Open Rheumatology Journal最新文献

{"title":"Biological Effects of Phosphocitrate on Osteoarthritic Articular Chondrocytes.","authors":"Yubo Sun,&nbsp;Atiya M Franklin,&nbsp;David R Mauerhan,&nbsp;Edward N Hanley","doi":"10.2174/1874312901711010062","DOIUrl":"https://doi.org/10.2174/1874312901711010062","url":null,"abstract":"<p><strong>Background: </strong>Phosphocitrate (PC) inhibits osteoarthritis (OA) in Hartley guinea pigs. However, the underlying molecular mechanisms remain poorly understood.</p><p><strong>Objective: </strong>This study sought to examine the biological effect of PC on OA chondrocytes and test the hypothesis that PC may exert its OA disease modifying effect, in part, by inhibiting the expression of genes implicated in OA disease process and stimulating the production of extracellular matrices.</p><p><strong>Method: </strong>OA chondrocytes were cultured in the absence or presence of PC. Total RNA was extracted and subjected to microarray analyses. The effect of PC on proliferation and chondrocyte-mediated calcification were examined in monolayer culture. The effect of PC on the production of extracellular matrices was examined in micromass culture.</p><p><strong>Results: </strong>PC downregulated the expression of numerous genes classified in proliferation and apoptosis while upregulating the expression of many genes classified in transforming growth factor-β (TGF-β) receptor signaling pathway and ossification. PC also downregulated the expressions of many genes classified in inflammatory response and Wnt receptor signaling pathways. Consistent with its effect on the expression of genes classified in proliferation, ossification, and skeletal development, PC inhibited the proliferation of OA chondrocytes and chondrocyte-mediated calcification while stimulating the production of extracellular matrices.</p><p><strong>Conclusion: </strong>PC may exert its OA disease modifying effect, in part, through a crystal-independent mechanism or by inhibiting the expressions of many genes implicated in OA disease process, and at the same time, stimulating the expression of genes implicated in chondroprotection and production of extracellular matrices.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"11 ","pages":"62-74"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35129291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of patient Reported Outcome Measures for Rheumatoid Arthritis in Japan: A Systematic Literature Review.","authors":"Ann Chuo Tang,&nbsp;Hyunchung Kim,&nbsp;Bruce Crawford,&nbsp;Taeko Ishii,&nbsp;Tamas Treuer","doi":"10.2174/1874312901711010043","DOIUrl":"https://doi.org/10.2174/1874312901711010043","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported outcomes (PRO) obtained through routine medical care may identify patients' day-to-day burden and help tackle the disease from the patients' perspective. However, there is a paucity of information regarding the availability of PRO data and PRO tools for rheumatoid arthritis (RA) in Japan.</p><p><strong>Objective: </strong>We reviewed the literature on PRO data availability and to identify PRO measures implemented in Japan for RA patients.</p><p><strong>Method: </strong>We conducted a systematic literature review using ICHUSHI and the PubMed databases on PRO measures for RA published from January 2011 to August 2015 in Japan.</p><p><strong>Results: </strong>After removing duplicates, 2423 manuscripts were found. From these, 100 manuscripts were included for review and analysis. We found 29 PRO tools that were used to assess various domains of health such as general well-being, pain, functionality, and fatigue. More than 90% of the studies utilized PRO tools for research purpose. Only one study reported PRO tool implementation in the routine medical care.</p><p><strong>Conclusion: </strong>The importance of PROs is recognized in Japan. PRO tools varied significantly and were mostly used for research purposes, while reports on the use of PRO measures in routine medical care were limited. Despite the awareness of PROs in the research community, unmet needs remain among RA patients in Japan. Further work is needed to investigate ways in which PROs can better reflect these unmet needs and be utilized in routine medical care.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"11 ","pages":"43-52"},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35035735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip Abductor Strengthening Improves Physical Function Following Total Knee Replacement: One-Year Follow-Up of a Randomized Pilot Study.","authors":"Karvannan Harikesavan,&nbsp;Raj D Chakravarty,&nbsp;Arun G Maiya,&nbsp;Sanjay P Hegde,&nbsp;Shivakumar Y Shivanna","doi":"10.2174/1874312901711010030","DOIUrl":"https://doi.org/10.2174/1874312901711010030","url":null,"abstract":"<p><strong>Background: </strong>Total knee replacement (TKR) is the commonest surgical procedure for patients with severe pain and impaired physical function following end stage knee osteoarthritis. The hip abductors are well renowned in stabilization of the trunk and hip during walking, maintaining the lower limb position, and transferring the forces from the lower limbs to the pelvis.</p><p><strong>Objective: </strong>To assess the efficacy of hip abductor strengthening exercise on functional outcome using performance based outcome measures following total knee replacement.</p><p><strong>Methods: </strong>An observer blinded randomized pilot trial design was conducted at Manipal hospital, Bangalore, India. Participants designated for elective TKR were randomized to experimental group hip abductor strengthening along with standard rehabilitation (n=10) or control group standard rehabilitation alone (n=10). Participants followed for one year to assess physical function using performance based outcomes, such as timed up and go test, single leg stance test, six minute walk test, knee extensor strength and hip abductor strength.</p><p><strong>Result: </strong>Eighteen participants with a mean age of 63.1 ± 5.5 years (8 Males and 10 Females) completed the study. Improvement in hip abduction strength, single leg stand test was superior in hip abductor strengthening group at 3 months and 1 year when compared to standard rehabilitation alone.</p><p><strong>Conclusion: </strong>Hip abductor strengthening showed superior improvements in single leg stance test and six minute walk test. Hip abductor strengthening exercises has the potential to improve physical function following total knee replacement.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"11 ","pages":"30-42"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874312901711010030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35047056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Cytokine Profile in Asian Indian Patients with Takayasu Arteritis and its Association with Disease Activity.","authors":"Ruchika Goel,&nbsp;Jayakanthan Kabeerdoss,&nbsp;Babu Ram,&nbsp;John Antony Jude Prakash,&nbsp;Sudhir Babji,&nbsp;Aswin Nair,&nbsp;Lakshmanan Jeyaseelan,&nbsp;Visalakshi Jeyaseelan,&nbsp;John Mathew,&nbsp;Veeraraghavan Balaji,&nbsp;George Joseph,&nbsp;Debashish Danda","doi":"10.2174/1874312901711010023","DOIUrl":"https://doi.org/10.2174/1874312901711010023","url":null,"abstract":"<p><strong>Background: </strong>Arterial inflammation Takayasu arteritis (TA) is an outcome of balance between pro- and anti-inflammatory cytokines. Comprehensive assessment of these cytokines is important for understanding pathogenesis and assessing disease activity.</p><p><strong>Objective: </strong>To study pro- and anti-inflammatory cytokines representing different T-helper cell pathway in serum samples of Asian Indian patients with TA and to assess their association with disease activity.</p><p><strong>Methods: </strong>Consecutive Indian patients with TA were assayed for serum interferon-γ, interleukin-6, interleukin-23, interleukin-17, interleukin-10 and transforming growth factor- β levels at baseline and follow up visit. Patients were grouped into active and stable disease based on Indian Takyasu Arteritis clinical Activity Score-2010. Serum levels of these cytokines between active and stable disease and between baseline and follow up visits were compared by non-parametric tests.</p><p><strong>Results: </strong>Among 32 patients enrolled, 15 were classified as active while 17 as stable disease at baseline. IFN-γ levels were significantly higher in active disease than stable disease (p=0.0129) while other cytokines did not differ significantly between 2 groups. Serum levels of none of the cytokines changed significantly over 2 visits in both responders and non-responders. IL23 levels positively correlate with disease duration ((r=0.999; p<0.005). Modest correlation was observed between IFN-γ and IL23 levels at both baseline and follow up and between IFN-γ and IL-6 and CRP at follow up.