Sensitivity and specificity of Xpert MTB/RIF for extrapulmonary non-spinal osteoarticular tuberculosis

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-07-01 DOI:10.1016/j.ijtb.2024.08.008

Sanika Rapole, Siddharth Aiyer, Warid Altaf, Parag Sancheti

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引用次数: 0

Abstract

Background

Conventional diagnostics for Osteoarticular Tuberculosis (OATB) are slow and prone to inaccuracy due to low bacterial load, delaying treatment. Xpert MTB/RIF is WHO-recommended for TB cases, but there is a dearth of literature for non-spinal OATB.

Methods

In a 4-year study (Sept 2016–Feb 2020), non-spinal osteoarticular infections were retrospectively analyzed. Xpert MTB/RIF sensitivity and specificity were evaluated against tuberculosis defined by histology and culture against patients having culture-isolated pyogenic infections as a reference standard for negative tuberculosis.

Results

Among 26 OATB patients, 2 were culture-positive, 4 histopathology-positive, and 2 positive for both. The overall results of Xpert MTB/RIF were 86.9% negative predictive value (NPV), 100% specificity, 100% positive predictive value (PPV), & 65.3% sensitivity.

Conclusion

The sensitivity & specificity of Xpert MTB/RIF in non-spinal OATB are lower, despite its effectiveness in diagnosing pulmonary tuberculosis.

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Xpert MTB/RIF对肺外非脊柱骨关节结核的敏感性和特异性

背景：骨关节结核（OATB）的常规诊断速度慢，而且由于细菌负荷低，容易出现不准确，延误了治疗。专家MTB/RIF是世卫组织对结核病病例的推荐，但缺乏关于非脊柱ooatb的文献。方法回顾性分析一项为期4年（2016年9月- 2020年2月）的非脊柱骨关节感染病例。Xpert MTB/RIF对由组织学和培养确定的结核病患者的敏感性和特异性进行评估，作为培养分离的化脓性感染的阴性结核病的参考标准。结果26例ooatb患者中，培养阳性2例，组织病理阳性4例，两种病理均阳性2例。Xpert MTB/RIF的总体结果为阴性预测值（NPV） 86.9%，特异性100%，阳性预测值（PPV） 100%；65.3%的敏感性。结论：该方法的灵敏度和灵敏度；Xpert MTB/RIF在非脊柱性OATB中的特异性较低，尽管它在诊断肺结核方面很有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline