary care model","authors":"Vishal Chopra ,&nbsp;Kranti Garg","doi":"10.1016/j.ijtb.2025.03.009","DOIUrl":"10.1016/j.ijtb.2025.03.009","url":null,"abstract":"<div><div>There has been an increasing awareness regarding need for recognition of co-morbidities in patients with Tuberculosis (TB) in the past few years. Emphasis has been laid down under the National TB Elimination Program (NTEP) for identification and treatment of Human immunodeficiency virus (HIV) and diabetes mellitus (DM) in patients diagnosed with TB, and provide nutritional support, in order to improve the TB treatment outcomes.</div><div>An array of other co-morbidities which remain undiagnosed and untreated have an association with TB. There is an urgent need to establish and develop multidisciplinary care clinics, at least in medical colleges, where diagnosis and treatment of different co-morbidities is done along with TB, under the same roof. This shall help manage patients in totality, save time and prove cost-effective in the long run. In addition, such an approach shall also help in formulating further recommendations regarding appropriate management and follow-up of TB patients with co-morbidities which may decrease the morbidity and mortality.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 143-145"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the cycle of tuberculosis: power of incentives and barriers","authors":"K.K. Chopra ,&nbsp;V.K. Arora ,&nbsp;Kaushal Kumar Dwivedi ,&nbsp;Sanjay Rajpal","doi":"10.1016/j.ijtb.2025.04.007","DOIUrl":"10.1016/j.ijtb.2025.04.007","url":null,"abstract":"","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 141-142"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nebulized dexmedetomidine prior to flexible bronchoscopy in reducing procedural cough episodes a randomized double blind clinical trial. (NCT: CTRI/2022/07/044389, NICOBAR group of investigators)","authors":"Jahanvi Grover ,&nbsp;Mohit Garg ,&nbsp;Pawan Kumar Singh ,&nbsp;Savita Verma ,&nbsp;Dhruva Chaudhry ,&nbsp;Puneet Saxena ,&nbsp;Aman Ahuja ,&nbsp;Geetika Arya","doi":"10.1016/j.ijtb.2024.04.003","DOIUrl":"10.1016/j.ijtb.2024.04.003","url":null,"abstract":"<div><h3>Background</h3><div><span><span>Flexible bronchoscopy<span> (FOB) or video bronchoscopy is a day-care procedure indicated in the diagnosis of various pulmonary disorders<span>. FOB is done under conscious sedation with the use of local lignocaine to reduce </span></span></span>cough episodes. Nebulized </span>dexmedetomidine<span> has been shown to have local anaesthetic<span> as well as systemic action. This study investigated the role of Nebulized dexmedetomidine delivered prior to FOB to reduce cough episodes.</span></span></div></div><div><h3>Methods</h3><div>It was a double blind, randomized controlled trial<span> conduced on subject undergoing diagnostic FOB. Subjects with recent history of myocardial infarction or cerebrovascular accidents were excluded. Subjects undergoing therapeutic bronchoscopy or endobronchial ultrasound were also excluded. Subjects in intervention arm received Nebulized dexmedetomidine at a dose of 2 μg/kg whereas control arm subjects were nebulized with normal saline. Primary outcome of the study was to compare the proportion of subjects with moderate-to-severe cough among the two groups.</span></div></div><div><h3>Results</h3><div><span>Over a period of 6 months, 128 cases were screened and 100 were randomized in a ratio of 1:1. Mean age of study population was 49.5 ± 15.6 years with majority being males (64%). Baseline characteristics were similar in the two groups. A higher number of cases in Nebulized dexmedetomidine arm underwent bronchoalveolar lavage (50% versus 24%) whereas a higher number of subjects in control groups underwent “bronchoscopy for airway inspection” (42% versus 20%). The difference in the proportion of subjects with moderate to severe cough in the two groups was not statistically significant (22% versus 18% in Nebulized dexmedetomidine group and control group, respectively, p &gt; 0.05). Doses of anaesthetic drugs (fentanyl, midazolam, locally instilled lignocaine) were also similar in the two groups. However, the </span><em>discomfort level</em> experienced by the patient as well as <em>ease of doing procedure</em><span> for the operator, as measure by VAS score, were significantly lower in the intervention arm as compared to the control arm (51 ± 20.6 versus 72.2 ± 13.1, for patient reported discomfort and 12.5 ± 9.8 versus 36.6 ± 27.2, for operator </span><em>ease of doing procedure</em><span><span>). Mean Richmond Agitation Sedation Scale score was significantly lower in the Nebulized dexmedetomidine arm (−0.22 ± 0.1 versus 0.12 ± 0.1). Dexmedetomidine as well as normal saline were equally well tolerated in nebulized form. None of the study subjects reported any intervention related </span>adverse events.</span></div></div><div><h3>Conclusion</h3><div>This study demonstrated that Nebulized dexmedetomidine has insignificant topical action to reduce cough episodes as compared to normal saline in diagnostic FOB, but systemic effects remain to be investigated.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 243-248"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140761620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and Stigma among tuberculosis patients in a tertiary care hospital in India","authors":"Roshna Lytton ,&nbsp;Nanda Kumar Paniyadi ,&nbsp;Prasanta Raghab Mohapatra ,&nbsp;Priyanka Singh ,&nbsp;Anuradha Kumari ,&nbsp;Dishani Harh ,&nbsp;Rakesh Vadakkethil Radhakrishnan","doi":"10.1016/j.ijtb.2025.04.001","DOIUrl":"10.1016/j.ijtb.2025.04.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals diagnosed with tuberculosis often experience concerns regarding potential social isolation affecting their family life, education, marriage, occupation, treatment, and social life. The goal of the present study was to determine the prevalence of stigma and depression in tuberculosis patients as well as their association with clinical and demographic factors.</div></div><div><h3>Methods</h3><div>A cross-sectional study was done on tuberculosis patients reporting to Pulmonology OPD of tertiary care, settling with an estimated sample size of 303. Convenience sampling was used to collect the data after obtaining permission from the Institutional Ethical Committee. Written Informed consent was obtained from the participants prior to data collection. The Hamilton Depression Rating Scale (HDRS) was employed to assess depression, while stigma was evaluated using the Tuberculosis Stigma Scale (TSS).</div></div><div><h3>Results</h3><div>The mean age was 44.33 ± 15.6 years, with a majority being males (54.8 %) and 58.7 % were married. The majority of patients (70 %) exhibited depression, followed by 30 % who did not show depression. Regarding stigma, 80 % of the patients experienced stigma, while 20 % did not have stigma. The correlation was estimated as a negative significant relationship between depression and stigma (r = −0.186; P-value = 0.05).</div></div><div><h3>Conclusion</h3><div>This study shows a high prevalence of depression and stigma among patients with tuberculosis. It also highlights the disability associated with tuberculosis and the burden it places on patients and caregivers.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 157-161"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of glycated hemoglobin trajectories on outcomes in patients with pulmonary tuberculosis in India","authors":"Dylan Landis,&nbsp;Alex Sutter,&nbsp;Kenneth Nugent","doi":"10.1016/j.ijtb.2024.03.013","DOIUrl":"10.1016/j.ijtb.2024.03.013","url":null,"abstract":"","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 273-274"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of anti-tubercular treatment in vitro fertilization (IVF)","authors":"Kaberi Banerjee ,&nbsp;Bhavana Singla ,&nbsp;Priyanka Verma","doi":"10.1016/j.ijtb.2024.01.011","DOIUrl":"10.1016/j.ijtb.2024.01.011","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the role of anti-tubercular treatment (ATT) in vitro fertilization (IVF).</div></div><div><h3>Design</h3><div>Retrospective analysis.