Open Respiratory Medicine Journal最新文献

{"title":"Rare Unicentric Intrapulmonary Castleman Disease: A Systematic Review and Report of a Case.","authors":"Manjinder Kaur Pannu, Jonas Peter Ehrsam, Olga Meier Adamenko, Ilhan Inci, Othmar Markus Schöb","doi":"10.2174/0118743064348696250107092627","DOIUrl":"https://doi.org/10.2174/0118743064348696250107092627","url":null,"abstract":"<p><strong>Objectives: </strong>Castleman disease (CD) is a very rare B-cell lymphoproliferative disorder marked by the abnormal enlargement of lymph node tissue. It can present as either unicentric (UCD) or multicentric, with the former often appearing in intrathoracic regions, although its presence within the lungs is uncommon.</p><p><strong>Methods: </strong>We report the case of a 42-year-old woman who underwent resection of an 11 cm intrapulmonary UCD. Additionally, we conducted a systematic review of the demographics, clinical presentation, diagnosis, and treatment approaches for intrapulmonary UCD.</p><p><strong>Results: </strong>Our review identified 35 documented cases of intrapulmonary UCD, including our case. The average age was 34 years, with a female predominance of 57.7%. Tumor sizes ranged from 1.5 to 11 cm, with our case being the largest. Of the 24 cases with reported anamnesis, 58.3% were asymptomatic, while 41.7% had nonspecific symptoms such as cough, chest pain, or fever (as in our case). Histological analysis was available for 24 cases, with 83.3% identified as the hyaline vascular type. Biopsies through small needle aspiration or fresh-frozen samples failed in all attempts, requiring resection for diagnosis and treatment. Due to high vascularity, delicate location, and lack of diagnosis, lobectomy or pneumonectomy was performed in 45.7% of cases. Among the 11 cases with reported follow-up, no disease recurrence was observed over an average of 3 years.</p><p><strong>Conclusion: </strong>Our systematic review highlights the rarity of UCD in the lungs. The demographics of intrapulmonary UCD align with the general disease profile. Surgical removal is crucial for both diagnosis and treatment. The significant vascularity and pulmonary location of these tumors present challenges, requiring pre-operative awareness and precautions.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"19 ","pages":"e18743064348696"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Aerobic Exercise on Oxygenation, Pulmonary Function, and Nasal Nitric Oxide in Primary Ciliary Dyskinesia.","authors":"Gabriel Gonzalez-Diaz, Zachary J Demetriou, Jose Muñiz-Hernandez, Marcos J Ramos-Benitez, Ricardo A Mosquera, Wilfredo De Jesús-Rojas","doi":"10.2174/0118743064365386250212050147","DOIUrl":"https://doi.org/10.2174/0118743064365386250212050147","url":null,"abstract":"<p><strong>Background: </strong>Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by impaired mucociliary clearance, resulting in chronic respiratory complications. While exercise benefits respiratory health, its impacts on PCD remain understudied.</p><p><strong>Objective: </strong>The objective of this study was to assess how moderate aerobic exercise influences FEV1, SpO2, and nNO levels in PCD patients, with a focus on short-term post-exercise changes.</p><p><strong>Methods: </strong>This is a matched case-control pilot study involving 12 PCD patients homozygous for the RSPH4A (c.921+3_921+6del) mutation and 12 healthy controls (HC). Baseline FEV1, SpO2, and nNO levels were measured before participants underwent a six-minute exercise challenge test (ECT) on a stationary bicycle. Post-exercise measurements included FEV1 at 5, 10, 15, and 20 minutes, nNO after final spirometry, and SpO2 at 5 minutes.</p><p><strong>Results: </strong>The PCD group experienced a significant increase in SpO2 from 95.5% ± 2.1 to 97.7% ± 1.5 post-exercise (p < 0.05), while the HC group had stable SpO2 levels with a minor increase from 97.9% ± 1.5 to 98.9% ± 1.4 (p = 0.14). No significant changes in FEV1 or nNO levels were observed post-exercise in either group. One HC participant exhibited exercise-induced bronchoconstriction.</p><p><strong>Conclusion: </strong>Aerobic exercise improves oxygenation in PCD patients without adverse effects on pulmonary function or nNO levels. Further research is necessary due to the small sample size and genetic homogeneity to confirm these findings and evaluate long-term outcomes. Moreover, this pilot study highlights the safety and potential respiratory benefits of aerobic exercise in PCD patients, supporting further investigation into its role in clinical management.