Open Respiratory Medicine Journal最新文献

{"title":"Sex-specificity in Surgical Stages of Lung Cancer in Young Adults.","authors":"Mahdi Abdennadher, Mariem Hadj Dahmane, Sarra Zair, Hazem Zribi, Amina Abdelkbir, Imen Bouassida, Mouna Mlika, Imen Sahnoun, Amani Ben Mansour, Adel Marghli","doi":"10.2174/18743064-v17-230818-2022-20","DOIUrl":"https://doi.org/10.2174/18743064-v17-230818-2022-20","url":null,"abstract":"<p><strong>Background: </strong>Young Patients with lung cancer represent a distinct subset of patients with this neoplasm. Young International studies show increased lung cancer rates in females, while the incidence in males continues to decline. There is evidence to suggest that this trend recurs in younger patients. We studied the effects of gender differences on the incidence of surgical stages of lung cancer in young adults and its mortality rate.</p><p><strong>Methods: </strong>This study is a retrospective review (2010-2020) of young adults (aged under 45 years) with surgical-stage of lung cancer. We calculated female-to-male differences in incidence rate ratios, tumor characteristics, surgical management, and survival. Cumulative survival curves were generated by the Kaplan-Meier method.</p><p><strong>Results: </strong>We examined 46 men and 24 women, under 45 years. Female patients were diagnosed at earlier stages. The proportion of stage IA disease was significantly higher in women than in men (46% <i>versus</i> 13%, respectively) (p=0.03). Women were more likely never smokers (42% <i>versus</i> 83%, p=0.02). A histologic subtype, females were more likely to have typical carcinoid tumors (13.54% <i>versus</i> 10.21% for males) (p>0.05). The largest histological type in men was adenocarcinoma (25.53% <i>versus</i> 4.16%, p>0.05). All the patients were operated. Three men had neoadjuvant chemotherapy and one was operated on for cerebral oligometastatic before his chest surgery. Adjuvant chemotherapy was given to 7 women and 21 men. Despite the small number of postoperative complications in our study (n= 8, 11.2%), the male sex was significant in predicting this complication (p<0.05). The mortality rate was 1.4%. The 5-year overall survival rates were 84% in men and 87% in women.</p><p><strong>Conclusion: </strong>Our study identified sex differences in the incidence and mortality rates for surgical lung cancers in young adults, but the biological and endocrine mechanisms implicated in these disparities have not yet been determined.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"17 ","pages":"e187430642307140"},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11041390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Average Volume-assured Pressure Support as Rescue Therapy after CPAP Failure in Pediatric Obstructive Sleep Apnea: A Retrospective Case Series Study.","authors":"Victor T Peng,&nbsp;Nauras Hwig,&nbsp;Anayansi Lasso-Pirot,&nbsp;Amal Isaiah,&nbsp;Montserrat Diaz-Abad","doi":"10.2174/18743064-v17-e230418-2022-18","DOIUrl":"10.2174/18743064-v17-e230418-2022-18","url":null,"abstract":"<p><strong>Background: </strong>Continuous positive airway pressure (CPAP) is frequently prescribed for patients with residual obstructive sleep apnea (OSA) following adenotonsillectomy.</p><p><strong>Objectives: </strong>The goal was to examine the efficacy of noninvasive ventilation with average volume-assured pressure support (AVAPS) as a potential option for children with failed CPAP titration.</p><p><strong>Methods: </strong>In a single-center retrospective study, we included children aged 1-17 years, with polysomnographically confirmed OSA who underwent AVAPS titration following failed CPAP titration. In addition to describing the clinical characteristics of the included patients, we compared polysomnographic parameters before and after AVAPS.</p><p><strong>Results: </strong>Nine patients met the inclusion criteria; out of them, 8 (89%) were males with an age range of 6.7 ± 3.9 years and a body mass index percentile of 81.0 ± 28.9. Reasons for failed CPAP titration were: 3 (33%) patients due to inability to control apnea-hypopnea index (AHI), 3 (33%) patients due to sleep-related hypoventilation, 2 (22%) patients due to treatment-emergent central sleep apnea, and 1 (11%) patient due to intolerance to CPAP. AVAPS resulted in a greater reduction in AHI than CPAP (reduction following CPAP = 24.6 ± 29.3, reduction following AVAPS = 42.5 ± 37.6, p = 0.008). All patients had resolution of the problems which caused CPAP failure.