</p><p><strong>Conclusion: </strong>IFN-γ levels are raised in active disease in TA and correlates well with other biomarkers of disease activity and proinflammatory cytokines. There is also a direct correlation between Il-23 levels and disease duration.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"11 ","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34906336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Saline as a Placebo in Intra-articular Injections in Osteoarthritis: Potential Contributions to Nociceptive Pain Relief.","authors":"David Bar-Or,&nbsp;Leonard T Rael,&nbsp;Edward N Brody","doi":"10.2174/1874312901711010016","DOIUrl":"https://doi.org/10.2174/1874312901711010016","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis of the knee (OAK) is a severe debilitating condition characterized by joint pain, stiffness, and resultant limited mobility. In recent years, intra-articular (IA) injections have been used to relieve symptoms and have succeeded to varying degrees either with sodium hyaluronate preparations or with a biologic.</p><p><strong>Objective: </strong>The objective of this review is to evaluate multiple studies that demonstrate some relief from the symptoms of OAK in the saline arm of various clinical trials.</p><p><strong>Method: </strong>A thorough literature search (PubMed) was performed assessing the pain efficacy of various compounds compared to saline injections in clinical trials. A total of 73 studies were identified in the literature search including a total of 5,816 patients. These clinical trials all involved the IA injection of a viscosupplement (hyaluronate, platelet rich plasma (PRP), <i>etc</i>.) or a biologic (the low molecular weight fraction (< 5kDa) of human serum albumin (LMWF-5A)). For all of these studies, the control arm was injection of sterile physiological saline that approximates the salt concentration and total solute concentration of blood and most tissues.</p><p><strong>Results: </strong>Based on our review of the current literature, the tested compounds performed with mixed results when compared to saline injections. Moreover, OAK is a variable disease, with severity measured on the Kellgren and Lawrence (KL) scale where various hyaluronate preparations have a therapeutic effect mostly on KL 2-3 patients while a biologic works best on KL 3-4 patients.</p><p><strong>Conclusion: </strong>Since the effect of saline injection is always greater than no treatment, the evaluations of these treatments can be confounded in clinical trials. Therefore, the question of whether there are known therapeutic effects of saline injections might explain these results.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"11 ","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2017-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/c5/TORJ-11-16.PMC5366377.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34906335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Autoantibodies in Patients with Primary and Secondary Sjogren's Syndrome.","authors":"Ellen De Langhe,&nbsp;Xavier Bossuyt,&nbsp;Long Shen,&nbsp;Kishore Malyavantham,&nbsp;Julian L Ambrus,&nbsp;Lakshmanan Suresh","doi":"10.2174/1874312901711010010","DOIUrl":"https://doi.org/10.2174/1874312901711010010","url":null,"abstract":"<p><strong>Background: </strong>Antibodies to salivary gland protein 1 (SP1), carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP) were discovered in an animal model of Sjogren's syndrome (SS). Their expression was noted in patients with SS, especially those with lower focus scores on lip biopsies and those with early disease lacking antibodies to Ro and La.</p><p><strong>Objective: </strong>The current studies evaluated these autoantibodies in patients with long-standing SS expressing high levels of anti-Ro antibodies and in patients with Sjogren's syndrome secondary to systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and mixed connective tissue disease (MCTD).</p><p><strong>Method: </strong>Sera were obtained from patients and evaluated by ELISA for IgG, IgA and IgM antibodies to SP1, CA6 and PSP.</p><p><strong>Results: </strong>IgA anti-CA6 antibodies were noted in 38% of these patients, but anti-SP1, CA6 and PSP IgM or IgG antibodies were identified only in a minority of patients. In patients with secondary SS, antibodies to SP1/CA6/PSP were more sensitive and specific than anti-Ro .