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"19 ","pages":"e18743064365386"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Acute Decompensated Right Ventricle Failure in Pulmonary Arterial Hypertension.","authors":"Rohit Masih, Vivek Paudyal, Yogendra Mani Basnet, Shaleen Sunesara, Munish Sharma, Salim Surani","doi":"10.2174/0118743064359315250210080743","DOIUrl":"https://doi.org/10.2174/0118743064359315250210080743","url":null,"abstract":"<p><p>Pulmonary Arterial Hypertension (PAH) is a progressive vascular disease characterized by elevated Pulmonary Vascular Resistance (PVR) leading to Right Ventricular (RV) dysfunction and, ultimately, Right Heart Failure (RHF). Acute decompensation of PAH presents a life-threatening consequence marked by sudden worsening of clinical signs of right heart failure, systemic circulatory insufficiency, and multi-system organ failure. Clinicians are encountering more and more patients with PAH and RHF in the critical care units. These patients require admission and management in a critical care unit until they can be stabilized. The pathogenesis involves an imbalance between RV afterload and its adaptation capacity, ultimately resulting in RV dilation and failure. While the causes of acute decompensation remain subtle in many cases, infections, drug noncompliance, and pulmonary embolism are common culprits. Early identification of signs and symptoms of acute decompensation of RV failure, determination of possible etiology, and timely initiation of optimal treatment approaches are pivotal in avoiding detrimental outcomes. Optimization of pre-load and use of pulmonary vasodilators and inotropic agents are cornerstones of management. In refractory cases, mechanical circulatory support such as Extracorporeal Membrane Oxygenation (ECMO) or Right Ventricular Assist Devices (RVADs) may be necessary. Balloon Atrial Septostomy (BAS) serves as a bridge to definitive therapy, offering decompression of the right atrium and right ventricle. The prognosis of acute decompensated RV failure in PAH patients remains poor, highlighting the critical need for early diagnosis and intervention to improve outcomes. Currently, there are no strict standard guidelines to manage acute decompensated RV failure in PAH patients. We aim to revisit current evidence and practice trends in PAH and its acute decompensation.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"19 ","pages":"e18743064359315"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Herbal Plants and their Phytoconstituents Based Remedies for Respiratory Diseases: A Review.","authors":"Luca Campbell","doi":"10.2174/0118743064341009241210045737","DOIUrl":"https://doi.org/10.2174/0118743064341009241210045737","url":null,"abstract":"<p><p>Despite medical science advancements in recent years, pulmonary diseases are still hard to control and can be potentially life-threatening. These include asthma, COPD, lung cancer, cystic fibrosis, pneumonia, pleurisy, and sarcoidosis. These illnesses often cause severe breathing problems, which can be fatal if not treated properly. While some chemical drugs are used to treat these conditions, they can cause side effects and are not always effective. Herbal medicine offers an alternative treatment option with fewer side effects and has shown promise in treating respiratory issues. Certain medicinal plants, such as garlic (Allium sativum), hawthorn (Crataegus rhipidophylla), moringa (Moringa oleifera), and ashwagandha (Withania somnifera), may help manage lung diseases. Natural compounds found in plants, like apple polyphenol, ligustrazine, salidroside, resveratrol, and quercetin, can also help reduce symptoms. These plants and compounds work by reducing cell overgrowth, fighting oxidative stress, lowering inflammation, stopping tumor growth, improving blood flow, and relaxing the airways. This review outlines the types of plants and compounds that can be utilized in treating pulmonary conditions, along with their respective mechanisms of action.