</div></div><div><h3>Methods</h3><div>A retrospective study was performed in 45 women suffering from infertility with a diagnosis of thin endometrium<span><span><span>, history of repeated IVF failure, recurrent miscarriages<span> or hysteroscopic or laparoscopic adhesiolysis in 4 years duration. Based on composite reference standard (CRS), in all females, Akt 4 Kit (combination of four medicines – Isoniazid 300 mg, </span></span>rifampicin<span> 450 mg, ethambutol 800 mg and </span></span>pyrazinamide<span><span> 750 mg) was started for 2 months with supportive medicines followed by AKT 2 (combination of two medicines – Isoniazid 300 mg and rifampicin 450 mg) for 4 months. </span>Fertility treatment<span> was started after 2 months of Akt 4 medication. In all cases, frozen embryo transfer<span> was planned with tab estradiol valerate 6–8 mg in divided doses followed by endometrial thickness scanning. In all cases, embryo transfer was planned when endometrial thickness &gt;8 mm in transvaginal scanning. The efficacy of ATT in above cases was evaluated by assessing the endometrium thickness before embryo transfer, pregnancy rates and clinical pregnancy rates.</span></span></span></span></div></div><div><h3>Results</h3><div>There was no significant difference regarding demographic variables, egg reserve, sperm parameters, number of embryos transferred and embryo quality in all cases. Out of 45 cases, the pregnancy was positive in 31 cases (Pregnancy rate – 68.8 %). The clinical pregnancy rate was 64.4 % (29/45).</div></div><div><h3>Conclusion</h3><div>There is a significant role of anti-tubercular treatment (ATT) in infertility in case of thin endometrium not responsive to medications, repeated IVF failure, recurrent miscarriages or hysteroscopic or laparoscopic adhesiolysis. It improved the endometrial thickness, pregnancy rate and the clinical pregnancy rate in IVF. But further studies are needed with large sample size to collaborate our findings.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 217-219"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoniazid-induced hepatotoxicity in patients with latent tuberculosis – experience from a tuberculosis center","authors":"Bruno S. Silva ,&nbsp;Beatriz Ferraz ,&nbsp;Nuno Faria ,&nbsp;Maria Inês Costa ,&nbsp;Ricardo Reis","doi":"10.1016/j.ijtb.2023.12.010","DOIUrl":"10.1016/j.ijtb.2023.12.010","url":null,"abstract":"<div><h3>Background</h3><div><span>Although the prevalence of isoniazid-induced hepatotoxicity (IIH) has been documented in patients with tuberculosis, its prevalence in latent </span>tuberculosis infection<span> (LTBI) patients is less studied. The aim of this study was to investigate the prevalence of IIH in a group of LTBI patients who received isoniazid monotherapy.</span></div></div><div><h3>Methods</h3><div><span>Retrospective cohort study<span> including patients who underwent isoniazid monotherapy for LTBI in an outpatient clinic between January 1st</span></span>^, 2020, and June 30th^, 2021.</div></div><div><h3>Results</h3><div><span><span>A total of 274 cases were analyzed. About half (50.4 %) were male; median age was 53 years-old (minimum: six; maximum 89). The most common comorbidities were dyslipidemia (25.5 %), </span>body mass index between 25 and 30 kg/m</span>²<span><span> (20.4 %), obesity (14.7 %) and chronic hepatic disease (CHD; 12.8 %). 47.4 % had systemic inflammatory diseases<span><span>. Significant elevation of liver enzymes was documented in 27 % of patients. IIH was documented in 20.4 % of patients; there was a statistically significant relation with </span>dyslipidemia (p &lt; 0.001), CHD (p = 0.023), </span></span>psoriasis<span> (p = 0.025), spondyloarthropathies (p = 0.017) and male sex (p = 0.042). Dyslipidemia showed a strong correlation to IIH (adjusted odds ratio: 8.045).</span></span></div></div><div><h3>Conclusion</h3><div>Patients with dyslipidemia had an adjusted odds ratio of 8.045 to develop IIH. Future multicentric studies should be started to better explore this relation, as well as treatment options.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 2","pages":"Pages 194-197"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139023371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}