</p><p><strong>Conclusion: </strong>While more studies are needed, antibodies to SP1, CA6 and PSP provide valuable markers for the diagnosis of primary and secondary SS, especially early in the course of the disease.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"11 ","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2017-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/8a/TORJ-11-10.PMC5366390.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34906333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>ERAP1</i>, <i>IL23R</i> and <i>PTGER4</i> Polymorphisms with Radiographic Severity of Ankylosing Spondylitis.","authors":"Gulsen Ozen,&nbsp;Rabia Deniz,&nbsp;Fatih Eren,&nbsp;Can Erzik,&nbsp;Ali Ugur Unal,&nbsp;Sule Yavuz,&nbsp;Sibel Zehra Aydin,&nbsp;Nevsun Inanc,&nbsp;Haner Direskeneli,&nbsp;Pamir Atagunduz","doi":"10.2174/1874312901711010001","DOIUrl":"https://doi.org/10.2174/1874312901711010001","url":null,"abstract":"<p><strong>Background: </strong>Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early.</p><p><strong>Objective: </strong>To study the association between <i>ERAP1</i>, <i>IL23R</i> and <i>PTGER4</i> single nucleotide polymorphisms (SNPs) and radiographic severity in AS patients.</p><p><strong>Methods: </strong>rs27044 and rs30187 (<i>ERAP1</i>), rs11209032 (<i>IL23R</i>) and rs10440635 (<i>PTGER4</i>) SNPs were genotyped in 235 AS patients fulfilling the modified New York criteria. Patients were classified as mild- and severe-AS according to modified Stoke AS spinal score (mSASSS). Mild-AS is defined as having mSASSS of \"0\" following at least 10 years of disease duration. Severe-AS is defined as having mSASSS of >20 (patients with mild vertebral changes (<i>i.e.</i> squaring or erosions) were omitted for clear stratification) regardless of disease duration.</p><p><strong>Results: </strong>The genotype distributions and allele frequencies of <i>ERAP1</i> rs27044 and rs30187, <i>IL23R</i> rs11209032 and <i>PTGER4</i> rs10440635 SNPs were similar in mild- (n=171, mSASSS=0, 55.6% HLA-B27 positive) and severe-AS patients (n=64, mSASSS=48.5±17.8, 73.4% HLA-B27 positive). After adjustment for clinical differences between groups (gender, disease duration, HLA-B27 and smoking status) by logistic regression analysis, none of the alleles in the investigated SNPs were found to be associated with radiographic severity of AS.</p><p><strong>Conclusion: </strong>In radiographically well-categorized AS patients, <i>ERAP1</i> rs27044 and rs30187, <i>IL23R</i> rs11209032 and <i>PTGER4</i> rs10440635 SNPs are not found to be associated with radiographic severity of AS.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"11 ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/c8/TORJ-11-1.PMC5366379.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34906334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage Degeneration, Subchondral Mineral and Meniscal Mineral Densities in Hartley and Strain 13 Guinea Pigs.","authors":"Yubo Sun,&nbsp;Brian P Scannell,&nbsp;Patrick R Honeycutt,&nbsp;David R Mauerhan,&nbsp;James Norton H,&nbsp;Edward N Hanley","doi":"10.2174/1874312901409010065","DOIUrl":"https://doi.org/10.2174/1874312901409010065","url":null,"abstract":"<p><p>Osteoarthritis is a joint disease involved in articular cartilage, subchondral bone, meniscus and synovial membrane. This study sought to examine cartilage degeneration, subchondral bone mineral density (BMD) and meniscal mineral density (MD) in male Hartley, female Hartley and female strain 13 guinea pigs to determine the association of cartilage degeneration with subchondral BMD and meniscal MD. Cartilage degeneration, subchondral BMD and meniscal MD in 12 months old guinea pigs were examined with histochemistry, X-ray densitometry and calcium analysis. We found that male Hartley guinea pigs had more severe cartilage degeneration, subchondral BMD and meniscal MD than female Hartley guinea pigs, but not female strain 13 guinea pigs. Female strain 13 guinea pigs had more severe cartilage degeneration and higher subchondral BMD, but not meniscal MD, than female Hartley guinea pigs. These findings indicate that higher subchondral BMD, not meniscal MD, is associated with more severe cartilage degeneration in the guinea pigs and suggest that abnormal subchondral BMD may be a therapeutic target for OA treatment. These findings also indicate that the pathogenesis of OA in the male guinea pigs and female guinea pigs are different. Female strain 13 guinea pig may be used to study female gender-specific pathogenesis of OA. </p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"9 ","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/1a/TORJ-9-65.PMC4578142.