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"19 ","pages":"e18743064341009"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence and Severity of Dyspnea in Young Saudi Female Adults: A Cross-sectional Study.","authors":"Saleh S Algarni, Majd A Altamimi, Haifa F Alqudaimi, Noura M Aleid, Taha Ismaeil, Hassan Aljohani, Mohammed M Alqahtani, Mobarak K Alqahtani, Tareq F Alotaibi","doi":"10.2174/0118743064364924250203074821","DOIUrl":"https://doi.org/10.2174/0118743064364924250203074821","url":null,"abstract":"<p><strong>Background: </strong>Dyspnea impacts daily activities; women tend to report a higher perception of dyspnea and experience greater emotional distress compared to men. Therefore, the study aims to assess the prevalence and severity of dyspnea among Saudi women aged 18 to 35 years and explore associated risk factors.</p><p><strong>Method: </strong>A quantitative cross-sectional study was conducted in Saudi Arabia. The data were collected using an electronic online questionnaire survey. The questionnaire consisted of participants' demographic data, and the status of factors associated with dyspnea, such as body mass index, physical activity, and smoking status. Using the modified Medical Research Council (mMRC) dyspnea scale is another option. The modified Medical Research Council (mMRC) dyspnea scale was used in a descriptive analysis to characterize the prevalence and score of dyspnea.A Mann-Whitney U test and Chi-square tests were conducted to determine the differences and associations according to the dyspnea risk factors. A p-value of <0.05 determined the statistical significance.</p><p><strong>Results: </strong>A total of 554 participants were recruited. The overall prevalence of dyspnea was reported by 115 (21%) participants, with a mean score of 1.42 (SD 1.38) on the MRC Dyspnea Scale. The majority of participants were from the central region (74%) and aged 18 to 24 years (65.5%). No statistically significant differences were found between participants with and without dyspnea in terms of body mass index (22.6 [19.6-25.6] vs 22.8 [20.1-26.2], p=0.68, respectively), passive smoking status (p=0.07), or physical activity level (p=0.37).</p><p><strong>Conclusion: </strong>The study concludes that approximately one in five young females experienced dyspnea, suggesting that this symptom may be quite prevalent. However, no significant association was found between dyspnea and factors such as body mass index, passive smoking, or physical activity levels.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"19 ","pages":"e18743064364924"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on Pulmonary Hypertension.","authors":"Vivek Paudyal, Rubi Thapa, Sagarika Basnet, Munish Sharma, Salim Surani, Joseph Varon","doi":"10.2174/0118743064344024250203101417","DOIUrl":"https://doi.org/10.2174/0118743064344024250203101417","url":null,"abstract":"<p><p>Pulmonary Arterial Hypertension (PAH) is an uncommon condition with high mortality. It is an underrecognized condition both in developing and developed countries, especially in developing countries, due to a lack of advanced healthcare facilities and resources for timely diagnosis. More than half of the individuals diagnosed with PAH live less than five years after diagnosis. In recent years, tremendous advancements have been made in diagnostic and therapeutic strategies for PAH patients. Phosphodiesterase 5 (PDE5) inhibitors, endothelin receptor antagonists, and prostacyclin inhibitors in various forms (oral, inhaled, intravenous, or subcutaneous) have been the cornerstone of medical treatment. Atrial septostomy, heart and lung transplant, balloon pulmonary angioplasty, and pulmonary thromboendarterectomy are existing therapeutic options currently available. There has been a continuous effort to introduce newer therapies to improve life expectancy and modify disease. Newer therapies have shown promising results but require future data to guarantee long-term safety and efficacy. We aim to discuss a few of these critical updates in the constantly evolving field of PAH.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"19 ","pages":"e18743064344024"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Control of Asthma and its Influencing Factors in Children Followed in Pneumo-pediatrics Consultation at the Mother-child Hospital in the City of Marrakech, Morocco.","authors":"Maryem Labyad, Ghizlane Draiss, Karima El Fakiri, Nadia Ouzennou, Mohammed Bouskraoui","doi":"10.2174/0118743064340759241209041049","DOIUrl":"https://doi.org/10.2174/0118743064340759241209041049","url":null,"abstract":"<p><strong>Introduction: </strong>Evaluate asthma control and determine its influencing factors to ensure adequate management and improve the quality of life for asthmatic children.