</p><p><strong>Conclusion: </strong>In this case a series of children with OSA and with failed CPAP titration, AVAPS resulted in a greater reduction in AHI compared with CPAP as well as resolution of the problems which caused CPAP failure.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":" ","pages":"e187430642303080"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46296120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAR Selectively Enhances the Pulmonary Vasodilatory Effect of Fasudil in a Microsphere Model of Pulmonary Hypertension.","authors":"Abraham Rothman,&nbsp;Humberto Restrepo,&nbsp;William N Evans,&nbsp;Valeri Sarukhanov,&nbsp;David Mann","doi":"10.2174/18743064-v17-e230404-2022-19","DOIUrl":"10.2174/18743064-v17-e230404-2022-19","url":null,"abstract":"<p><strong>Background: </strong>Despite the approval of several medications for pulmonary hypertension, morbidity and mortality are unacceptably high. Systemic hypotension may limit the use of pulmonary hypertension medications.</p><p><strong>Objectives: </strong>This study aimed to assess whether the homing peptide CAR (CARSKNKDC) improves the vasodilatory selectivity of fasudil in the pulmonary circulation or systemic circulation in a porcine pulmonary hypertension model.</p><p><strong>Materials and methods: </strong>Pulmonary hypertension (to approximately 2/3-3/4 systemic pressure levels) was induced by chronic and acute administration of microspheres in 3 micro Yucatan pigs (mean weight 19.9 kg, mean age 4.3 months). Fasudil (0.3 mg/kg) was administered without and with CAR (1.5 mg/kg), and the effect on aortic (Ao) and right ventricular (RV) pressure was recorded with indwelling catheters.</p><p><strong>Results: </strong>Immediately after fasudil administration, there was a decrease in Ao pressure followed by prompt recovery to baseline. The RV pressure decrease was progressive and sustained. Fasudil alone resulted in a 12% decrease in RV pressure, whereas co-administration of CAR with fasudil resulted in a 22% decrease in RV pressure (p < 0.0001). Fasudil alone caused an average decrease of 34% in the RV/Ao pressure ratio, and fasudil + CAR caused an average decrease of 40% in the RV/Ao pressure ratio (p < 0.0001).</p><p><strong>Conclusion: </strong>The homing peptide CAR selectively enhanced the acute vasodilatory effects of fasudil on the pulmonary vascular bed in a porcine experimental model of pulmonary hypertension.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"1 1","pages":"e187430642303160"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43728072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Related to the Death of Admitted COVID-19 Patients: A Buffalo Study.","authors":"Doan Le Minh Hanh,&nbsp;Phan Thai Hao,&nbsp;Do Thi Tuong Oanh,&nbsp;Nguyen Van Tho","doi":"10.2174/18743064-v17-e230322-2022-21","DOIUrl":"https://doi.org/10.2174/18743064-v17-e230322-2022-21","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) may result in a severe acute respiratory syndrome that leads to a worldwide pandemic. Despite the increasing understanding of COVID-19 disease, the mortality rate of hospitalized COVID-19 patients remains high.</p><p><strong>Objective: </strong>To investigate the risk factors related to the mortality of admitted COVID-19 patients during the peak of the epidemic from August 2021 to October 2021 in Vietnam.</p><p><strong>Methods: </strong>This is a prospective cohort study performed at the Hospital for Rehabilitation-Professional diseases. The baseline and demographic data, medical history, clinical examination, the laboratory results were recorded for patients admitted to the hospital with confirmed COVID-19. A radiologist and a pulmonologist will read the chest radiographs on admission and calculate the Brixia scores to classify the severity of lung abnormalities. Patients were followed up until beingrecovered or their death. Comparison of clinical and subclinical characteristics between recovery and death groups to find out risk factors related to the death of COVID-19 patients.