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34199844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allele Specific Expression of MICA Variants in Human Fibroblasts Suggests a Pathogenic Mechanism.","authors":"Chunhua Shi,&nbsp;Hongye Li,&nbsp;Jacob P Couturier,&nbsp;Karen Yang,&nbsp;Xinjian Guo,&nbsp;Dongyi He,&nbsp;Dorothy E Lewis,&nbsp;Xiaodong Zhou","doi":"10.2174/1874312901409010060","DOIUrl":"https://doi.org/10.2174/1874312901409010060","url":null,"abstract":"<p><p>The major histocompatibility complex class I chain-related gene A (MICA) is involved in immune responses of both nature killer (NK) cells and subsets of T cells with its receptor NKG2D. MICA is highly polymorphic in sequence which leads to MICA protein variants with distinct features. Specific polymorphisms of MICA have been associated with inflammatory diseases, including ankylosing spondylitis (AS), ulcerative colitis (UC) and Behçet's disease. Studies herein characterize expression features of three MICA variants including MICA*008, a common variant in general population, and *MICA*007 and *019, which are associated with susceptibility to inflammatory diseases. MICA*019 was highly expressed on the surface of fibroblasts whereas expression of MICA*007 was the lowest in the culture supernatant. MICA*008 had low cell surface expression but was the only MICA allele in which exosomal material was detected. Surface or membrane-bound MICA activates NKG2D-mediated cytotoxicity, whereas soluble and exosomal MICAs down-regulate NKG2D. Therefore, comparisons of these three MICA variants in fibroblasts provides insight into understanding how MICA associated immune responses could be regulated to influence levels of inflammation. </p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"9 ","pages":"60-4"},"PeriodicalIF":0.0,"publicationDate":"2015-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/9f/TORJ-9-60.PMC4550945.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33964805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LETTER TO THE EDITOR Atypical Granulomatous Myositis and Pulmonary Sarcoidosis.","authors":"Renata Siciliani Scalco,&nbsp;Stefen Brady,&nbsp;Jefferson Becker,&nbsp;Irenio Gomes,&nbsp;Janice L Holton,&nbsp;Henrique L Staub","doi":"10.2174/1874312901409010057","DOIUrl":"https://doi.org/10.2174/1874312901409010057","url":null,"abstract":"A 45-year-old Brazilian white female was admitted with a four-year history of progressive proximal muscle weakness and myalgia. A chest radiogram was normal at the beginning of the clinical presentation. A few weeks before hospital admission, she developed diffuse weakness, dysphagia and exertion dyspnea. A physical examination showed weakness of facial and proximal muscles and severe wasting of hand muscles. Her family history was negative for neuromuscular diseases. The erythrocyte sedimentation rate was 92 mm in the first hour, and the serum creatine kinase level was high (6,683 IU/L, with a normal range being up to 176 IU/L). Antinuclear antibodies (1/640, granular pattern) and circulating anti-Ro/SSA antibodies (56.7 IU) were present. No other autoantibodies were found. A dried blood spot test for Pompe disease was negative. Neurophysiology assessment showed myopathic changes. A muscle biopsy performed 4 years after disease onset showed increased variation in fibre size, increased connective tissue, internal nuclei, occasional atrophic fibres and necrotic fibres. There was a prominent endomysial and perimysial inflammatory infiltrate composed of lymphoctes and macrophages with the formation of non-necrotic granulomas including small numbers of multinucleate giant cells (Fig. 1). A second piece of tissue taken from the same muscle showed no inflammatory features. Investigations for tuberculosis, fungi and brucellosis were negative. Lung computed tomography performed after 4 years of disease onset showed typical bilateral hilar lymphadenopathy and interstitial pneumonitis","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"9 ","pages":"57-9"},"PeriodicalIF":0.0,"publicationDate":"2015-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/c2/TORJ-9-57.PMC4541420.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33955913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}