</p><p><strong>Method: </strong>A prospective cross-sectional study was conducted over a two-month period, from 02/11/2022 to 01/01/2023, at the pneumo-pediatric consultation at the MCH. The target population was asthmatic children aged 4 to 11 and their parents. The Arabic version of the C-ACT and PMAQ-3W were used to assess asthma control and medication compliance, respectively.Statistical analysis was performed with SPSS, using descriptive and correlational analysis (bivariate and multivariate).</p><p><strong>Results: </strong>203 asthmatic children were included in the study, out of which 60.6% were male, with a mean age of 6 years. Asthma was uncontrolled in 53% of children. Factors associated with uncontrolled asthma were rural residence, low parental education, low monthly family income, lack of awareness of triggers, presence of conjunctivitis or allergic rhinitis, occurrence of respiratory infections, parental history of asthma, exposure to smoking, and non-compliance with treatment.</p><p><strong>Conclusion: </strong>53% of children had uncontrolled asthma. A range of predictive factors were significantly associated with suboptimal asthma control. Recommended actions to improve childhood asthma control include education on trigger prevention and medication compliance, treatment of comorbidities, and accessibility of care for all socio-economic classes.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"19 ","pages":"e18743064340759"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Prevalence of Chronic Pulmonary Effusion Causes and Response to Treatment (Pleurodesis) in Patients.","authors":"Alireza Shirzadi, Izadmehr Ahmadinejad, Mojtaba Ahmadinejad, Saeed Hatami, Ali Soltanian, Yasmina Ahmadinejad","doi":"10.2174/0118743064336968250113102919","DOIUrl":"https://doi.org/10.2174/0118743064336968250113102919","url":null,"abstract":"<p><strong>Background: </strong>Pleural effusion, the pathological accumulation of fluid in the pleural space, is widespread. This study investigates pleural effusion in terms of malignancy among patients referred to tertiary health care centers and evaluates the response rates to different pleurodesis techniques.</p><p><strong>Methods: </strong>This cross-sectional study enrolled all patients with pleural effusion referred to a tertiary health care center. Laboratory data, including White Blood Cell count and differentiation (WBC), Hemoglobin levels (HB), Erythrocyte Sedimentation Rate (ESR), and biochemical analysis results of the pleural fluid (protein, glucose, and lactate dehydrogenase) were recorded. Data from pleural fluid cytopathological examination, including cell count, cell types, gram staining, and pleural fluid culture, were also documented. Patients undergoing pleurodesis were assessed for response rates, which were categorized as complete, partial, or no response based on clinical and radiological criteria. Collected data were subjected to statistical analysis.</p><p><strong>Results: </strong>The study investigated 144 patients with chronic pleural effusion, with an average age of 47.59 years. Of these, 97 patients (66%) were male and 47 patients (34%) were female. The most common cause of chronic pleural effusion was malignancy, with a prevalence of 65.9%. Among patients treated with pleurodesis, the overall response rate was 78.4%, with chemical pleurodesis achieving a higher complete response rate (65%) compared to mechanical pleurodesis (55%). Other prevalent causes of chronic pleural effusion, in descending order, included heart failure, liver cirrhosis, chronic kidney failure, and unknown factors.</p><p><strong>Conclusion: </strong>This study highlights malignancy and chronic heart failure as the predominant etiologies of chronic pleural effusion in a tertiary healthcare setting. Furthermore, it emphasizes the efficacy of pleurodesis techniques, with chemical pleurodesis demonstrating superior outcomes. These findings offer valuable insights into the pathogenesis and management of chronic pleural effusion.