</p><p><strong>Results: </strong>Among 104 admitted COVID-19 patients, men accounted for 42.3%, average age of 61.7 ± 13.7. The most common symptoms were fever 76.9%, breathlessness 74%, and fatigue 53.8%. The majority (84.6%) of the study population had at least one co-morbidity, including hypertension (53.8%), diabetes (25.9%), gastritis (19.2%), ischemic heart disease (15.4) %), stroke (9.6%) and osteoarthritis (9.6%). The rate of mild and moderate COVID-19 is 13.4%, severe 32.7%, and critical 40.4%. There are 88 inpatients (84.6%) who needed respiratory support. The median hospital stay was 13 days (IQR 10-17.75 days). The rate of intubated patients with mechanical ventilation was 31.7%. The overall mortality rate was 29.8%. Risk factors related to death included Brixia scores > 9, Urea > 7 mmol/L, Ferrtin > 578 ng/ml, Failure to get vaccinated, Age > 60 years, and Low Oxygen SpO2 < 87% (BUFFALO).</p><p><strong>Conclusion: </strong>The main result of the study is the independent risk factors related to the death of admitted COVID-19 patients including Brixia scores > 9, Urea > 7 mmol/L, Ferrtin > 578 ng/ml, Failure to get vaccinated, Age > 60 years, and Low Oxygen SpO2 < 87% ((BUFFALO) which suggests that these COVID-19 patients should be closely followed up.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"17 ","pages":"e187430642302200"},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Related to the Death of Admitted COVID-19 Patients: A Buffalo Study","authors":"Doan Le Minh Hanh, Phan Thai Hao, Do Thi Tuong Oanh, N. V. Tho","doi":"10.2174/18743064-v17-e230403-2022-21","DOIUrl":"https://doi.org/10.2174/18743064-v17-e230403-2022-21","url":null,"abstract":"\u0000 \u0000 Coronavirus disease 2019 (COVID-19) may result in a severe acute respiratory syndrome that leads to a worldwide pandemic. Despite the increasing understanding of COVID-19 disease, the mortality rate of hospitalized COVID-19 patients remains high.\u0000 \u0000 \u0000 \u0000 To investigate the risk factors related to the mortality of admitted COVID-19 patients during the peak of the epidemic from August 2021 to October 2021 in Vietnam.\u0000 \u0000 \u0000 \u0000 This is a prospective cohort study performed at the Hospital for Rehabilitation–Professional diseases. The baseline and demographic data, medical history, clinical examination, the laboratory results were recorded for patients admitted to the hospital with confirmed COVID-19. A radiologist and a pulmonologist will read the chest radiographs on admission and calculate the Brixia scores to classify the severity of lung abnormalities. Patients were followed up until beingrecovered or their death. Comparison of clinical and subclinical characteristics between recovery and death groups to find out risk factors related to the death of COVID-19 patients\u0000 \u0000 \u0000 \u0000 Among 104 admitted COVID-19 patients, men accounted for 42.3%, average age of 61.7 ± 13.7. The most common symptoms were fever 76.9%, breathlessness 74%, and fatigue 53.8%. The majority (84.6%) of the study population had at least one co-morbidity, including hypertension (53.8%), diabetes (25.9%), gastritis (19.2%), ischemic heart disease (15.4) %), stroke (9.6%) and osteoarthritis (9.6%). The rate of mild and moderate COVID-19 is 13.4%, severe 32.7%, and critical 40.4%. There are 88 inpatients (84.6%) who needed respiratory support. The median hospital stay was 13 days (IQR 10-17.75 days). The rate of intubated patients with mechanical ventilation was 31.7%. The overall mortality rate was 29.8%. Risk factors related to death included Brixia scores > 9, Urea > 7 mmol/L, Ferrtin > 578 ng/ml, Failure to get vaccinated, Age > 60 years, and Low Oxygen SpO2 < 87% (BUFFALO).\u0000 \u0000 \u0000 \u0000 The main result of the study is the independent risk factors related to the death of admitted COVID-19 patients including Brixia scores > 9, Urea > 7 mmol/L, Ferrtin > 578 ng/ml, Failure to get vaccinated, Age > 60 years, and Low Oxygen SpO2 < 87% ((BUFFALO) which suggests that these COVID-19 patients should be closely followed up.