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"19 ","pages":"e18743064336968"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations on Rapid Diagnostic Point-of-care Molecular Tests for Respiratory Infections in the United Arab Emirates.","authors":"Liliane Dhaini, Rashi Verma, Mazin A Gadir, Harmandeep Singh, Mohamed Farghaly, Tamir Abdelmutalib, Amar Osman, Khulood Alsayegh, Somaia Bin Gharib, Bassam Mahboub, Eldaw Suliman, Sofia Konstantinopoulou, Srinivasa Rao Polumuru, Sandeep Pargi","doi":"10.2174/0118743064319029240815074449","DOIUrl":"10.2174/0118743064319029240815074449","url":null,"abstract":"<p><p>Traditional testing methods in the Middle East Region, including the United Arab Emirates (UAE), particularly the testing of Respiratory Syncytial Virus (RSV), influenza, group A streptococcus (GAS), and COVID-19 have the potential to be upgraded to new and advanced diagnostics methods that improve lead time to diagnosis, consumption of healthcare resources and patient experience. In addition, based on the research, it was reported that there is an underreporting of respiratory cases, overuse of antibiotics, and prolonged hospitalizations which is posing pressure on UAE healthcare stakeholders. A literature review was done exploring UAE's current diagnostic practices, recommended guidelines, diagnostic gaps, and challenges in RSV, GAS, Influenza, and COVID-19. This was followed by stakeholder discussions focusing on assessing current diagnostic practices, usage of rapid molecular point-of-care (POC) diagnostic tests, current gaps in diagnosis, targeted profiles for POC testing, and potential impact on patient management for targeted respiratory infections. A round table discussion with healthcare experts, insurance experts, key opinion leaders, and pulmonologists discussed challenges and opportunities in treating respiratory diseases. UAE healthcare stakeholders suggest that introducing alternative and up-to-date diagnostic methods such as POC molecular testing is expected to improve healthcare outcomes, optimize resources, and develop a robust case management of respiratory tract infections. It is essential to emphasize that by introducing POC testing, precision medicine is reinforced, efficiency is achieved, and the overall management of population health is enhanced.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"18 ","pages":"e18743064319029"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of Heated, Humidified, High-flow Nasal Cannulas, and Length of Hospital Stay Among Extremely Preterm Infants.","authors":"Tareq F Alotaibi, Dana Alzahrani, Fawzeah Alenazi, Sarah Altokhais, Afnan Slemani, Kamal Ali, Raghad Alzahrani, Abdullah M Alanazi, Taha Ismaeil, Mohammed Alqahtani, Saif Alsaif, Saleh S Algarni","doi":"10.2174/0118743064336750241115115435","DOIUrl":"10.2174/0118743064336750241115115435","url":null,"abstract":"<p><strong>Background: </strong>Extremely preterm infants (EPIs) often require advanced respiratory support to survive, and one such intervention is the heated, humidified, high-flow nasal cannula (HHHFNC). While the use of this cannula in EPIs has been studied, the relationship between its use and the length of hospital stay is an important yet unexplored research area that we aim to investigate in this study.</p><p><strong>Methods: </strong>In a quantitative retrospective cohort study, data were extracted from an electronic database. The study included all EPIs younger than 28 weeks of gestational age admitted to the neonatal intensive care unit of a tertiary hospital from January 1, 2020, to December 31, 2022. The descriptive analysis was conducted to describe each infant's demographic, maternal, and neonatal characteristics. A chi-squared test was also conducted, and a <i>p</i>-value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The findings suggest that infants who receive an HHHFNC have a longer hospital stay than those who do not. Specifically, infants who did not receive a cannula spent 42.5 days on average in the hospital, compared with 99 days among those who received it, with a significant <i>p</i>-value (p=0.0001).</p><p><strong>Conclusion: </strong>Infants receiving a cannula stay in hospital on average for twice as long as those who do not. However, to reduce the possibility of bias and produce more reliable results, we advise conducting clinical trials or prospective studies in future research.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"18 ","pages":"e18743064336750"},"PeriodicalIF":0.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}