\u0000","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46959661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spirometry Reference Equations Including Existing and Novel Parameters.","authors":"Douglas Clark Johnson,&nbsp;Bradford Gardner Johnson","doi":"10.2174/18743064-v16-e221227-2022-14","DOIUrl":"10.2174/18743064-v16-e221227-2022-14","url":null,"abstract":"<p><strong>Introduction: </strong>Spirometry is an essential component of pulmonary function testing, with interpretation dependent upon comparing results to normal. Reference equations for mean and lower limit of normal (LLN) are available for usual parameters, including forced vital capacity (FVC), forced expiratory volume in the first second of an FVC maneuver (FEV1), and FEV1/FVC. However, standard parameters do not fully characterize the flow-volume loop and equations are unavailable for the upper limit of normal (ULN). The aim of this study was to develop reference equations for existing and novel spirometry parameters, which more fully describe the flow-volume loop, and to compare these to previously reported equations.</p><p><strong>Methods: </strong>Data from healthy participants in NHANES III was used to derive reference equations for existing and novel spirometry parameters accounting for birth sex, age, height, and ethnicity (Caucasian, Mexican American, Black) for ages 8 to 90 years. An iterative process determined %predicted LLN and ULN. Equations were compared to published reported equations.</p><p><strong>Results: </strong>Reference equations were developed for mean, LLN and ULN for existing and novel spirometry parameters for ages 8 to 90. The derived equations closely match mean values of previously published equations, but more closely fit the LLN. Mexican-American and Caucasian values were similar (within 2%) so they were combined, while Black relative to Caucasian/Mexican-American values were lower for some parameters.</p><p><strong>Conclusion: </strong>These reference equations, which account for birth sex, age, height, and ethnicity for existing and novel spirometry parameters, provide a more comprehensive and quantitative evaluation of spirometry and the flow-volume curve.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":" ","pages":"e187430642212260"},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48144420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Incontinence and Quality of Life in Women With Cystic Fibrosis","authors":"Marinice Nunes Soares, Luciana L. Paiva, P. Dalcin, B. Ziegler","doi":"10.2174/18743064-v16-e220927-2022-9","DOIUrl":"https://doi.org/10.2174/18743064-v16-e220927-2022-9","url":null,"abstract":"\u0000 \u0000 Stress urinary incontinence (SUI) is recognized as a common complication in women with CF.\u0000 \u0000 \u0000 \u0000 The primary objective of this study was to verify the prevalence of urinary incontinence (UI) and its associations with quality of life (QoL) in adult women with CF. The secondary objective was to identify possible associations of UI with cough score, nutritional parameters, and pulmonary function.\u0000 \u0000 \u0000 \u0000 This cross-sectional study included female patients aged 18 years and older. All patients answered the International Consultation on Incontinence Questionnaire Short Form, the Kings Health Questionnaire, and the Leicester Cough Questionnaire. Nutritional assessment was obtained. Sputum bacteriology and lung function were also performed.\u0000 \u0000 \u0000 \u0000 Fifty-two women were included, with mean age of 29.0±9.7 years and mean forced expiratory volume in one second (FEV1) of 50.1±21.7% of predicted. Thirty-two patients (61.5%) presented symptoms of UI, 23 (44.2%) of stress UI and 9 (17.3%) of mixed UI. However, there was no significant association between UI and pulmonary function, sputum bacteriology, and cough score (p>0.05). There was a significant association between UI and QoL variables (p<0.05).\u0000 \u0000 \u0000 \u0000 This study identified a prevalence of 61.5% of UI in women with CF. The presence of UI in women with CF resulted in a negative impact on QoL.\u0000","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47013007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm Ultrasound in the Evaluation of Diaphragmatic Dysfunction in Lung Disease","authors":"S. Lux, Daniel Ramos, A. Pinto, Sara Schilling, M. Salinas","doi":"10.2174/1874306402115010082","DOIUrl":"https://doi.org/10.2174/1874306402115010082","url":null,"abstract":"The diaphragm is the most important respiratory muscle, and its function may be limited by acute and chronic diseases. A diaphragmatic ultrasound, which quantifies dysfunction through different approaches, is useful in evaluating work of breathing and diaphragm atrophy, predicting successful weaning, and diagnosing critically ill patients. This technique has been used to determine reduced diaphragmatic function in patients with chronic obstructive pulmonary disease and interstitial diseases, while in those with COVID-19, diaphragmatic ultrasound has been used to predict weaning failure from mechanical ventilation.","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41581562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxemia and Respiratory Failure: Clinical Conditions and Pathophysiological Approaches","authors":"R. Castillo","doi":"10.2174/1874306402115010059","DOIUrl":"https://doi.org/10.2174/1874306402115010059","url":null,"abstract":"Type 1 (hypoxemic) RF has a PaO2 < 60 mmHg with normal or subnormal PaCO2. In this type, the gas exchange is impaired at the level of the aveolo-capillary membrane. Examples of type I RF are carcinogenic or non-cardiogenic pulmonary edema and severe pneumonia. Type 2 (hypercapnic) RF has a PaCO2 > 50 mmHg. Hypoxemia is common, and it is due to respiratory pump failure. Also, respiratory failure is classified according to its onset, course, and duration into acute and chronic; acute (ARF) on top of chronic respiratory failure (CRF) [1].","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44114863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Flow Nasal Cannula as Support in Immunocompromised Patients with Acute Respiratory Failure: A Retrospective Study","authors":"C. Giugliano-Jaramillo, J. Leon, Cristobal Enriquez, J. Keymer, R. Pérez-Araos","doi":"10.2174/1874306402115010061","DOIUrl":"https://doi.org/10.2174/1874306402115010061","url":null,"abstract":"\u0000 \u0000 High Flow Nasal Cannula (HFNC) is a novel technique for respiratory support that improves oxygenation. In some patients, it may reduce the work of breathing. In immunocompromised patients with Acute Respiratory Failure (ARF), Non-Invasive Ventilation (NIV) is the main support recommended strategy, since invasive mechanical ventilation could increase mortality rates. NIV used for more than 48 hours may be associated with increased in-hospital mortality and hospital length of stay. Therefore HFNC seems like a respiratory support alternative.\u0000 \u0000 \u0000 \u0000 To describe clinical outcomes of immunocompromised patients with ARF HFNC-supported.\u0000 \u0000 \u0000 \u0000 Retrospective study in patients admitted with ARF and HFNC-supported. 25 adult patients were included, 21 pharmacologically and 4 non- pharmacologically immunosuppressed. Median age of the patients was 64 [60-76] years, APACHE II 15 [11-19], and PaO2:FiO2 218 [165-248]. Demographic information, origin of immunosuppression, Respiratory Rate (RR), Heart Rate (HR), Mean Arterial Pressure (MAP), oxygen saturation (SpO2) and PaO2:FiO2 ratio were extracted from clinical records of our HFNC local protocol. Data acquisition was performed before and after the first 24 hours of connection. In addition, the need for greater ventilatory support after HFNC, orotracheal intubation, in-hospital mortality and 90 days out-patients’ mortality was recorded.\u0000 \u0000 \u0000 \u0000 Mean RR before the connection was 25±22 breaths/min and 22±4 breaths/min after the first 24 hours of HFNC use (95% CI; p=0.02). HR mean before connection to HFNC was 96±22 beats/min, and after, it was 86±15 beats/min (95%CI; p=0.008). Previous mean MAP was 86±15 mmHg, and after HFNC, it was 80±12 mmHg (95%CI; p=0.09); mean SpO2 after was 93±5% and before it was 95±4% (95% CI; p=0.13); and previous PaO2:FiO2 mean was 219±66, and after it was 324±110 (95%CI; p=0.52). In-hospital mortality was 28% and 90 days out-patients’ mortality was 32%.\u0000 \u0000 \u0000 \u0000 HFNC in immunosuppressed ARF subjects significantly decreases HR and RR, being apparently an effective alternative to decrease work of breathing. In-hospital mortality in ARF immunosuppressed patients was high even though respiratory support was used. Better studies are needed to define the role of HFNC-support in ARF.\u0000","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46492682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}